Michael J Pishvaian

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. doi request reprint Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas
    Michael Pishvaian
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC Electronic address
    Clin Colorectal Cancer 15:345-351. 2016
  2. pmc A Phase I clinical trial of the combination of imatinib and paclitaxel in patients with advanced or metastatic solid tumors refractory to standard therapy
    Michael J Pishvaian
    Lombardi Comprehensive Cancer Center, Developmental Therapeutics Program, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 70:843-53. 2012
  3. pmc A phase 1 study of efatutazone, an oral peroxisome proliferator-activated receptor gamma agonist, administered to patients with advanced malignancies
    Michael J Pishvaian
    Lombardi Comprehensive Cancer Center, Developmental Therapeutics Program, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer 118:5403-13. 2012
  4. pmc A phase I study of liposomal-encapsulated docetaxel (LE-DT) in patients with advanced solid tumor malignancies
    John F Deeken
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 71:627-33. 2013
  5. pmc Human Pancreatic Cancer-Associated Stellate Cells Remain Activated after in vivo Chemoradiation
    M Carla Cabrera
    National Cancer Informatics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC, USA
    Front Oncol 4:102. 2014
  6. doi request reprint Phase II study of lapatinib and capecitabine in second-line treatment for metastatic pancreatic cancer
    Zheng Wu
    Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW, Washington, DC, 20007, USA
    Cancer Chemother Pharmacol 76:1309-14. 2015
  7. ncbi request reprint Quality of life and acute radiation toxicity following hypofractionated stereotactic body radiation therapy with concurrent full-dose gemcitabine for unresectable pancreatic adenocarcinoma
    Marie Kate Gurka
    Georgetown University Hospital, Washington, DC Georgetown University School of Medicine, Washington, DC Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC Southampton General Hospital, Southhampton, United Kingdom
    J Clin Oncol 30:336. 2012
  8. pmc Circulating microRNA profile predicts disease progression in patients receiving second-line treatment of lapatinib and capecitabine for metastatic pancreatic cancer
    Xuefei Tian
    Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Oncol Lett 11:1645-1650. 2016
  9. pmc Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma
    Jimmy J Hwang
    Lombardi Cancer Center, Georgetown Medical Center, 3800 Reservoir Road NW, Washington, DC 20007 2113, USA
    Clin Cancer Res 16:4038-45. 2010
  10. ncbi request reprint Maintenance therapy with capecitabine in patients with resected pancreatic adenocarcinoma after adjuvant therapy
    Xuezhong Yang
    Georgetown University Hospital Lombardi Cancer Center, Washington, DC Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC Georgetown University Hospital, Washington, DC
    J Clin Oncol 30:333. 2012

Collaborators

Detail Information

Publications15

  1. doi request reprint Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas
    Michael Pishvaian
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC Electronic address
    Clin Colorectal Cancer 15:345-351. 2016
    ....
  2. pmc A Phase I clinical trial of the combination of imatinib and paclitaxel in patients with advanced or metastatic solid tumors refractory to standard therapy
    Michael J Pishvaian
    Lombardi Comprehensive Cancer Center, Developmental Therapeutics Program, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 70:843-53. 2012
    ..We conducted a Phase I study of imatinib in combination with paclitaxel in patients with advanced or metastatic solid tumors...
  3. pmc A phase 1 study of efatutazone, an oral peroxisome proliferator-activated receptor gamma agonist, administered to patients with advanced malignancies
    Michael J Pishvaian
    Lombardi Comprehensive Cancer Center, Developmental Therapeutics Program, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer 118:5403-13. 2012
    ..The authors conducted a phase 1 study to determine the recommended phase 2 dose, safety, tolerability, and pharmacokinetics of efatutazone...
  4. pmc A phase I study of liposomal-encapsulated docetaxel (LE-DT) in patients with advanced solid tumor malignancies
    John F Deeken
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 71:627-33. 2013
    ....
  5. pmc Human Pancreatic Cancer-Associated Stellate Cells Remain Activated after in vivo Chemoradiation
    M Carla Cabrera
    National Cancer Informatics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC, USA
    Front Oncol 4:102. 2014
    ..These data support the idea that stellate cells play an essential role in supporting and promoting pancreatic cancer and further research is needed to develop novel treatments targeting the pancreatic tumor microenvironment...
  6. doi request reprint Phase II study of lapatinib and capecitabine in second-line treatment for metastatic pancreatic cancer
    Zheng Wu
    Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW, Washington, DC, 20007, USA
    Cancer Chemother Pharmacol 76:1309-14. 2015
    ..We conducted a single-arm phase II study to evaluate the combination of lapatinib and capecitabine in the second-line treatment of metastatic, gemcitabine-refractory pancreatic cancer...
  7. ncbi request reprint Quality of life and acute radiation toxicity following hypofractionated stereotactic body radiation therapy with concurrent full-dose gemcitabine for unresectable pancreatic adenocarcinoma
    Marie Kate Gurka
    Georgetown University Hospital, Washington, DC Georgetown University School of Medicine, Washington, DC Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC Southampton General Hospital, Southhampton, United Kingdom
    J Clin Oncol 30:336. 2012
    ..The aim of this study is to report QoL outcomes and acute radiation toxicity in patients with pancreatic cancer treated with stereotactic body radiation therapy (SBRT) and concurrent gemcitabine...
  8. pmc Circulating microRNA profile predicts disease progression in patients receiving second-line treatment of lapatinib and capecitabine for metastatic pancreatic cancer
    Xuefei Tian
    Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Oncol Lett 11:1645-1650. 2016
    ..Additional investigation is required with regard to the application of the miRNA panel investigated in the present study as a potential predictor of patient responses to anti-EGFR/HER2 treatment...
  9. pmc Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma
    Jimmy J Hwang
    Lombardi Cancer Center, Georgetown Medical Center, 3800 Reservoir Road NW, Washington, DC 20007 2113, USA
    Clin Cancer Res 16:4038-45. 2010
    ..The two studies, GX001 and GX005, evaluated the safety and tolerability of weekly 1-hour and 3-hour infusions of obatoclax, respectively...
  10. ncbi request reprint Maintenance therapy with capecitabine in patients with resected pancreatic adenocarcinoma after adjuvant therapy
    Xuezhong Yang
    Georgetown University Hospital Lombardi Cancer Center, Washington, DC Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC Georgetown University Hospital, Washington, DC
    J Clin Oncol 30:333. 2012
    ..To evaluate this hypothesis, we retrospectively evaluated our patient (pts) who were treated with maintenance capecitabine (cape)...
  11. pmc Phase II study of temozolomide and veliparib combination therapy for sorafenib-refractory advanced hepatocellular carcinoma
    Andrew Gabrielson
    Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, 3800 Reservoir Road, NW, Washington, DC, 20007, USA
    Cancer Chemother Pharmacol 76:1073-9. 2015
    ..To determine the antitumor efficacy and tolerability of combination temozolomide (TMZ) and veliparib (ABT-888) in patients with advanced, sorafenib-refractory hepatocellular carcinoma (HCC)...
  12. pmc Pharmacogenomic characterization of gemcitabine response--a framework for data integration to enable personalized medicine
    Michael Harris
    aInnovation Center for Biomedical Informatics bLombardi Comprehensive Cancer Center, Developmental Therapeutics Program cDepartment of Neurology, Georgetown University Medical Center dDepartment of Mathematics and Statistics, Georgetown University, Washington, District of Columbia eESAC Inc, Rockville fUS Food and Drug Administration, Silver Spring, Maryland, USA
    Pharmacogenet Genomics 24:81-93. 2014
    ..The aim of our in-silico study was to identify gene variants significantly associated with gemcitabine response that may help to personalize treatment in the clinic...
  13. pmc Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: a pilot trial demonstrating safety
    Marie K Gurka
    Department of Radiation Oncology, Georgetown University Hospital, Washington, DC 20007, USA
    Radiat Oncol 8:44. 2013
    ..This Pilot study assessed the safety of concurrent full-dose gemcitabine with SBRT for LAPC...
  14. pmc Incorporating Yttrium-90 trans-arterial radioembolization (TARE) in the treatment of metastatic pancreatic adenocarcioma: a single center experience
    Alexander Y Kim
    Department of Radiology, Division of Interventional Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, USA
    BMC Cancer 16:492. 2016
    ....
  15. pmc The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway
    M Carla Cabrera
    Department of Oncology, Georgetown University, Washington, DC 20057, USA
    Cancer Prev Res (Phila) 5:810-21. 2012
    ..In summary, the study distinguished CDK4 and phosphorylated pRb as targets for chemoprevention regimens targeting reversal of hyperplasia and dysplasia...