Andrew M Kaz
Affiliation: Fred Hutchinson Cancer Research Center
- DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclassesAndrew M Kaz
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Epigenetics 6:1403-12. 2011..Additional validation of those CpG sites that distinguished BE from BE + HGD and EAC may lead to the discovery of useful biomarkers with potential clinical applications in the diagnosis and prognosis of BE and EAC...
- Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinomaAndrew M Kaz
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genes Chromosomes Cancer 51:384-93. 2012..Thus, PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of BE to EAC in a subset of patients via decreased desmosome assembly and increased cell motility...
- Epigenetic biomarkers in esophageal cancerAndrew M Kaz
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States Research and Development Service, VA Puget Sound Health Care System, Seattle, WA, United States Electronic address
Cancer Lett 342:193-9. 2014..Finally, special attention will be paid to some of the challenges that must be overcome in order to develop clinically useful esophageal cancer biomarkers...
- Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's EsophagusMing Yu
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
Cancer Epidemiol Biomarkers Prev 24:1890-7. 2015..Unfortunately, many patients with BE go undiagnosed under the current BE screening guidelines. The development of noninvasive and accurate BE detection assays could potentially identify many of these undiagnosed BE patients...
- Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancerYanxin Luo
Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Electronic address
Gastroenterology 147:418-29.e8. 2014..We compared methylomes of normal colon mucosa, tubular adenomas, and colorectal cancers to determine how epigenetic alterations might contribute to cancer formation...
- Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal AdenocarcinomaAndrew M Kaz
R and D Department, VA Puget Sound Health Care System, 1660 South Columbian Way, S 111 Gastro, Seattle, WA 98109, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, USA Department of Internal Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
Gastroenterol Clin North Am 44:473-89. 2015..Assays to detect molecular alterations associated with neoplastic progression could be used to improve the pathologic assessment of BE/EAC and to select high-risk patients for more intensive surveillance. ..