Affiliation: GlaxoSmithKline Research and Development
- Antiparasitic activities of novel, orally available fumagillin analogsChristopher Arico-Muendel
PRAECIS Pharmaceuticals, 830 Winter Street, Waltham, MA 02451, USA
Bioorg Med Chem Lett 19:5128-31. 2009..A subset of the compounds showed efficacy in a murine malaria model. The observed SAR forms a basis for further optimization of fumagillin based inhibitors against parasitic targets by inhibition of MetAP2...
- Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activityChristopher C Arico-Muendel
GlaxoSmithKline, 830 Winter Street, Waltham, MA 02451 1420, USA
Drug Metab Dispos 41:814-26. 2013..5]octan-6-yl] N-(2-chloroacetyl)carbamate). The high level of MetAP2 inhibition achieved in vivo supports the value of fumagillin-derived therapeutics for angiogenic diseases...
- Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2Christopher C Arico-Muendel
PRAECIS Pharmaceuticals, Inc, Waltham, MA 02451 1420, USA
J Med Chem 52:8047-56. 2009....