Alanna Ruddell

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Neoplasia 10:706-13, 1 p following 713. 2008
  2. pmc B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Neoplasia 13:748-57. 2011
  3. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
  4. ncbi Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation
    Pau Mezquita
    Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Oncogene 24:889-901. 2005
  5. pmc Lymph node mapping in the mouse
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol Methods 332:170-4. 2008
  6. pmc Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1
    Momoko Furuya
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5769-77. 2010
  7. pmc Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth
    Sheila N Ganti
    Department of Comparative Medicine, University of Washington, Seattle, WA, USA
    Sci Rep 5:12255. 2015
  8. pmc B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, the Department of Biological Structure, and the Department of Comparative Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Am J Pathol 163:2233-45. 2003
  9. ncbi Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis
    Sean S Parghi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, MS C2 023, Seattle, WA 98109, USA
    Oncogene 23:4413-21. 2004
  10. pmc Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy
    Lauren M Habenicht
    Department of Comparative Medicine, University of Washington, Seattle, WA, USA
    Oncoimmunology 5:e1204505. 2016

Collaborators

  • Kenneth R Maravilla
  • Paul E Neiman
  • Jonathan S Alexander
  • Brian M Iritani
  • Tina C Albershardt
  • Maria I Harrell
  • Kimberly L Jordan-Williams
  • Lauren M Habenicht
  • Sheila N Ganti
  • Andrew G Farr
  • Sean S Parghi
  • Momoko Furuya
  • Pau Mezquita
  • Kimberly A Brandvold
  • Neela Ramanujam
  • Sara B Kirschbaum
  • Bendicht U Pauli
  • Heidi Zhang
  • Amanda Paulovich
  • Sandra J Bowers

Detail Information

Publications14

  1. pmc Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Neoplasia 10:706-13, 1 p following 713. 2008
    ..Low-molecular weight gadolinium contrast is already used for 1.5-T MRI scanning in humans, which should facilitate translation of this imaging assay...
  2. pmc B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Neoplasia 13:748-57. 2011
    ....
  3. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    ..Lymph node lymphangiogenesis and increased lymph flow through tumor-draining lymph nodes may actively promote metastasis via the lymphatics...
  4. ncbi Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation
    Pau Mezquita
    Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Oncogene 24:889-901. 2005
    ..Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway, which does not involve alteration of eIF4E activity...
  5. pmc Lymph node mapping in the mouse
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol Methods 332:170-4. 2008
    ..These techniques allow accurate and rapid identification of lymph nodes and lymphatic drainage in normal as well as diseased mice...
  6. pmc Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1
    Momoko Furuya
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5769-77. 2010
    ....
  7. pmc Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth
    Sheila N Ganti
    Department of Comparative Medicine, University of Washington, Seattle, WA, USA
    Sci Rep 5:12255. 2015
    ..This local response may be an early and critical step in generating an immunosuppressive environment to permit tumor growth and metastasis. ..
  8. pmc B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, the Department of Biological Structure, and the Department of Comparative Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Am J Pathol 163:2233-45. 2003
    ..These results indicate that constitutive c-Myc expression stimulates angiogenesis and lymphangiogenesis, which may promote the rapid growth and metastasis of c-Myc-expressing cancer cells, respectively...
  9. ncbi Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis
    Sean S Parghi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, MS C2 023, Seattle, WA 98109, USA
    Oncogene 23:4413-21. 2004
    ....
  10. pmc Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy
    Lauren M Habenicht
    Department of Comparative Medicine, University of Washington, Seattle, WA, USA
    Oncoimmunology 5:e1204505. 2016
    ..These mechanisms regulating TDLN hypertrophy could provide new targets to manipulate lymphocyte responses to cancer. ..
  11. doi Tumor-induced alterations in lymph node lymph drainage identified by contrast-enhanced MRI
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Magn Reson Imaging 42:145-52. 2015
    ..To use high resolution MRI lymphography to characterize altered tumor-draining lymph node (TDLN) lymph drainage in response to growth of aggressive tumors...
  12. pmc Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes
    Tina C Albershardt
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Immunol Methods 384:196-9. 2012
    ..We provide a shortlist of reference genes to use for normalization and recommend freely available software programs as a rapid approach to validate potential reference genes...
  13. pmc The Lymphatic Endothelial mCLCA1 Antibody Induces Proliferation and Growth of Lymph Node Lymphatic Sinuses
    Kimberly L Jordan-Williams
    Department of Comparative Medicine, University of Washington, Seattle, WA, United States of America
    PLoS ONE 11:e0156079. 2016
    ..These findings demonstrate that 10.1.1 Ab rapidly and specifically induces proliferation and growth of LN lymphatic sinuses and stroma, suggesting a key role of mCLCA1 in coordinating LN remodeling during immune responses. ..
  14. pmc Tumors induce coordinate growth of artery, vein, and lymphatic vessel triads
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    BMC Cancer 14:354. 2014
    ..These processes have generally been studied separately, so that it is not known how peritumoral blood and lymphatic vessels grow relative to each other...