Jamil Azzi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Immunological aspects of pancreatic islet cell transplantation
    Jamil Azzi
    Transplantation Research Center TRC, Brigham and Women s Hospital, Harvard Medical School, 227 Longwood Avenue, Boston, MA 02115, USA
    Expert Rev Clin Immunol 6:111-24. 2010
  2. doi request reprint The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells
    Najib El Haddad
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 187:2252-60. 2011
  3. pmc Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 191:2319-27. 2013
  4. pmc Mesenchymal stem cells express serine protease inhibitor to evade the host immune response
    Najib El Haddad
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Blood 117:1176-83. 2011
  5. doi request reprint Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch
    Leonardo V Riella
    1 Schuster Family Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 2 Division of Transplant Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 3 Department of Nephrology, Beaumont Hospital, Dublin, Ireland 4 Address correspondence to Anil Chandraker, MD, Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, 221 Longwood Ave, Boston MA 02115
    Transplantation 97:1247-52. 2014
  6. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
  7. pmc Targeted Delivery of Immunomodulators to Lymph Nodes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 15:1202-13. 2016
  8. doi request reprint Clinical transplantation tolerance: a myth no more, but
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 54:1005-11. 2009
  9. pmc Polylactide-cyclosporin A nanoparticles for targeted immunosuppression
    Jamil Azzi
    Transplant Research Center, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    FASEB J 24:3927-38. 2010
  10. doi request reprint Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted Gaussia luciferase, Firefly luciferase, and secreted alkaline phosphatase
    Grant K Lewandrowski
    Experimental Therapeutics and Molecular Imaging Laboratory, Department of Neurology, Neuroscience Center, Massachusetts General Hospital, Boston, MA, USA
    Methods Mol Biol 1098:211-27. 2014

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Immunological aspects of pancreatic islet cell transplantation
    Jamil Azzi
    Transplantation Research Center TRC, Brigham and Women s Hospital, Harvard Medical School, 227 Longwood Avenue, Boston, MA 02115, USA
    Expert Rev Clin Immunol 6:111-24. 2010
    ..We will also briefly discuss the immunosuppressive regimens used and the recent radiologic techniques in the detection of engraftment and early rejection of islet cells...
  2. doi request reprint The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells
    Najib El Haddad
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 187:2252-60. 2011
    ..These findings contribute to the development of MSC-based therapies for diseases...
  3. pmc Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 191:2319-27. 2013
    ..These data could have significant clinical implications for Treg-based therapy in immune-mediated diseases. ..
  4. pmc Mesenchymal stem cells express serine protease inhibitor to evade the host immune response
    Najib El Haddad
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Blood 117:1176-83. 2011
    ..Our data could serve as a basis for future SPI-based strategies to regulate the survival and function of MSCs after administration and to enhance the efficacy of MSC-based therapy for diseases...
  5. doi request reprint Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch
    Leonardo V Riella
    1 Schuster Family Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 2 Division of Transplant Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 3 Department of Nephrology, Beaumont Hospital, Dublin, Ireland 4 Address correspondence to Anil Chandraker, MD, Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, 221 Longwood Ave, Boston MA 02115
    Transplantation 97:1247-52. 2014
    ..However, limited data is available regarding long-term outcomes, in particular for the highest risk group with a positive complement-dependent cytotoxicity crossmatch (CDC XM) before desensitization...
  6. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
    ..These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes...
  7. pmc Targeted Delivery of Immunomodulators to Lymph Nodes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 15:1202-13. 2016
    ..Using MECA79 conjugation, we have demonstrated targeted delivery of tacrolimus to the lymph nodes following systemic administration, with the capacity for immune modulation in vivo. ..
  8. doi request reprint Clinical transplantation tolerance: a myth no more, but
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 54:1005-11. 2009
    ....
  9. pmc Polylactide-cyclosporin A nanoparticles for targeted immunosuppression
    Jamil Azzi
    Transplant Research Center, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    FASEB J 24:3927-38. 2010
    ..This innovative nanoparticulate CsA delivery technology constitutes a strong basis for future targeted delivery of immunosuppressive drugs with improved efficiency and reduced toxicity...
  10. doi request reprint Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted Gaussia luciferase, Firefly luciferase, and secreted alkaline phosphatase
    Grant K Lewandrowski
    Experimental Therapeutics and Molecular Imaging Laboratory, Department of Neurology, Neuroscience Center, Massachusetts General Hospital, Boston, MA, USA
    Methods Mol Biol 1098:211-27. 2014
    ..Furthermore, this novel technique has applications not only in autoimmunity and alloimmunity, but also in the wider field of immunology. ..
  11. ncbi request reprint Impairment of immune systems in diabetes
    Christopher Ting
    Transplantation Research Center Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Adv Exp Med Biol 771:62-75. 2012
    ..Like any complex disease, the variation in severity and incidence of T1DM can be attributed to a combination of genetic and environmental factors...
  12. pmc PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 12:e0169695. 2017
    ..These studies demonstrate the key role of the PI3Kγ pathway in regulating autoimmune-diabetes and provide rationales for future devise of anti- PI3Kγ therapy in T1D...
  13. pmc PI3kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization
    Marwan Mounayar
    Transplantation Research Center, Brigham and Women s and Children s Hospital, Boston, Massachusetts, USA
    Stem Cells 33:1892-901. 2015
    ..Our results for the first time identify critical upstream signals for the induced production of IDO in MSCs that could be manipulated therapeutically to enhance their immunosuppressive phenotype...
  14. pmc Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice
    Esilida Sula Karreci
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 113:E8425-E8432. 2016
    ....
  15. pmc Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes
    Mollie Jurewicz
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:3139-47. 2010
    ..Here, we examine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to reverse recent-onset type 1 diabetes in NOD mice, as well as determine the immunomodulatory effects of NOR MSCs in vivo...