Sanjeev Mariathasan

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
  2. ncbi request reprint Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    Sanjeev Mariathasan
    Department of Translational Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Immunol 7:31-40. 2007
  3. pmc Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins
    Wouter L W Hazenbos
    Dept of Infectious Diseases, Genentech, Inc, San Francisco, California, United States of America
    PLoS Pathog 9:e1003653. 2013
  4. ncbi request reprint ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome
    Sanjeev Mariathasan
    Department of Translational Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Microbes Infect 9:664-71. 2007
  5. ncbi request reprint Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  6. pmc Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 202:1043-9. 2005
  7. pmc POPing the fire into the pyrin?
    Sanjeev Mariathasan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Biochem J 373:e1-2. 2003
  8. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
  9. ncbi request reprint Development of autoreactive diabetogenic T cells in the thymus of NOD mice
    Hyokjoon Kwon
    Julia McFarlane Diabetes Research Centre, Faculty of Medicine, The University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1 Canada
    J Autoimmun 24:11-23. 2005
  10. ncbi request reprint The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
    Dario S Zamboni
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Immunol 7:318-25. 2006

Collaborators

  • Vishva M Dixit
  • David S Weiss
  • Michael Karin
  • Li Chung Hsu
  • Domagoj Vucic
  • Wouter L W Hazenbos
  • Dario S Zamboni
  • Richard A Flavell
  • Hyokjoon Kwon
  • J Hiroshi Morisaki
  • Qui Phung
  • Eric J Brown
  • Janice Kim
  • Richard Vandlen
  • Yana Khalfin
  • Man Wah Tan
  • Tim Beaumont
  • Peter S Andersen
  • Satish Ramakrishnan
  • Klaus Koefoed
  • Binh An Diep
  • Tao Sai
  • Min Xu
  • Byoung Chul Lee
  • S Jack Lin
  • Magnus Strandh
  • Andrew Sebrell
  • Chris Koth
  • Sophie M Lehar
  • Kimberly K Kajihara
  • Angela Oh
  • Arjen Q Bakker
  • Lee R Swem
  • Ishita M Shah
  • Mark J Kwakkenbos
  • Hergen Spits
  • Keisuke Kuida
  • William F Dietrich
  • Russell E Vance
  • E Michelle Long
  • Koichi S Kobayashi
  • Yasunori Ogura
  • Craig R Roy
  • Tiana Kohlsdorf
  • Yang Yang
  • Conchi Mora
  • Hee Sook Jun
  • Ji Won Yoon
  • Pamela S Ohashi

Detail Information

Publications10

  1. ncbi request reprint Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
    ..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways...
  2. ncbi request reprint Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    Sanjeev Mariathasan
    Department of Translational Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Immunol 7:31-40. 2007
    ..Here we review recent work on the activation of the inflammasome in response to various bacterial pathogens and tissue damage...
  3. pmc Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins
    Wouter L W Hazenbos
    Dept of Infectious Diseases, Genentech, Inc, San Francisco, California, United States of America
    PLoS Pathog 9:e1003653. 2013
    ....
  4. ncbi request reprint ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome
    Sanjeev Mariathasan
    Department of Translational Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Microbes Infect 9:664-71. 2007
    ..The analysis of mice deficient in ASC, Ipaf and Cryopyrin/Nalp3 has revealed that the inflammasome is a dynamic entity that is assembled from different adapters in a stimulus-dependent manner...
  5. ncbi request reprint Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  6. pmc Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, South San Francisco, CA 94080, USA
    J Exp Med 202:1043-9. 2005
    ....
  7. pmc POPing the fire into the pyrin?
    Sanjeev Mariathasan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Biochem J 373:e1-2. 2003
    ..identifies a new member of the pyrin family that may control signalling by sequestering pro-inflammatory components, shedding light on the origin of human inflammatory disorders...
  8. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    ..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion...
  9. ncbi request reprint Development of autoreactive diabetogenic T cells in the thymus of NOD mice
    Hyokjoon Kwon
    Julia McFarlane Diabetes Research Centre, Faculty of Medicine, The University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1 Canada
    J Autoimmun 24:11-23. 2005
    ..scid mice. We conclude that the development of autoreactive diabetogenic T cells results from inordinate positive selection due to the low activation threshold of DP thymocytes in NOD mice...
  10. ncbi request reprint The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
    Dario S Zamboni
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Immunol 7:318-25. 2006
    ..These results establish Birc1e as a nucleotide-binding oligomerization-leucine-rich repeat protein involved in the detection and control of intracellular L. pneumophila...