Brandon Whitcher

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. doi A Bayesian hierarchical model for DCE-MRI to evaluate treatment response in a phase II study in advanced squamous cell carcinoma of the head and neck
    Brandon Whitcher
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, Imperial College, London W120HS, UK
    MAGMA 24:85-96. 2011
  2. ncbi Wavelet-based cluster analysis: data-driven grouping of voxel time courses with application to perfusion-weighted and pharmacological MRI of the rat brain
    Brandon Whitcher
    Research Statistics Unit, GlaxoSmithKline, Harlow CM19 5AW, United Kingdom
    Neuroimage 24:281-95. 2005
  3. ncbi Using the wild bootstrap to quantify uncertainty in diffusion tensor imaging
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Hum Brain Mapp 29:346-62. 2008
  4. pmc Statistical group comparison of diffusion tensors via multivariate hypothesis testing
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Magn Reson Med 57:1065-74. 2007
  5. doi Quantitative analysis of dynamic contrast-enhanced MR images based on Bayesian P-splines
    Volker J Schmid
    Institute of Biomedical Engineering, Imperial College, SW7 2AZ London, UK
    IEEE Trans Med Imaging 28:789-98. 2009
  6. ncbi Semi-parametric analysis of dynamic contrast-enhanced MRI using Bayesian P-splines
    Volker J Schmid
    Institute for Biomedical Engineering, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Med Image Comput Comput Assist Interv 9:679-86. 2006
  7. ncbi Bayesian methods for pharmacokinetic models in dynamic contrast-enhanced magnetic resonance imaging
    Volker J Schmid
    Institute of Biomedical Engineering, Imperial College, London SW7 2AZ, UK
    IEEE Trans Med Imaging 25:1627-36. 2006
  8. ncbi Study-level wavelet cluster analysis and data-driven signal models in pharmacological MRI
    Adam J Schwarz
    Department of Neuroimaging, Psychiatry Centre of Excellence in Drug Discovery, GlaxoSmithKline Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy
    J Neurosci Methods 159:346-60. 2007
  9. doi Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease
    Becky Inkster
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    Neurobiol Aging 33:457-65. 2012
  10. doi A multi-center randomized proof-of-concept clinical trial applying [¹⁸F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease
    Sofia Tzimopoulou
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, UK
    J Alzheimers Dis 22:1241-56. 2010

Collaborators

Detail Information

Publications13

  1. doi A Bayesian hierarchical model for DCE-MRI to evaluate treatment response in a phase II study in advanced squamous cell carcinoma of the head and neck
    Brandon Whitcher
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, Imperial College, London W120HS, UK
    MAGMA 24:85-96. 2011
    ..A Bayesian hierarchical model (BHM) is proposed, as an alternative to voxel-wise estimation procedures, to test for a treatment effect while explicitly modeling known sources of variability...
  2. ncbi Wavelet-based cluster analysis: data-driven grouping of voxel time courses with application to perfusion-weighted and pharmacological MRI of the rat brain
    Brandon Whitcher
    Research Statistics Unit, GlaxoSmithKline, Harlow CM19 5AW, United Kingdom
    Neuroimage 24:281-95. 2005
    ..Following an acute cocaine challenge, WCA localized subtle differences in the pharmacokinetic profile of the cerebral response. We conclude that WCA provides a robust method for blind analysis of time series image data...
  3. ncbi Using the wild bootstrap to quantify uncertainty in diffusion tensor imaging
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Hum Brain Mapp 29:346-62. 2008
    ..The wild bootstrap method can provide empirical distributions for tensor-derived quantities, such as fractional anisotropy and principal eigenvector direction, even when the exact distributions are not easily derived...
  4. pmc Statistical group comparison of diffusion tensors via multivariate hypothesis testing
    Brandon Whitcher
    Clinical Imaging Centre, GlaxoSmithKline, Hammersmith Hospital, London, UK
    Magn Reson Med 57:1065-74. 2007
    ..When applying the Cramér test of the diffusion tensor in a clinical population with a history of migraine, a 169% increase was observed in the volume of a significant cluster compared to the univariate FA test...
  5. doi Quantitative analysis of dynamic contrast-enhanced MR images based on Bayesian P-splines
    Volker J Schmid
    Institute of Biomedical Engineering, Imperial College, SW7 2AZ London, UK
    IEEE Trans Med Imaging 28:789-98. 2009
    ..Detailed validation of the method, both with simulated and in vivo data, is provided...
  6. ncbi Semi-parametric analysis of dynamic contrast-enhanced MRI using Bayesian P-splines
    Volker J Schmid
    Institute for Biomedical Engineering, Imperial College, South Kensington, London SW7 2AZ, United Kingdom
    Med Image Comput Comput Assist Interv 9:679-86. 2006
    ..Further kinetic parameters are obtained by fitting a non-linear model to the estimated response function and detailed validation of the method, both with simulated and in vivo data is..
  7. ncbi Bayesian methods for pharmacokinetic models in dynamic contrast-enhanced magnetic resonance imaging
    Volker J Schmid
    Institute of Biomedical Engineering, Imperial College, London SW7 2AZ, UK
    IEEE Trans Med Imaging 25:1627-36. 2006
    ....
  8. ncbi Study-level wavelet cluster analysis and data-driven signal models in pharmacological MRI
    Adam J Schwarz
    Department of Neuroimaging, Psychiatry Centre of Excellence in Drug Discovery, GlaxoSmithKline Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy
    J Neurosci Methods 159:346-60. 2007
    ..This approach is illustrated with simulated data and two representative in vivo phMRI studies in the rat (nicotine and apomorphine challenges)...
  9. doi Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease
    Becky Inkster
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    Neurobiol Aging 33:457-65. 2012
    ..The greater effect size in AD patients also suggests that the GG genotype could be a risk factor for the expression of cognitive deficits in AD...
  10. doi A multi-center randomized proof-of-concept clinical trial applying [¹⁸F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease
    Sofia Tzimopoulou
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, UK
    J Alzheimers Dis 22:1241-56. 2010
    ..It suggests that Rosiglitazone is associated with an early increase in whole brain glucose metabolism, but not with any biological or clinical evidence for slowing progression over a 1 year follow up in the symptomatic stages of AD...
  11. ncbi Wavelets and functional magnetic resonance imaging of the human brain
    Ed Bullmore
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroimage 23:S234-49. 2004
    ..We conclude that the wavelet domain is a rich source of new concepts and techniques to enhance the power of statistical analysis of human fMRI data...
  12. ncbi A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs
    Sophie Achard
    Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 26:63-72. 2006
    ..Because the major hubs of this network are critical for cognition, its slow dynamics could provide a physiological substrate for segregated and distributed information processing...
  13. pmc Resampling methods for improved wavelet-based multiple hypothesis testing of parametric maps in functional MRI
    Levent Sendur
    Brain Mapping Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Neuroimage 37:1186-94. 2007
    ....