Genomes and Genes
Affiliation: Harvard University
- Of flies and men--studying human disease in DrosophilaA Bernards
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
Curr Opin Genet Dev 11:274-8. 2001..Conventional Drosophila genetics is being used increasingly to place human disease genes of unknown function in the context of functional pathways...
- GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and DrosophilaAndre Bernards
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129 2000, USA
Biochim Biophys Acta 1603:47-82. 2003....
- GAPs in growth factor signallingAndre Bernards
Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA
Growth Factors 23:143-9. 2005..Here, some of these mechanisms of GAP regulation in the context of signaling responses to growth factors are reviewed...
- Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neuronsJames A Walker
Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Genes Dev 20:3311-23. 2006....
- Ras superfamily and interacting proteins databaseAndre Bernards
Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts, USA
Methods Enzymol 407:1-9. 2006..A database was compiled to provide easy access to this information. This database also includes information on approximately 360 putative Ras superfamily effector proteins and may be a useful tool for those interested in GTPase biology...
- GEFs in growth factor signalingAndre Bernards
Harvard Medical School and Massachusetts General Hospital, Center for Cancer Research, Charlestown, MA 02129, USA
Growth Factors 25:355-61. 2007..In this companion review, we highlight recent findings relating to the regulation of another major class of Ras superfamily regulatory proteins, the guanine nucleotide exchange factors...
- GAP control: regulating the regulators of small GTPasesAndre Bernards
MGH Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Trends Cell Biol 14:377-85. 2004..So far, findings suggest that GAP activity is regulated by several mechanisms, including protein-protein interactions, phospholipid interactions, phosphorylation, subcellular translocation and proteolytic degradation...
- ANALYSIS OF NEUROFIBROMATOSIS TYPE 1 GENE FUNCTIONAndre Bernards; Fiscal Year: 2003..These studies will help us understand the normal function of the NF1 gene in vivo and will contribute to our understanding of the diverse manifestations of the disease process. ..