Lori Rink

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study
    Yun Shin Chun
    Hepato Pancreato Biliary Programs, Virginia Piper Cancer Institute, 800 E, 28th Street, Suite 602, Minneapolis, MN 55407, USA
    World J Surg Oncol 12:231. 2014
  2. pmc ZNF-mediated resistance to imatinib mesylate in gastrointestinal stromal tumor
    Lori Rink
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e54477. 2013
  3. pmc Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor
    Lori Rink
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 8:2172-82. 2009
  4. pmc The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cell Cycle 7:2949-55. 2008
  5. pmc Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
    Chi Tarn
    Departments of Medical Oncology and Pathology and Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 105:8387-92. 2008
  6. pmc Clinical and molecular characteristics of gastrointestinal stromal tumors in the pediatric and young adult population
    Lori Rink
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Curr Oncol Rep 11:314-21. 2009
  7. pmc High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 48:886-96. 2009
  8. pmc Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor
    Phillip Zook
    Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Clin Cancer Res . 2016
  9. pmc Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case
    Martin G Belinsky
    Molecular Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111 2497, USA
    BMC Cancer 15:887. 2015
  10. pmc Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 52:214-24. 2013

Collaborators

Detail Information

Publications10

  1. pmc Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study
    Yun Shin Chun
    Hepato Pancreato Biliary Programs, Virginia Piper Cancer Institute, 800 E, 28th Street, Suite 602, Minneapolis, MN 55407, USA
    World J Surg Oncol 12:231. 2014
    ..The aim of this study is to determine expression levels of IGFs and receptors in NAFLD-associated HCC...
  2. pmc ZNF-mediated resistance to imatinib mesylate in gastrointestinal stromal tumor
    Lori Rink
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e54477. 2013
    ..Knockdown of the 14 IM-sensitizing genes (10 ZNFs) universally led to downregulation of six genes, including TGFb3, periostin, and NEDD9. These studies implicate a role of KRAB-ZNFs in modulating response to TKIs in GIST...
  3. pmc Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor
    Lori Rink
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 8:2172-82. 2009
    ....
  4. pmc The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cell Cycle 7:2949-55. 2008
    ..We also discuss how the IGF pathway may provide additional molecular targets for the treatment of GISTs that respond poorly to IM therapy...
  5. pmc Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
    Chi Tarn
    Departments of Medical Oncology and Pathology and Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 105:8387-92. 2008
    ....
  6. pmc Clinical and molecular characteristics of gastrointestinal stromal tumors in the pediatric and young adult population
    Lori Rink
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Curr Oncol Rep 11:314-21. 2009
    ....
  7. pmc High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 48:886-96. 2009
    ..These results suggest that GISTs without activating kinase mutations, whether pediatric or adult, generally exhibit a much lower level of cytogenetic progression than that observed in mutant GISTs...
  8. pmc Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor
    Phillip Zook
    Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Clin Cancer Res . 2016
    ..Inhibiting additional molecular targets may provide more substantial disease control. Recent studies have implicated the PI3K/AKT pathway in the survival of imatinib mesylate-resistant GIST cell lines and tumors...
  9. pmc Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case
    Martin G Belinsky
    Molecular Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111 2497, USA
    BMC Cancer 15:887. 2015
    ..An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex has been identified for a subset of these "wild type" GISTs...
  10. pmc Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 52:214-24. 2013
    ..As a novel finding, inactivation of the SDHC gene from a combination of a heterozygous coding-region mutation and hypermethylation of the wild-type allele was found in one SDHB-negative case...