Bai Lu

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc BDNF facilitates L-LTP maintenance in the absence of protein synthesis through PKMζ
    Fan Mei
    School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e21568. 2011
  2. doi request reprint BDNF and synaptic plasticity, cognitive function, and dysfunction
    B Lu
    GlaxoSmithKline, R and D China, Building 3, 898 Halei Road, Zhangjiang Hi Tech Park, Pudong, Shanghai, 201203, China
    Handb Exp Pharmacol 220:223-50. 2014
  3. doi request reprint BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
    Bai Lu
    GlaxoSmithKline, R and D China, Shanghai, 201203, China
    Nat Rev Neurosci 14:401-16. 2013
  4. pmc Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior
    Keri Martinowich
    Genes, Cognition and Psychosis Program GCAP, National Institute of Mental Health NIMH, Bethesda, MD 20892, USA
    Mol Brain 4:11. 2011
  5. pmc Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation
    H Shawn Je
    Genes, Cognition and Psychosis Program GCAP, National Institute of Mental Health NIH, Bethesda, MD 20892, U S A
    Mol Brain 4:1. 2011
  6. pmc Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning
    Brita Fritsch
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 66:198-204. 2010
  7. ncbi request reprint Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis
    Mingrui Zhao
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Biol Psychiatry 62:381-90. 2007
  8. pmc Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression
    Tina Tze Tsang Tang
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Section on Neural Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 106:21395-400. 2009
  9. ncbi request reprint Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
    Newton H Woo
    Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 8:1069-77. 2005
  10. pmc eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation
    Zhihong Jiang
    Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:2582-94. 2010

Collaborators

Detail Information

Publications48

  1. pmc BDNF facilitates L-LTP maintenance in the absence of protein synthesis through PKMζ
    Fan Mei
    School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e21568. 2011
    ..These results suggest that BDNF sustains L-LTP through PKMζ in a protein synthesis-independent manner, revealing an unexpected link between BDNF and PKMζ...
  2. doi request reprint BDNF and synaptic plasticity, cognitive function, and dysfunction
    B Lu
    GlaxoSmithKline, R and D China, Building 3, 898 Halei Road, Zhangjiang Hi Tech Park, Pudong, Shanghai, 201203, China
    Handb Exp Pharmacol 220:223-50. 2014
    ..Thus, manipulating BDNF pathways represents a viable treatment approach to a variety of neurological and psychiatric disorders. ..
  3. doi request reprint BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
    Bai Lu
    GlaxoSmithKline, R and D China, Shanghai, 201203, China
    Nat Rev Neurosci 14:401-16. 2013
    ..This article reviews the key issues in translating BDNF biology into synaptic repair therapies...
  4. pmc Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior
    Keri Martinowich
    Genes, Cognition and Psychosis Program GCAP, National Institute of Mental Health NIMH, Bethesda, MD 20892, USA
    Mol Brain 4:11. 2011
    ..Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis...
  5. pmc Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation
    H Shawn Je
    Genes, Cognition and Psychosis Program GCAP, National Institute of Mental Health NIH, Bethesda, MD 20892, U S A
    Mol Brain 4:1. 2011
    ..However, it is unclear whether the long-term synaptic modulation by neurotrophins depends on protein synthesis in pre- or post-synaptic cells...
  6. pmc Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning
    Brita Fritsch
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 66:198-204. 2010
    ..We propose that tDCS may improve motor skill learning through augmentation of synaptic plasticity that requires BDNF secretion and TrkB activation within M1...
  7. ncbi request reprint Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis
    Mingrui Zhao
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Biol Psychiatry 62:381-90. 2007
    ..Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic plasticity and learning and memory...
  8. pmc Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression
    Tina Tze Tsang Tang
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Section on Neural Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 106:21395-400. 2009
    ..These results reveal subunit-specific regulation of NMDARs by dysbindin, providing an unexpected link between these two proteins implicated in schizophrenia...
  9. ncbi request reprint Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
    Newton H Woo
    Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 8:1069-77. 2005
    ....
  10. pmc eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation
    Zhihong Jiang
    Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:2582-94. 2010
    ..The present study sheds light on the critical importance of gene-specific translations for hippocampal memory consolidation...
  11. pmc Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses
    Feng Yang
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 185:727-41. 2009
    ..These results support a model in which postsynaptic secretion of a single molecule, pro-BDNF, may stabilize or eliminate presynaptic terminals depending on its proteolytic conversion at the synapses...
  12. doi request reprint Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons
    Yuanyuan Ji
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Neurosci 13:302-9. 2010
    ..Thus, the kinetics of TrkB activation is critical for cell signaling and functions. This temporal dimension in cellular signaling may also have implications for the therapeutic drug design...
  13. pmc Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms
    Hyun Soo Je
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:1029-42. 2006
    ..These findings may have implications in the general mechanisms of long-term synaptic modulation by neurotrophins...
  14. pmc NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis
    Kazuhiro Shimazu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Learn Mem 13:307-15. 2006
    ..In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory...
  15. pmc Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
    Jing Du
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892 4480, USA
    J Cell Biol 163:385-95. 2003
    ..These results demonstrate an activity- and Ca2+-dependent modulation of TrkB tyrosine kinase and its internalization, and they provide new insights into the cell biology of tyrosine kinase receptors...
  16. ncbi request reprint Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e
    Hong Lou
    Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 45:245-55. 2005
    ..Thus, we have identified a mechanism whereby a specific motif I(16)E(18)I(105)D(106) interacts with CPE to sort proBDNF into regulated pathway vesicles for activity-dependent secretion...
  17. ncbi request reprint Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Cell Mol Neurobiol 26:755-80. 2006
    ....
  18. pmc Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex
    Kazuko Sakata
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 106:5942-7. 2009
    ..These results demonstrate the importance of promoter IV-dependent Bdnf transcription in GABAergic function and reveal an unexpected regulation of STDP in the PFC by BDNF...
  19. pmc Cell biology of BDNF and its relevance to schizophrenia
    Bai Lu
    Genes, Cognition and Psychosis Program GCAP, NIMH and Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Novartis Found Symp 289:119-29; discussion 129-35, 193-5. 2008
    ..Extending these studies to synaptic plasticity in other areas of the brain may help us to better understand how altered BDNF signalling could contribute to intermediate phenotypes associated with schizophrenia...
  20. ncbi request reprint Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, NIH, Bethesda, MD 20892 1264, USA
    J Neurosci Res 79:756-71. 2005
    ....
  21. ncbi request reprint Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
    ..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression...
  22. pmc Role of dysbindin in dopamine receptor trafficking and cortical GABA function
    Yuanyuan Ji
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:19593-8. 2009
    ..Taken together, these results suggest that dysbindin regulates PFC function by facilitating D2-mediated modulation of GABAergic function...
  23. pmc Control of extracellular cleavage of ProBDNF by high frequency neuronal activity
    Guhan Nagappan
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 106:1267-72. 2009
    ..Our study demonstrates activity-dependent control of extracellular proteolytic cleavage of a secretory protein, and reveals an important mechanism that controls diametrically opposed functions of BDNF isoforms...
  24. pmc TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus
    Kang Zheng
    Gene, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Proc Natl Acad Sci U S A 108:17201-6. 2011
    ..Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV(-/-) mice, resulting in decreased rhythmic network activity in the gamma-frequency band...
  25. pmc BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
    Yuan Lu
    Gene, Cognition and Psychosis Program GCAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neurobiol Learn Mem 89:312-23. 2008
    ..Finally, specific roles of BDNF in the acquisition, retention or extinction of LTM remain to be established...
  26. pmc Ca2+ influx-independent synaptic potentiation mediated by mitochondrial Na(+)-Ca2+ exchanger and protein kinase C
    Feng Yang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    J Cell Biol 163:511-23. 2003
    ..Inhibition of PKC blocked the TISP as well as mitochondrial Ca2+ release. These results reveal a novel form of synaptic plasticity and suggest a role of PKC in mitochondrial Ca2+ release during synaptic transmission...
  27. pmc TrkB as a potential synaptic and behavioral tag
    Yuan Lu
    Gene, Cognition and Psychosis Program, NIMH, National Institutes of Health, Bethesda, Maryland 20892 3714, USA
    J Neurosci 31:11762-71. 2011
    ..Inhibition of TrkB during STM training blocked such consolidation. These results suggest TrkB as a potential tag for synapse-specific expression of L-LTP and LTM...
  28. ncbi request reprint Distinct mechanisms for neurotrophin-3-induced acute and long-term synaptic potentiation
    Hyun Soo Je
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3714, USA
    J Neurosci 25:11719-29. 2005
    ..These results reveal fundamental differences between acute and long-term modulation by neurotrophins...
  29. ncbi request reprint Pro-region of neurotrophins: role in synaptic modulation
    Bai Lu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 39:735-8. 2003
    ..These results demonstrate new mechanisms by which neurotrophins regulate synaptic plasticity and memory function...
  30. ncbi request reprint Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications
    Guhan Nagappan
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, MSC 3714, Bethesda, MD 20892 4480, USA
    Trends Neurosci 28:464-71. 2005
    ..Finally, neuronal activity promotes BDNF-induced TrkB endocytosis, a signaling event important for many long-term BDNF functions. These mechanisms could collectively underlie synapse-specific regulation by BDNF...
  31. ncbi request reprint BDNF and activity-dependent synaptic modulation
    Bai Lu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland 20892 4480, USA
    Learn Mem 10:86-98. 2003
    ..Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner...
  32. doi request reprint Ama "zinc" link between TrkB transactivation and synaptic plasticity
    Guhan Nagappan
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892 3714, USA
    Neuron 57:477-9. 2008
    ..have now identified a novel mechanism of TrkB transactivation. They show that zinc ions can transactivate TrkB independent of neurotrophins and that such a transactivation is important for mossy fiber long-term potentiation (LTP)...
  33. ncbi request reprint Acute and long-term synaptic modulation by neurotrophins
    Bai Lu
    Section on Neural Development and Plasticity, NICHD, NIH, Building 49, Rm 6A80, 49 Convent Dr, MSC4480, Bethesda, MD 20892 4480, USA
    Prog Brain Res 146:137-50. 2004
    ..Further study of these mechanisms will help us better understand how neurotrophins can achieve diverse and synapse-specific modulation...
  34. pmc Molecular mechanisms underlying neural circuit formation
    Bai Lu
    Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD 20892, United States
    Curr Opin Neurobiol 19:162-7. 2009
    ..Intriguingly, several transcription factors, as well as activity-dependent transcription of BDNF through promoter IV, have been shown to selectively regulate cortical inhibitory circuits by promoting GABAergic synapse formation...
  35. ncbi request reprint Cerebellar deficits and hyperactivity in mice lacking Smad4
    Yong Xing Zhou
    Mammalian Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892, USA
    J Biol Chem 278:42313-20. 2003
    ..Accompanied by the abnormality in the cerebellum, mutant mice also exhibited significantly increased vertical activity. Thus, our study reveals an unexpected role for Smad4 in cerebellar development and in the control of motor function...
  36. pmc A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    Stephen J Huffaker
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Med 15:509-18. 2009
    ..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target...
  37. pmc Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping
    Keri Martinowich
    Mood and Anxiety Disorders Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Biol Psychiatry 71:75-83. 2012
    ..This study investigated whether and how p75(NTR), via regulation of the cholinergic system and hippocampal synaptic plasticity, influences stress-related behaviors...
  38. ncbi request reprint Neurotrophic regulation of the development and function of the neuromuscular synapses
    Bai Lu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892 4480, USA
    J Neurocytol 32:931-41. 2003
    ..Further studies of the mechanisms underlying these regulatory effects will help us better understand how neurotrophic factors can achieve diverse and synapse-specific modulation in the brain...
  39. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  40. ncbi request reprint Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    Deborah E Cabin
    Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 4472, USA
    J Neurosci 22:8797-807. 2002
    ..These results reveal, for the first time, the normal function of endogenous alpha-synuclein in regulating synaptic vesicle mobilization at nerve terminals...
  41. ncbi request reprint The yin and yang of neurotrophin action
    Bai Lu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892 3714, USA
    Nat Rev Neurosci 6:603-14. 2005
    ..New insights into the 'yin and yang' of neurotrophin activity have profound implications for our understanding of the role of neurotrophins in a wide range of cellular processes...
  42. ncbi request reprint Regulation of cortical interneurons by neurotrophins: from development to cognitive disorders
    Newton H Woo
    Section on Neural Development and Plasticity, NICHD, Bethesda, MD 20892 3714, USA
    Neuroscientist 12:43-56. 2006
    ..The authors also discuss the importance of neurotrophin regulation of GABAergic neurons in schizophrenia and epilepsy...
  43. ncbi request reprint Interaction between BDNF and serotonin: role in mood disorders
    Keri Martinowich
    Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neuropsychopharmacology 33:73-83. 2008
    ..There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes...
  44. ncbi request reprint New insights into BDNF function in depression and anxiety
    Keri Martinowich
    Mood and Anxiety Program, National Institute of Mental Health, Building 35, Room 1C1004, 35 Convent Drive, MSC 3714, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 10:1089-93. 2007
    ..Opposing influences of mBDNF and proBDNF on long-term potentiation and long-term depression might contribute to the dichotomy of BDNF actions on behaviors mediated by the brain stress and reward systems...
  45. pmc Persistent neural activity in the prefrontal cortex: a mechanism by which BDNF regulates working memory?
    Evan M Galloway
    Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD, USA
    Prog Brain Res 169:251-66. 2008
    ..We review the research on persistent activity and suggest that BDNF/TrkB signaling in a distinct class of interneurons plays an important role in organizing persistent neural activity at the single-neuron and network levels...
  46. ncbi request reprint Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturin
    Chang Yu Wang
    Unit on Synapse Development and Plasticity, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:10614-25. 2002
    ..Neurturin had very similar effects as GDNF. These results suggest that GDNF and NRTN are new neuromodulators that regulate the development of the neuromuscular synapse through both pre- and postsynaptic mechanisms...
  47. ncbi request reprint Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity
    Ryota Hashimoto
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Neuropharmacology 43:1173-9. 2002
    ..Taken together, these data suggest that the BDNF/TrkB pathway plays an essential role in mediating the neuroprotective effect of lithium...
  48. pmc SHED: stem cells from human exfoliated deciduous teeth
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:5807-12. 2003
    ..Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering...