James Olson

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc A class of models for analyzing GeneChip gene expression analysis array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    BMC Genomics 6:16. 2005
  2. pmc Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop D4 100, PO Box 19024, Seattle, WA 98109, USA
    Biomark Res 1:14. 2013
  3. pmc Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method
    Michelle Jeung Eun Lee
    Clinical Research Division, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e9536. 2010
  4. pmc Therapeutic opportunities for medulloblastoma come of age
    James M Olson
    Fred Hutchinson Cancer Research Center and Seattle Children s Hospital, Seattle WA 98109, USA Electronic address
    Cancer Cell 25:267-9. 2014
  5. pmc A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Theor Biol Med Model 3:19. 2006
  6. pmc Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo
    Seung Joon Lee
    Nemours Center for Childhood Cancer Research, Alfred I, duPont Hospital for Children, 1701 Rockland Road, Wilmington, DE 19803, USA
    BMC Cancer 11:144. 2011
  7. pmc Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data
    Lesley Jones
    Depts of Psychological Medicine and Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK
    BMC Bioinformatics 7:211. 2006
  8. ncbi request reprint NeuroD2 is necessary for development and survival of central nervous system neurons
    J M Olson
    Clinical Research and Human Biology Divisions and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Biol 234:174-87. 2001
  9. pmc In vivo bio-imaging using chlorotoxin-based conjugates
    Mark R Stroud
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Curr Pharm Des 17:4362-71. 2011
  10. ncbi request reprint p38 MAP kinase: a convergence point in cancer therapy
    James M Olson
    Fred Hutchinson Cancer Research Center, and Department of Pediatrics, University of Washington, Seattle, WA, USA
    Trends Mol Med 10:125-9. 2004

Research Grants

Detail Information

Publications45

  1. pmc A class of models for analyzing GeneChip gene expression analysis array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    BMC Genomics 6:16. 2005
    ....
  2. pmc Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop D4 100, PO Box 19024, Seattle, WA 98109, USA
    Biomark Res 1:14. 2013
    ..Additionally, we examined the functional consequence of p27Kip1 loss in the SmoA1 medulloblastoma model to distinguish whether p27Kip1 reduces tumor initiation or slows tumor progression...
  3. pmc Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method
    Michelle Jeung Eun Lee
    Clinical Research Division, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e9536. 2010
    ..Unfortunately, these studies are rarely done in a timely fashion because many nanotechnology labs lack the resources and expertise to synthesize radioactive nanoparticles and evaluate them in mice...
  4. pmc Therapeutic opportunities for medulloblastoma come of age
    James M Olson
    Fred Hutchinson Cancer Research Center and Seattle Children s Hospital, Seattle WA 98109, USA Electronic address
    Cancer Cell 25:267-9. 2014
    ..This molecular dissection of the SHH subclass is not simply a cutting-edge advance; the data have profound impact on clinical trial design and decision-making. ..
  5. pmc A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Theor Biol Med Model 3:19. 2006
    ..This additional capacity motivated us to develop a method to predict alternative splicing, taking advance of extensive repositories of GeneChip gene expression array data...
  6. pmc Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo
    Seung Joon Lee
    Nemours Center for Childhood Cancer Research, Alfred I, duPont Hospital for Children, 1701 Rockland Road, Wilmington, DE 19803, USA
    BMC Cancer 11:144. 2011
    ..In this study we evaluated the anti-cancer potential of curcumin in medulloblastoma by testing its ability to induce apoptosis and inhibit tumor growth in vitro and in vivo using established medulloblastoma models...
  7. pmc Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data
    Lesley Jones
    Depts of Psychological Medicine and Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK
    BMC Bioinformatics 7:211. 2006
    ..We conducted an experiment hybridising RNA from human brain to 117 U133A Affymetrix GeneChips and used these data to explore the relationship between 4 pre-chip variables and 22 post-chip outcomes and quality control measures...
  8. ncbi request reprint NeuroD2 is necessary for development and survival of central nervous system neurons
    J M Olson
    Clinical Research and Human Biology Divisions and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Biol 234:174-87. 2001
    ....
  9. pmc In vivo bio-imaging using chlorotoxin-based conjugates
    Mark R Stroud
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Curr Pharm Des 17:4362-71. 2011
    ..In this article, we review the history of chlorotoxin and its tumor specificity and discuss the research currently being generated to target optical imaging agents to cancer tissue...
  10. ncbi request reprint p38 MAP kinase: a convergence point in cancer therapy
    James M Olson
    Fred Hutchinson Cancer Research Center, and Department of Pediatrics, University of Washington, Seattle, WA, USA
    Trends Mol Med 10:125-9. 2004
    ..Here, we review p38-MAPK-mediated tumor cell apoptosis and implications for cancer therapeutics...
  11. ncbi request reprint Gene expression in Huntington's disease skeletal muscle: a potential biomarker
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 14:1863-76. 2005
    ..Furthermore, an understanding of the molecular basis of muscle dysfunction in HD should provide insight into mechanisms involved in neuronal abnormalities and neurodegeneration...
  12. ncbi request reprint Regulation of thalamocortical patterning and synaptic maturation by NeuroD2
    Gulayse Ince-Dunn
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 49:683-95. 2006
    ..These observations indicate that NeuroD2 plays a critical role in regulating synaptic maturation and the patterning of thalamocortical connections...
  13. ncbi request reprint N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Res 66:8655-61. 2006
    ....
  14. pmc Conservation of regional gene expression in mouse and human brain
    Andrew D Strand
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 3:e59. 2007
    ..Finally, these data on very divergent species provide context for studies in more closely related species that address questions such as the origins of cognitive differences...
  15. ncbi request reprint Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
    Alexandre Kuhn
    Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Hum Mol Genet 16:1845-61. 2007
    ....
  16. ncbi request reprint Assessing bias in experiment design for large scale mass spectrometry-based quantitative proteomics
    Amol Prakash
    Departments of Computer Science and Engineering, University of Washington, Seattle, Washington 98195, USA
    Mol Cell Proteomics 6:1741-8. 2007
    ..Moreover we show that reducing bias by correcting for just a few steps, for example randomizing the run order, does not provide much gain in statistical power for biomarker discovery...
  17. ncbi request reprint Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
    Andrew D Strand
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 27:11758-68. 2007
    ..Based on these findings, we present a testable model of HD pathogenesis that, unlike most models, begins to account for regional specificity in human HD and the absence of such specificity in genetic mouse models of HD...
  18. ncbi request reprint Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA)
    Susan E Spiller
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Neurooncol 87:133-41. 2008
    ..We tested the hypothesis that these drugs additively induce BMP-2 transcription and apoptosis...
  19. pmc Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas
    Joel I Pritchard
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Genet Cytogenet 180:47-50. 2008
    ..Future directions include examination of distal regions of the PTCHlb promoter as well as alternative exon variants, most notably the CpG island containing PTCH1-1C promoter...
  20. doi request reprint E protein dosage influences brain development more than family member identity
    Ali C Ravanpay
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci Res 86:1472-81. 2008
    ..These findings, together with homology in the primary peptide sequence of E proteins, suggest functional compensation among E proteins during development of the nervous system...
  21. doi request reprint The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Res 68:1768-76. 2008
    ..The Smo/Smo model is the first mouse medulloblastoma model to show leptomeningeal spread. The adherence to human pathology, high incidence, and early onset of tumors thus make Smo/Smo mice an efficient model for preclinical studies...
  22. ncbi request reprint Regional and cellular gene expression changes in human Huntington's disease brain
    Angela Hodges
    Department of Psychological Medicine, Wales College of Medicine and School of Biosciences, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Hum Mol Genet 15:965-77. 2006
    ..These data from bona fide HD brains comprise an important reference for hypotheses related to HD and other neurodegenerative diseases...
  23. ncbi request reprint Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity
    Barbara L Apostol
    Department of Psychiatry and Human Behavior, University of California, Irvine, 92697, USA
    Hum Mol Genet 15:273-85. 2006
    ..These studies suggest that pharmacological intervention in MAPK pathways, particularly at the level of ERK activation, may be an appropriate approach to HD therapy...
  24. ncbi request reprint Evaluating test statistics to select interesting genes in microarray experiments
    Charles Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2223-32. 2002
    ..A small simulation study compares the effectiveness of the proposed procedure with the significance analysis of microarrays (SAM) procedure...
  25. ncbi request reprint Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor
    Andrew P Lieberman
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 11:1967-76. 2002
    ..Our findings suggest that polyglutamine expansion alters androgen receptor function by promoting its degradation and by modifying its activity as a transcription factor...
  26. ncbi request reprint A regression-based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington's disease transgenic model
    Xie L Xu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 11:1977-85. 2002
    ..A permutation test was also used to estimate the number of false-positives, providing an alternative measurement of statistical significance useful for investigators to make decisions on follow-up studies...
  27. ncbi request reprint Medulloblastoma growth inhibition by hedgehog pathway blockade
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 297:1559-61. 2002
    ....
  28. ncbi request reprint Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2207-21. 2002
    ..The method is intended to complement the Affymetrix software and to rationalize gene selection for experimental designs involving limited replication...
  29. ncbi request reprint Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
    Edmond Y W Chan
    Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children s and Women s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4
    Hum Mol Genet 11:1939-51. 2002
    ..Furthermore, our findings suggest that short N-terminal fragments of mutant htt might be responsible for the gene expression alterations observed in human HD brain...
  30. ncbi request reprint BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
    Andrew R Hallahan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Med 9:1033-8. 2003
    ....
  31. ncbi request reprint Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays
    Min Kyu Oh
    Rose Moss Neurogenetics Laboratory for Parkinson and Related Diseases, CSMS Burns and Allen Research Institute, Division of Neurology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    J Cell Biochem 90:1068-78. 2003
    ..Based on these analyses, we recommend that replications of experiments with several selected cell lines are necessary to assess biological effects of induced gene expression...
  32. ncbi request reprint Regulation of neuroD2 expression in mouse brain
    Chin Hsing Lin
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 265:234-45. 2004
    ....
  33. ncbi request reprint The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
    Andrew R Hallahan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:7794-800. 2004
    ..Medulloblastomas in ND2:SmoA1 mice and humans have concomitant increase in Shh and Notch pathway activities, both of which contribute to tumor survival...
  34. ncbi request reprint Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1927-37. 2002
    ..These results demonstrate that some of the gene expression effects of expanded polyglutamine proteins occur independently of protein context...
  35. ncbi request reprint Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1911-26. 2002
    ..The complete dataset is available at www.neumetrix.info...
  36. ncbi request reprint Significance testing for small microarray experiments
    Charles Kooperberg
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA
    Stat Med 24:2281-98. 2005
    ..Standard t-tests are inferior and offer almost no power when the sample size is small...
  37. ncbi request reprint Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease
    Caroline L Benn
    King s College London, Medical and Molecular Genetics, GKT School of Medicine, UK
    Hum Mol Genet 14:3065-78. 2005
    ..However, our data suggest that cytoplasmic mutant exon 1 htt, if present, contributes to disease progression...
  38. ncbi request reprint Prediction of central nervous system embryonal tumour outcome based on gene expression
    Scott L Pomeroy
    Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:436-42. 2002
    ..We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis...
  39. ncbi request reprint Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease
    Marta Valenza
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Neurosci 25:9932-9. 2005
    ..We conclude that the cholesterol biosynthetic pathway is impaired in HD cells, mice, and human subjects, and that the search for HD therapies should also consider cholesterol levels as both a potential target and disease biomarker...
  40. ncbi request reprint Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
    Simonetta Sipione
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Hum Mol Genet 11:1953-65. 2002
    ..Interestingly, this study revealed differential expression of a number of genes involved in cholesterol and fatty acid metabolism, suggesting that these metabolic pathways may play a role in HD pathogenesis...
  41. ncbi request reprint Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas
    James G Douglas
    Department of Radiation Oncology, University of Washington, Seattle, 98195, USA
    J Pediatr Hematol Oncol 28:36-9. 2006
    ..6-36 Gy) retains the excellent survival rates for patients with localized, pure germinomas of the CNS. A higher rate of ventricular relapse rate is observed, although salvage of those patients is feasible...
  42. pmc Congenital hypothyroidism (cretinism) in neuroD2-deficient mice
    Chin Hsing Lin
    Clinical Research, Fred Hutchinson Cancer Research Center, Mailstop D4 100, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 26:4311-5. 2006
    ..These data indicate that neuroD2 is expressed throughout the HPT axis and that all levels of the axis are functionally affected by its absence in mice...
  43. ncbi request reprint Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma
    Susan E Spiller
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Neurooncol 79:259-70. 2006
    ..We investigated SAHA in preclinical medulloblastoma models to determine its anti-cancer efficacy as well as its ability to affect intracranial lesions when administered systemically...
  44. pmc The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning
    Chin Hsing Lin
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:14877-82. 2005
    ..Thus, neuroD2 is essential for amygdala development and genes involved in amygdala function are altered in neuroD2-deficient mice...
  45. ncbi request reprint Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci
    Mandana Veiseh
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Cancer Res 67:6882-8. 2007
    ..Mouse studies revealed that CTX:Cy5.5 has favorable biodistribution and toxicity profiles. These studies show that CTX:Cy5.5 has the potential to fundamentally improve intraoperative detection and resection of malignancies...

Research Grants2

  1. Mechanisms of Gene Dysregulation in HD
    James Olson; Fiscal Year: 2004
    ..Our long-term goal is to identify early pathogenic events in Huntington's disease in order to provide rational targets for the development of prophylactic drugs. ..
  2. bHLH Factors in Medulloblastoma Genesis and Maintenance
    James Olson; Fiscal Year: 2008
    ..abstract_text> ..