Ioannis Eleftherianos

Summary

Affiliation: George Washington University
Country: USA

Publications

  1. doi request reprint Dissecting the immune response to the entomopathogen Photorhabdus
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA
    Trends Microbiol 18:552-60. 2010
  2. ncbi request reprint Insect Immunity to Entomopathogenic Nematodes and Their Mutualistic Bacteria
    I Eleftherianos
    Department of Biological Sciences, The George Washington University, 800 22nd Street NW, Washington DC, 20052, USA
    Curr Top Microbiol Immunol . 2016
  3. pmc TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC, USA Electronic address
    Immunobiology 221:1362-1368. 2016
  4. pmc Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, Washington, DC, USA
    Infect Immun 82:4169-81. 2014
  5. pmc Endosymbiotic bacteria in insects: guardians of the immune system?
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Columbian College of Arts and Sciences, Institute for Biomedical Sciences, The George Washington University Washington, DC, USA
    Front Physiol 4:46. 2013
  6. doi request reprint Probing the tri-trophic interaction between insects, nematodes and Photorhabdus
    I Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Parasitology 137:1695-706. 2010
  7. doi request reprint Role and importance of phenoloxidase in insect hemostasis
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
    J Innate Immun 3:28-33. 2011
  8. ncbi request reprint Drosophila immunity research on the move
    Ioannis Eleftherianos
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    Fly (Austin) 5:247-54. 2011
  9. ncbi request reprint The immunoglobulin family protein Hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, UK
    Cell Microbiol 9:1137-47. 2007
  10. ncbi request reprint Prior infection of Manduca sexta with non-pathogenic Escherichia coli elicits immunity to pathogenic Photorhabdus luminescens: roles of immune-related proteins shown by RNA interference
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Insect Biochem Mol Biol 36:517-25. 2006

Collaborators

Detail Information

Publications28

  1. doi request reprint Dissecting the immune response to the entomopathogen Photorhabdus
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA
    Trends Microbiol 18:552-60. 2010
    ....
  2. ncbi request reprint Insect Immunity to Entomopathogenic Nematodes and Their Mutualistic Bacteria
    I Eleftherianos
    Department of Biological Sciences, The George Washington University, 800 22nd Street NW, Washington DC, 20052, USA
    Curr Top Microbiol Immunol . 2016
    ....
  3. pmc TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC, USA Electronic address
    Immunobiology 221:1362-1368. 2016
    ..Understanding the molecular mechanisms of host anti-nematode processes will potentially lead to the development of novel means for the efficient control of parasitic nematodes...
  4. pmc Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, Washington, DC, USA
    Infect Immun 82:4169-81. 2014
    ..Such studies will significantly contribute toward a better understanding of the genetic variation between D. melanogaster reference strains. ..
  5. pmc Endosymbiotic bacteria in insects: guardians of the immune system?
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Columbian College of Arts and Sciences, Institute for Biomedical Sciences, The George Washington University Washington, DC, USA
    Front Physiol 4:46. 2013
    ..We finally point out unresolved questions for future research and speculate how the current knowledge can be employed to design and implement measures for the effective control of agricultural insect pests and vectors of diseases...
  6. doi request reprint Probing the tri-trophic interaction between insects, nematodes and Photorhabdus
    I Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Parasitology 137:1695-706. 2010
    ..These results imply that both bacteria and nematodes contribute separately to the pathogenic modulation of host immune responses during natural infections by the mutualistic Heterorhabdus-Photorhabdus complex...
  7. doi request reprint Role and importance of phenoloxidase in insect hemostasis
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
    J Innate Immun 3:28-33. 2011
    ..Here we review our current knowledge of the association between PO and coagulation and discuss the implications of the previous findings on insect innate immunity and hemostasis...
  8. ncbi request reprint Drosophila immunity research on the move
    Ioannis Eleftherianos
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    Fly (Austin) 5:247-54. 2011
    ..Here, we give an overview of the presented work and we explain how these findings will open new avenues in Drosophila immunity research...
  9. ncbi request reprint The immunoglobulin family protein Hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, UK
    Cell Microbiol 9:1137-47. 2007
    ..In contrast, RNAi of PGRP had no effect on any of these cellular immune functions. These results demonstrate the vital role of Hemolin in Manduca cellular immune responses...
  10. ncbi request reprint Prior infection of Manduca sexta with non-pathogenic Escherichia coli elicits immunity to pathogenic Photorhabdus luminescens: roles of immune-related proteins shown by RNA interference
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Insect Biochem Mol Biol 36:517-25. 2006
    ..Given the continuous normal exposure of insects to environmental and symbiotic bacteria, we suggest that prior infection is likely to play a significant and underestimated role in determining the level of insect immunity found in nature...
  11. doi request reprint The KdpD/KdpE two-component system of Photorhabdus asymbiotica promotes bacterial survival within M. sexta hemocytes
    Isabella Vlisidou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    J Invertebr Pathol 105:352-62. 2010
    ....
  12. doi request reprint A single locus from the entomopathogenic bacterium Photorhabdus luminescens inhibits activated Manduca sexta phenoloxidase
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    FEMS Microbiol Lett 293:170-6. 2009
    ..5-kb locus, which contained three ORFs and was homologous to the maltodextrin phosphorylase locus of E. coli. The implications of this novel inhibitory factor of insect phenoloxidase for Photorhabdus virulence are discussed...
  13. pmc Effects of co-occurring Wolbachia and Spiroplasma endosymbionts on the Drosophila immune response against insect pathogenic and non-pathogenic bacteria
    Upasana Shokal
    Insect Infection and Immunity Lab, Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, 5675 Science and Engineering Hall, 800 22nd Street NW, Washington, D C 20052, USA
    BMC Microbiol 16:16. 2016
    ..melanogaster adult flies affects the immune response against the virulent insect pathogen Photorhabdus luminescens and against non-pathogenic Escherichia coli bacteria...
  14. pmc An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 104:2419-24. 2007
    ..Thus, ST has a dual function both as a PO inhibitor to counter host immune reactions and also as an antibiotic to exclude microbial competitors from the insect cadaver...
  15. pmc Identification of candidate infection genes from the model entomopathogenic nematode Heterorhabditis bacteriophora
    Jonathan Vadnal
    Department of Biological Sciences, George Washington University, Science and Engineering Hall, Suite 6000, 800 22nd Street NW, Washington DC, 20052, USA
    BMC Genomics 18:8. 2017
    ....
  16. ncbi request reprint RNAi suppression of recognition protein mediated immune responses in the tobacco hornworm Manduca sexta causes increased susceptibility to the insect pathogen Photorhabdus
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Dev Comp Immunol 30:1099-107. 2006
    ..These results show not only that Photorhabdus is recognized by the Manduca sexta immune system but also that the insect's immune system plays an active, but ultimately ineffective, role in countering infection...
  17. doi request reprint Insect immune responses to nematode parasites
    Julio Cesar Castillo
    Insect Infection and Immunity Lab, Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA
    Trends Parasitol 27:537-47. 2011
    ..Such information can be used to model diseases caused by human parasitic nematodes and provide clues indicating directions for research into the interplay between vector insects and their invading tropical parasites...
  18. pmc Hemocyte density increases with developmental stage in an immune-challenged forest caterpillar
    Teresa M Stoepler
    Department of Biological Sciences, George Washington University, Washington, D C, United States of America
    PLoS ONE 8:e70978. 2013
    ..While the underlying raison d' être for this improvement remains unclear, these findings may be useful in explaining natural patterns of stage-dependent parasitism and pathogen infection. ..
  19. pmc A novel method for infecting Drosophila adult flies with insect pathogenic nematodes
    Julio Cesar Castillo
    Insect Infection and Immunity Lab, Department of Biological Sciences, The George Washington University, Washington, DC, USA
    Virulence 3:339-47. 2012
    ..The protocol we present can be readily adapted for studying parasitic strategies of other insect nematodes using Drosophila as the host infection model...
  20. pmc Rapid Virulence Annotation (RVA): identification of virulence factors using a bacterial genome library and multiple invertebrate hosts
    Nicholas R Waterfield
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 105:15967-72. 2008
    ..The application of RVA to other pathogen genomes promises to ascribe biological function to otherwise uncharacterized virulence genes...
  21. pmc The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
    Sarah McCormack
    Insect Infection and Immunity Laboratory, Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, 800 Science and Engineering Hall, 22nd Street NW, Washington, D C, 20052 USA
    Immun Ageing 13:15. 2016
    ..Here we investigated the immune phenotypes, immune signaling activation and immune function of chico mutant adult flies against the virulent insect pathogen Photorhabdus luminescens as well as to non-pathogenic Escherichia coli bacteria...
  22. doi request reprint The Yersinia pseudotuberculosis and Yersinia pestis toxin complex is active against cultured mammalian cells
    Michelle C Hares
    University of Bath, Department of Biology and Biochemistry, Claverton Down, Bath, UK
    Microbiology 154:3503-17. 2008
    ..pseudotuberculosis and Y. pestis have been adapted for mammalian pathogenicity. We further conclude that Tc proteins from Y. pseudotuberculosis and Y. pestis display differential mammalian cell specificity in their toxicity...
  23. pmc Entomopathogenic and plant pathogenic nematodes as opposing forces in agriculture
    Eric Kenney
    Department of Biological Sciences, The George Washington University, 800 22nd Street NW, Washington DC 20052, United States
    Int J Parasitol 46:13-9. 2016
    ..Using this information, an opportunity has formed to adapt this relationship to large-scale, field conditions and potentially relieve the agricultural industry of one of its most substantial burdens. ..
  24. pmc RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora
    Ramesh Ratnappan
    Department of Microbiology Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC, 20037, USA
    Parasit Vectors 9:160. 2016
    ..In this paper we describe microinjection in adult H. bacteriophora as a suitable means of dsRNA delivery to knockdown gene transcripts...
  25. pmc Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq
    Julio C Castillo
    Insect Infection and Immunity Lab, Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, Washington DC, 20052, USA
    BMC Genomics 16:519. 2015
    ..Although we currently know that the insect immune system interacts with Photorhabdus, information on interaction with the nematode vector is scarce...
  26. doi request reprint Thioester-Containing Protein-4 Regulates the Drosophila Immune Signaling and Function against the Pathogen Photorhabdus
    Upasana Shokal
    Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, Washington, D C, USA
    J Innate Immun 9:83-93. 2017
    ..Together, these findings generate novel insights into the immune role of TEP4 as a regulator and effector of the D. melanogaster antibacterial immune response...
  27. pmc An improved method for generating axenic entomopathogenic nematodes
    Shruti Yadav
    Insect Infection and Immunity Lab, Department of Biological Sciences, Institute for Biomedical Sciences, The George Washington University, Washington DC, USA
    BMC Res Notes 8:461. 2015
    ....
  28. pmc Molecular mechanisms of aging and immune system regulation in Drosophila
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Microbiology and Immunology Program, Institute for Biomedical Sciences, The George Washington University, Lisner Hall 336, 2023 G Street NW, Washington, DC 20052, USA E mail
    Int J Mol Sci 13:9826-44. 2012
    ....