Y Huang

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Semiparametric methods for evaluating risk prediction markers in case-control studies
    Ying Huang
    Fred Hutchinson Cancer Research Center, Public Health Sciences, 1100 Fairview Avenue N, Seattle, Washington 98109 1024, U S A
    Biometrika 96:991-997. 2009
  2. pmc Selection of HIV vaccine candidates for concurrent testing in an efficacy trial
    Ying Huang
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Electronic address
    Curr Opin Virol 17:57-65. 2016
  3. pmc Evaluating and comparing biomarkers with respect to the area under the receiver operating characteristics curve in two-phase case-control studies
    Ying Huang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, Seattle, WA 98109, USA
    Biostatistics 17:499-522. 2016
  4. ncbi request reprint Statistical methods for down-selection of treatment regimens based on multiple endpoints, with application to HIV vaccine trials
    Ying Huang
    Biostatistics, Bioinformatics, and Epidemiology Program, Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA
    Biostatistics . 2016
  5. pmc Identifying optimal biomarker combinations for treatment selection through randomized controlled trials
    Ying Huang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Biostatistics, University of Washington, Seattle, WA, USA
    Clin Trials 12:348-56. 2015
  6. pmc Characterizing expected benefits of biomarkers in treatment selection
    Ying Huang
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle WA, 98109, USA
    Biostatistics 16:383-99. 2015
  7. pmc Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative
    Yasmin Mossavar-Rahmani
    Department of Epidemiology and Population Health, Division of Health Promotion and Nutrition Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nutr J 12:63. 2013
  8. pmc Design and estimation for evaluating principal surrogate markers in vaccine trials
    Ying Huang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biometrics 69:301-9. 2013
  9. pmc Assessing treatment-selection markers using a potential outcomes framework
    Ying Huang
    Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA
    Biometrics 68:687-96. 2012
  10. pmc Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
    Ying Huang
    Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, and Vaccine and Infectious Diseases, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Genome Med 3:42. 2011

Collaborators

Detail Information

Publications16

  1. pmc Semiparametric methods for evaluating risk prediction markers in case-control studies
    Ying Huang
    Fred Hutchinson Cancer Research Center, Public Health Sciences, 1100 Fairview Avenue N, Seattle, Washington 98109 1024, U S A
    Biometrika 96:991-997. 2009
    ..The semiparametric methods are flexible, and naturally generalize methods previously developed for cohort data. Applications to prostate cancer risk prediction markers illustrate the methods...
  2. pmc Selection of HIV vaccine candidates for concurrent testing in an efficacy trial
    Ying Huang
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Electronic address
    Curr Opin Virol 17:57-65. 2016
    ..We illustrate the selection approaches using data from HIV-1 vaccine trials. ..
  3. pmc Evaluating and comparing biomarkers with respect to the area under the receiver operating characteristics curve in two-phase case-control studies
    Ying Huang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, Seattle, WA 98109, USA
    Biostatistics 17:499-522. 2016
    ..We demonstrate the use of the analytical variance formula for optimizing sampling schemes in biomarker study design and the application of the proposed AUC estimators to examples in HIV vaccine research and prostate cancer research. ..
  4. ncbi request reprint Statistical methods for down-selection of treatment regimens based on multiple endpoints, with application to HIV vaccine trials
    Ying Huang
    Biostatistics, Bioinformatics, and Epidemiology Program, Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA
    Biostatistics . 2016
    ..We demonstrate the application of the proposed methods through the comparison of immune responses between several HIV vaccine regimens. The methods are applicable to general down-selection applications in clinical trials...
  5. pmc Identifying optimal biomarker combinations for treatment selection through randomized controlled trials
    Ying Huang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Biostatistics, University of Washington, Seattle, WA, USA
    Clin Trials 12:348-56. 2015
    ..Our aim in this article is to further extend the algorithm to allow for variable selection in the presence of a large number of candidate markers...
  6. pmc Characterizing expected benefits of biomarkers in treatment selection
    Ying Huang
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle WA, 98109, USA
    Biostatistics 16:383-99. 2015
    ..We illustrate our methods using the Diabetes Control and Complications Trial where we evaluate the expected benefit of baseline hemoglobin A1C in selecting diabetes treatment. ..
  7. pmc Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative
    Yasmin Mossavar-Rahmani
    Department of Epidemiology and Population Health, Division of Health Promotion and Nutrition Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nutr J 12:63. 2013
    ..The extent to which psychosocial and diet behavior factors affect dietary self-report remains unclear. We examine the contribution of these factors to measurement error of self-report...
  8. pmc Design and estimation for evaluating principal surrogate markers in vaccine trials
    Ying Huang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biometrics 69:301-9. 2013
    ....
  9. pmc Assessing treatment-selection markers using a potential outcomes framework
    Ying Huang
    Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA
    Biometrics 68:687-96. 2012
    ..Finally, we illustrate the methods using an HIV vaccine trial where we explore the value of the level of preexisting immunity to adenovirus serotype 5 for predicting a vaccine-induced increase in the risk of HIV acquisition...
  10. pmc Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
    Ying Huang
    Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, and Vaccine and Infectious Diseases, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Genome Med 3:42. 2011
    ..Genotype by environment interactions may contribute further to such explanation, and may help to refine the genomic regions of interest...
  11. pmc A parametric ROC model-based approach for evaluating the predictiveness of continuous markers in case-control studies
    Y Huang
    Fred Hutchinson Cancer Research Center Public Health Sciences, 1100 Fairview Avenue N, Seattle, Washington 98109 1024, USA
    Biometrics 65:1133-44. 2009
    ..We apply the methods to prostate-specific antigen (PSA), a marker for predicting risk of prostate cancer...
  12. pmc Comparing biomarkers as principal surrogate endpoints
    Ying Huang
    Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington 98109, USA
    Biometrics 67:1442-51. 2011
    ..The methodology is illustrated using a simulated example set and a real data set in the context of HIV vaccine trials...
  13. ncbi request reprint Expressing estimators of expected quality adjusted survival as functions of Nelson-Aalen estimators
    Y Huang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Lifetime Data Anal 5:199-212. 1999
    ..Monte Carlo studies show that these estimation procedures perform well for practical sample sizes. We illustrate the methods using data from a national, multicenter AIDS clinical trial...
  14. ncbi request reprint The two-sample problem with induced dependent censorship
    Y Huang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biometrics 55:1108-13. 1999
    ..Simulation studies demonstrate that the proposed tests, with a wide range of weight choices, perform well under moderate sample sizes...