Joseph Guiles

Summary

Country: USA

Publications

  1. pmc Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors
    Joseph W Guiles
    Replidyne, Inc, Louisville, CO, USA
    Org Med Chem Lett 2:5. 2012
  2. doi request reprint Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III
    Joseph Guiles
    Replidyne, Inc, 1450 Infinite Dr, Louisville, CO 80027, USA
    Bioorg Med Chem Lett 19:800-2. 2009
  3. pmc Antibacterial activity of REP8839, a new antibiotic for topical use
    Ian A Critchley
    Replidyne, Inc, Louisville, CO 80027, USA
    Antimicrob Agents Chemother 49:4247-52. 2005
  4. ncbi request reprint New agents for Clostridium difficile-associated disease
    Joseph Guiles
    Replidyne, Inc, Louisville, CO 80027, USA
    Expert Opin Investig Drugs 17:1671-83. 2008

Detail Information

Publications4

  1. pmc Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors
    Joseph W Guiles
    Replidyne, Inc, Louisville, CO, USA
    Org Med Chem Lett 2:5. 2012
    ..abstract:..
  2. doi request reprint Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III
    Joseph Guiles
    Replidyne, Inc, 1450 Infinite Dr, Louisville, CO 80027, USA
    Bioorg Med Chem Lett 19:800-2. 2009
    ..The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described...
  3. pmc Antibacterial activity of REP8839, a new antibiotic for topical use
    Ian A Critchley
    Replidyne, Inc, Louisville, CO 80027, USA
    Antimicrob Agents Chemother 49:4247-52. 2005
    ..aureus highlights the need for a new topical antibiotic with the ability to inhibit high-level mupirocin-resistant strains and other emerging phenotypes, such as vancomycin-resistant and community-acquired methicillin-resistant isolates...
  4. ncbi request reprint New agents for Clostridium difficile-associated disease
    Joseph Guiles
    Replidyne, Inc, Louisville, CO 80027, USA
    Expert Opin Investig Drugs 17:1671-83. 2008
    ..The mainstay of treatment options has relied upon metronidazole and vancomycin, but these treatments routinely result in high relapse rates (20%) and, in the case of metronidazole, decreasing efficacy...