N G Bowery

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. ncbi request reprint Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy
    Douglas A Richards
    Department of Pharmacology, Division of Neuroscience, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Epilepsy Res 54:97-107. 2003
  2. ncbi request reprint Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus
    Kate E Chandler
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 23:11382-91. 2003
  3. ncbi request reprint GABAB receptor: a site of therapeutic benefit
    Norman G Bowery
    GlaxoSmithKline, Verona Biology, Psychiatry Centre of Excellence for Drug Discovery Psychiatry, Via A Fleming 4, 37135 Verona, Italy
    Curr Opin Pharmacol 6:37-43. 2006
  4. pmc GABA and glycine as neurotransmitters: a brief history
    N G Bowery
    GlaxoSmithKline, Biology, PsyCEDD, Verona 37135, Italy
    Br J Pharmacol 147:S109-19. 2006
  5. pmc Allosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brain
    M Mugnaini
    GlaxoSmithKline Group, GlaxoWellcome S p A, Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy
    Br J Pharmacol 132:1883-97. 2001
  6. doi request reprint Reversal of GABA-mediated inhibition of the electrically and potassium chloride evoked [3H]-GABA release from rat substantia nigra slices by DL-3-hydroxy-3-phenyl pentanamide
    Sergio E Meza-Toledo
    Departamento de Bioquimica, Escuela Nacional de Ciencias Biologicas del Instituto Politecnico Nacional, ProlongaciĆ³n de Carpio y Plan de Ayala, Mexico D F, Mexico
    Arzneimittelforschung 58:53-61. 2008
  7. ncbi request reprint Modification of GABA(B1) and GABA(B2) receptor subunits in the somatosensory cerebral cortex and thalamus of rats with absence seizures (GAERS)
    Alessandra P Princivalle
    Department of Pharmacology, Division of Neuroscience, University of Birmingham, The Medical School, Birmingham B15 2TT, UK
    Epilepsy Res 55:39-51. 2003
  8. ncbi request reprint Pharmacology of absence epilepsy
    Jon Paul A Manning
    Department of Pharmacology, Division of Neuroscience, Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Trends Pharmacol Sci 24:542-9. 2003
  9. ncbi request reprint GABA(B) receptor alterations as indicators of physiological and pharmacological function
    S J Enna
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical School, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, Kansas 66160 0227, USA
    Biochem Pharmacol 68:1541-8. 2004
  10. pmc Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration
    Diana Amantea
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Pharmacol 4:24. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy
    Douglas A Richards
    Department of Pharmacology, Division of Neuroscience, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Epilepsy Res 54:97-107. 2003
    ..These results suggest that targeting of the thalamus alone may be insufficient for an immediate and full anti-absence action for ETX. Concomitant or exclusive actions in the cortex remain a possibility...
  2. ncbi request reprint Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus
    Kate E Chandler
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 23:11382-91. 2003
    ..Failure of GABA(B) receptor-mediated modulation of mossy fiber transmission at mossy fibers may contribute to the development of spontaneous seizures after status epilepticus...
  3. ncbi request reprint GABAB receptor: a site of therapeutic benefit
    Norman G Bowery
    GlaxoSmithKline, Verona Biology, Psychiatry Centre of Excellence for Drug Discovery Psychiatry, Via A Fleming 4, 37135 Verona, Italy
    Curr Opin Pharmacol 6:37-43. 2006
    ..However, activation of this receptor can produce numerous effects that might be amenable to drug development. Evidence from preclinical studies also suggests that antagonism of the GABAB receptor produces beneficial clinical effects...
  4. pmc GABA and glycine as neurotransmitters: a brief history
    N G Bowery
    GlaxoSmithKline, Biology, PsyCEDD, Verona 37135, Italy
    Br J Pharmacol 147:S109-19. 2006
    ....
  5. pmc Allosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brain
    M Mugnaini
    GlaxoSmithKline Group, GlaxoWellcome S p A, Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy
    Br J Pharmacol 132:1883-97. 2001
    ..Finally, this study provides the first detailed anatomical description of the regional distribution of [(3)H]-CGP39653 binding sites in human brain...
  6. doi request reprint Reversal of GABA-mediated inhibition of the electrically and potassium chloride evoked [3H]-GABA release from rat substantia nigra slices by DL-3-hydroxy-3-phenyl pentanamide
    Sergio E Meza-Toledo
    Departamento de Bioquimica, Escuela Nacional de Ciencias Biologicas del Instituto Politecnico Nacional, ProlongaciĆ³n de Carpio y Plan de Ayala, Mexico D F, Mexico
    Arzneimittelforschung 58:53-61. 2008
    ..The mechanism of action of DL-HEPP is not known but, it might act as a negative GABA modulator in rat brain slices...
  7. ncbi request reprint Modification of GABA(B1) and GABA(B2) receptor subunits in the somatosensory cerebral cortex and thalamus of rats with absence seizures (GAERS)
    Alessandra P Princivalle
    Department of Pharmacology, Division of Neuroscience, University of Birmingham, The Medical School, Birmingham B15 2TT, UK
    Epilepsy Res 55:39-51. 2003
    ..The main finding was an up-regulation of GABA(B) receptor protein in the corticothalamic circuit in GAERS compared to controls...
  8. ncbi request reprint Pharmacology of absence epilepsy
    Jon Paul A Manning
    Department of Pharmacology, Division of Neuroscience, Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Trends Pharmacol Sci 24:542-9. 2003
  9. ncbi request reprint GABA(B) receptor alterations as indicators of physiological and pharmacological function
    S J Enna
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical School, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, Kansas 66160 0227, USA
    Biochem Pharmacol 68:1541-8. 2004
    ..This, together with results from other types of studies, indicates the potential therapeutic value of developing drugs capable of selectively activating, inhibiting, or modulating GABA(B) receptor function...
  10. pmc Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration
    Diana Amantea
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Pharmacol 4:24. 2004
    ....
  11. ncbi request reprint Reduced G-protein coupling to the GABAB receptor in the nucleus accumbens and the medial prefrontal cortex of the rat after chronic treatment with nicotine
    Diana Amantea
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neurosci Lett 355:161-4. 2004
    ....