Genomes and Genes
Affiliation: Harvard University
- Localization of apical epithelial determinants by the basolateral PDZ protein ScribbleD Bilder
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 403:676-80. 2000..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions...
- Cooperative regulation of cell polarity and growth by Drosophila tumor suppressorsD Bilder
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Science 289:113-6. 2000..scrib, dlg, and lgl show strong genetic interactions. Our data indicate that the three tumor suppressors act together in a common pathway to regulate cell polarity and growth control...
- Cell polarity: squaring the circleD Bilder
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Massachusetts, Boston 02115, USA
Curr Biol 11:R132-5. 2001..The results illustrate the reiterated use of groups of proteins to dictate cell polarity in epithelial and non-epithelial cells...
- Hedgehog and wingless induce metameric pattern in the Drosophila visceral mesodermD Bilder
Department of Genetics, Howard Hughes Medical Institute, Beckman Center, 279 Campus Drive, Stanford, California, 94305 5329, USA
Dev Biol 201:43-56. 1998..The resultant map suggests a model for the origins of VM-specific Hox expression in which Hox domains clonally inherited from blastoderm ancestors are modified by diffusible signals acting on VM-specific enhancers...
- PDZ proteins and polarity: functions from the flyD Bilder
Dept of Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
Trends Genet 17:511-9. 2001..Here, I discuss what the Drosophila data tell us about the roles and mechanisms of PDZ protein activity, and how this informs our understanding of PDZ function in other organisms...
- Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterningD Bilder
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5427, USA
Development 125:1781-90. 1998..pnt activation is required to determine the appropriate numbers of mesodermal cells in the third midgut chamber...
- Genomic regions required for morphogenesis of the Drosophila embryonic midgutD Bilder
Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427, USA
Genetics 141:1087-100. 1995..Another genomic region is required to activate transcription of the homeotic genes Antp and Scr specifically in visceral mesoderm. The genomic regions identified by this screen provide a map to novel midgut development regulators...
- Distinct hox protein sequences determine specificity in different tissuesS Chauvet
Laboratoire de Génétique et Biologie du Développement, Institut de Biologie du Developpement de Marseille, Centre National de la Recherche Scientifique Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille, France
Proc Natl Acad Sci U S A 97:4064-9. 2000..Hox tissue specificity is therefore achieved by sensing distinct Hox protein structures in different tissues...