Andrew D Strand

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data
    Lesley Jones
    Depts of Psychological Medicine and Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK
    BMC Bioinformatics 7:211. 2006
  2. ncbi Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
    Andrew D Strand
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 27:11758-68. 2007
  3. pmc Conservation of regional gene expression in mouse and human brain
    Andrew D Strand
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 3:e59. 2007
  4. ncbi Gene expression in Huntington's disease skeletal muscle: a potential biomarker
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 14:1863-76. 2005
  5. ncbi Significance testing for small microarray experiments
    Charles Kooperberg
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA
    Stat Med 24:2281-98. 2005
  6. ncbi Evaluating test statistics to select interesting genes in microarray experiments
    Charles Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2223-32. 2002
  7. ncbi Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2207-21. 2002
  8. ncbi BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
    Andrew R Hallahan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Med 9:1033-8. 2003
  9. ncbi Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration
    Patrick Weydt
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Cell Metab 4:349-62. 2006
  10. doi Distinct neuroinflammatory profile in post-mortem human Huntington's disease
    Aurelio Silvestroni
    Department of Neurology bCenter for Neurogenetics and Neurotherapeutics, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Neuroreport 20:1098-103. 2009

Research Grants

  1. Muscle Gene Expression Biomarkers of HD
    Andrew Strand; Fiscal Year: 2006

Collaborators

Detail Information

Publications17

  1. pmc Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data
    Lesley Jones
    Depts of Psychological Medicine and Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK
    BMC Bioinformatics 7:211. 2006
    ..We conducted an experiment hybridising RNA from human brain to 117 U133A Affymetrix GeneChips and used these data to explore the relationship between 4 pre-chip variables and 22 post-chip outcomes and quality control measures...
  2. ncbi Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
    Andrew D Strand
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 27:11758-68. 2007
    ..Based on these findings, we present a testable model of HD pathogenesis that, unlike most models, begins to account for regional specificity in human HD and the absence of such specificity in genetic mouse models of HD...
  3. pmc Conservation of regional gene expression in mouse and human brain
    Andrew D Strand
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 3:e59. 2007
    ..Finally, these data on very divergent species provide context for studies in more closely related species that address questions such as the origins of cognitive differences...
  4. ncbi Gene expression in Huntington's disease skeletal muscle: a potential biomarker
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 14:1863-76. 2005
    ..Furthermore, an understanding of the molecular basis of muscle dysfunction in HD should provide insight into mechanisms involved in neuronal abnormalities and neurodegeneration...
  5. ncbi Significance testing for small microarray experiments
    Charles Kooperberg
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA
    Stat Med 24:2281-98. 2005
    ..Standard t-tests are inferior and offer almost no power when the sample size is small...
  6. ncbi Evaluating test statistics to select interesting genes in microarray experiments
    Charles Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2223-32. 2002
    ..A small simulation study compares the effectiveness of the proposed procedure with the significance analysis of microarrays (SAM) procedure...
  7. ncbi Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2207-21. 2002
    ..The method is intended to complement the Affymetrix software and to rationalize gene selection for experimental designs involving limited replication...
  8. ncbi BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
    Andrew R Hallahan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Med 9:1033-8. 2003
    ....
  9. ncbi Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration
    Patrick Weydt
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Cell Metab 4:349-62. 2006
    ..Finally, HD striatal neurons expressing exogenous PGC-1alpha were resistant to 3-nitropropionic acid treatment. Altered PGC-1alpha function may thus link transcription dysregulation and mitochondrial dysfunction in HD...
  10. doi Distinct neuroinflammatory profile in post-mortem human Huntington's disease
    Aurelio Silvestroni
    Department of Neurology bCenter for Neurogenetics and Neurotherapeutics, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Neuroreport 20:1098-103. 2009
    ..Our data suggest that neuroinflammation is a prominent feature associated with Huntington's disease and may constitute a novel target for therapeutic intervention...
  11. ncbi Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease
    Caroline L Benn
    King s College London, Medical and Molecular Genetics, GKT School of Medicine, UK
    Hum Mol Genet 14:3065-78. 2005
    ..However, our data suggest that cytoplasmic mutant exon 1 htt, if present, contributes to disease progression...
  12. ncbi Regional and cellular gene expression changes in human Huntington's disease brain
    Angela Hodges
    Department of Psychological Medicine, Wales College of Medicine and School of Biosciences, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Hum Mol Genet 15:965-77. 2006
    ..These data from bona fide HD brains comprise an important reference for hypotheses related to HD and other neurodegenerative diseases...
  13. ncbi Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays
    Min Kyu Oh
    Rose Moss Neurogenetics Laboratory for Parkinson and Related Diseases, CSMS Burns and Allen Research Institute, Division of Neurology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    J Cell Biochem 90:1068-78. 2003
    ..Based on these analyses, we recommend that replications of experiments with several selected cell lines are necessary to assess biological effects of induced gene expression...
  14. ncbi Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor
    Andrew P Lieberman
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 11:1967-76. 2002
    ..Our findings suggest that polyglutamine expansion alters androgen receptor function by promoting its degradation and by modifying its activity as a transcription factor...
  15. ncbi Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
    Alexandre Kuhn
    Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Hum Mol Genet 16:1845-61. 2007
    ....
  16. ncbi Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1927-37. 2002
    ..These results demonstrate that some of the gene expression effects of expanded polyglutamine proteins occur independently of protein context...
  17. ncbi Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1911-26. 2002
    ..The complete dataset is available at www.neumetrix.info...

Research Grants1

  1. Muscle Gene Expression Biomarkers of HD
    Andrew Strand; Fiscal Year: 2006
    ..This aim of this proposal is to develop muscle gene expression changes in HD biomarkers that will be more sensitive to disease progression than the current clinical rating scale. ..