S Spiro

Summary

Affiliation: Georgia Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Nitric oxide-sensing mechanisms in Escherichia coli
    S Spiro
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332 0230, USA
    Biochem Soc Trans 34:200-2. 2006
  2. ncbi request reprint Mechanism of transcriptional regulation by the Escherichia coli nitric oxide sensor NorR
    N P Tucker
    Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK
    Biochem Soc Trans 34:191-4. 2006
  3. ncbi request reprint Detoxification of nitric oxide by the flavorubredoxin of Salmonella enterica serovar Typhimurium
    P C Mills
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem Soc Trans 33:198-9. 2005
  4. ncbi request reprint DNA binding properties of the Escherichia coli nitric oxide sensor NorR: towards an understanding of the regulation of flavorubredoxin expression
    N Tucker
    Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK
    Biochem Soc Trans 33:181-3. 2005
  5. ncbi request reprint The FNR family of transcriptional regulators
    S Spiro
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Antonie Van Leeuwenhoek 66:23-36. 1994
  6. ncbi request reprint FNR and its role in oxygen-regulated gene expression in Escherichia coli
    S Spiro
    Department of Molecular Biology and Biotechnology, University of Sheffield, U K
    FEMS Microbiol Rev 6:399-428. 1990
  7. ncbi request reprint Isolation of intact FNR protein (Mr 30,000) of Escherichia coli
    M Trageser
    Institut fur Mikrobiologie, J W Goethe Universitat, Frankfurt, FRG
    Mol Microbiol 4:21-7. 1990
  8. ncbi request reprint Interconversion of the DNA-binding specificities of two related transcription regulators, CRP and FNR
    S Spiro
    Department of Molecular Biology and Biotechnology, University of Sheffield, UK
    Mol Microbiol 4:1831-8. 1990
  9. ncbi request reprint Adaptive responses to oxygen limitation in Escherichia coli
    S Spiro
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, UK
    Trends Biochem Sci 16:310-4. 1991
  10. ncbi request reprint Inactivation of the FNR protein of Escherichia coli by targeted mutagenesis in the N-terminal region
    S Spiro
    Department of Microbiology, University of Sheffield, UK
    Mol Microbiol 2:701-7. 1988

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Nitric oxide-sensing mechanisms in Escherichia coli
    S Spiro
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332 0230, USA
    Biochem Soc Trans 34:200-2. 2006
    ..coli transcriptome to NO and nitrosative stress. Drawing on the array data, I review our current understanding of the E. coli regulatory systems that are involved...
  2. ncbi request reprint Mechanism of transcriptional regulation by the Escherichia coli nitric oxide sensor NorR
    N P Tucker
    Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK
    Biochem Soc Trans 34:191-4. 2006
    ..Site-directed mutagenesis has identified candidate protein ligands to the ferrous iron centre in the GAF domain...
  3. ncbi request reprint Detoxification of nitric oxide by the flavorubredoxin of Salmonella enterica serovar Typhimurium
    P C Mills
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem Soc Trans 33:198-9. 2005
    ..Typhimurium, but did recover growth after a transient inhibition. The mutant phenotype suggests that multiple enzymes are employed by S. Typhimurium to detoxify NO under anaerobic conditions, one of which is flavorubredoxin...
  4. ncbi request reprint DNA binding properties of the Escherichia coli nitric oxide sensor NorR: towards an understanding of the regulation of flavorubredoxin expression
    N Tucker
    Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK
    Biochem Soc Trans 33:181-3. 2005
    ..The identification of a consensus for NorR binding sites will help to elucidate additional members of the NorR regulon...
  5. ncbi request reprint The FNR family of transcriptional regulators
    S Spiro
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Antonie Van Leeuwenhoek 66:23-36. 1994
    ..denitrificans, A. faecalis, Paracoccus denitrificans and a number of Pseudomonas species...
  6. ncbi request reprint FNR and its role in oxygen-regulated gene expression in Escherichia coli
    S Spiro
    Department of Molecular Biology and Biotechnology, University of Sheffield, U K
    FEMS Microbiol Rev 6:399-428. 1990
    ..The relationships between FNR and other oxygen-related systems in E. coli are discussed, as well as parallel systems in other organisms.(ABSTRACT TRUNCATED AT 400 WORDS)..
  7. ncbi request reprint Isolation of intact FNR protein (Mr 30,000) of Escherichia coli
    M Trageser
    Institut fur Mikrobiologie, J W Goethe Universitat, Frankfurt, FRG
    Mol Microbiol 4:21-7. 1990
    ..The N-terminal sequence of FNR (Mr 30,000) was identical to that predicted from the fnr gene starting with the initiating methionine residue and including a four-cysteine cluster (16)Cys-X3-Cys-X2-Cys-X5-Cys(29)...
  8. ncbi request reprint Interconversion of the DNA-binding specificities of two related transcription regulators, CRP and FNR
    S Spiro
    Department of Molecular Biology and Biotechnology, University of Sheffield, UK
    Mol Microbiol 4:1831-8. 1990
    ..Altering Asp-199 in FNR failed to produce a positive control phenotype, unlike substitutions at the comparable site in CRP. Implications for the mechanism of sequence discrimination by FNR and CRP are discussed...
  9. ncbi request reprint Adaptive responses to oxygen limitation in Escherichia coli
    S Spiro
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, UK
    Trends Biochem Sci 16:310-4. 1991
    ..This article reviews the properties of two transcriptional regulators, ArcA and FNR, which control the expression of networks of genes in response to oxygen limitation...
  10. ncbi request reprint Inactivation of the FNR protein of Escherichia coli by targeted mutagenesis in the N-terminal region
    S Spiro
    Department of Microbiology, University of Sheffield, UK
    Mol Microbiol 2:701-7. 1988
    ..Possible mechanisms by which this cysteine residue might function in the response of FNR to anaerobiosis are discussed...
  11. ncbi request reprint Activation of the lac operon of Escherichia coli by a mutant FNR protein
    S Spiro
    Department of Microbiology, University of Sheffield, UK
    Mol Microbiol 1:53-8. 1987
    ..FNR-215 did not have a uniform effect on the expression of other cAMP-CRP-dependent genes, but the results demonstrate the fundamental similarity between FNR- and CRP-mediated transcriptional activation...
  12. ncbi request reprint Isolation, characterisation and expression of the bacterioferritin gene of Rhodobacter capsulatus
    C N Penfold
    Centre for Metalloprotein Spectroscopy and Biology, School of Biological Sciences, University of East Anglia, Norwich, UK
    FEMS Microbiol Lett 139:143-8. 1996
    ..coli are conversed in the R. capsulatus protein. The sequences of bacterioferritins, ferritin-like proteins, and proteins similar to Dps of E. coli are compared, and membership of the bacterioferritin family re-evaluated...