DAVID CHARLES ALSOP

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Efficiency of inversion pulses for background suppressed arterial spin labeling
    Dairon M Garcia
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 54:366-72. 2005
  2. ncbi request reprint Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Magn Reson Med 48:242-54. 2002
  3. pmc High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma
    Xiaoen Wang
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Transl Med 9:220. 2011
  4. pmc Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas
    Eric T Wong
    Beth Israel Deaconess Medical Center, Brain Tumor Center and Neuro Oncology Unit, Boston, MA 02215, USA
    Cerebrospinal Fluid Res 5:1. 2008
  5. pmc Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease
    David C Alsop
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Alzheimers Dis 20:871-80. 2010
  6. ncbi request reprint The role of neuroimaging in elucidating delirium pathophysiology
    David C Alsop
    Department of Radiology, Ansin 226, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 61:1287-93. 2006
  7. ncbi request reprint Markedly reduced apparent blood volume on bolus contrast magnetic resonance imaging as a predictor of hemorrhage after thrombolytic therapy for acute ischemic stroke
    David C Alsop
    Department of Radiology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Mass 02215, USA
    Stroke 36:746-50. 2005
  8. pmc Hippocampal hyperperfusion in Alzheimer's disease
    David C Alsop
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 42:1267-74. 2008
  9. ncbi request reprint In vivo estimation of the flow-driven adiabatic inversion efficiency for continuous arterial spin labeling: a method using phase contrast magnetic resonance angiography
    Ruth L O'Gorman
    King s College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, UK
    Magn Reson Med 55:1291-7. 2006
  10. pmc Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes
    Vera Novak
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St, Boston, MA 02215, USA
    Diabetes Care 29:1529-34. 2006

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Efficiency of inversion pulses for background suppressed arterial spin labeling
    Dairon M Garcia
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 54:366-72. 2005
    ..Knowledge of efficiency will aid optimization of the number of suppression pulses and provide more accurate quantification of blood flow...
  2. ncbi request reprint Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Magn Reson Med 48:242-54. 2002
    ..5T functional data, with reduced fractional perfusion signal change and increased intersubject variability. Possible reasons for these experimental results, including susceptibility effects and physiological noise, are discussed...
  3. pmc High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma
    Xiaoen Wang
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Transl Med 9:220. 2011
    ..However, resistance to therapy develops at a median of 5 months. In an effort to increase efficacy, we studied the effects of increased sorafenib dose and intermittent scheduling in a murine RCC xenograft model...
  4. pmc Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas
    Eric T Wong
    Beth Israel Deaconess Medical Center, Brain Tumor Center and Neuro Oncology Unit, Boston, MA 02215, USA
    Cerebrospinal Fluid Res 5:1. 2008
    ..This study determined whether doxycycline can block MMP activity in vitro. We also measured MMP-2 and MMP-9 levels in cerebrospinal fluid (CSF) from patients with recurrent malignant gliomas...
  5. pmc Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease
    David C Alsop
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Alzheimers Dis 20:871-80. 2010
    ..The existing literature describing ASL blood flow imaging applied to Alzheimer's disease and related dementia is reviewed, and the potential role of ASL in treatment and prevention studies of early Alzheimer's disease is discussed...
  6. ncbi request reprint The role of neuroimaging in elucidating delirium pathophysiology
    David C Alsop
    Department of Radiology, Ansin 226, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 61:1287-93. 2006
    ....
  7. ncbi request reprint Markedly reduced apparent blood volume on bolus contrast magnetic resonance imaging as a predictor of hemorrhage after thrombolytic therapy for acute ischemic stroke
    David C Alsop
    Department of Radiology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Mass 02215, USA
    Stroke 36:746-50. 2005
    ..This study sought to define characteristics of hemodynamic magnetic resonance imaging (MRI), which best predict hemorrhage...
  8. pmc Hippocampal hyperperfusion in Alzheimer's disease
    David C Alsop
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 42:1267-74. 2008
    ..This suggests compensatory or pathological elevation of neural activity, inflammation, or elevated production of vasodilators...
  9. ncbi request reprint In vivo estimation of the flow-driven adiabatic inversion efficiency for continuous arterial spin labeling: a method using phase contrast magnetic resonance angiography
    Ruth L O'Gorman
    King s College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, UK
    Magn Reson Med 55:1291-7. 2006
    ....
  10. pmc Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes
    Vera Novak
    Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis St, Boston, MA 02215, USA
    Diabetes Care 29:1529-34. 2006
    ....
  11. pmc Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
    Ze Wang
    Center for Functional Neuroimaging, Department of Radiology, School of Medicine, University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104, USA
    Neuroimage 39:973-8. 2008
    ..These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function...
  12. ncbi request reprint Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling
    Laura Biagi
    Department of Developmental Neuroscience, Stella Maris Scientific Institute, Pisa, Italy
    J Magn Reson Imaging 25:696-702. 2007
    ..To study the normal dependence of cerebral perfusion changes on age, to measure values of perfusion early in life, and to create a reference dataset...
  13. doi request reprint B1-insensitive fast spin echo using adiabatic square wave enabling of the echo train (SWEET) excitation
    Ananth J Madhuranthakam
    Global MR Applied Science Lab, GE Healthcare, Boston, Massachusetts 02215, USA
    Magn Reson Med 59:1386-93. 2008
    ..This RF field-insensitive sequence may overcome challenges of body imaging at high field and in patients with ascites...
  14. ncbi request reprint Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1)
    Cedric De Bazelaire
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215
    Acad Radiol 12:347-57. 2005
    ....
  15. ncbi request reprint Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy
    Beau M Ances
    Department of Neurology, Department of Neurosurgery, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuroimaging 14:133-8. 2004
    ..78, P < .05) but not in the posterior distribution (r = .25, P = .63). CASL-pMRI may provide a convenient, inexpensive, noninvasive method for identifying CEA patients at risk for hyperperfusion following carotid revascularization...
  16. ncbi request reprint MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results
    Cedric M J de Bazelaire
    Department of Radiology, Center for Advanced Imaging West, CC090, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Boston, MA 02215, USA
    Radiology 230:652-9. 2004
    ..To measure T1 and T2 relaxation times of normal human abdominal and pelvic tissues and lumbar vertebral bone marrow at 3.0 T...
  17. ncbi request reprint Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 Tesla
    Jiongjiong Wang
    Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    Magn Reson Imaging 22:1-7. 2004
    ..ASL images, either with or without subtraction of the control, provide a robust alternative to blood oxygenation level dependant (BOLD) methods for activation imaging in regions of high static field inhomogeneity...
  18. ncbi request reprint Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 50:599-607. 2003
    ..Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities...
  19. ncbi request reprint Evaluation of systematic quantification errors in velocity-selective arterial spin labeling of the brain
    Guillaume Duhamel
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 50:145-53. 2003
    ..Gray matter blood flow of 27.7 ml 100 g(-1) min(-1), approximately half the value reported in studies using spatially-selective ASL, was measured. Potential sources for this underestimation are discussed...
  20. pmc Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity
    David Last
    Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St, Boston, MA 02215, USA
    Diabetes Care 30:1193-9. 2007
    ..The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation...
  21. ncbi request reprint Activation and baseline changes in functional MRI studies of Alzheimer disease
    David C Alsop
    Neurology 69:1645-6. 2007
  22. ncbi request reprint Effects of cord motion on diffusion imaging of the spinal cord
    Hardave S Kharbanda
    Department of Engineering Science, University of Oxford, Oxford, UK
    Magn Reson Med 56:334-9. 2006
    ..However, this same cord motion may contain diagnostically valuable information when probed using appropriate diffusion imaging approaches...
  23. ncbi request reprint Limits on activation-induced temperature and metabolic changes in the human primary visual cortex
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 56:348-55. 2006
    ..Limits on Lac concentration changes were too weak to constrain theories of the metabolic use of elevated Glc consumption during stimulation, and emphasize the challenges of measuring even large Lac changes accompanying stimulation...
  24. ncbi request reprint Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement
    Cedric De Bazelaire
    Radiology Department, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75475, Paris, Cedex 10, France
    Eur Radiol 16:2083-91. 2006
    ..The T2* effect of gadolinium contrast agents should therefore be accounted for when performing tumors study with T1-weighted sequences at high field strength...
  25. ncbi request reprint Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study
    Jiongjiong Wang
    Department of Radiology, and Center for Functional Neuroimaging, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Radiology 235:218-28. 2005
    ..Comparison of multisection continuous and pulsed arterial spin-labeling methods at 3.0 T showed a 33% improvement in signal-to-noise ratio by using the former approach...
  26. ncbi request reprint Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease
    Ronald L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuroimaging 13:17-27. 2003
    ....

Research Grants3

  1. Diagnostic Imaging of Cerebral Blood Flow with MRI
    David Alsop; Fiscal Year: 2003
    ..These developments will make reliable CBF imaging by Arterial Spin Labeling a widely applicable technique for diagnostic imaging. ..
  2. Blood Flow MRI for Monitoring of Renal Cell Carcinoma
    David Alsop; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Blood Flow MRI for Monitoring Glioma Angiogenesis
    DAVID CHARLES ALSOP; Fiscal Year: 2010
    ..If successful, this method could also become an important clinical tool for planning and monitoring therapy. ..