Fred Hutchinson Cancer Research Center

Summary

Organization: Fred Hutchinson Cancer Research Center
Country: USA

Top Publications

  1. doi Having a diagnosis of diabetes is not associated with general diabetes knowledge in rural Hispanics
    Rachel M Ceballos
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Rural Health 26:342-51. 2010
  2. ncbi Genomic instability during Myc-induced lymphomagenesis in the bursa of Fabricius
    P E Neiman
    Division of Basic Science, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA 98109 1024, USA
    Oncogene 25:6325-35. 2006
  3. ncbi Differences in colorectal carcinoma stage and survival by race and ethnicity
    Chloe Chien
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer 104:629-39. 2005
  4. ncbi Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
  5. ncbi Serum trans-fatty acids are associated with risk of prostate cancer in beta-Carotene and Retinol Efficacy Trial
    Irena B King
    Cancer Prevention Program, Division of Public Health Sciences, Public Health Sciences Laboratories, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Suite M 5A864, Seattle WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:988-92. 2005
  6. ncbi Comparison of lung function after myeloablative and 2 Gy of total body irradiation-based regimens for hematopoietic stem cell transplantation
    Jason W Chien
    Clinical Research Division, Fred Hutchinson Cancer Research Center Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 11:288-96. 2005
  7. ncbi Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy
    Susan E Spiller
    Division of Hematology Oncology, Children s Hospital and Regional Medical Center, Seattle, Washington 98105 0371, USA
    Pediatr Blood Cancer 45:60-3. 2005
  8. pmc Finding a place for tumor-specific T cells in targeted cancer therapy
    Stanley R Riddell
    Program in Immunology, D3 110, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Exp Med 200:1533-7. 2004
  9. ncbi Semiparametric estimation of time-dependent ROC curves for longitudinal marker data
    Yingye Zheng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biostatistics 5:615-32. 2004
  10. ncbi The evolution of a radiation safety audit program for a research institution
    David Gillette
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N J5 400, PO Box 19024, Seattle, WA 98109, USA
    Health Phys 86:S80-4. 2004

Detail Information

Publications62

  1. doi Having a diagnosis of diabetes is not associated with general diabetes knowledge in rural Hispanics
    Rachel M Ceballos
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Rural Health 26:342-51. 2010
    ..To address this we conducted a study to identify factors associated with general diabetes knowledge in a rural Hispanic population...
  2. ncbi Genomic instability during Myc-induced lymphomagenesis in the bursa of Fabricius
    P E Neiman
    Division of Basic Science, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA 98109 1024, USA
    Oncogene 25:6325-35. 2006
    ..Palindromic loci in TF and tumors, however, were expressed, many at high levels, suggesting an abundance of RNA species with long double-stranded segments generated during tumorigenesis...
  3. ncbi Differences in colorectal carcinoma stage and survival by race and ethnicity
    Chloe Chien
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer 104:629-39. 2005
    ..Data regarding other races/ethnicities were limited, especially for Asian/Pacific Islander and Hispanic white subgroups...
  4. ncbi Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
    ..01). The current study provides some support for a role of IGFs in colorectal cancer etiology, particularly in mediating the relationship of common risk factors (physical activity, BMI, and postmenopausal hormone use)...
  5. ncbi Serum trans-fatty acids are associated with risk of prostate cancer in beta-Carotene and Retinol Efficacy Trial
    Irena B King
    Cancer Prevention Program, Division of Public Health Sciences, Public Health Sciences Laboratories, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Suite M 5A864, Seattle WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:988-92. 2005
    ..Additional studies are needed to confirm these findings and better control for factors, such as use of prostate-specific antigen screening, which may confound this association...
  6. ncbi Comparison of lung function after myeloablative and 2 Gy of total body irradiation-based regimens for hematopoietic stem cell transplantation
    Jason W Chien
    Clinical Research Division, Fred Hutchinson Cancer Research Center Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 11:288-96. 2005
    ....
  7. ncbi Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy
    Susan E Spiller
    Division of Hematology Oncology, Children s Hospital and Regional Medical Center, Seattle, Washington 98105 0371, USA
    Pediatr Blood Cancer 45:60-3. 2005
    ..This case illustrates an unusual presentation of bone marrow failure secondary to malignant melanoma in a young child with symptomatic metastatic marrow infiltration, a rarely reported site of melanoma involvement in adults or children...
  8. pmc Finding a place for tumor-specific T cells in targeted cancer therapy
    Stanley R Riddell
    Program in Immunology, D3 110, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Exp Med 200:1533-7. 2004
    ..Recent success using the adoptive transfer of tumor-specific T cells has fueled optimism that this approach may find a place as a targeted therapy for some human cancers...
  9. ncbi Semiparametric estimation of time-dependent ROC curves for longitudinal marker data
    Yingye Zheng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biostatistics 5:615-32. 2004
    ..1999, Medical Decision Making, 19, 242-251) suggests that the ability to relax distributional assumptions may be important in practice...
  10. ncbi The evolution of a radiation safety audit program for a research institution
    David Gillette
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N J5 400, PO Box 19024, Seattle, WA 98109, USA
    Health Phys 86:S80-4. 2004
    ..At the Fred Hutchinson Cancer Research Center (FHCRC), the radiation safety office has developed an audit program that accomplishes these two ..
  11. ncbi Functional link between Myc and the Werner gene in tumorigenesis
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell Cycle 3:22-5. 2004
    ..In addition, we address the apparent paradox of why patients with WS, lacking WRN function, have increased incidence of certain cancers...
  12. ncbi Association between late age at infectious mononucleosis, Epstein-Barr virus antibodies, and ovarian cancer risk
    Alyson J Littman
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Scand J Infect Dis 35:728-35. 2003
    ..5-18.4) increased risk of ovarian cancer. Together, these two studies provide some support for the hypothesis that late age at primary infection with a common agent (conceivably, EBV) may play a role in the etiology of ovarian cancer...
  13. ncbi Nitrate in public water supplies and the risk of colon and rectum cancers
    Anneclaire J De Roos
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Epidemiology 14:640-9. 2003
    ..N-nitroso compound formation is inhibited by certain nutrients, such as vitamin C, and increased by meat intake...
  14. pmc Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder after high-dose immunosuppressive therapy and autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases
    Richard A Nash
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 9:583-91. 2003
    ..The differences between equine and rabbit ATG are not yet clearly defined, and they should not be considered interchangeable in this regimen without further study...
  15. ncbi Revisiting the role of dose intensity in hematological malignancies
    Leona A Holmberg
    Fred Hutchinson Cancer Research Center, Clinical Division, and University of Washington School of Medicine, Department of Medicine, Seattle, WA 98109 1024, USA
    Exp Hematol 34:811-25. 2006
  16. ncbi Prospective study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis
    Zhen Yan
    Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Arthritis Rheum 54:2069-73. 2006
    ....
  17. ncbi Recognition of breast cancer cells by CD8+ cytotoxic T-cell clones specific for NY-BR-1
    Wei Wang
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Res 66:6826-33. 2006
    ..Taken together, these results show that the p904 epitope derived from NY-BR-1 is efficiently processed and presented endogenously and identify NY-BR-1 as a promising target for T-cell-based immunotherapy for breast cancer...
  18. pmc Lack of utility of chimerism studies obtained 2-3 months after myeloablative hematopoietic cell transplantation for ALL
    Kc Doney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Bone Marrow Transplant 42:271-4. 2008
    ..There was no correlation of mixed chimerism with transplant outcome. Routine 'day 80' chimerism studies in this group of patients who receive intensive, myeloablative conditioning regimens are not recommended...
  19. doi Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma
    Ulrike Peters
    Public Health Science, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1144-54. 2008
    ..We therefore investigated whether genetic variants in selenoenzymes abundantly expressed in the colon are associated with advanced colorectal adenoma, a cancer precursor...
  20. doi A forensic evaluation of the National Emphysema Treatment Trial using the expected value of information approach
    Scott D Ramsey
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    Med Care 46:542-8. 2008
    ....
  21. ncbi Systemic autoimmune disease mortality and occupational exposures
    L S Gold
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Arthritis Rheum 56:3189-201. 2007
    ..To generate hypotheses regarding occupational exposures that may cause systemic autoimmune diseases...
  22. ncbi Attitudes and beliefs about colorectal cancer among Mexican Americans in communities along the US-Mexico border
    Gloria D Coronado
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Ave N, M3 B232, Seattle, WA 98109, USA
    Ethn Dis 16:421-7. 2006
    ..The purpose of this study was to examine Mexican American knowledge, attitudes, and beliefs about colorectal cancer and barriers to receiving colorectal cancer screening exams...
  23. ncbi Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 67:7534-9. 2007
    ..Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone...
  24. ncbi Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:962-8. 2007
    ..This has stimulated extensive laboratory and clinical research, as well as much commercial and public enthusiasm. However, the epidemiologic evidence remains inconclusive...
  25. pmc Stable trichimerism after marrow grafting from 2 DLA-identical canine donors and nonmyeloablative conditioning
    Scott S Graves
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 110:418-23. 2007
    ....
  26. pmc Data quality assessment of ungated flow cytometry data in high throughput experiments
    Nolwenn Le Meur
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cytometry A 71:393-403. 2007
    ..Especially, data quality control and quality assessment are crucial steps in processing and analyzing high throughput flow cytometry data...
  27. pmc Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort
    Yumie Takata
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI, USA
    BMC Cancer 7:30. 2007
    ..This cross-sectional analysis examined the relation between mammographic density and the CYP1A2*1F and COMT Val58 Met polymorphisms among 332 breast cancer cases and 254 controls in the Hawaii component of the Multiethnic Cohort...
  28. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    ..Lymph node lymphangiogenesis and increased lymph flow through tumor-draining lymph nodes may actively promote metastasis via the lymphatics...
  29. ncbi A haplotype-linkage analysis method for estimating recombination rates using dense SNP trio data
    Lue Ping Zhao
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genet Epidemiol 31:154-72. 2007
    ....
  30. ncbi How flies get their size: genetics meets physiology
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, B 2152, Seattle, Washington 98109, USA
    Nat Rev Genet 7:907-16. 2006
    ..However, we still understand little about how size is actually sensed, or how organ-intrinsic size controls interface with whole-body physiology...
  31. ncbi Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:876-81. 2003
    ..We estimate that the Ser217Leu genotype may account for approximately 14% of less aggressive prostate cancer cases and 9% of all sporadic cases in the general United States population of white men <age 65 years...
  32. ncbi A parametric empirical Bayes method for cancer screening using longitudinal observations of a biomarker
    Martin W McIntosh
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue MP 900, Seattle, WA 98109, USA
    Biostatistics 4:27-40. 2003
    ..Our method was specifically developed for use in screening for cancer with a new biomarker, but it is appropriate whenever the pre-clinical behavior of the disease and/or biomarker is uncertain...
  33. ncbi At the interfaces of epidemiology, genetics and genomics
    J D Potter
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Rev Genet 2:142-7. 2001
    ..The only recourse is to teach each other the rules of your own game and then decide whether you can collectively invent a new sport. Welcome to the dialogue at the intersections of epidemiology with genetics and genomics...
  34. ncbi Breast cancer risk and "delayed" primary Epstein-Barr virus infection
    Y Yasui
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:9-16. 2001
    ..018). Adjusting for additional potential confounders did not modify the associations appreciably. The implications of the findings and a potential biological mechanism are presented...
  35. pmc Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae
    E J Foss
    Division of Basic Sciences, A3 023, Fred Hutchinson Cancer Research Center, 1100 Faiorview Ave, Seattle, WA 98109 1024, USA
    Genetics 157:567-77. 2001
    ..I suggest a model in which Tof1p functions to link Mec1p with Rad53p...
  36. ncbi Gene silencing: two faces of SIR2
    D E Gottschling
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Biol 10:R708-11. 2000
    ..But recent discoveries about the most evolutionarily conserved silencing protein, Sir2p, have provided new mechanistic insights into these processes...
  37. ncbi Flow cytometric screening of cell-based libraries
    P S Daugherty
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, 98109, Seattle, WA, USA
    J Immunol Methods 243:211-27. 2000
    ..With this aim, an analysis of the various parameters involved in screening cell-based libraries for rare target cells possessing a desired trait is presented...
  38. ncbi Evidence that juvenile myelomonocytic leukemia can arise from a pluripotential stem cell
    L J Cooper
    Departments of Pediatrics, Medicine, and Laboratory Medicine, University of Washington, and Hematologics, Inc, Seattle WA, USA
    Blood 96:2310-3. 2000
    ..These data support the hypothesis that JMML can arise in a pluripotent hematopoietic cell...
  39. ncbi T-cell therapy of cytomegalovirus and human immunodeficiency virus infection
    S R Riddell
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle 98109, USA
    J Antimicrob Chemother 45:35-43. 2000
    ..The progress of these studies in cytomegalovirus and human immunodeficiency virus infection is the subject of this review...
  40. ncbi Hemopoietic stem cell transplantation for myelodysplastic syndrome
    H J Deeg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Curr Opin Oncol 12:116-20. 2000
    ..High treatment-related morbidity and mortality rates, particularly after allogeneic transplantation, remain challenges that must be addressed with innovative approaches...
  41. ncbi Prospects for whole-genome linkage disequilibrium mapping of common disease genes
    L Kruglyak
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Genet 22:139-44. 1999
    ..Second, the extent of LD is similar in isolated populations unless the founding bottleneck is very narrow or the frequency of the variant is low (<5%)...
  42. ncbi Durability and diffusion of the nutrition intervention in the Working Well Trial
    R E Patterson
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Prev Med 27:668-73. 1998
    ..We used data from 107 worksites in the WWT to test whether the nutrition intervention activities were maintained after the research program (i.e., durability) or were adopted by control sites (i.e., diffusion)...
  43. ncbi Ensuring the quality of quality of life data: the Southwest Oncology Group experience
    C M Moinpour
    Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Stat Med 17:641-51. 1998
    ....
  44. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons...
  45. ncbi Polymerase chain reaction-based detection of minimal residual disease in acute lymphoblastic leukemia predicts relapse after allogeneic BMT
    J Radich
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Biol Blood Marrow Transplant 1:24-31. 1995
    ..The PCR assay for MRD appears to be a sensitive and specific test, identifying patients at high risk of relapse following allogeneic BMT who might benefit from further therapeutic interventions...
  46. ncbi The role of HLA matching in hematopoietic cell transplantation
    J A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Rev Immunogenet 1:359-73. 1999
    ..There remain, however, important unanswered questions about the relative importance of different HLA loci in matching strategies, as well as incomplete information about permissible limits of mismatching in different patient populations...
  47. ncbi Human papillomaviruses and cervical cancer in Bangkok. III. The role of husbands and commercial sex workers
    D B Thomas
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 153:740-8. 2001
    ..Commercial sex workers in Bangkok are reservoirs of oncogenic HPV, and cervical cancer in monogamous Thai women develops in part as a result of transmission of these viruses to them by their husbands from prostitutes...
  48. ncbi Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury
    R A Zager
    University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Kidney Int 59:1750-61. 2001
    ..The present studies sought to provide initial insights into these issues...
  49. ncbi Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg)
    Eric L Sievers
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood Cells Mol Dis 31:7-10. 2003
    ..Information assembled from prospective, ongoing studies in the United States and the United Kingdom should help us use this novel immunoconjugate in a safe and effective manner...
  50. ncbi Birthweight and risk of overall and cause-specific childhood mortality
    Christopher I Li
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Paediatr Perinat Epidemiol 17:164-70. 2003
    ..Our results suggest that birthweight exerts important influences on children's risk of age-specific and cause-specific mortalities, particularly those with a strong biological component...
  51. ncbi Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation
    Jason W Chien
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3 190, P O Box 19024, Seattle, WA 98109 1024, USA
    Am J Respir Crit Care Med 168:208-14. 2003
    ....
  52. ncbi Life-threatening thrombocytopenia associated with acute Epstein-Barr virus infection in an older adult
    R B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, WA 98109 1024, USA
    Ann Hematol 81:672-5. 2002
    ..In this report we also briefly summarize the literature on EBV-associated severe thrombocytopenia...
  53. ncbi Diet and exercise habits of patients with diabetes, dyslipidemia, cardiovascular disease or hypertension
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Coll Nutr 21:394-401. 2002
    ....
  54. ncbi Risk of prostate cancer in relation to polymorphisms of metabolic genes
    C Chen
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, DE320, Seattle, WA 98109, USA
    Epidemiol Rev 23:30-5. 2001
    ..Since gene-gene and gene-environment interactions may contribute to cancer risk, it would be desirable to conduct studies in which both biomarkers (or other measures) of exposure and polymorphisms of multiple genes are examined...
  55. ncbi An evaluation of phase I clinical trial designs in the continuous dose-response setting
    B E Storer
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stat Med 20:2399-408. 2001
    ..Allowing interpolation between doses for updating during CRM did not improve overall performance...
  56. ncbi Relative impact of patient and clinic factors on adherence to primary care preventive service guidelines: an exploratory study
    S D Ramsey
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Med Care 39:979-89. 2001
    ..Preventive care service use is commonly compared across health plans, clinics, or individual providers, yet little is known about the influence of the clinic versus patient factors on utilization of these services...
  57. ncbi Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants
    M Boeckh
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    J Infect Dis 184:350-4. 2001
    ..Thus, palivizumab appears to be safe and well tolerated in HSCT recipients...
  58. ncbi Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
    C M Ulrich
    Public Health Sciences Division and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Blood 98:231-4. 2001
    ..23; 34% slower to 20 000/microL, P =.08). Patients with decreased MTHFR activity appear at risk of higher MTX toxicity. Because of the high prevalence of the TT genotype, these results may have implications for MTX dosage...
  59. ncbi FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    D L Stirewalt
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 97:3589-95. 2001
    ..Blood. 2001;97:3589-3595)..
  60. ncbi Use of perfluorochemical liquid allows earlier detection of gene expression and use of less vector in normal lung and enhances gene expression in acutely injured lung
    D J Weiss
    Division of Pulmonary and Critical Care Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mol Ther 3:734-45. 2001
    ..Thus, PFC liquid may be a useful adjunct for clinical lung gene transfer, particularly for injured or diseased lungs...
  61. pmc Statistical modeling of large microarray data sets to identify stimulus-response profiles
    L P Zhao
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98006, USA
    Proc Natl Acad Sci U S A 98:5631-6. 2001
    ..The method provides estimates of the mean activation and deactivation times, induced and basal expression levels, and statistical measures of the precision of these estimates for each periodic transcript...
  62. pmc Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks
    W D Downs
    Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder 80309 0215, USA
    RNA 2:718-32. 1996
    ..Specific binding sites for Mg2+ may make this cation particularly efficient at electrostatic stabilization during folding of these ribozyme structures...

Research Grants62

  1. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  2. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  3. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  4. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  5. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993
    ..By addressing the above, new insights into heme protein/low molecular weight protein nephrotoxicity and shock-induced renal damage will be obtained which should have direct relevance to crush syndrome induced ARF...
  6. A Multi-State Study of Cancer Treatment and Outcomes Among American Indians
    Scott Ramsey; Fiscal Year: 2007
    ..Our study is greatly enhanced by the close working partnerships among the Fred Hutchinson Cancer Research Center, the Medicaid programs of all three states, and two tribal health boards with tribal epidemiology ..
  7. A Genetic Screening Policy Model for Colorectal Cancer
    Scott Ramsey; Fiscal Year: 2006
    ..The model will incorporate QOL information from Aim 2, along with family history, clinical, and screening information from the Seattle CFR. ..
  8. A Multi-State Study of Cancer Treatment and Outcomes Among American Indians
    Scott D Ramsey; Fiscal Year: 2010
    ..Our study is greatly enhanced by the close working partnerships among the Fred Hutchinson Cancer Research Center, the Medicaid programs of all three states, and two tribal health boards with tribal epidemiology ..
  9. COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER
    Scott Ramsey; Fiscal Year: 2002
    ....
  10. Tamoxifen & Second Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2007
    ..which women have increased or decreased risks of developing CBC if they use tamoxifen? (4) Among the CBC cases, how does tamoxifen alter the expression of these tumor markers in first compared to contralateral cancers? ..
  11. Protein Biomarkers of Cancer Risk in Older Persons
    Christopher Li; Fiscal Year: 2007
    ....
  12. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2007
    ..such as parity and body mass index, modify this association?; and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR? ..
  13. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    The candidate has recently accepted a junior faculty member position in epidemiology at the Fred Hutchinson Cancer Research Center. His immediate goals are to pursue his interests in breast cancer etiology, and to further his research ..
  14. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2009
    ..such as parity and body mass index, modify this association?; and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR? ..
  15. Risk Factors for Second Primary Breast Cancer Among DCIS Survivors
    Christopher I Li; Fiscal Year: 2010
    ....
  16. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2010
    ....
  17. Cell Death and Clonal Survival in Myelodysplastic Syndr*
    H Deeg; Fiscal Year: 2007
    ..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
  18. WT1 Expression in Patients with MDS Treated with ATG an*
    H Deeg; Fiscal Year: 2007
    ....
  19. NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROME
    H Deeg; Fiscal Year: 2003
    ..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..
  20. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2010
    ..Our ultimate goal is to gain information for use in translational programs of prostate cancer prevention and treatment. ..
  21. Diet and Genetic Risks for Prostate Cancer
    Marian Neuhouser; Fiscal Year: 2005
    ..To date, there are 718 confirmed cases of primary prostatic carcinoma. This proposed study will provide important information about prostate cancer etiology and suggest new strategies for prevention and control. ..
  22. USE OF ANTIOXIDANT SUPPLEMENTS AND OXIDATIVE DNA DAMAGE
    Marian Neuhouser; Fiscal Year: 2006
    ....
  23. Postprandial glycemic response to 4-week low and high glycemic load diets
    Marian Neuhouser; Fiscal Year: 2007
    ..Volunteers enrolled in a randomized cross-over feeding study will be asked to eat two additional meals; we will monitor the postprandial responses by measuring biomarkers in the blood for eight hours after the meals. ..
  24. Hepatitis B ESL Education for Chinese
    Victoria Taylor; Fiscal Year: 2009
    ..Our primary outcome will be HBV serologic testing. Knowledge about key hepatitis B facts will be examined as a secondary outcome. ..