Affiliation: Harvard University
- RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in miceArturo Bravo-Nuevo
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Pathol 178:245-52. 2011..We propose that RhoB is a modifier of diabetes, important for the induction of β-cell loss. Suppression of RhoB expression may have potential application in the treatment of diabetes and associated complications...
- RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesisShiva Kazerounian
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Cancer Res 73:50-61. 2013..More generally, they illustrate how differential gene function effects on signaling pathways in the tumor stromal component can complicate the challenge of developing therapeutics to target cancer pathophysiology...
- RhoB deficiency in thymic medullary epithelium leads to early thymic atrophyArturo Bravo-Nuevo
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Int Immunol 23:593-600. 2011..Nevertheless, our findings strongly support a physiological role of RhoB in regulation of thymus development and maintenance through the inhibition of TGF-β signaling in thymic medullary epithelium...