- Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob miceAndrea C Haynes
GlaxoSmithKline, Third Avenue, Harlow, Essex, CM19 5AW, UK
Regul Pept 104:153-9. 2002..OX1 receptor mRNA was detected in BAT, and its expression was increased by 58% by treatment with SB-334867-A. This is the first demonstration that OX1 receptor antagonists have potential as both anti-obesity and anti-diabetic agents...
- Orexins and the treatment of obesityDarren Smart
Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
Eur J Pharmacol 440:199-212. 2002....