Chi Tarn

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint The molecular pathogenesis of gastrointestinal stromal tumors
    Chi Tarn
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Clin Colorectal Cancer 6:S7-17. 2006
  2. pmc Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
    Chi Tarn
    Departments of Medical Oncology and Pathology and Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 105:8387-92. 2008
  3. ncbi request reprint Molecular research directions in the management of gastrointestinal stromal tumors
    Chi Tarn
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Curr Treat Options Oncol 6:473-86. 2005
  4. ncbi request reprint Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms
    Chi Tarn
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 66:5477-86. 2006
  5. pmc High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 48:886-96. 2009
  6. ncbi request reprint Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling
    Chi Tarn
    Department of Medical Oncology, Basic Sciences, and Pathology, Fox Case Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 11:3668-77. 2005
  7. ncbi request reprint Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines
    Sook Lee
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907 1246, USA
    J Biol Chem 277:8730-40. 2002

Detail Information

Publications7

  1. ncbi request reprint The molecular pathogenesis of gastrointestinal stromal tumors
    Chi Tarn
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Clin Colorectal Cancer 6:S7-17. 2006
    ..This article will discuss the molecular basis of pathogenesis and genetic and genomic alterations that contribute to GIST tumorigenesis and disease progression as well as the heterogeneity of this disease...
  2. pmc Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
    Chi Tarn
    Departments of Medical Oncology and Pathology and Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 105:8387-92. 2008
    ....
  3. ncbi request reprint Molecular research directions in the management of gastrointestinal stromal tumors
    Chi Tarn
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Curr Treat Options Oncol 6:473-86. 2005
    ..As with most recent efforts to derive novel molecular target therapies to treat cancer, improved therapy of GIST will continue to benefit from advances in the molecular characterization of this disease...
  4. ncbi request reprint Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms
    Chi Tarn
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 66:5477-86. 2006
    ....
  5. pmc High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 48:886-96. 2009
    ..These results suggest that GISTs without activating kinase mutations, whether pediatric or adult, generally exhibit a much lower level of cytogenetic progression than that observed in mutant GISTs...
  6. ncbi request reprint Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling
    Chi Tarn
    Department of Medical Oncology, Basic Sciences, and Pathology, Fox Case Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 11:3668-77. 2005
    ..In this study, KIT and PDGFRalpha mutation status was analyzed and protein modeling approaches were used to assess the potential effect of KIT mutations in response to imatinib therapy...
  7. ncbi request reprint Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines
    Sook Lee
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907 1246, USA
    J Biol Chem 277:8730-40. 2002
    ..We propose that in 4pX-1 cells, pX deregulates the G(2)/M checkpoint, thus rescuing cells from pX-mediated apoptosis...