Michael S D Agus

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Design and rationale of Heart and Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children
    Michael Sd Agus
    Boston Children s Hospital Division of Medicine Critical Care, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States Electronic address
    Contemp Clin Trials . 2016
  2. pmc Tight glycemic control after pediatric cardiac surgery in high-risk patient populations: a secondary analysis of the safe pediatric euglycemia after cardiac surgery trial
    Michael S D Agus
    From the Division of Medicine Critical Care M S D A, G M S, J L A, M S and Department of Cardiology L A A, D W, Boston Children s Hospital and Harvard Medical School, Boston, MA Department of Biostatistics, Harvard School of Public Health, Boston, MA D W and Division of Pediatric Cardiology, C S Mott Children s Hospital and University of Michigan Medical School, Ann Arbor M G G
    Circulation 129:2297-304. 2014
  3. pmc Tight glycemic control versus standard care after pediatric cardiac surgery
    Michael S D Agus
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 367:1208-19. 2012
  4. pmc The correlation and level of agreement between end-tidal and blood gas pCO2 in children with respiratory distress: a retrospective analysis
    James M Moses
    Department of Medicine, Children s Hospital Boston, 300 Longwood Ave, AU 522, Boston, MA 02115, USA
    BMC Pediatr 9:20. 2009
  5. pmc Critically low hormone and catecholamine concentrations in the primed extracorporeal life support circuit
    Michael S D Agus
    Endocrinology and Critical Care, Children s Boston, Massachusetts 02115, USA
    ASAIO J 50:65-7. 2004
  6. ncbi request reprint Continuous non-invasive end-tidal CO2 monitoring in pediatric inpatients with diabetic ketoacidosis
    Michael S D Agus
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Diabetes 7:196-200. 2006
  7. doi request reprint Utility of immediate hemoglobin A1c in children with type I diabetes mellitus
    Michael S D Agus
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Diabetes 11:450-4. 2010
  8. pmc Association between intraoperative and early postoperative glucose levels and adverse outcomes after complex congenital heart surgery
    Angelo Polito
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circulation 118:2235-42. 2008
  9. pmc The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support
    Michael S D Agus
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Ann Surg 244:536-44. 2006
  10. ncbi request reprint Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery
    Hannah G Piper
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 118:1176-84. 2006

Collaborators

Detail Information

Publications30

  1. pmc Design and rationale of Heart and Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children
    Michael Sd Agus
    Boston Children s Hospital Division of Medicine Critical Care, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, United States Electronic address
    Contemp Clin Trials . 2016
    ..Test whether hyperglycemic critically ill children with cardiovascular and/or respiratory failure experience more ICU-free days when assigned to tight glycemic control with a normoglycemic versus hyperglycemic blood glucose target range...
  2. pmc Tight glycemic control after pediatric cardiac surgery in high-risk patient populations: a secondary analysis of the safe pediatric euglycemia after cardiac surgery trial
    Michael S D Agus
    From the Division of Medicine Critical Care M S D A, G M S, J L A, M S and Department of Cardiology L A A, D W, Boston Children s Hospital and Harvard Medical School, Boston, MA Department of Biostatistics, Harvard School of Public Health, Boston, MA D W and Division of Pediatric Cardiology, C S Mott Children s Hospital and University of Michigan Medical School, Ann Arbor M G G
    Circulation 129:2297-304. 2014
    ..Heterogeneity of treatment effect may exist within this population...
  3. pmc Tight glycemic control versus standard care after pediatric cardiac surgery
    Michael S D Agus
    Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 367:1208-19. 2012
    ..We tested the hypothesis that tight glycemic control reduces morbidity after pediatric cardiac surgery...
  4. pmc The correlation and level of agreement between end-tidal and blood gas pCO2 in children with respiratory distress: a retrospective analysis
    James M Moses
    Department of Medicine, Children s Hospital Boston, 300 Longwood Ave, AU 522, Boston, MA 02115, USA
    BMC Pediatr 9:20. 2009
    ..To investigate the correlation and level of agreement between end-tidal carbon dioxide (EtCO2) and blood gas pCO2 in non-intubated children with moderate to severe respiratory distress...
  5. pmc Critically low hormone and catecholamine concentrations in the primed extracorporeal life support circuit
    Michael S D Agus
    Endocrinology and Critical Care, Children s Boston, Massachusetts 02115, USA
    ASAIO J 50:65-7. 2004
    ..These concentrations may cause significant and precipitous dilutional reductions in the patient's circulating levels immediately after connection to the ECLS circuit and hence contribute to hemodynamic instability...
  6. ncbi request reprint Continuous non-invasive end-tidal CO2 monitoring in pediatric inpatients with diabetic ketoacidosis
    Michael S D Agus
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Diabetes 7:196-200. 2006
    ..We extend these findings to the inpatient portion of the hospitalization during which the majority of blood tests are sent...
  7. doi request reprint Utility of immediate hemoglobin A1c in children with type I diabetes mellitus
    Michael S D Agus
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Diabetes 11:450-4. 2010
    ..Our objective is to determine whether IFB of HbA1c results to children with type 1 diabetes will improve patient care and glycemic control...
  8. pmc Association between intraoperative and early postoperative glucose levels and adverse outcomes after complex congenital heart surgery
    Angelo Polito
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circulation 118:2235-42. 2008
    ..This study sought to determine whether associations exist between perioperative glucose exposure, prolonged hospitalization, and morbid events after complex congenital heart surgery...
  9. pmc The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support
    Michael S D Agus
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Ann Surg 244:536-44. 2006
    ..This study sought to determine if the administration of the anabolic hormone insulin improved net protein balance in neonates on ECLS...
  10. ncbi request reprint Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery
    Hannah G Piper
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 118:1176-84. 2006
    ....
  11. doi request reprint Tight Glycemic Control in Critically Ill Children
    Michael S D Agus
    From the Division of Medicine Critical Care M S D A, J L A, G M S and the Department of Cardiology D W, L A A, Boston Children s Hospital and Harvard Medical School, Boston the Division of Pediatric Critical Care, University of Utah Medical School, Primary Children s Hospital, Salt Lake City, and Intermountain Medical Center, Murray both in Utah E L H Children s Hospital of Philadelphia V S, V M N and the Perelman School of Medicine V S, M A Q C, V M N and the School of Nursing M A Q C, University of Pennsylvania all in Philadelphia Yale School of Medicine, New Haven, CT E V F and Children s Medical Center Dallas and the University of Texas Southwestern Medical School, Dallas P M L
    N Engl J Med . 2017
    ..Funded by the National Heart, Lung, and Blood Institute and others; HALF-PINT ClinicalTrials.gov number, NCT01565941 .)...
  12. pmc Value of continuous glucose monitoring for minimizing severe hypoglycemia during tight glycemic control
    Garry M Steil
    Department of Surgery and Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 12:643-8. 2011
    ..3 mmol/L]) during standard care or tight glycemic control effected with a proportional integral derivative insulin titration algorithm...
  13. pmc Use of a continuous glucose sensor in an extracorporeal life support circuit
    Garry M Steil
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Diabetes Sci Technol 5:93-8. 2011
    ..The present study was designed to assess performance and clinical applicability of a subcutaneous glucose sensor technology modified for use as a blood-contacting sensor within the ECLS circuit...
  14. pmc Tight Glycemic Control With Insulin Does Not Affect Skeletal Muscle Degradation During the Early Postoperative Period Following Pediatric Cardiac Surgery
    Jeremy G Fisher
    1Center for Advanced Intestinal Rehabilitation and Department of Surgery, Boston Children s Hospital, Boston, MA 2Harvard Medical School, Boston, MA 3Division of Medicine Critical Care, Boston Children s Hospital, Boston, MA 4Department of Cardiology, Boston Children s Hospital, Boston, MA 5Department of Biostatistics, Harvard School of Public Health, Boston, MA 6Division of Pediatric Cardiology, C S Mott Children s Hospital and University of Michigan Medical School, Ann Arbor, MI 7Center for Advanced Intestinal Rehabilitation and Division of Gastroenterology and Nutrition, Boston Children s Hospital, Boston, MA 8Shriners Hospital for Children and Massachusetts General Hospital, Boston, MA
    Pediatr Crit Care Med 16:515-21. 2015
    ..The objective was to evaluate the effect of postoperative tight glycemic control and clinically dosed insulin on skeletal muscle degradation in children after cardiac surgery with cardiopulmonary bypass...
  15. doi request reprint Cardiac parameters in children recovered from acute illness as measured by electrical cardiometry and comparisons to the literature
    Jackson Wong
    Medicine Critical Care Program, Department of Medicine, Boston Children s Hospital, Boston, MA 02115, USA
    J Clin Monit Comput 27:81-91. 2013
    ..Adjustment of target value is required for EC goal-directed therapies...
  16. pmc Impact of Tight Glycemic Control on Neurodevelopmental Outcomes at 1 Year of Age for Children with Congenital Heart Disease: A Randomized Controlled Trial
    Anjali Sadhwani
    Cardiac Neurodevelopmental Program, Boston Children s Hospital and Harvard Medical School, Boston, MA Department of Psychiatry, Boston Children s Hospital and Harvard Medical School, Boston, MA Electronic address
    J Pediatr 174:193-198.e2. 2016
    ..To assess the association of postoperative tight glycemic control and hypoglycemia in children undergoing cardiac surgery with neurodevelopmental outcomes at 1 year of age...
  17. pmc Closed-loop insulin therapy improves glycemic control in children aged <7 years: a randomized controlled trial
    Andrew Dauber
    Division of Endocrinology, Boston Children s Hospital, Boston, MA, USA
    Diabetes Care 36:222-7. 2013
    ..To assess the possibility of improving nocturnal glycemic control as well as meal glycemic response using closed-loop therapy in children aged <7 years...
  18. pmc Critical illness hyperglycemia: is failure of the beta-cell to meet extreme insulin demand indicative of dysfunction?
    Garry M Steil
    Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Crit Care 13:129. 2009
    ..However, alternative explanations that the failure is secondary to an increase in insulin resistance leading to beta-cell exhaustion, or a negative impact of exogenous glucocorticoid therapy, may be equally likely...
  19. ncbi request reprint The first use of live continuous glucose monitoring in patients on extracorporeal life support
    Patrick J Javid
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Technol Ther 7:431-9. 2005
    ..This pilot study reports the first in vitro and in vivo evaluations of EGMS in an extracorporeal circuit...
  20. pmc Suspected Cerebral Edema in Diabetic Ketoacidosis: Is There Still a Role for Head CT in Treatment Decisions?
    Carmen L Soto-Rivera
    1Division of Medicine Critical Care, Department of Medicine, Boston Children s Hospital and Harvard Medical School, Boston, MA 2Division of Endocrinology, Department of Medicine, Boston Children s Hospital and Harvard Medical School, Boston, MA 3Department of Cardiology, Boston Children s Hospital, Boston, MA
    Pediatr Crit Care Med . 2017
    ..The objective of this study was to describe the characteristics of pediatric patients with diabetic ketoacidosis who develop altered mental status and evaluate the role of head CT in this cohort...
  21. pmc Endocrinologic Diseases in Pediatric Cardiac Intensive Care
    Carmen L Soto-Rivera
    1Department of Pediatrics, Section of Endocrinology, Harvard Medical School, Boston Children s Hospital, Boston, MA 2Department of Pediatrics, Section of Critical Care Medicine and Cardiology, Section of Cardiac Critical Care Medicine, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada 3Division of Pharmacy, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 4Pediatric Critical Care, Royal Brompton Hospital, London, United Kingdom 5Division of Medicine Critical Care, Department of Pediatrics, Harvard Medical School, Boston Children s Hospital, Boston, MA
    Pediatr Crit Care Med 17:S296-301. 2016
    ..The objectives of this review are to discuss the pathophysiology, clinical impact and treatment of hyperglycemia, and disturbances in thyroid and adrenal function prior to and following cardiac surgery in children...
  22. pmc Extreme stress hyperglycemia during acute illness in a pediatric emergency department
    Scott L Weiss
    Medicine Critical Care Program, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA
    Pediatr Emerg Care 26:626-32. 2010
    ....
  23. doi request reprint Increasing use of hypertonic saline over mannitol in the treatment of symptomatic cerebral edema in pediatric diabetic ketoacidosis: an 11-year retrospective analysis of mortality*
    Danielle D Decourcey
    1Division of Medicine Critical Care, Boston Children s Hospital, Boston, MA 2Department of Cardiology, Boston Children s Hospital, Boston, MA 3Department of Biostatistics, Harvard School of Public Health, Boston, MA
    Pediatr Crit Care Med 14:694-700. 2013
    ..We sought to assess if changes in the use of hyperosmolar therapies for treatment of cerebral edema in diabetic ketoacidosis may have influenced mortality over the last decade...
  24. pmc Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation
    Michael S D Agus
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 39:839-44; discussion 839-44. 2004
    ..In this pilot study, the authors sought to use the anabolic hormone insulin to reduce the profound protein degradation in this cohort...
  25. doi request reprint Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Hormone Replacement Therapy
    Carmen L Soto-Rivera
    1Divisions of Endocrinology and Medicine Critical Care, Department of Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA 2Division of Pharmacy, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 3Paediatric Critical Care Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom
    Pediatr Crit Care Med 17:S59-68. 2016
    ..To provide an overview of the current literature on the use of hormone replacement therapies in pediatric cardiac critical care...
  26. doi request reprint Thyroid function in the critically ill newborn and child
    Judy L Shih
    Medicine Critical Care Program, Department of Medicine, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, USA
    Curr Opin Pediatr 21:536-40. 2009
    ..Here we review typical thyroid function alterations observed in the critically ill pediatric patient...
  27. ncbi request reprint Diabetic ketoacidosis in children
    Michael S D Agus
    Division of Endocrinology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Clin North Am 52:1147-63, ix. 2005
    ..The efficacy and cost effectiveness of strategies to reduce the incidence of diabetic ketoacidosis-before diagnosis and in patients with established diabetes-are important issues for future investigation...
  28. doi request reprint Non-invasive cardiac output and oxygen delivery measurement in an infant with critical anemia
    Garry M Steil
    Department of Medicine Medicine Critical Care Program, Children s Hospital Boston, 330 Longwood Avenue 11 South, Boston, MA 02115, USA
    J Clin Monit Comput 25:113-9. 2011
    ..To assess the combination of a non-invasive blood oxygen content (CaO(2)) monitor and a non-invasive cardiac output (CO) monitor to continuously measure oxygen delivery (DO(2); DO(2) = CaO(2) × CO)...
  29. pmc Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review
    Kusum Menon
    1Division of Pediatric Critical Care, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON 2Division of Critical Care, Seattle Children s Hospital, University of Washington, Seattle, WA 3Division of Critical Care Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA 4Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 5Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, ON
    Pediatr Crit Care Med . 2017
    ....
  30. ncbi request reprint Nutritional support of the critically ill child
    Michael S D Agus
    Division of Pediatric Critical Care Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Pediatr 14:470-81. 2002
    ....