Emery N Brown

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A statistical model of the human core-temperature circadian rhythm
    E N Brown
    Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Massachusetts Institute of Technology, Boston 02114 2696, USA
    Am J Physiol Endocrinol Metab 279:E669-83. 2000
  2. ncbi request reprint A stochastic differential equation model of diurnal cortisol patterns
    E N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 280:E450-61. 2001
  3. ncbi request reprint The time-rescaling theorem and its application to neural spike train data analysis
    Emery N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Neural Comput 14:325-46. 2002
  4. pmc Motor cortical networks for skilled movements have dynamic properties that are related to accurate reaching
    David F Putrino
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neural Plast 2011:413543. 2011
  5. pmc Local cortical dynamics of burst suppression in the anaesthetized brain
    Laura D Lewis
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain 136:2727-37. 2013
  6. pmc Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
    Laura D Lewis
    Department of Brain and Cognitive Sciences, Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:E3377-86. 2012
  7. ncbi request reprint An analysis of hippocampal spatio-temporal representations using a Bayesian algorithm for neural spike train decoding
    Riccardo Barbieri
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    IEEE Trans Neural Syst Rehabil Eng 13:131-6. 2005
  8. ncbi request reprint Construction of point process adaptive filter algorithms for neural systems using sequential Monte Carlo methods
    Ayla Ergun
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114 2698, USA
    IEEE Trans Biomed Eng 54:419-28. 2007
  9. pmc Statistical inference for assessing functional connectivity of neuronal ensembles with sparse spiking data
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    IEEE Trans Neural Syst Rehabil Eng 19:121-35. 2011
  10. pmc Active emergence from propofol general anesthesia is induced by methylphenidate
    Jessica J Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesthesiology 116:998-1005. 2012

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint A statistical model of the human core-temperature circadian rhythm
    E N Brown
    Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Massachusetts Institute of Technology, Boston 02114 2696, USA
    Am J Physiol Endocrinol Metab 279:E669-83. 2000
    ....
  2. ncbi request reprint A stochastic differential equation model of diurnal cortisol patterns
    E N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 280:E450-61. 2001
    ..Our modeling paradigm provides a framework for simulation studies and data analysis that should be readily adaptable to the analysis of other endocrine hormone systems...
  3. ncbi request reprint The time-rescaling theorem and its application to neural spike train data analysis
    Emery N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Neural Comput 14:325-46. 2002
    ..Our paradigm makes it possible to compare parametric and histogram-based neural spike train models directly. These results suggest that the time-rescaling theorem can be a valuable tool for neural spike train data analysis...
  4. pmc Motor cortical networks for skilled movements have dynamic properties that are related to accurate reaching
    David F Putrino
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neural Plast 2011:413543. 2011
    ..The results of this study indicate that reach-related neurons in MI form dynamic spiking dependencies whose temporal features are highly sensitive to unforced movement errors...
  5. pmc Local cortical dynamics of burst suppression in the anaesthetized brain
    Laura D Lewis
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain 136:2727-37. 2013
    ..Overall, these results suggest new research directions and methods that could improve patient monitoring in clinical practice. ..
  6. pmc Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
    Laura D Lewis
    Department of Brain and Cognitive Sciences, Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:E3377-86. 2012
    ....
  7. ncbi request reprint An analysis of hippocampal spatio-temporal representations using a Bayesian algorithm for neural spike train decoding
    Riccardo Barbieri
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    IEEE Trans Neural Syst Rehabil Eng 13:131-6. 2005
    ..95 confidence regions was 0.71. These results illustrate how the Bayesian neural spike train decoding paradigm may be used to investigate spatio-temporal representations of position by an ensemble of hippocampal neurons...
  8. ncbi request reprint Construction of point process adaptive filter algorithms for neural systems using sequential Monte Carlo methods
    Ayla Ergun
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114 2698, USA
    IEEE Trans Biomed Eng 54:419-28. 2007
    ..Our results suggest an approach for constructing point process adaptive filters using SMC methods...
  9. pmc Statistical inference for assessing functional connectivity of neuronal ensembles with sparse spiking data
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    IEEE Trans Neural Syst Rehabil Eng 19:121-35. 2011
    ..The identification of spiking dependencies in physiologically acquired data was encouraging, since their sparse nature would have previously precluded them from successful analysis using traditional methods...
  10. pmc Active emergence from propofol general anesthesia is induced by methylphenidate
    Jessica J Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesthesiology 116:998-1005. 2012
    ..The objective of this study was to test the hypothesis that methylphenidate actively induces emergence from propofol general anesthesia...
  11. pmc Assessment of hippocampal and autonomic neural activity by point process models
    Riccardo Barbieri
    Neuroscience Statistics Research Laboratory, Dept of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:3679. 2008
    ..The first studies how hippocampal neural activity represents and transmits information, whereas the second is aimed at characterizing activity of the central autonomic network as involved in cardiovascular control...
  12. pmc Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression
    Jessica Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 10:056017. 2013
    ....
  13. doi request reprint Feedback-controlled parallel point process filter for estimation of goal-directed movements from neural signals
    Maryam M Shanechi
    Department of Electrical Engineering and Computer Science EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Neural Syst Rehabil Eng 21:129-40. 2013
    ..Using the feedback-controlled model and even a coarse discretization, the decoder significantly reduces the root mean square error in estimation of reaching movements performed by a monkey...
  14. pmc Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:5336-9. 2009
    ..Our proposed statistical indices provide a valuable quantitative assessment of instantaneous cardiorespiratory control and heart rate variability (HRV) during general anesthesia...
  15. ncbi request reprint General-purpose filter design for neural prosthetic devices
    Lakshminarayan Srinivasan
    Center for Nervous System Repair, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurophysiol 98:2456-75. 2007
    ..These simulated results predict that the unified framework outperforms previous approaches under various conditions, in the control of position and velocity, based on trajectory and endpoint mean squared errors...
  16. ncbi request reprint Dynamic analyses of information encoding in neural ensembles
    Riccardo Barbieri
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Neural Comput 16:277-307. 2004
    ..These findings improve significantly on our previous results and suggest an integrated approach to dynamically reading neural codes, measuring their properties, and quantifying the accuracy with which encoded information is extracted...
  17. pmc Assessment of autonomic control and respiratory sinus arrhythmia using point process models of human heart beat dynamics
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 56:1791-802. 2009
    ..Our paradigm suggests a possible framework for designing a device for ambulatory monitoring and assessment of autonomic control in both laboratory research and clinical practice...
  18. pmc Characterizing nonlinear heartbeat dynamics within a point process framework
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:2781-4. 2008
    ..The proposed probabilistic model was examined with two recorded heartbeat interval data sets. Preliminary results show that our model is beneficial to characterize the inherent nonlinearity of the heartbeat dynamics...
  19. pmc A transition in brain state during propofol-induced unconsciousness
    Eran A Mukamel
    Swartz Program for Theoretical Neuroscience, Harvard University, Cambridge, Massachusetts 02138, Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California 92093 and Computational Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California 92037, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Harvard Medical School, Boston, Massachusetts 02115, Division of Health Science and Technology, Harvard Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
    J Neurosci 34:839-45. 2014
    ..These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia. ..
  20. pmc Thalamocortical mechanisms for the anteriorization of α rhythms during propofol-induced unconsciousness
    Sujith Vijayan
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 33:11070-5. 2013
    ..Our model generalizes to other anesthetics that include GABA as a target, since the molecular targets of many such anesthetics alter the model dynamics in a manner similar to that of propofol. ..
  21. pmc Electroencephalogram signatures of loss and recovery of consciousness from propofol
    Patrick L Purdon
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:E1142-51. 2013
    ....
  22. pmc Uncovering spatial topology represented by rat hippocampal population neuronal codes
    Zhe Chen
    Neuroscience Statistics Research Lab, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Comput Neurosci 33:227-55. 2012
    ..This study would also provide useful insights for future exploratory data analysis of population neuronal codes during periods of sleep...
  23. pmc Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia
    Kin Foon Kevin Wong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:4705-8. 2011
    ..The posterior probability densities of model parameters and the response probability are computed within a Bayesian framework using Markov Chain Monte Carlo methods...
  24. pmc Characterizing nonlinear heartbeat dynamics within a point process framework
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 57:1335-47. 2010
    ..In comparison to other nonlinear modeling approaches, the point process probability model is useful in revealing nonlinear heartbeat dynamics at a fine timescale and with only short duration recordings...
  25. pmc A differential autoregressive modeling approach within a point process framework for non-stationary heartbeat intervals analysis
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:3567-70. 2010
    ..Results further demonstrate the ability of the method to appropriately quantify the non-stationary evolution of baroreflex sensitivity in changing physiological and pharmacological conditions...
  26. pmc Analysis of between-trial and within-trial neural spiking dynamics
    Gabriela Czanner
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA, USA
    J Neurophysiol 99:2672-93. 2008
    ....
  27. pmc Discrete- and continuous-time probabilistic models and algorithms for inferring neuronal UP and DOWN states
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neural Comput 21:1797-862. 2009
    ..Our approach provides a statistical characterization of UP-DOWN state dynamics that can serve as a basis for verifying and refining mechanistic descriptions of this process...
  28. pmc Using point process models to compare neural spiking activity in the subthalamic nucleus of Parkinson's patients and a healthy primate
    Sridevi V Sarma
    Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 57:1297-305. 2010
    ..The point process framework suggests a useful approach for developing quantitative neural correlates that may be related directly to the movement and behavioral disorders characteristic of PD...
  29. pmc Denoising two-photon calcium imaging data
    Wasim Q Malik
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e20490. 2011
    ..This approach to analyzing two-photon calcium imaging data may be readily adapted to other computational biology problems which apply correlated noise models...
  30. pmc A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis
    Oluwaseun Akeju
    From the Department of Anesthesia, Critical Care, and Pain Medicine O A, K J P, R V, M J P, P G H, K E H, J R, A L S, G L, E T P, J L W, E N B, P L P and Department of Neurology M B W, Massachusetts General Hospital, Boston, Massachusetts Clinical Research Center, Massachusetts General Hospital, Boston, Massachusetts K H Harvard Medical School, Boston, Massachusetts O A, M B W, R V, M J P, P G H, J R, G L, E T P, J L W, E N B, P L P Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, University of Southern Colorado
    Anesthesiology 121:978-89. 2014
    ..However, these drugs have different molecular mechanisms and behavioral properties and are likely accompanied by distinguishing neural circuit dynamics...
  31. doi request reprint Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling
    Kin Foon Kevin Wong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02129, USA
    IEEE Trans Biomed Eng 60:1118-25. 2013
    ..This paradigm can be readily adapted to analyze the dynamics of other respiratory variables before and after pharmacologic treatments...
  32. pmc Functional biases in visual cortex neurons with identified projections to higher cortical targets
    Beata Jarosiewicz
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Biol 22:269-77. 2012
    ....
  33. pmc Dynamic assessment of baroreflex control of heart rate during induction of propofol anesthesia using a point process method
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Biomed Eng 39:260-76. 2011
    ....
  34. ncbi request reprint Analyzing functional connectivity using a network likelihood model of ensemble neural spiking activity
    Murat Okatan
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114 2698, USA
    Neural Comput 17:1927-61. 2005
    ..These results suggest that the network likelihood model can be an efficient tool for the analysis of ensemble spiking activity...
  35. doi request reprint Differential involvement of excitatory and inhibitory neurons of cat motor cortex in coincident spike activity related to behavioral context
    David Putrino
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 30:8048-56. 2010
    ..Different populations of excitatory and inhibitory neurons appear to be synchronized during skilled movement and quiet sitting...
  36. pmc Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats
    Jonathan D Kenny
    From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts
    Anesth Analg 123:1210-1219. 2016
    ..The objective of this study was to test the hypothesis that physostigmine, a centrally acting cholinesterase inhibitor, induces reanimation from isoflurane anesthesia in adult rats...
  37. pmc A closed-loop anesthetic delivery system for real-time control of burst suppression
    Max Y Liberman
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Neural Eng 10:046004. 2013
    ..Our objective is to design a CLAD system for burst suppression control to automate management of medically-induced coma...
  38. pmc Neural population partitioning and a concurrent brain-machine interface for sequential motor function
    Maryam M Shanechi
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 15:1715-22. 2012
    ..On the basis of these findings, we developed a BMI that concurrently decodes a full motor sequence in advance of movement and can then accurately execute it as desired...
  39. ncbi request reprint Hippocampal plasticity across multiple days of exposure to novel environments
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 24:7681-9. 2004
    ..These results show that the hippocampus can form new spatial representations quickly but that stable hippocampal representations are not sufficient for a place to be treated as familiar...
  40. ncbi request reprint Analysis of heartbeat dynamics by point process adaptive filtering
    Riccardo Barbieri
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston 02114 2696, USA
    IEEE Trans Biomed Eng 53:4-12. 2006
    ..Our results suggest a new approach for characterizing heartbeat dynamics...
  41. ncbi request reprint Dynamic analysis of neural encoding by point process adaptive filtering
    Uri T Eden
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, and Division of Health Sciences and Technology, Harvard Medical School Massachusetts Institute of Technology, Cambridge, MA, USA
    Neural Comput 16:971-98. 2004
    ..Our results provide a paradigm for adaptive estimation for point process observations and suggest a practical approach for constructing filtering algorithms to track neural receptive field dynamics on a millisecond timescale...
  42. ncbi request reprint Adaptive filtering for global interference cancellation and real-time recovery of evoked brain activity: a Monte Carlo simulation study
    Quan Zhang
    Harvard Medical School, Massachusetts General Hospital, Neural Systems Group, 13th Street, Building 149, Room 2651, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:044014. 2007
    ..The technique can be performed in real time, an important feature required for applications such as brain activity localization, biofeedback, and potential neuroprosthetic devices...
  43. pmc Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness
    Kin Foon Kevin Wong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA Electronic address
    J Neurosci Methods 227:65-74. 2014
    ....
  44. pmc Real-time segmentation of burst suppression patterns in critical care EEG monitoring
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 219:131-41. 2013
    ..Develop a real-time algorithm to automatically discriminate suppressions from non-suppressions (bursts) in electroencephalograms of critically ill adult patients...
  45. pmc Real-time closed-loop control in a rodent model of medically induced coma using burst suppression
    Shinung Ching
    Research Fellow, Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts Research Fellow, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts Research Assistant, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Instructor, Department of Neurology, Harvard Medical School Assistant in Neurology, Department of Neurology, Massachusetts General Hospital Assistant Professor, Department of Anaesthesia, Harvard Medical School Assistant Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Instructor, Department of Anaesthesia, Harvard Medical School Instructor, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Warren M Zapol Professor of Anaesthesia, Department of Anaesthesia, Harvard Medical School Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Professor of Computational Neuroscience
    Anesthesiology 119:848-60. 2013
    ..The authors hypothesized that a closed-loop anesthetic delivery system could automatically and precisely control the electroencephalogram state of burst suppression and efficiently maintain a medically induced coma...
  46. pmc A spatiotemporal dynamic distributed solution to the MEG inverse problem
    Camilo Lamus
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, USA
    Neuroimage 63:894-909. 2012
    ....
  47. pmc Instantaneous assessment of autonomic cardiovascular control during general anesthesia
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:8444-7. 2011
    ....
  48. doi request reprint Broad range of neural dynamics from a time-varying FitzHugh-Nagumo model and its spiking threshold estimation
    Rose T Faghih
    Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, MA 02139, USA
    IEEE Trans Biomed Eng 59:816-23. 2012
    ..We demonstrate that the dynamics of the spiking threshold can be recovered even in the absence of complete specifications for the system...
  49. ncbi request reprint Dynamic analysis of learning in behavioral experiments
    Anne C Smith
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    J Neurosci 24:447-61. 2004
    ....
  50. pmc Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness
    Shinung Ching
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:22665-70. 2010
    ..The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state...
  51. pmc Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum
    Terra D Barnes
    McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, MA 02139, USA
    J Neurophysiol 105:1861-78. 2011
    ..Deficits in such representations of learned sequential behaviors could contribute to motor and cognitive problems in a range of neurological disorders affecting the basal ganglia, including Parkinson's disease...
  52. pmc Single-neuron dynamics in human focal epilepsy
    Wilson Truccolo
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:635-41. 2011
    ..These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons...
  53. pmc Methylphenidate actively induces emergence from general anesthesia
    Ken Solt
    Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:791-803. 2011
    ..In this study, the authors tested the hypothesis that methylphenidate (an inhibitor of dopamine and norepinephrine transporters) induces emergence from isoflurane general anesthesia...
  54. pmc Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations
    Oluwaseun Akeju
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America
    PLoS ONE 11:e0163431. 2016
    ..Additionally, these signatures may aid the development of control systems for principled neurophysiological based brain-state targeting...
  55. doi request reprint Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent
    Luca Citi
    Neuroscience Statistics Research Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:3124-7. 2012
    ..Further investigation will focus on evolving our mathematical approach towards a promising monitoring tool for an accurate, noninvasive assessment of general anesthesia...
  56. ncbi request reprint Multiple neural spike train data analysis: state-of-the-art and future challenges
    Emery N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Division of Health Sciences and Technology, Harvard Medical School, Boston, 02114, USA
    Nat Neurosci 7:456-61. 2004
    ..Here we review statistical methods for the analysis of multiple neural spike-train data and discuss future challenges for methodology research...
  57. pmc A hierarchical Bayesian approach for learning sparse spatio-temporal decompositions of multichannel EEG
    Wei Wu
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroimage 56:1929-45. 2011
    ....
  58. pmc Efficient decoding with steady-state Kalman filter in neural interface systems
    Wasim Q Malik
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    IEEE Trans Neural Syst Rehabil Eng 19:25-34. 2011
    ..This far more efficient neural decoding approach will facilitate the practical implementation of future large-dimensional, multisignal neural interface systems...
  59. ncbi request reprint An application of reversible-jump Markov chain Monte Carlo to spike classification of multi-unit extracellular recordings
    David P Nguyen
    Neuroscience Statistics Research Laboratory, Department of Anesthesia, Massachusetts General Hospital, Division of Health Sciences, Harvard Medical School Massachusetts Institute of Technology, Boston, MA 02114, USA
    Network 14:61-82. 2003
    ..Our findings suggest that a reversible-jump MCMC algorithm could offer a new strategy for designing automated spike-sorting algorithms...
  60. pmc Tracking brain states under general anesthesia by using global coherence analysis
    Aylin Cimenser
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:8832-7. 2011
    ..Our findings suggest that combined spectral and global coherence analyses may offer a new approach to tracking brain states under general anesthesia...
  61. doi request reprint A probabilistic framework for learning robust common spatial patterns
    Wei Wu
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4658-61. 2009
    ..The efficacy of the proposed robust algorithm is validated with both simulated and real EEG data...
  62. doi request reprint Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia
    Fanuel Muindi
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, United States Electronic address
    Behav Brain Res 306:20-5. 2016
    ..The results are consistent with the hypothesis that the PBN provides critical arousal input during emergence from isoflurane anesthesia. ..
  63. pmc The human burst suppression electroencephalogram of deep hypothermia
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Department of Neurology, Harvard Medical School, Boston, MA, USA Electronic address
    Clin Neurophysiol 126:1901-14. 2015
    ..We set out to investigate the electroencephalogram changes induced by cooling the human brain through increasing depths of BS through isoelectricity...
  64. pmc A real-time automated point-process method for the detection and correction of erroneous and ectopic heartbeats
    Luca Citi
    Department of Anesthesia, Massachusetts General Hospital Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Biomed Eng 59:2828-37. 2012
    ....
  65. pmc Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia
    Norman E Taylor
    Department of Anaesthesia, Harvard Medical School, Boston, MA, USA
    Anesthesiology 118:30-9. 2013
    ..Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia...
  66. pmc Mapping of visual receptive fields by tomographic reconstruction
    Gordon Pipa
    Neuroscience Statistics Research Lab, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neural Comput 24:2543-78. 2012
    ....
  67. pmc Eye movements modulate the spatiotemporal dynamics of word processing
    Simona Temereanca
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
    J Neurosci 32:4482-94. 2012
    ..Together, these results suggest a complex interplay between visual and central saccadic mechanisms during reading...
  68. pmc A neurophysiological-metabolic model for burst suppression
    Shinung Ching
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:3095-100. 2012
    ..Consequently, the model makes a number of specific predictions of experimental and clinical relevance...
  69. pmc Robust time-varying multivariate coherence estimation: application to electroencephalogram recordings during general anesthesia
    Kin Foon Kevin Wong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:4725-8. 2011
    ....
  70. pmc A regularized point process generalized linear model for assessing the functional connectivity in the cat motor cortex
    Zhe Chen
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:5006-9. 2009
    ..The point process model was applied to an ensemble of neurons recorded from the cat motor cortex during a skilled reaching task. The implications of this analysis to the coding of skilled movement in primary motor cortex is discussed...
  71. ncbi request reprint Persistent activity and memory in the entorhinal cortex
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Neurosci 26:400-1. 2003
    ..These findings suggest that layer-5 EC neurons could play a central role in the formation of associations among stimuli that occur at different times...
  72. pmc Static and dynamic autonomic response with increasing nausea perception
    Lauren T LaCount
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth St, 2301, Charlestown, MA 02129, USA
    Aviat Space Environ Med 82:424-33. 2011
    ..Nausea is a commonly occurring symptom typified by epigastric discomfort with urge to vomit. The relationship between autonomic nervous system (ANS) outflow and increasing nausea perception is not fully understood...
  73. pmc A point process model for auditory neurons considering both their intrinsic dynamics and the spectrotemporal properties of an extrinsic signal
    Eric Plourde
    Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 58:1507-10. 2011
    ..The STRF-like representation estimated jointly with the neuron's intrinsic dynamics may offer more accurate characterizations of neural activity in the auditory system than current ones based solely on the STRF...
  74. pmc Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis
    Premananda Indic
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Early Hum Dev 87:477-87. 2011
    ....
  75. pmc A statistical model for multiphoton calcium imaging of the brain
    Wasim Q Malik
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:7002-5. 2009
    ..We apply this model to in vivo characterization of cells from the ferret visual cortex. The results demonstrate substantially improved tuning curve fitting and image contrast...
  76. pmc Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex
    Corey J Keller
    Department of Neurology, 30 Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Brain 133:1668-81. 2010
    ....
  77. ncbi request reprint Correction of erroneous and ectopic beats using a point process adaptive algorithm
    Riccardo Barbieri
    Dept of Anesthesia and Critical Care, Massachusetts Gen Hosp, Boston, MA 02114 2696, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3373-6. 2006
    ..Results demonstrate the efficacy of the method, and show new heart rate and heart rate variability dynamics corrected for artifacts introduced by incorrect and/or irregular R-R intervals...
  78. pmc Point-process analysis of neural spiking activity of muscle spindles recorded from thin-film longitudinal intrafascicular electrodes
    Luca Citi
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:2311-4. 2011
    ..This important result is a first step towards a point process decoding algorithm to estimate the muscle length and possibly provide closed loop Functional Electrical Stimulation (FES) systems with natural sensory feedback information...
  79. doi request reprint Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case study
    Quan Zhang
    Massachusetts General Hospital, Harvard Medical School, Neural Systems Group, 13th Street, Building 149, Room 2651, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:064009. 2007
    ..In addition, the results suggested that association between the superficial layer hemodynamics and the total global interference is time-varying...
  80. pmc Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker
    Premananda Indic
    Biomathematical Modeling Unit, Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Chronobiol Int 22:613-29. 2005
    ..Experiments derived from model predictions are proposed to test the influence of low amplitude recovery on the physiological and neurobehavioral functions...
  81. ncbi request reprint Analysis and design of behavioral experiments to characterize population learning
    Anne C Smith
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Clinics 3, Boston, MA 02114 2696, USA
    J Neurophysiol 93:1776-92. 2005
    ..The SSRE model offers a practical approach to dynamic analysis of population learning and a theoretical framework for optimal design of learning experiments...
  82. ncbi request reprint Measuring period of human biological clock: infill asymptotic analysis of harmonic regression parameter estimates
    Emery N Brown
    Department of Anesthesia and Critical Care, Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute Technology, Boston, Massachusetts 02114, USA
    Methods Enzymol 383:382-405. 2004
  83. pmc Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation
    Michelle M McCarthy
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:13488-504. 2008
    ..As correlates of behavioral phenomenology, these networks may refine our understanding of the specific behavioral states associated with general anesthesia...
  84. ncbi request reprint A statistical model of diurnal variation in human growth hormone
    Elizabeth B Klerman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E1118-26. 2003
    ..Our analysis paradigm suggests an approach to decomposing GH diurnal patterns that can be used to characterize the physiological properties of this hormone under normal and pathological conditions...
  85. pmc Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia
    Patrick L Purdon
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1157:61-70. 2009
    ....
  86. ncbi request reprint Contrasting patterns of receptive field plasticity in the hippocampus and the entorhinal cortex: an adaptive filtering approach
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard University Massachusetts Institute of Technology, Boston, Massachusetts 02114, USA
    J Neurosci 22:3817-30. 2002
    ..We hypothesize that this subset of deep EC neurons may receive more direct input from CA1 and may be part of a neural circuit that transmits information about the animal's location to the neocortex...
  87. ncbi request reprint Estimating a state-space model from point process observations
    Anne C Smith
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, U S A
    Neural Comput 15:965-91. 2003
    ..We illustrate the model with two simulated data examples: an ensemble of Poisson neurons driven by a common stimulus and a single neuron whose conditional intensity function is approximated as a local Bernoulli process...
  88. pmc A synaptic strategy for consolidation of convergent visuotopic maps
    Marnie A Phillips
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 71:710-24. 2011
    ..These data implicate spike-timing plasticity as a mechanism for cortical input survival, and support a cooperative strategy for retinal and cortical coinnervation of the sSC...
  89. pmc Rapid changes in thalamic firing synchrony during repetitive whisker stimulation
    Simona Temereanca
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 28:11153-64. 2008
    ....
  90. pmc Mathematical model of network dynamics governing mouse sleep-wake behavior
    Cecilia G Diniz Behn
    Department of Mathematics and Center for BioDynamics, Boston University, MA, USA
    J Neurophysiol 97:3828-40. 2007
    ..Because circadian and other factors alter the fine architecture of sleep-wake behavior, this model provides a novel framework to explore dynamical principles that may underlie normal and pathologic sleep-wake physiology...
  91. ncbi request reprint Spatiotemporal wavelet analysis for functional MRI
    Chris Long
    MGH HMS MIT Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 23:500-16. 2004
    ..Our spatiotemporal wavelet framework suggests a useful tool for the analysis of fMRI studies...
  92. ncbi request reprint Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI
    Giorgio Bonmassar
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroimage 16:1127-41. 2002
    ..Our adaptive filter approach can be implemented in real-time to allow for continuous monitoring of EEG and fMRI during clinical and cognitive studies...
  93. pmc A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control
    Zhe Chen
    Neuroscience Statistics Research Lab, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA
    Front Physiol 3:4. 2012
    ..We also discuss the limitations and other alternative modeling strategies of our point process approach...
  94. pmc Activity in the barrel cortex during active behavior and sleep
    Sujith Vijayan
    Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    J Neurophysiol 103:2074-84. 2010
    ..These data suggest that low firing rates do not typify the output of the barrel cortex during awake activity and during sleep and indicate that sensory coding at both the individual and population levels may be nonsparse...
  95. pmc Brain correlates of autonomic modulation: combining heart rate variability with fMRI
    Vitaly Napadow
    MGH MIT HMS Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02119, USA
    Neuroimage 42:169-77. 2008
    ..Our approach should be optimized and applied to study the human brain correlates of autonomic modulation for various stimuli in both physiological and pathological states...
  96. pmc Application of dynamic point process models to cardiovascular control
    Riccardo Barbieri
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Jackson 4, 55 Fruit Street, Boston, MA 02114, USA
    Biosystems 93:120-5. 2008
    ....
  97. ncbi request reprint A state-space analysis for reconstruction of goal-directed movements using neural signals
    Lakshminarayan Srinivasan
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neural Comput 18:2465-94. 2006
    ..The corresponding reconstruction procedure may also be useful in brain-driven prosthetic devices to generate control signals for goal-directed movements...
  98. ncbi request reprint A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability
    Riccardo Barbieri
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Clinics 3, Boston, MA 02114 2696, USA
    Am J Physiol Heart Circ Physiol 288:H424-35. 2005
    ....
  99. pmc General anesthesia and altered states of arousal: a systems neuroscience analysis
    Emery N Brown
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Neurosci 34:601-28. 2011
    ..Each altered arousal state results from the anesthetic drugs acting at multiple targets in the central nervous system. Our analysis shows that general anesthesia is less mysterious than currently believed...
  100. doi request reprint The Fitzhugh-Nagumo model: Firing modes with time-varying parameters & parameter estimation
    Rose T Faghih
    Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:4116-9. 2010
    ....
  101. pmc Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex
    Wei Chung Allen Lee
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Biol 4:e29. 2006
    ..These results are consistent with the idea that dendritic structural remodeling is a substrate for adult plasticity and they suggest that circuit rearrangement in the adult cortex is restricted by cell type-specific rules...