JOHN J MCATEE

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. doi request reprint Development of potent and selective small-molecule human Urotensin-II antagonists
    JOHN J MCATEE
    Department of Medicinal Chemistry, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Bioorg Med Chem Lett 18:3500-3. 2008
  2. doi request reprint Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles
    JOHN J MCATEE
    Department of Medicinal Chemistry, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA
    Bioorg Med Chem Lett 18:3716-9. 2008
  3. doi request reprint Aminomethylpiperazines as selective urotensin antagonists
    Mark A Hilfiker
    Department of Medicinal Chemistry, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA
    Bioorg Med Chem Lett 18:4470-3. 2008

Collaborators

Detail Information

Publications3

  1. doi request reprint Development of potent and selective small-molecule human Urotensin-II antagonists
    JOHN J MCATEE
    Department of Medicinal Chemistry, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Bioorg Med Chem Lett 18:3500-3. 2008
    ..hUT binding affinity relative to compound 1 was improved by more than 40-fold in some analogs, and a structural modification was identified which significantly attenuated both off-target activities...
  2. doi request reprint Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles
    JOHN J MCATEE
    Department of Medicinal Chemistry, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA
    Bioorg Med Chem Lett 18:3716-9. 2008
    ..The relationship between stereochemistry and selectivity for hUT over the kappa-opioid receptor was also explored...
  3. doi request reprint Aminomethylpiperazines as selective urotensin antagonists
    Mark A Hilfiker
    Department of Medicinal Chemistry, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA
    Bioorg Med Chem Lett 18:4470-3. 2008
    ..Select compounds were found to inhibit urotensin-induced vasoconstriction in isolated rat aortic rings consistent with the hypothesis that an urotensin antagonist may be useful for the treatment of hypertension...