L A Milner

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation
    L A Milner
    The Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 93:2431-48. 1999
  2. ncbi request reprint Absence of major histocompatibility class II expression does not impair hematopoiesis in mice
    A I Benito
    Program in Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Exp Hematol 29:1070-5. 2001
  3. pmc Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
    A Bigas
    The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 18:2324-33. 1998
  4. ncbi request reprint Bone marrow transplantation for children less than 2 years of age with acute myelogenous leukemia or myelodysplastic syndrome
    A E Woolfrey
    Fred Hutchinson Cancer Research Center and University of Washington Departments of Pediatrics and Medicine, Seattle, WA, USA
    Blood 92:3546-56. 1998
  5. ncbi request reprint Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
    S S Huppert
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 405:966-70. 2000
  6. ncbi request reprint A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
    L A Milner
    Pediatric Oncology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109
    Blood 83:2057-62. 1994
  7. ncbi request reprint The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
    L Li
    Stower Institute for Medical Research, Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunity 8:43-55. 1998
  8. pmc Inhibition of granulocytic differentiation by mNotch1
    L A Milner
    Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle 98104, USA
    Proc Natl Acad Sci U S A 93:13014-9. 1996
  9. ncbi request reprint Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation
    J Ingles-Esteve
    Centre Oncologia Molecular, Institut de Recerca Oncologica Hospitalet, Barcelona 08907, Spain
    J Biol Chem 276:44873-80. 2001
  10. ncbi request reprint Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation
    L A Milner
    The Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 93:2431-48. 1999
  2. ncbi request reprint Absence of major histocompatibility class II expression does not impair hematopoiesis in mice
    A I Benito
    Program in Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Exp Hematol 29:1070-5. 2001
    ..We examined the role of MHC II antigens during hematopoiesis using a mouse model of MHC II deficiency related to the absence of the critical transcriptional activator, CIITA...
  3. pmc Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
    A Bigas
    The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 18:2324-33. 1998
    ..These findings suggest that the multiple forms of Notch found in mammals have structural differences that allow their function to be modulated by specific differentiation signals...
  4. ncbi request reprint Bone marrow transplantation for children less than 2 years of age with acute myelogenous leukemia or myelodysplastic syndrome
    A E Woolfrey
    Fred Hutchinson Cancer Research Center and University of Washington Departments of Pediatrics and Medicine, Seattle, WA, USA
    Blood 92:3546-56. 1998
    ..In addition, allogeneic BMT provides effective therapy for the majority of infants with MDS...
  5. ncbi request reprint Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
    S S Huppert
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 405:966-70. 2000
    ..Our results show that efficient intramembranous processing of Notch1 is indispensable for embryonic viability and proper early embryonic development in vivo...
  6. ncbi request reprint A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
    L A Milner
    Pediatric Oncology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109
    Blood 83:2057-62. 1994
    ..These findings, together with the known role of Notch homologues in other systems, suggest that members of the Notch family, including TAN-1, may be involved in mediating cell-fate decisions during hematopoiesis...
  7. ncbi request reprint The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
    L Li
    Stower Institute for Medical Research, Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunity 8:43-55. 1998
    ..These observations suggest that hJagged1 may function as a ligand for Notch1 and play a role in mediating cell fate decisions during hematopoiesis...
  8. pmc Inhibition of granulocytic differentiation by mNotch1
    L A Milner
    Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle 98104, USA
    Proc Natl Acad Sci U S A 93:13014-9. 1996
    ....
  9. ncbi request reprint Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation
    J Ingles-Esteve
    Centre Oncologia Molecular, Institut de Recerca Oncologica Hospitalet, Barcelona 08907, Spain
    J Biol Chem 276:44873-80. 2001
    ..Our results further indicate that Ser(2078) is a critical residue for phosphorylation and modulation of Notch2 activity in the context of G-CSF-induced differentiation of 32D cells...
  10. ncbi request reprint Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...