Wei Wang

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Antitumor effect of an antibody against gastrointestinal cancer-associated antigen CA19.9
    Zheng Li
    State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, PUMC, Beijing, China
    Cancer Biother Radiopharm 22:597-606. 2007
  2. ncbi request reprint [Expression of hCTLA4-Ig mediated by adeno-associated virus in porcine islets and their biological activity]
    Zhao Hui Mo
    Cell Transplantation and Gene Therapy Institute of the Third Xiangya Hospital of Central South University, Department of Endocrinology, Changsha 410013, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:36-40. 2007
  3. ncbi request reprint Recognition of breast cancer cells by CD8+ cytotoxic T-cell clones specific for NY-BR-1
    Wei Wang
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Res 66:6826-33. 2006
  4. doi request reprint The meaning of global outcome measures in pain clinical trials: more than just change in pain intensity
    Mark P Jensen
    Department of Rehabilitation Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Clin J Pain 29:289-95. 2013
  5. pmc Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells
    Veronika Groh
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:6461-6. 2005
  6. doi request reprint Reliability and validity of individual and composite recall pain measures in patients with cancer
    Mark P Jensen
    Department of Rehabilitation Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Pain Med 13:1284-91. 2012
  7. ncbi request reprint Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis
    Eric C LaCasse
    Aegera Therapeutics, Inc, Montreal, Quebec, Canada
    Clin Cancer Res 12:5231-41. 2006
  8. ncbi request reprint [Experimental study on apoptosis of leukemia cell line NB4 transfected with WT1 gene]
    Hui Ling Shen
    Jiangsu Institute of Hematology, The First Hospital Affiliated to Suzhou University, Suzhou 215006, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:989-95. 2005
  9. ncbi request reprint Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines
    Wei Wang
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Oncol Rep 12:1365-70. 2004
  10. ncbi request reprint Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer
    Lakshmi Sampath
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nucl Med 48:1501-10. 2007

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Antitumor effect of an antibody against gastrointestinal cancer-associated antigen CA19.9
    Zheng Li
    State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, PUMC, Beijing, China
    Cancer Biother Radiopharm 22:597-606. 2007
    ..9. Based on the observations from this study, we postulated that the mAb, LC44, could be a promising antitumor agent for gastrointestinal cancer and worthy of further investigation...
  2. ncbi request reprint [Expression of hCTLA4-Ig mediated by adeno-associated virus in porcine islets and their biological activity]
    Zhao Hui Mo
    Cell Transplantation and Gene Therapy Institute of the Third Xiangya Hospital of Central South University, Department of Endocrinology, Changsha 410013, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:36-40. 2007
    ..To evaluate the expression of hCTLA4-Ig and their biological function in newborn porcine islets (NPIs) transfected with AAV-hCTLA4-Ig...
  3. ncbi request reprint Recognition of breast cancer cells by CD8+ cytotoxic T-cell clones specific for NY-BR-1
    Wei Wang
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Res 66:6826-33. 2006
    ..Taken together, these results show that the p904 epitope derived from NY-BR-1 is efficiently processed and presented endogenously and identify NY-BR-1 as a promising target for T-cell-based immunotherapy for breast cancer...
  4. doi request reprint The meaning of global outcome measures in pain clinical trials: more than just change in pain intensity
    Mark P Jensen
    Department of Rehabilitation Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Clin J Pain 29:289-95. 2013
    ..To understand the factors that contribute to patient and physician global outcome ratings and the extent to which receiving different doses of opioids or placebo might influence the importance of these factors better...
  5. pmc Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells
    Veronika Groh
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:6461-6. 2005
    ..These results further suggest that antibody targeting of MICA might be applicable to elicit T cell immunity against tumors of diverse tissue origins in cancer patients...
  6. doi request reprint Reliability and validity of individual and composite recall pain measures in patients with cancer
    Mark P Jensen
    Department of Rehabilitation Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Pain Med 13:1284-91. 2012
    ..To evaluate and compare the validity and reliability of individual and composite recall pain intensity measures...
  7. ncbi request reprint Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis
    Eric C LaCasse
    Aegera Therapeutics, Inc, Montreal, Quebec, Canada
    Clin Cancer Res 12:5231-41. 2006
    ....
  8. ncbi request reprint [Experimental study on apoptosis of leukemia cell line NB4 transfected with WT1 gene]
    Hui Ling Shen
    Jiangsu Institute of Hematology, The First Hospital Affiliated to Suzhou University, Suzhou 215006, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:989-95. 2005
    ..It is concluded that the introduction and expression of exogenous WTA gene can lead to apoptosis of NB4/WTA cells by down-regulating the Bcl-2 gene expression and up-regulating the p21 and c-myc genes expression...
  9. ncbi request reprint Effect of lung resistance-related protein on the resistance to cisplatin in human ovarian cancer cell lines
    Wei Wang
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Oncol Rep 12:1365-70. 2004
    ..Thus, LRP was involved in the resistance of ovarian cancer cells to cisplatin and has an important role in the transport of cisplatin both in exocytotic vesicles and between the nucleus and cytoplasm...
  10. ncbi request reprint Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer
    Lakshmi Sampath
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nucl Med 48:1501-10. 2007
    ..The stoichiometric ratios "n" and "m" refer to the number of diethylenetriaminepentaacetic acid dianhydride (DTPA) and IRDye 800CW molecules bound per trastuzumab molecule, respectively...
  11. ncbi request reprint [The expression of CXCR4 on acute leukemia cells and its implication for extramedullary infiltration]
    Sheng Li
    The First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 25:405-8. 2004
    ..To study the expression of CXCR4 in acute leukemic cells and its clinical significance...
  12. ncbi request reprint A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
    Xiao Jun Ma
    Arcturus Bioscience, Inc, 2715 Loker Avenue West, Carlsbad, CA 92008, USA
    Cancer Cell 5:607-16. 2004
    ..The HOXB13:IL17BR expression ratio may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer...
  13. ncbi request reprint Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL/6 mice
    Norma Ostlie
    Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 170:604-12. 2003
    ..These results suggest that in B6 mice, regulatory mechanisms that involve IL-4 contribute to preventing the development of a chronic Ab-mediated autoimmune response to the AChR...
  14. ncbi request reprint Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages
    Eleanor C Tsark
    Division of Immunology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA
    J Immunol 169:6625-33. 2002
    ..These data support the hypothesis that CII and HCgp39 are autoantigens and that their class II-mediated presentation by DC and Mphi to T cells in vivo has a critical role in the pathogenesis of human rheumatoid arthritis...
  15. ncbi request reprint Fibronectin-mediated activation of Akt2 protects human ovarian and breast cancer cells from docetaxel-induced apoptosis via inhibition of the p38 pathway
    Hui Xing
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Apoptosis 13:213-23. 2008
    ..The present findings may help us to understand the formation of FN adhesion-mediated chemoresistance and facilitate development of novel antineoplastic strategies...
  16. ncbi request reprint Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells
    Huaining Teng
    Institute of Biochemistry and Cell Biology, Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 39:278-84. 2007
    ..These results widen the clinical application of the microencapsulated cell endostatin delivery system in cancer treatment...
  17. doi request reprint Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy
    Aiyue Luo
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 271:323-32. 2008
    ....
  18. ncbi request reprint A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain
    Wei Wang
    Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
    Bioconjug Chem 18:397-402. 2007
    ..The cross validation and direct comparison of optical and nuclear imaging of a tumor was achieved using a single injection, and the preliminary results show the conjugate has tumor targeting capabilities in vivo...
  19. ncbi request reprint Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells
    Ni Sima
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei 430030, PR China
    Gynecol Oncol 106:299-304. 2007
    ....
  20. ncbi request reprint Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapy
    Hui Wang
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 1670 University Boulevard, 113 Volker Hall, 35294, USA
    Mol Cancer Ther 5:2106-14. 2006
    ..Based on the present results, we believe that the IMO is a good candidate for clinical development for breast cancer therapy used either alone or in combination with conventional cancer therapeutic agents...
  21. ncbi request reprint Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721
    Wei Wang
    Department of Physiology, China Pharmaceutical University, Nanjing, PRC
    Anticancer Drugs 17:797-805. 2006
    ....
  22. ncbi request reprint Proliferation, viability, and metabolism of human tumor and normal cells cultured in microcapsule
    Xulang Zhang
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
    Appl Biochem Biotechnol 134:61-76. 2006
    ..In addition, it lays a solid foundation for the use of microencapsulation in cell culture in vitro and cell implantation in vivo...
  23. ncbi request reprint Conditional gene modification in mouse liver using hydrodynamic delivery of plasmid DNA encoding Cre recombinase
    Huan Zhang Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    FEBS Lett 580:4346-52. 2006
    ..Thus, hydrodynamic gene delivery of the Cre recombinase provides a valuable approach for Cre-loxP-mediated conditional gene modification in the liver of mice...
  24. ncbi request reprint Human renal UOK130 tumor cells: a drug resistant cell line with highly selective over-expression of glutathione S-transferase-pi isozyme
    Wei Wang
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Eur J Pharmacol 568:61-7. 2007
    ..In conclusion, we developed a multiple drug resistant tumor cell line with selective over-expression of GST-pi. The cell model provides a unique tool for mechanistic studies of drug resistance mediated by over-expression of GST-pi...
  25. ncbi request reprint Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi
    Lingbao Kong
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei Province 430072, PR China
    Virus Res 128:9-17. 2007
    ..Taken together, these results indicated that Fructus Ligustri Lucidi might offer a promising source of antiviral drugs against HCV NS5B. Purification of the active compound(s) and antiviral effect are clearly required in the future...
  26. ncbi request reprint Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth
    Weimin Liu
    Department of Radiation Oncology, University of Rochester, Rochester, New York 14642, USA
    Am J Clin Oncol 26:S103-9. 2003
    ....
  27. ncbi request reprint Preparation and identification of monoclonal antibodies against recombinant human thioredoxins
    Wen Xin Tang
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Hybridoma (Larchmt) 26:338-41. 2007
    ..We further analyzed their isotypes, titer, and affinity and found that those MAbs belong to the G1 subclass with kappa light chains, respectively. The MAbs were capable of recognizing hTrx-1, as determined by Western blotting...
  28. ncbi request reprint Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease
    Wei Wang
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Gerontol A Biol Sci Med Sci 63:127-34. 2008
    ..The results suggest that the association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene...
  29. ncbi request reprint Ciliary neurotrophic factor-treated astrocyte conditioned medium regulates the L-type calcium channel activity in rat cortical neurons
    Xiaojing Wang
    Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, Hubei 430030, PR China
    Neurochem Res 33:826-32. 2008
    ..Taken together, these findings indicate that CNTF induces the release of factors, including FGF-2, from astrocytes, thereby potentiating the activity of LCC in cortical neurons...
  30. ncbi request reprint The therapeutic efficacy of anti vascular endothelial growth factor antibody, bevacizumab, and pemetrexed against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice
    Qi Li
    Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Cancer Res 13:5918-25. 2007
    ..The vascular endothelial growth factor (VEGF) has been reported to be an ideal therapeutic target, and a multitargeted antifolate, pemetrexed, has been clinically used for the treatment of MPM...
  31. ncbi request reprint MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    David C Corney
    Department of Biomedical Sciences and Microarray Core Facility, Cornell University, Ithaca, New York, USA
    Cancer Res 67:8433-8. 2007
    ..Taken together, these results show the existence of a novel mechanism by which p53 suppresses such critical components of neoplastic growth as cell proliferation and adhesion-independent colony formation...
  32. doi request reprint EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:1451-61. 2008
    ....
  33. doi request reprint Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid
    Jie Zhao
    Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University, Nanjing, PR China
    Eur J Pharmacol 589:127-31. 2008
    ..Thus we concluded for the first time that gambogic acid could inhibit the adhesion and migration of B16-F10 cells in vitro and in vivo, in which down-regulation of alpha(4) integrin expression was involved...
  34. ncbi request reprint Role of glycosylation in corin zymogen activation
    Xudong Liao
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:27728-35. 2007
    ..Mutations altering the two N-glycosylation sites in the protease domain of rat corin prevented its activation in HEK 293 and HL-1 cells. Our results indicate that N-linked oligosaccharides play an important role in corin activation...
  35. doi request reprint Determination of physiological thiols by electrochemical detection with piazselenole and its application in rat breast cancer cells 4T-1
    Wei Wang
    Key Laboratory of Eco Chemical Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China
    J Am Chem Soc 130:10846-7. 2008
    ..0952 + 0.4287 x CGSH (10(-8) M) and the detection limit (3sigma) as 83 pM. The proposed method was satisfactorily applied to the extracts of rat breast cancer cells 4T-1 for intracellular thiols detection...
  36. ncbi request reprint [Antisense targeting to human papillomavirus 18 E6/E7 affects the proliferation and apoptosis of human cervical carcinoma: an in vitro experiment with HeLa cells]
    Ni Sima
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Yi Xue Za Zhi 87:1618-21. 2007
    ..To investigate the effect of eukaryotic fluorescent expression vector carrying antisense human papillomavirus (HPV) 18 E6/E7 on the growth and proliferation of human cervical carcinoma...
  37. ncbi request reprint Reversal of the malignant phenotype of cervical cancer CaSki cells through adeno-associated virus-mediated delivery of HPV16 E7 antisense RNA
    Sufang Wu
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Republic of China
    Clin Cancer Res 12:2032-7. 2006
    ....
  38. ncbi request reprint [The role of costimulatory molecule 4-1BB and CD28 in activating of various T cell subsets from human peripheral blood]
    Jun ying Wu
    Department of Immunology, Bengbu Medical College, Bengbu 233003, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:533-6. 2004
    ..To explore the role of 4-1BB molecule in the activation and proliferation of CD4(+) T cells and CD8(+) T cells and compare it with that of CD28 molecule...
  39. ncbi request reprint Adoptive protection from experimental myasthenia gravis with T cells from mice treated nasally with acetylcholine receptor epitopes
    Cristina Monfardini
    Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Neuroimmunol 123:123-34. 2002
    ..CD4(+) cells from C57Bl/6 mice treated with just one AChR peptide protected IL4(-/-) mice from EMG without affecting antibody synthesis...
  40. ncbi request reprint TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein
    Wei Wang
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cancer Res 2:442-52. 2004
    ..GADD45a null cells are not subject to TAFII70 inhibition, further supporting the relevance of this interaction...
  41. ncbi request reprint Expression cloning of functional receptor used by SARS coronavirus
    Peigang Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Biochem Biophys Res Commun 315:439-44. 2004
    ..When human ACE2 cDNA was transduced into NIH3T3 cells, the ACE2 expressing NIH3T3 cells could be infected with HIV/SARS pseudovirus. These data clearly demonstrated that ACE2 was the functional receptor for SARS-CoV...
  42. ncbi request reprint The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells
    Wei Wang
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA
    J Immunol 172:97-103. 2004
    ....
  43. ncbi request reprint Computational design and characterization of a monomeric helical dinuclear metalloprotein
    Jennifer R Calhoun
    Department of Biochemistry and Molecular Biophysics, Johnson Foundation, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Biol 334:1101-15. 2003
    ..DFsc is then a realization of complete de novo design, where backbone structure, activity, and sequence are specified in the design process...
  44. ncbi request reprint T cells and cytokines in the pathogenesis of acquired myasthenia gravis
    Monica Milani
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann N Y Acad Sci 998:284-307. 2003
    ..Circumstantial evidence supports a pathogenic role of IL-10 also in human MG. On the other hand, there is no direct or circumstantial evidence yet indicating a role of IL-4 in the modulatory or immunosuppressive circuits in MG...
  45. ncbi request reprint [Selective apoptosis in HeLa cells induced by sodium butyrate and its mechanism]
    Ling Xi
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:401-5. 2003
    ..To investigate apoptosis induced by sodium butyrate in cervix cancer cell line HeLa and primary human embryo lung fibroblasts and its mechanism...
  46. ncbi request reprint The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells
    Wei Wang
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota 55455 0217, USA
    J Biol Chem 278:36848-58. 2003
    ..These studies suggest interplay between a di-leucine motif and the carboxyl tail in the lysosomal targeting of the receptor...
  47. ncbi request reprint Large quantity of ribosomal RNA exists extracellularly in mouse spleen
    Wen Pu Zhao
    Department of Immunology, Peking University Health Science Center, Peking University, Beijing 100083, China
    Histochem J 34:391-6. 2002
    ..This is supported by the fact that 'thymus supernatant' also contained significant amount of RNA. A possible correlation between spleen extracellular RNA and autoimmune diseases is discussed...
  48. pmc Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells
    Xiao Yu Zhang
    Department of Immunology, Peking University Health Science Center, Peking University, Beijing, China
    Immunology 108:465-73. 2003
    ..Implications of this observation for our understanding of the immunoregulation and peripheral tolerance are discussed...
  49. ncbi request reprint [Coexpression of vascular endothelial growth factor and its receptors in human tumor cell lines]
    Jian Xin Fu
    Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou University, Suzhou 215006, P R China
    Ai Zheng 21:1217-21. 2002
    ..This study was designed to explore the gene coexpression pattern of VEGF and its receptors (Flt-1 and KDR) in variety of human malignant cell lines...
  50. ncbi request reprint Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter
    Wei Wang
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Free Radic Biol Med 37:1231-43. 2004
    ..These studies also suggest that alterations in NQO2 activity might be an important factor in susceptibility to Parkinson's disease...
  51. ncbi request reprint A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression
    Wei Wang
    University of Massachusetts Medical School, Department of Molecular and Cellular Physiology, 55 Lake Ave N, Worcester, MA 01655, USA
    J Biol Chem 279:53491-7. 2004
    ..These studies define a new role for NFI proteins as neuronal subtype-enriched transcriptional regulators that participate in an intrinsic transcriptional program directing the differentiation of cerebellar granule neurons...
  52. ncbi request reprint Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay
    Xiao Jun Ma
    Research and Development, Arcturus Bioscience, Inc, Carlsbad, CA 92008, USA
    Arch Pathol Lab Med 130:465-73. 2006
    ..Microarray-based gene expression profiling has shown great promise as a new tool to address this challenge...
  53. ncbi request reprint Sodium nitrite-induced cytotoxicity in cultured human gastric epithelial cells
    Juan Sun
    School of Public Health and Family Medicine, Capital University of Medical Sciences, Beijing, China
    Toxicol In Vitro 20:1133-8. 2006
    ..Our data demonstrate that sodium nitrite can induce the release of these inflammatory cytokines and that high concentrations of sodium nitrite decrease AGS cell proliferation...
  54. ncbi request reprint [Inhibitory effect of WT1 gene isoform transfection on proliferation of leukemia cell line NB4]
    Hui Ling Shen
    Jiangsu Provincial Institute of Hematology, The First Affiliated Hospital, Suchoow University, Suzhou, Jiangsu 215006, P R China
    Ai Zheng 25:163-9. 2006
    ..This study was designed to explore the potential effects of exogenous WT1 gene isoforms on proliferation of leukemia cell line NB4 and its possible molecular mechanisms...
  55. ncbi request reprint [Mechanism of differentiation and apoptosis in leukemia cells induced by tributyrin]
    Hong Yin
    Jiangsu Institute of Hematology, The First Affiliated Hospital, Suzhou University, Suzhou 215006, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:774-7. 2005
    ..In conclusion, the mechanism of differentiation and apoptosis in NB4, K562 cells induced by tributyrin may associate with its up-regulation of acetylated histone and p21(WAF1) mRNA level...
  56. ncbi request reprint The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:43079-86. 2005
    ..These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution...
  57. ncbi request reprint [Quantitative analysis of gene expression for vascular endothelial growth factor and its application]
    Xia Bai
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:548-52. 2005
    ....
  58. ncbi request reprint Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis
    Huidong Yuan
    Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Oncogene 24:5069-78. 2005
    ..Thus, upregulation of c-IAP2 by E6 and E7 may confer resistance to apoptosis that is necessary for sustained growth of some HPV16- and HPV18-positive cancer cells...
  59. ncbi request reprint Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer
    Wei Wang
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Oncogene 24:2705-14. 2005
    ..Therefore, this simple method of dynamic transcriptional profiling yielded a series of novel methylation-sensitive genes in breast cancer including the BRCA1 and p53 responsive gene, GADD45a...
  60. pmc Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)
    Erin Convery
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 102:1345-50. 2005
    ....
  61. pmc Expression pattern of epithelial cell adhesion molecule on normal and malignant colon tissues
    Xin Xie
    Department of Immunology, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 11:344-7. 2005
    ..To investigate the expression pattern of epithelial cell adhesion molecule (Ep-CAM) on normal and malignant colon tissues to evaluate its diagnostic and therapeutic significance...
  62. ncbi request reprint [The effects of herb lithospermum extract on MCF-7 cell and estrogen and progestogen levels in mice]
    Wei Wang
    Department of Combination of Traditional Chinese Medicine and Western Medicine, Oncology School of Peking University, Beijing 100036, China
    Zhongguo Zhong Yao Za Zhi 28:1062-7. 2003
    ..To study the effects of lithospermum extract on MCF-7 cell and estrogen and progestogen levels in mice...
  63. pmc Role of the progressive ankylosis gene (ank) in cartilage mineralization
    Wei Wang
    Department of Orthopaedics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    Mol Cell Biol 25:312-23. 2005
    ....
  64. ncbi request reprint [Electroporation-mediated gene transduction and expression of class 1 aldehyde dehydrogenase (ALDH1) and multidrug resistance gene (MDR1)]
    Xiao Wei Yang
    Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou University, Suzhou 215006, P R China
    Ai Zheng 21:138-41. 2002
    ..This study was designed to seek an efficient and safe method for transfer of genes of large size...