Wendy W Yang
Affiliation: Genzyme Corporation
- Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouseWendy W Yang
Genzyme Corporation, 49 New York Ave, Framingham, MA 01701 9322, USA
Exp Neurol 227:287-95. 2011..Hence, our findings support a role for astrocytes in modulating the progression of non-cell autonomous degeneration of motor neurons, with microglia playing a role in clearing degenerating neurons...
- Intraparenchymal injections of acid sphingomyelinase results in regional correction of lysosomal storage pathology in the Niemann-Pick A mouseWendy W Yang
Genzyme Corporation, One Mountain Road, Framingham, MA 01701 9322, USA
Exp Neurol 207:258-66. 2007..These results indicate that intraparenchymal injection of hASM is associated with minimal toxicity and can lead to regional reductions in storage pathology in the ASMKO mouse...
- Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouseMarco A Passini
Genzyme Corporation, Framingham, MA 01701, USA
Proc Natl Acad Sci U S A 104:9505-10. 2007..These data demonstrate that combination therapy is a promising therapeutic modality for treating NPD and suggest a potential strategy for treating disease indications that cause both visceral and CNS pathologies...