Edward B Brown

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
    Mark Stroh
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Nat Med 11:678-82. 2005
  2. ncbi request reprint Measurement of macromolecular diffusion coefficients in human tumors
    Edward B Brown
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Boston, MA 02114, USA
    Microvasc Res 67:231-6. 2004
  3. ncbi request reprint Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors
    George Alexandrakis
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 10:203-7. 2004
  4. pmc Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo
    Vikash P Chauhan
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biophys J 97:330-6. 2009
  5. pmc Diffusion and convection in collagen gels: implications for transport in the tumor interstitium
    Saroja Ramanujan
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biophys J 83:1650-60. 2002
  6. ncbi request reprint Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
    Robert B Campbell
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 62:6831-6. 2002
  7. ncbi request reprint Differential transplantability of tumor-associated stromal cells
    Dan G Duda
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 64:5920-4. 2004
  8. pmc Red blood cells augment leukocyte rolling in a virtual blood vessel
    Cristiano Migliorini
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Biophys J 83:1834-41. 2002
  9. ncbi request reprint Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002
  10. pmc Real-time imaging of nuclear permeation by EGFP in single intact cells
    Xunbin Wei
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Biophys J 84:1317-27. 2003

Collaborators

Detail Information

Publications15

  1. pmc Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
    Mark Stroh
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Nat Med 11:678-82. 2005
    ..These examples show the versatility of quantum dots for studying tumor pathophysiology and creating avenues for treatment...
  2. ncbi request reprint Measurement of macromolecular diffusion coefficients in human tumors
    Edward B Brown
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Boston, MA 02114, USA
    Microvasc Res 67:231-6. 2004
    ..These measurements should help in modeling the transport of novel large MW therapeutics, and hence in estimating their distribution and efficacy in tumors...
  3. ncbi request reprint Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors
    George Alexandrakis
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 10:203-7. 2004
    ..The ratio of these two components depends on molecular size and can be altered in vivo with hyaluronidase and collagenase. These studies indicate that TPFCM is a promising tool to dissect the barriers to drug delivery in tumors...
  4. pmc Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo
    Vikash P Chauhan
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biophys J 97:330-6. 2009
    ..Through these studies, we show that interstitial hyaluronan paradoxically improves diffusion and that reducing cellularity enhances diffusive macromolecular transport in solid tumors...
  5. pmc Diffusion and convection in collagen gels: implications for transport in the tumor interstitium
    Saroja Ramanujan
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biophys J 83:1650-60. 2002
    ..These findings have significant implications for drug delivery in tumors and for tissue engineering applications...
  6. ncbi request reprint Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
    Robert B Campbell
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 62:6831-6. 2002
    ..Our results suggest that optimizing physicochemical properties of liposomes that exploit physiological features of tumors and control the intratumor distribution of these drug carriers should improve vascular-specific delivery...
  7. ncbi request reprint Differential transplantability of tumor-associated stromal cells
    Dan G Duda
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 64:5920-4. 2004
    ..These studies of tumor tissue transplantation provide a platform for exploring the role of epithelial-stromal interactions in studies of tumor heterogeneity and drug resistance...
  8. pmc Red blood cells augment leukocyte rolling in a virtual blood vessel
    Cristiano Migliorini
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Biophys J 83:1834-41. 2002
    ..This novel approach can be applied to a large number of biological and industrial problems involving the complex flow of particulate suspensions...
  9. ncbi request reprint Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002
    ..These findings suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically...
  10. pmc Real-time imaging of nuclear permeation by EGFP in single intact cells
    Xunbin Wei
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Biophys J 84:1317-27. 2003
    ..We also found that EGFP exchange was not altered significantly during the cell cycle...
  11. ncbi request reprint A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy
    James A Tyrrell
    Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180 3590, USA
    Microvasc Res 70:165-78. 2005
    ..The resulting measures are expressed in units of information (bits). Synthetic and real-data examples are provided to illustrate the proposed measures...
  12. ncbi request reprint Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series
    Muhammad Amri Abdul-Karim
    Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Microvasc Res 66:113-25. 2003
    ....
  13. pmc Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching
    Hartmut Schmidt
    Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
    Biophys J 84:2599-608. 2003
    ..Our experimental approach represents a versatile tool for quantifying the mobility of proteins in neuronal dendrites...
  14. ncbi request reprint Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones
    Hartmut Schmidt
    Carl Ludwig Institut für Physiologie, Abteilung Neurophysiologie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    J Neurochem 100:727-35. 2007
    ..Our findings support the notion that PV functions as a pure Ca(2+) buffer and will aid simulations of neuronal Ca(2+) signalling...
  15. ncbi request reprint Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma
    Xiaoxing Han
    Institute of Optics, University of Rochester, Rochester, NY, 14627, USA
    Opt Express 16:1846-59. 2008
    ..This suggests that the SHGproducing subpopulation of collagen is unaffected by the altered collagen synthesis of the tumor stroma, and protected from its aberrant degradative environment...