Genomes and Genes
Organization: Harvard University
- Use of nonsteroidal antiinflammatory agents and incidence of ovarian cancer in 2 large prospective cohortsSimone P Pinheiro
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Epidemiol 169:1378-87. 2009..In this large prospective study, the authors found no compelling evidence to support an association between regular use of aspirin, nonaspirin NSAIDs, or acetaminophen and ovarian cancer incidence...
- Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assayRobert Sackstein
Department of Dermatology and Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Mailstop HIM, Room 671, Boston, MA, 02115, USA
Methods Mol Biol 536:343-54. 2009..This method thus allows for the identification, within a complex mixture and without prior isolation or purification, of both known and previously uncharacterized adhesion molecules operational under dynamic conditions...
- Distribution of fiducial registration error in rigid-body point-based registrationMehdi Hedjazi Moghari
Harvard Medical School, Boston, MA 02215, USA
IEEE Trans Med Imaging 28:1791-801. 2009..The solution uses maximum likelihood estimation to calculate the probability density function of registration error at each fiducial point. Extensive numerical simulations are performed to validated the proposed solution...
- "Complementing" toll signalingJonathan C Kagan
Division of Gastroenterology and Harvard Medical School, Department of Pediatrics, Children s Hospital Boston, Boston, MA 02115, USA
Sci Signal 3:pe15. 2010..A new study attempts to model such conditions in vitro and reveals that when macrophages encounter bacteria, two signal transduction pathways interact in a way that profoundly alters the cellular response to infection...
- Cultivating quality: reducing surgical site infections in children undergoing cardiac surgeryPatricia Galvin
Children s Hospital, Boston, MA, USA
Am J Nurs 109:49-55. 2009..Based on what they learned, the nurses were able to recommend, implement, and evaluate a practice change. This has resulted in reduced SSI rates and improved patient outcomes...
- Technical advances of interventional fluoroscopy and flat panel image receptorPei Jan Paul Lin
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Health Phys 95:650-7. 2008..Finally, rotational angiography with computed tomography (CT) and three dimensional (3-D) images utilizing flat panel technology will be reviewed as they pertain to diagnostic imaging in cardiovascular disease...
- Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PETGeorges El Fakhri
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Nucl Med 50:1062-71. 2009....
- Prospective study of prostate tumor angiogenesis and cancer-specific mortality in the health professionals follow-up studyLorelei A Mucci
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 27:5627-33. 2009..We examined whether microvessel morphology contributes to the considerable biologic heterogeneity of prostate cancer...
- Swine-origin influenza a (H1N1) viral infection in children: initial chest radiographic findingsEdward Y Lee
Departments of Radiology, Medicine, Pulmonary Division, Laboratory Medicine, Infectious Diseases Diagnostic Laboratory, and Anesthesia and Surgery, Children s Hospital Boston and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Radiology 254:934-41. 2010..c) rsna, 2009...
- Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000)L B Silverman
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Leukemia 24:320-34. 2010..Current studies continue to focus on improving efficacy while minimizing acute and late toxicities...
- Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathyRoy Freeman
Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Curr Diab Rep 9:423-31. 2009..Prospective studies to investigate the prevalence of other disorders that might be responsible for a peripheral neuropathy in individuals with diabetes are warranted...
- Progression through the RNA polymerase II CTD cycleStephen Buratowski
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 36:541-6. 2009..Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination...
- Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancyJeffrey I Zwicker
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Clin Cancer Res 15:6830-40. 2009..We evaluated the hypothesis that tumor-derived tissue factor-bearing microparticles in plasma contribute to cancer-associated thrombosis...
- Synthetic lethality: a framework for the development of wiser cancer therapeuticsWilliam G Kaelin
Howard Hughes Medical Institute, Dana Farber Cancer Institute and Brigham and Women s Hospital, 44 Binney St, Boston, MA 02115, USA
Genome Med 1:99. 2009..These approaches will hopefully facilitate the discovery of safer, more efficacious anticancer drugs that exploit vulnerabilities that are unique to cancer cells by virtue of the mutations they have accrued during tumor progression...
- Heart rate, autonomic markers, and cardiac mortalityRichard L Verrier
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Heart Rhythm 6:S68-75. 2009..of these parameters? (3) What mechanisms are responsible for the cardiovascular pathology associated with elevated heart rates? (4) Does reducing heart rate independent of effects on other factors protect against cardiovascular events?..
- Mechanics of dynamic needle insertion into a biological materialMohsen Mahvash
Mechanical Engineering, Boston University, Boston, MA 02215, USA
IEEE Trans Biomed Eng 57:934-43. 2010..Experiments confirm the analytical predictions with multilayered porcine cardiac tissue...
- Inconsistency between peri-saccadic mislocalization and compression: evidence for separate "what" and "where" visual systemsGang Luo
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, USA
J Vis 10:32. 2010....
- High throughput transmission optical projection tomography using low cost graphics processing unitClaudio Vinegoni
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Opt Express 17:22320-32. 2009..By implementing the GPU we have obtained a 300 fold performance enhancement in comparison to a CPU workstation implementation. This enables to obtain on-the-fly reconstructions enabling for high throughput imaging...
- Phosphorylation-mediated negative regulation of RIG-I antiviral activityMichaela U Gack
Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
J Virol 84:3220-9. 2010..While Thr-170 phosphorylation keeps RIG-I latent, Lys-172 ubiquitination enables RIG-I to form a stable complex with MAVS, thereby inducing IFN signal transduction...
- Parental decision making about the HPV vaccineJennifer D Allen
Dana Farber Cancer Institute, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 19:2187-98. 2010..Prophylactic human papillomavirus (HPV) vaccines are available, but uptake is suboptimal. Information on factors influencing parental decisions regarding vaccination will facilitate the development of successful interventions...
- Value-based cleft lip-cleft palate care: a progress reportMegan M Abbott
Department of Plastic and Oral Surgery, Children s Hospital, Boston, Mass 02115, USA
Plast Reconstr Surg 126:1020-5. 2010..In addition, patients have a right to understand the value they receive from their care providers...
- Recent clinical trials of acupuncture in the West: responses from the practitionersTed J Kaptchuk
Harvard Medical School, Boston, MA 02215, USA
Chin J Integr Med 16:197-203. 2010..The paper also looks at recent neuroimaging experiments on acupuncture that may point to some worthwhile new avenues of investigation. Finally, the Euro-American health care policy consequences of these recent RCTs are discussed...
- Columnar cell lesions and subsequent breast cancer risk: a nested case-control studySarah A Aroner
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Breast Cancer Res 12:R61. 2010..However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood...
- Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPDI C Sørheim
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
COPD 7:262-8. 2010..In conclusion, polymorphisms in the SOD3 gene were associated with CT emphysema but not COPD susceptibility, highlighting the importance of phenotype definition in COPD genetics studies...
- Emerging adulthood and the perception of parental depressionGirija Kaimal
Temple University College of Education, Ritter Annex 443, 1301 Cecil B Moore Ave, Philadelphia, PA 19122, USA
Qual Health Res 20:1213-28. 2010..Some respondents with depression in both parents and/or siblings revealed changes in perception toward one parent but no change toward other family members with depression...
- Morgana/CHP-1 is a novel chaperone able to protect cells from stressWojciech Michowski
International Institute of Molecular and Cell Biology ul Ks Trojdena 4, 02 109 Warsaw, Poland
Biochim Biophys Acta 1803:1043-9. 2010....
- Validity of self-report of infections in a longitudinal cohort of patients with rheumatoid arthritis differs by source of report and infection severityJulia F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
J Clin Epidemiol 63:1358-62. 2010..We evaluated and compared the validity of patients' and rheumatologists' reports of infection with those confirmed by medical record review...
- Developing and evaluating comprehensive HIV infection control strategies: issues and challengesVictor DeGruttola
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 50:S102-7. 2010....
- Hybrid myocardial revascularization: an integrated approach to coronary revascularizationJeffrey J Popma
Cardiovascular Division, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Catheter Cardiovasc Interv 75:S28-34. 2010..The advantages and disadvantages of hybrid myocardial revascularization are reviewed in this report...
- Clinging carcinoma: an American perspectiveStuart J Schnitt
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Semin Diagn Pathol 27:31-6. 2010....
- Plasma homocysteine and cysteine and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 70:2397-405. 2010..The increased risk of breast cancer associated with high cysteine levels warrants further investigation...
- Clinical trial: renzapride treatment of women with irritable bowel syndrome and constipation - a double-blind, randomized, placebo-controlled, studyA J Lembo
Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center BIDMC, Harvard Medical School, Boston, MA 02215, USA
Aliment Pharmacol Ther 31:979-90. 2010..Renzapride, a 5-hydroxytryptamine type-4 (5-HT(4)) receptor agonist and 5-HT(3) receptor antagonist, has been proposed as a new treatment of irritable bowel syndrome with constipation (IBS-C)...
- Intake of total trans, trans-18:1, and trans-18:2 fatty acids and risk of sudden cardiac death in womenStephanie E Chiuve
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am Heart J 158:761-7. 2009....
- Radiation therapy options for malignant pleural mesotheliomaElizabeth H Baldini
Department of Radiation Oncology, Dana Farber Brigham and Women s Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Semin Thorac Cardiovasc Surg 21:159-63. 2009..New techniques such as helical tomotherapy and/or IMRT with the addition of electrons may also have a role in future treatment. RT can palliate symptoms provided the disease is confined to a tolerable radiation field...
- Making smart investments in health information technology: core principlesJohn D Halamka
Harvard Medical School and Beth Israel Deaconess Medical Center in Boston, Massachusetts, USA
Health Aff (Millwood) 28:w385-9. 2009..To ensure wise investment, I suggest guiding principles assembled from the input of hundreds of providers, patients, payers, vendors, government employees, and standards-development organizations...
- Increased prevalence of left-handedness in hemifacial microsomiaGary F Rogers
Department of Plastic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115
J Craniofac Surg 20:690-4. 2009..11%; P < 0.05). The frequency was higher, 36%, in those with bilateral involvement (P > 0.05). There was no correlation with predominant side or OMENS score. This study confirms that this disorder affects cerebral lateralization...
- Leukocyte trafficking in primary immunodeficienciesLuigi D Notarangelo
Division of Immunology, Children s Hospital, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA
J Leukoc Biol 85:335-43. 2009..Here, we review the mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-deficiency syndromes, Warts-Hypo-gamma-globulinemia-Infections-Myelokathexis syndrome and Wiskott-Aldrich syndrome...
- Neurophysiological alterations during strategy-based verbal learning in traumatic brain injuryGARY E STRANGMAN
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Neurorehabil Neural Repair 23:226-36. 2009..Verbal learning and strategic processing deficits are common sequelae of traumatic brain injury (TBI); however, the neurophysiological mechanisms underlying such deficits remain poorly understood...
- High-resolution melting curve analysis of genomic and whole-genome amplified DNAMichael H Cho
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Chem 54:2055-8. 2008..Few studies have compared the performance of high-resolution DNA melting curve analysis (HRM) in genomic and whole-genome amplified (WGA) DNA...
- The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic systemJhodie R Duncan
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Auton Neurosci 144:61-75. 2008..This study indicates parallel dynamic and complex changes in the medullary nicotinic and 5-HT systems throughout early life, i.e., the period of risk for SIDS...
- Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosisFarouc A Jaffer
MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
Circulation 118:1802-9. 2008..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization...
- Developmental regulation of neuromodulator function in the stomatogastric ganglion of the lobster, Homarus americanusKristina J Rehm
Volen Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Neurosci 28:9828-39. 2008..Moreover, neuromodulator responses change during development, perhaps contributing to the maturation of the output from the stomatogastric nervous system...
- Japanese-style acupuncture for endometriosis-related pelvic pain in adolescents and young women: results of a randomized sham-controlled trialPeter M Wayne
Harvard Medical School, Osher Research Center, Boston, Massachusetts 02215, USA
J Pediatr Adolesc Gynecol 21:247-57. 2008....
- Recent advances in head and neck cancerRobert I Haddad
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
N Engl J Med 359:1143-54. 2008
- Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potentialDavid E Sosnovik
Department of Cardiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Top Magn Reson Imaging 19:59-68. 2008..The application of molecular MRI in diseases of the vasculature and myocardium is then reviewed. The clinical experience to date, as well as the promise and potential impact of molecular MRI, is extensively discussed...
- An introduction to reading and appraising qualitative researchAyelet Kuper
Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
BMJ 337:a288. 2008
- Chipping away at diagnostics for neurodegenerative diseasesClemens R Scherzer
Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA
Neurobiol Dis 35:148-56. 2009..Advances in pre-analytical and analytical methods are improving search efficiency and reproducibility and may lead to a pipeline of biomarker candidates suitable for development into future neurologic diagnostics...
- Moving towards making social toxins mainstream in children's environmental healthRosalind J Wright
The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02067, USA
Curr Opin Pediatr 21:222-9. 2009..Although traditional disciplinary research theory and methods have focused separately on how social and physical environmental factors affect children's health, evolving research underscores important integrated effects...
- Utilization of an abbreviated diabetes impact management scale to assess change in subjective disability during a trial of pulsatile insulin delivery demonstrates benefitLarry A Weinrauch
Joslin Diabetes Center, Boston, MA 02215, USA
Metabolism 58:488-91. 2009..0144, 0.0004). Pulsatile intravenous insulin, when added to standard multiple-dose insulin therapy, was demonstrated to improve subjective perception of neurologic disability on repeated use of an abbreviated form of the DIMS...
- A cognitive neuroscience hypothesis of mood and depressionMoshe Bar
Martinos Center at Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA
Trends Cogn Sci 13:456-63. 2009....
- The role of body mass index in acute exacerbations of chronic obstructive pulmonary diseaseC L Tsai
Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Emerg Med J 26:701-5. 2009..Low body mass index (BMI) is a strong prognostic marker in stable chronic obstructive pulmonary disease (COPD); however, little is known about its role in acute exacerbations of COPD...
- Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolarsFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 106:11731-6. 2009....
- Accuracy and precision in quantitative fluorescence microscopyJennifer C Waters
Harvard Medical School, Department of Cell Biology, Boston, MA 02115, USA
J Cell Biol 185:1135-48. 2009..Here, I focus on the parameters of digital image acquisition that affect the accuracy and precision of quantitative fluorescence microscopy measurements...
- The evolution of carbon monoxide into medicineLeo E Otterbein
Beth Israel Deaconess Medical Center, Transplant Institute, Boston, MA 02215, USA
Respir Care 54:925-32. 2009..CO's mechanisms of action at the cellular level depend on the disease and the experimental focus, but the one constant is that CO reestablishes homeostasis...
- High b-value apparent diffusion-weighted images from CURVE-ball DTISharon Peled
Radiology Department, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Magn Reson Imaging 30:243-8. 2009..To investigate the utility of a proposed clinical diffusion imaging scheme for rapidly generating multiple b-value diffusion contrast in brain magnetic resonance imaging (MRI) with high signal-to-noise ratio (SNR)...
- Family-directed cognitive adaptation for schizophreniaMichelle S Friedman-Yakoobian
Massachusetts Mental Health Center, 180 Morton Street, Jamaica Plain, MA 02130, USA
J Clin Psychol 65:854-67. 2009..We conclude with a case example of a family who participated in the program...
- A prospective study of familial conflict, psychological stress, and the development of substance use disorders in adolescenceMargie Skeer
Department of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Drug Alcohol Depend 104:65-72. 2009..Evidence for this is largely based on cross-sectional studies which have been unable to establish the temporality of this association and investigate underlying pathways...
- Weight cycling and mortality among middle-aged or older womenAlison E Field
Division of Adolescent Medicine, Department of Medicine, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA
Arch Intern Med 169:881-6. 2009..Controversy exists about whether weight cycling increases morbidity and mortality...
- Strategic choices for global energy: constraints from feedbacks in the climate systemJames G Anderson
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
ChemSusChem 2:369-76. 2009..With ever-rising population numbers and energy demand, what should guide us when transforming our society into one that develops in a sustainable manner?..
- Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticlesTina Islam
Center for Molecular Imaging Research, Charlestown, Massachusetts, USA
Cancer Biomark 5:99-107. 2009..With the advent of multimodality imaging techniques like targeted nanoparticle-enhanced MRI and near infrared optical fluorescence imaging, the combined advantages of different systems can be exploited...
- Validity and reliability of a Fijian translation and adaptation of the Eating Disorder Examination QuestionnaireAnne E Becker
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Int J Eat Disord 43:171-8. 2010..Assessment of disordered eating has uncertain validity across culturally diverse populations. This study evaluated Eating Disorder Examination Questionnaire (EDE-Q) performance in an ethnic Fijian study population...
- Intravital imaging of CD8+ T cell function in cancerThorsten R Mempel
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Clin Exp Metastasis 26:311-27. 2009....
- Epigenetic Events and Colorectal Cancer EpidemiologyShuji Ogino; Fiscal Year: 2010..Through better understanding of epigenetic mechanisms of colorectal cancer development and progression, we can provide a scientific basis for dietary recommendations and help optimize preventive strategies. ..
- MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCERShuji Ogino; Fiscal Year: 2007..Charles Fuchs, a well-established researcher in clinical oncology and epidemiology. At the completion of the projects, I will have gained the experience to become an independent researcher in cancer epidemiology. ..
- Determinants and Cardiovascular Consequences of Diabetes in Older AdultsKenneth Mukamal; Fiscal Year: 2009....
- Quantifying the Value of Value-Based PurchasingRonald Kessler; Fiscal Year: 2006..abstract_text> ..
- Risk Factors for Psychopathology in the WHO WMH SurveysRonald Kessler; Fiscal Year: 2006..The unprecedented size and substantive richness of the WMH database will allow important contributions to be made in each of these six areas of investigation. ..
- Epidemiology - National Comorbidity Survey ReplicationRonald Kessler; Fiscal Year: 2007..physical disorders on family burden; and (vi) to analyze the temporal unfolding of multivariate comorbid disorder profiles over the life course. ..
- Risk Factors for Psychopathology in the WHO WMH SurveysRonald Kessler; Fiscal Year: 2009..Third, the level of detail in the description of data analysis plans has been substantially expanded in this revised submission in response to reviewer comments. ..
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Mukamal; Fiscal Year: 2009..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- Heavy Drinking & Coronary Disease: Acute/Chronic EffectsKenneth Mukamal; Fiscal Year: 2006..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
- MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERSRonald Kessler; Fiscal Year: 2003....
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Jay Mukamal; Fiscal Year: 2010..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- fMRI of Unconscious Affect Processing in AdolescenceWILLIAM KILLGORE; Fiscal Year: 2002..This knowledge will directly impact the understanding of the neurobiological bases of normal and abnormal emotional processing, and potentially lead to a better understanding of factors leading to emotional dysfunction. ..
- Determinants and Cardiovascular Consequences of Diabetes in Older AdultsSusan J Zieman; Fiscal Year: 2010....
- Outreach and Treatment for Depression in the Labor ForceRonald Kessler; Fiscal Year: 2005..This is an extremely important opportunity for rapid and widespread dissemination in an area of research where dissemination of positive results has traditionally been a serious problem. ..
- Hurricane Katrina Community Advisory GroupRonald C Kessler; Fiscal Year: 2010....
- Fatty Acids and Heart Failure in the Physicians' Health StudyLuc Djousse; Fiscal Year: 2009....
- Fatty Acids and Heart Failure in the Physicians' Health StudyLuc Djousse; Fiscal Year: 2010....
- Genetic Factors and Cardiovascular DiseaseLuc Djousse; Fiscal Year: 2005..Lastly, we will use data collected on participants of the GENCAC study to evaluate these genetic factors in relation to coronary calcification, a measure of coronary atherosclerosis. ..
- Defibrotide for the treatment of severe hepatic veno-cc*Paul Richardson; Fiscal Year: 2007..Abstract Not Provided ..
- Asthma Disparities: Advancing Multilevel Causal ModelsVENKATA SANKARANARAYANAN; Fiscal Year: 2007..integrative and transdisciplinary approach to these issues, drawing on the rich resources available within Harvard University, including access to community-based study populations as well as to expertise from multiple fields...
- MCLEAN STUDY OF ADULT DEVELOPMENTMary C Zanarini; Fiscal Year: 2010..This study will provide patients, their families, and those treating them with crucial information they need to plan for the future. ..
- MCLEAN STUDY OF ADULT DEVELOPMENTMary Zanarini; Fiscal Year: 2009..This proposed continuation will result in useful knowledge about the course of borderline psychopathology, with direct implications for patients, their families, and the clinicians treating them. ..
- MCLEAN STUDY OF ADULT DEVELOPMENTMary Zanarini; Fiscal Year: 2004..In addition, knowledgeable informants will be interviewed concerning each patient's psychosocial functioning, and medical, work, and school records will be collected and reviewed. ..
- Theory and methods for sufficient cause interactionsTyler VanderWeele; Fiscal Year: 2010..The research will make important advances to the statistical literature on the concept of interaction and on the implications of measurement error for causal inference. ..
- Medicare Part D Plan Generosity & Dual-Eligible Nursing Home ResidentsHaiden A Huskamp; Fiscal Year: 2010....
- Effects of Light at Night on Circadian System in NursesEva Schernhammer; Fiscal Year: 2005....
- Economics of Formulary Design and Mental Health PolicyHaiden Huskamp; Fiscal Year: 2006..Huskamp the training, mentoring, time and resources to develop the skills that will put her in a position to lead independent research on the economics of pharmaceutical treatment for mental illnesses. ..
- Clock Genes, Night Work, and Breast Cancer RiskEva Schernhammer; Fiscal Year: 2007..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
- A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer SurvivorsEva Schernhammer; Fiscal Year: 2007..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. ..
- The Interplay Between Sleep, Melatonin, and Mortality in Older MenEva S Schernhammer; Fiscal Year: 2010..We will use existing resources from 2,846 participants of the ongoing MrOS Sleep Study. If successful, our study could lay the groundwork for a melatonin trial for healthy aging in the elderly. ..