Sumitra Shantakumar

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc Occurrence of hepatotoxicity with pazopanib and other anti-VEGF treatments for renal cell carcinoma: an observational study utilizing a distributed database network
    Sumitra Shantakumar
    Worldwide Epidemiology, R and D, GlaxoSmithKline, 150 Beach Road, 26 00 Gateway West, Singapore, 189720, Singapore
    Cancer Chemother Pharmacol 78:559-66. 2016
  2. doi request reprint Prevalence and incidence of liver enzyme elevations in a pooled oncology clinical trial cohort
    Sumitra Shantakumar
    Worldwide Epidemiology, GlaxoSmithKline, Gateway West, Singapore Electronic address
    Regul Toxicol Pharmacol 77:257-62. 2016
  3. ncbi request reprint Age and menopausal effects of hormonal birth control and hormone replacement therapy in relation to breast cancer risk
    Sumitra Shantakumar
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA
    Am J Epidemiol 165:1187-98. 2007
  4. pmc Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancer
    Sharon K Sagiv
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Environ Res 109:287-91. 2009
  5. pmc Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis
    Marilie D Gammon
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Arch Environ Health 59:640-9. 2004
  6. ncbi request reprint Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res Treat 108:93-9. 2008
  7. ncbi request reprint Active and passive cigarette smoke and breast cancer survival
    Sharon K Sagiv
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Epidemiol 17:385-93. 2007
  8. ncbi request reprint Reproductive factors and breast cancer risk among older women
    Sumitra Shantakumar
    Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 102:365-74. 2007
  9. ncbi request reprint Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females
    Sumitra Shantakumar
    Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    J Expo Anal Environ Epidemiol 15:482-90. 2005
  10. pmc Disruptions in Liver Function among Cancer Patients and Patients Treated with Tyrosine Kinase Inhibiting Drugs: Comparisons of Two Population-Based Databases
    Sarah H Landis
    Worldwide Epidemiology, GlaxoSmithKline, Stockley Park West, Middlesex, London UB11 1BU, UK
    J Cancer Epidemiol 2013:358285. 2013

Detail Information

Publications12

  1. pmc Occurrence of hepatotoxicity with pazopanib and other anti-VEGF treatments for renal cell carcinoma: an observational study utilizing a distributed database network
    Sumitra Shantakumar
    Worldwide Epidemiology, R and D, GlaxoSmithKline, 150 Beach Road, 26 00 Gateway West, Singapore, 189720, Singapore
    Cancer Chemother Pharmacol 78:559-66. 2016
    ..To quantify the hepatic safety of pazopanib and comparator anti-vascular endothelial growth factor (VEGF) therapies in clinical practice among renal cell carcinoma (RCC) patients...
  2. doi request reprint Prevalence and incidence of liver enzyme elevations in a pooled oncology clinical trial cohort
    Sumitra Shantakumar
    Worldwide Epidemiology, GlaxoSmithKline, Gateway West, Singapore Electronic address
    Regul Toxicol Pharmacol 77:257-62. 2016
    ..These data support uniform LC stopping criteria in oncology trials. ..
  3. ncbi request reprint Age and menopausal effects of hormonal birth control and hormone replacement therapy in relation to breast cancer risk
    Sumitra Shantakumar
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA
    Am J Epidemiol 165:1187-98. 2007
    ..These results emphasize that timing of exogenous hormone use is important. Women who used these hormones before menopause had elevated risks, but the harmful effects began to decline with age after menopause...
  4. pmc Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancer
    Sharon K Sagiv
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Environ Res 109:287-91. 2009
    ..Results from this large population-based study do not provide strong support for an association between detectable PAH-DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment...
  5. pmc Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis
    Marilie D Gammon
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Arch Environ Health 59:640-9. 2004
    ..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development...
  6. ncbi request reprint Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res Treat 108:93-9. 2008
    ..p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function...
  7. ncbi request reprint Active and passive cigarette smoke and breast cancer survival
    Sharon K Sagiv
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Epidemiol 17:385-93. 2007
    ..The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study...
  8. ncbi request reprint Reproductive factors and breast cancer risk among older women
    Sumitra Shantakumar
    Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 102:365-74. 2007
    ..Moreover, breastfeeding, one of the few potentially modifiable risk factors for breast cancer, was an important factor in decreasing risk among older parous postmenopausal women...
  9. ncbi request reprint Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females
    Sumitra Shantakumar
    Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    J Expo Anal Environ Epidemiol 15:482-90. 2005
    ..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking...
  10. pmc Disruptions in Liver Function among Cancer Patients and Patients Treated with Tyrosine Kinase Inhibiting Drugs: Comparisons of Two Population-Based Databases
    Sarah H Landis
    Worldwide Epidemiology, GlaxoSmithKline, Stockley Park West, Middlesex, London UB11 1BU, UK
    J Cancer Epidemiol 2013:358285. 2013
    ....
  11. pmc Vehicular Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP)
    Irina Mordukhovich
    Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 124:30-8. 2016
    ..However, the association between PAHs and breast cancer in women is unclear. Vehicular traffic is a major ambient source of PAH exposure...
  12. doi request reprint Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...