Darrick T Balu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment
    D T Balu
    Harvard Medical School, Boston, MA, United States McLean Hospital, Belmont, MA, United States Electronic address
    Adv Pharmacol 76:351-82. 2016
  2. pmc Neuronal D-serine regulates dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, and Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Lett 517:77-81. 2012
  3. pmc Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments
    Darrick T Balu
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 18:71-7. 2010
  4. pmc Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neurosci Biobehav Rev 35:848-70. 2011
  5. pmc The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Neurobiol Dis 45:671-82. 2012
  6. pmc Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2400-9. 2013
  7. pmc D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA
    Cell Mol Neurobiol 34:419-35. 2014
  8. pmc D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI
    Martin A Santini
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Behav Brain Res 259:242-6. 2014
  9. pmc An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 41:2052-61. 2016
  10. pmc History of the Concept of Disconnectivity in Schizophrenia
    Joseph T Coyle
    From Harvard Medical School and McLean Hospital, Belmont, MA
    Harv Rev Psychiatry 24:80-6. 2016

Collaborators

Detail Information

Publications14

  1. doi request reprint The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment
    D T Balu
    Harvard Medical School, Boston, MA, United States McLean Hospital, Belmont, MA, United States Electronic address
    Adv Pharmacol 76:351-82. 2016
    ....
  2. pmc Neuronal D-serine regulates dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, and Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Lett 517:77-81. 2012
    ..Moreover, they highlight the glycine modulatory site (GMS) of the NMDAR as a potential target for therapeutic intervention in diseases characterized by synaptic deficits, like schizophrenia...
  3. pmc Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments
    Darrick T Balu
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 18:71-7. 2010
    ....
  4. pmc Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neurosci Biobehav Rev 35:848-70. 2011
    ....
  5. pmc The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Neurobiol Dis 45:671-82. 2012
    ..Moreover, they suggest that NMDAR hypofunction might, in part, be contributing to the dendritic and synaptic changes observed in schizophrenia and highlight this signaling pathway as a potential target for therapeutic intervention...
  6. pmc Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2400-9. 2013
    ..These results demonstrate that NMDAR hypofunction can reproduce the numerous hippocampal deficits associated with schizophrenia, which can be reversed by chronic peripheral D-serine treatment...
  7. pmc D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA
    Cell Mol Neurobiol 34:419-35. 2014
    ..It will be important to determine the functional significance for the separation of synthesis and storage of D-serine in neurons, as well as the presence of this NMDAR co-agonist in GABAergic interneurons...
  8. pmc D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI
    Martin A Santini
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Behav Brain Res 259:242-6. 2014
    ..Together, these findings suggest that D-serine-dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation. ..
  9. pmc An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 41:2052-61. 2016
    ..These results support positive allosteric modulation of mGlu5, particularly with VU0409551, as a viable mechanism to reverse the deficits in NMDAR function, synaptic plasticity, and memory that are known to be impaired in SCZ. ..
  10. pmc History of the Concept of Disconnectivity in Schizophrenia
    Joseph T Coyle
    From Harvard Medical School and McLean Hospital, Belmont, MA
    Harv Rev Psychiatry 24:80-6. 2016
    ..Thus, widespread loss of cortical synaptic connectivity appears to be the primary pathology in schizophrenia that is driven by multiple risk genes that adversely affect synaptogenesis and synapse maintenance, as hypothesized by Kety. ..
  11. pmc Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice
    Shunsuke Takagi
    Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Electronic address
    Schizophr Res 162:216-21. 2015
    ..Given the phenotypic disparity between the MK801 model and schizophrenia, our results suggest that SR-/- mice more accurately reflect NMDAR hypofunction in schizophrenia. ..
  12. pmc Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Brain Res 1392:1-7. 2011
    ..Similar to SR-/- mice, there were no protein changes observed in the PFC. These findings illustrate the complexity of synaptic adaptation to altered NMDAR function...
  13. pmc The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Curr Opin Pharmacol 20:109-15. 2015
    ..It also highlights potential treatment strategies that augment NMDA receptor function to treat the synaptic deficits and cognitive impairments...
  14. pmc Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neurochem Int 75:76-8. 2014
    ....