Kevin G Broadbelt
Affiliation: Harvard University
- Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndromeKevin G Broadbelt
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Proteomics 11:M111.009530. 2012..These data suggest a potential molecular defect in SIDS related to TPH2 regulation, as 14-3-3 is critical in this process...
- Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American populationKevin G Broadbelt
Department of Pathology, Enders Building Room 1111, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Res 66:631-5. 2009..128-(191_192)dupA). The polymorphism seems to be a common, likely nonpathogenic, variant in the African-American population...
- Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medullaKevin G Broadbelt
Department of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
Auton Neurosci 154:30-41. 2010..The developmental profile of GABAergic markers changed dramatically relative to the 5-HT markers. These data provide baseline information for medullary studies of human pediatric disorders, such as sudden infant death syndrome...
- Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndromeKevin G Broadbelt
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Neuropathol Exp Neurol 70:799-810. 2011..026). These data suggest that medullary GABAA receptors are abnormal in SIDS infants and that SIDS is a complex disorder of a homeostatic network in the medulla that involves deficits of the GABAergic and 5-HT systems...
- Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego DatasetDavid S Paterson
Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 68:409-13. 2010..These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS...
- Late development of the GABAergic system in the human cerebral cortex and white matterGang Xu
Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neuropathol Exp Neurol 70:841-58. 2011..This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant...
- Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infantsBradley B Randall
Department of Pathology, Enders Building Room 1112, Boston Children s Hospital, 61 Binney St, Boston, MA 02115
Pediatrics 132:e1616-25. 2013..g., supine), whereas infants with intermediate or borderline brainstem deficiencies require asphyxial stressors to precipitate death...
- The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasisHannah C Kinney
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, United States
J Chem Neuroanat 41:182-99. 2011..The delineation of the development and organization of the human caudal 5-HT system provides the critical foundation for the neuropathologic elucidation of its disorders directly in the human brain...
- Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage StudyRobin L Haynes
From the Department of Pathology, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts RLH, RDF, DSP, KGB, HT, HCK Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts RDF Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa SDZ, RHH, PS, EG Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa JJD, EB, SW National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa CW Department of Pathology, University of North Dakota, Grand Forks, North Dakota MAS Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota LN, BBR Community and Population Health Sciences, Sanford Research
J Neuropathol Exp Neurol . 2016..This study demonstrates feasibility of 5-HT1A binding analysis in the medulla in the Safe Passage Study...