Alexander Kutikov

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. doi Renal Mass Biopsy: Always, Sometimes, or Never?
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA Electronic address
    Eur Urol 70:403-6. 2016
  2. doi Urology Tag Ontology Project: Standardizing Social Media Communication Descriptors
    Alexander Kutikov
    Division of Urologic Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA Electronic address
    Eur Urol 69:183-5. 2016
  3. pmc Academic ranking score: a publication-based reproducible metric of thought leadership in urology
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Eur Urol 61:435-9. 2012
  4. pmc Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    Alexander Kutikov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Urology 78:968.e7-11. 2011
  5. pmc Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephrometry score
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center Philadelphia, PA 19111, USA
    Eur Urol 60:241-8. 2011
  6. doi Use of radical cystectomy as initial therapy for the treatment of high-grade T1 urothelial carcinoma of the bladder: a SEER database analysis
    Daniel Canter
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urol Oncol 31:866-70. 2013
  7. doi Partial nephrectomy for renal masses ≥ 7 cm: technical, oncological and functional outcomes
    Christopher J Long
    Department of Urologic Oncology Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 109:1450-6. 2012
  8. pmc Assessing the burden of complications after surgery for clinically localized kidney cancer by age and comorbidity status
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA Electronic address
    Urology 83:843-9. 2014
  9. doi Perioperative outcomes of robotic and open partial nephrectomy for moderately and highly complex renal lesions
    Jay Simhan
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 187:2000-4. 2012
  10. pmc Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 11:1510-7. 2012

Detail Information

Publications87

  1. doi Renal Mass Biopsy: Always, Sometimes, or Never?
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA Electronic address
    Eur Urol 70:403-6. 2016
    ..Renal mass biopsy is a useful clinical tool; nevertheless, in a majority of patients, renal mass biopsy in its current form does not alter clinical management. Its routine use in all-comers is not indicated outside of clinical protocols. ..
  2. doi Urology Tag Ontology Project: Standardizing Social Media Communication Descriptors
    Alexander Kutikov
    Division of Urologic Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA Electronic address
    Eur Urol 69:183-5. 2016
    ..Standardizing social media hashtag descriptors is likely to facilitate communication and promote collaboration in both health care provider and patient communities. ..
  3. pmc Academic ranking score: a publication-based reproducible metric of thought leadership in urology
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Eur Urol 61:435-9. 2012
    ..Hospital rankings have become integral to the marketing strategies of many health care systems. Methodology used in compiling these lists appears highly flawed...
  4. pmc Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    Alexander Kutikov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Urology 78:968.e7-11. 2011
    ..As such, we investigated whether cellular IL-6 production can predict TKI response in both in vitro and in vivo models...
  5. pmc Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephrometry score
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center Philadelphia, PA 19111, USA
    Eur Urol 60:241-8. 2011
    ..Counseling patients with enhancing renal mass currently occurs in the context of significant uncertainty regarding tumor pathology...
  6. doi Use of radical cystectomy as initial therapy for the treatment of high-grade T1 urothelial carcinoma of the bladder: a SEER database analysis
    Daniel Canter
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urol Oncol 31:866-70. 2013
    ..We analyzed the Surveillance Epidemiology and End Results (SEER) database to ascertain the use of RC as an initial therapy for clinical HGT1 bladder cancer...
  7. doi Partial nephrectomy for renal masses ≥ 7 cm: technical, oncological and functional outcomes
    Christopher J Long
    Department of Urologic Oncology Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 109:1450-6. 2012
    ..As such, partial nephrectomy should be a surgical option when feasible regardless of tumour size. Study Type - Therapy (case series) Level of Evidence 4...
  8. pmc Assessing the burden of complications after surgery for clinically localized kidney cancer by age and comorbidity status
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA Electronic address
    Urology 83:843-9. 2014
    ..To examine the association between high-risk patient status (age >75 years or Charlson comorbidity index count >2) and postoperative complications in patients undergoing surgical management for clinically localized renal tumors...
  9. doi Perioperative outcomes of robotic and open partial nephrectomy for moderately and highly complex renal lesions
    Jay Simhan
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 187:2000-4. 2012
    ..We compared outcomes in patients undergoing robotic vs open partial nephrectomy stratified by moderately and highly complex tumor nephrometry scores...
  10. pmc Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 11:1510-7. 2012
    ..Our findings underscore the importance of PTEN expression in relation to sunitinib resistance and imply a direct cytotoxic effect by sunitinib on tumor cells in addition to its antiangiogenic actions...
  11. pmc Assessing performance trends in laparoscopic nephrectomy and nephron-sparing surgery for localized renal tumors
    Marc C Smaldone
    Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 80:286-91. 2012
    ..To assess the impact of laparoscopy on usage of partial nephrectomy (PN) by comparing national usage trends in patients undergoing surgery for localized renal tumors...
  12. doi Trends in regionalization of radical cystectomy in three large northeastern states from 1996 to 2009
    Marc C Smaldone
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urol Oncol 31:1663-9. 2013
    ..To assess regionalization trends and short-term clinical outcomes in patients undergoing radical cystectomy for urothelial carcinoma...
  13. ncbi Is there a benefit to frozen section analysis at the time of partial nephrectomy?
    Steven N Sterious
    Department of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 1911, USA
    Can J Urol 20:6778-84. 2013
    ..The utility of frozen section performance during partial nephrectomy (PN) is controversial. We assessed the predictive value of frozen sections on final margin status for patients undergoing PN for localized renal tumors...
  14. doi Thermal ablation of the small renal mass: case selection using the R.E.N.A.L.-Nephrometry Score
    Jose Reyes
    Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urol Oncol 31:1292-7. 2013
    ..Here we correlate the salient anatomical attributes of renal masses undergoing TA with technical and oncologic outcomes...
  15. pmc Role of tumor location in selecting patients for percutaneous versus surgical cryoablation of renal masses
    Christopher J Long
    Department of Urology, Temple University Hospital, Philadelphia, Pennsylvania, USA
    Can J Urol 19:6417-22. 2012
    ..To characterize the relationship between tumor location and choice in selecting surgical cryoablation (SCA) versus percutaneous cryoablation (PCA) for treatment of renal masses...
  16. pmc Clinical characteristics associated with treatment type for localized renal tumors: implications for practice pattern assessment
    Marc C Smaldone
    Division of Urologic Oncology, Department of Surgery, Fox Chase Cancer Center Temple University Health System, Philadelphia, PA 19111, USA
    Urology 81:269-75. 2013
    ..To determine the associations between the pretreatment characteristics and treatment selection in patients presenting with clinical stage I renal masses...
  17. pmc Competing risks of death in patients with localized renal cell carcinoma: a comorbidity based model
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 188:2077-83. 2012
    ..These factors must be considered against the benefits of treatment. We constructed a model of competing causes of death to help contextualize treatment trade-off analyses in patients with localized renal cell carcinoma...
  18. pmc Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells
    Konstantin V Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Prostate 73:23-30. 2013
    ..In this study, we investigate the functional impact of piperlongumine (PL), a naturally occurring alkaloid present in the Long pepper (Piper longum), on AR expression in PC cells and delineate its mechanism of action...
  19. doi Pathological concordance and surgical outcomes of sporadic synchronous unilateral multifocal renal masses treated with partial nephrectomy
    Jay Simhan
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 189:43-7. 2013
    ..We characterized pathological concordance rates in this population and evaluated the outcomes of nephron preservation...
  20. pmc Are all multi-targeted tyrosine kinase inhibitors created equal? An in vitro study of sunitinib and pazopanib in renal cell carcinoma cell lines
    Daniel Canter
    Division of Urologic Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Can J Urol 18:5819-25. 2011
    ..We examined the in vitro cellular effects of the multi-targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and pazopanib on a series of human renal cell carcinoma (RCC) cell lines...
  21. pmc Objective measures of renal mass anatomic complexity predict rates of major complications following partial nephrectomy
    Jay Simhan
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 19111, USA
    Eur Urol 60:724-30. 2011
    ..The association between tumor complexity and postoperative complications after partial nephrectomy (PN) has not been well characterized...
  22. doi Percutaneous vs surgical cryoablation of the small renal mass: is efficacy compromised?
    Christopher J Long
    Departments of Urological Oncology and Biostatistics, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA, USA
    BJU Int 107:1376-80. 2011
    ..To review and analyse the cumulative literature to compare surgical and percutaneous cryoablation of small renal masses (SRMs)...
  23. doi Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy
    Daniel Canter
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Urology 77:160-5. 2011
    ..To evaluate the proportion of patients with muscle-invasive urothelial carcinoma (UC) who would be eligible to receive cisplatin-based chemotherapy before and after radical cystectomy based on renal function...
  24. pmc Comparison of prostate cancer diagnosis in patients receiving unrelated urological and non-urological cancer care
    Anthony T Corcoran
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 19111, USA
    BJU Int 112:161-8. 2013
    ..To evaluate prostate cancer diagnosis rates and survival outcomes in patients receiving unrelated (non-prostate) urological care with those in patients receiving non-urological care...
  25. doi Trends in regionalization of adrenalectomy to higher volume surgical centers
    Jay Simhan
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 188:377-82. 2012
    ..We determined the extent of regionalization of care for adrenal surgery and the extent to which this centralization has evolved with time...
  26. doi Delayed proximal ureteric stricture formation after complex partial nephrectomy
    Jose M Reyes
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 109:539-43. 2012
    ..To report and review our incidence of delayed ureteric stricture (US) after complex nephron-sparing surgery (NSS)...
  27. pmc Use of systemic therapy and factors affecting survival for patients undergoing cytoreductive nephrectomy
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 106:218-23. 2010
    ....
  28. pmc Prevalence of baseline chronic kidney disease in patients presenting with solid renal tumors
    Daniel Canter
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 77:781-5. 2011
    ..sCr inadequately reflects renal function. eGFR and chronic kidney disease CKD stage are more clinically relevant parameters to reflect the risk of morbidity and mortality in patients after nephron loss...
  29. pmc Robot-assisted partial nephrectomy: a large single-institutional experience
    Benjamin J Scoll
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 75:1328-34. 2010
    ..The robotic surgical system may enable faster and greater technical proficiency, facilitating a minimally invasive approach to more difficult lesions while reducing ischemia time...
  30. pmc Growth kinetics and short-term outcomes of cT1b and cT2 renal masses under active surveillance
    Reza Mehrazin
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center Temple University Health System, Philadelphia, Pennsylvania Electronic address
    J Urol 192:659-64. 2014
    ..We assessed the growth kinetics and outcomes of cT1b/T2 cortical renal tumors managed by an initial period of active surveillance. We compared these cases to those treated with definitive delayed intervention...
  31. pmc Patients with anatomically "simple" renal masses are more likely to be placed on active surveillance than those with anatomically "complex" lesions
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA Electronic address
    Urol Oncol 32:1267-71. 2014
    ..To determine if radiographically less complex renal lesions are deemed clinically less "worrisome" and therefore are more likely to be considered for active surveillance (AS)...
  32. ncbi Prolonged natural progression from localized to symptomatic renal cell carcinoma
    Steve Sterious
    Department of Surgucal Oncology, Division of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Can J Urol 19:6578-80. 2012
    ..We present a case of a localized, clinical stage T2 renal mass progressing to regional and systemic disease over 6 years, demonstrating that kinetics of disease progression may be prolonged and are yet to be fully understood...
  33. pmc Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity
    Peter Makhov
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 72:661-7. 2012
    ..Thus, we investigated whether the co-administration of piperine and docetaxel could increase docetaxel's pharmacokinetic activity in vitro and in vivo...
  34. pmc Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis
    Marc C Smaldone
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer 118:997-1006. 2012
    ..The authors systematically reviewed the literature and conducted a pooled analysis of studies on small renal masses who underwent active surveillance to identify the risk progression and the characteristics associated with metastases...
  35. pmc Genomic Copy Number Alterations in Renal Cell Carcinoma with Sarcomatoid Features
    Timothy Ito
    Cancer Biology Program and Blood Cell Development and Function Program ED, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    J Urol 195:852-8. 2016
    ..In this study we aimed to pinpoint unique copy number alterations in sarcomatoid renal cell carcinoma compared to classical renal cell carcinoma subtypes...
  36. ncbi Patient reported outcomes among treatment modalities for prostate cancer
    Matthew E Johnson
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Can J Urol 23:8535-8545. 2016
    ....
  37. pmc Care transitions between hospitals are associated with treatment delay for patients with muscle invasive bladder cancer
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Fox Chase Cancer Center Temple University Health System, Philadelphia, Pennsylvania
    J Urol 192:1349-54. 2014
    ....
  38. pmc Variation in performance of candidate surgical quality measures for muscle-invasive bladder cancer by hospital type
    Anthony T Corcoran
    Division of Urologic Oncology, Fox Chase Cancer Center Temple University Health System, Philadelphia, PA, USA
    BJU Int 115:230-7. 2015
    ..Proposed quality measures include receipt of neoadjuvant chemotherapy, timely treatment, adequate lymph node dissection, and continent urinary diversion...
  39. doi Renal pelvic anatomy is associated with incidence, grade, and need for intervention for urine leak following partial nephrectomy
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA, USA Electronic address
    Eur Urol 66:949-55. 2014
    ..Although the effect of tumor complexity on perioperative outcome measures is well established, the impact of renal pelvic anatomy on perioperative outcomes remains poorly defined...
  40. pmc Accelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, and efficient neoadjuvant treatment for muscle-invasive bladder cancer: results of a multicenter phase II study with molecular correlates of response and toxicity
    Elizabeth R Plimack
    Elizabeth R Plimack, Rosalia Viterbo, Eric A Ross, Richard E Greenberg, David Y T Chen, Yu Ning Wong, Alexander Kutikov, Efrat Dotan, Essel Dulaimi, Reza Mehrazin, Robert G Uzzo, and Gary R Hudes, Fox Chase Cancer Center, Temple Health Jean H Hoffman Censits, Edouard J Trabulsi, Costas D Lallas, Jianqing Lin, and William Kevin Kelly, Thomas Jefferson University Hospital, Philadelphia, PA Timothy A Brennan and Norma Palma, Foundation Medicine, Cambridge, MA and Stephen A Boorjian, Mayo Clinic, Rochester, MN
    J Clin Oncol 32:1895-901. 2014
    ....
  41. pmc Internal validation of the renal pelvic score: a novel marker of renal pelvic anatomy that predicts urine leak after partial nephrectomy
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA Electronic address
    Urology 84:351-7. 2014
    ..To internally validate the renal pelvic score (RPS) in an expanded cohort of patients undergoing partial nephrectomy (PN)...
  42. pmc Nephron-sparing management vs radical nephroureterectomy for low- or moderate-grade, low-stage upper tract urothelial carcinoma
    Jay Simhan
    Division of Urologic Oncology, Departments of Surgical Oncology, Philadelphia, PA, USA
    BJU Int 114:216-20. 2014
    ..To compare overall and cancer-specific outcomes between patients with upper tract urothelial carcinoma (UTUC) managed with either radical nephroureterectomy (RNU) or nephron-sparing measures (NSM) using a large population-based dataset...
  43. pmc Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells
    Serge Ginzburg
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA
    Prostate 74:177-86. 2014
    ..We look at the effects of piperlongumine (PL), a biologically active alkaloid/amide present in piper longum plant, on the NF-κB pathway in androgen-independent prostate cancer cells...
  44. doi Familiarity and self-reported compliance with American Urological Association best practice recommendations for use of thromboembolic prophylaxis among American Urological Association members
    Steve Sterious
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 190:992-8. 2013
    ....
  45. pmc Does partial nephrectomy result in a durable overall survival benefit in the Medicare population?
    Marc C Smaldone
    Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 188:2089-94. 2012
    ..We assessed whether the impact of partial nephrectomy and radical nephrectomy on overall mortality differed by patient age in a Medicare population undergoing surgery for T1a renal cell carcinoma...
  46. pmc The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells
    Ervin Teper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 80:1391.e1-7. 2012
    ....
  47. doi Clinical Stage T1 micropapillary urothelial carcinoma presenting with metastasis to the pancreas
    Daniel Canter
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 79:e9-10. 2012
    ..To our knowledge, this case represents the first report of a solitary metastatic urothelial carcinoma to the pancreas...
  48. doi Adrenocortical carcinoma masquerading as a benign adenoma on computed tomography washout study
    Jay Simhan
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 79:e19-20. 2012
    ..We present a case of a 5-cm adrenal lesion with computed tomography washout characteristics consistent with a benign adenoma, which proved upon resection to be an adrenocortical carcinoma...
  49. doi Temporal trends and factors associated with systemic therapy after cytoreductive nephrectomy: an analysis of the National Cancer Database
    Marc C Smaldone
    Division of Urologic Oncology, Fox Chase Cancer Center Temple University Health System, Philadelphia, Pennsylvania
    J Urol 193:1108-13. 2015
    ..We used data from a large national cancer registry and assessed characteristics associated with the receipt of systemic treatment...
  50. doi Evaluating toxicity from definitive radiation therapy for prostate cancer in men with inflammatory bowel disease: Patient selection and dosimetric parameters with modern treatment techniques
    Colin T Murphy
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania Electronic address
    Pract Radiat Oncol 5:e215-22. 2015
    ..Inflammatory bowel disease (IBD) is considered a contraindication to abdominopelvic radiation therapy (RT). We examined our experience in men with IBD who were treated with definitive RT for prostate cancer...
  51. ncbi Use of Postprostatectomy Radiation Therapy at an NCI-Designated Comprehensive Cancer Center
    Jeffrey M Martin
    From the Department of Radiation Oncology, Department of Biostatistics, and Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    J Natl Compr Canc Netw 13:525-30. 2015
    ..Characterize use of postprostatectomy radiation (PPRT) for patients with prostate cancer at an NCI-designated comprehensive cancer center...
  52. doi Surgical Apgar Score predicts an increased risk of major complications and death after renal mass excision
    Timothy Ito
    Fox Chase Cancer Center, Philadelphia, Pennsylvania Electronic address
    J Urol 193:1918-22. 2015
    ..We assessed the ability of the Surgical Apgar Score to identify patients most at risk for postoperative morbidity and mortality after renal mass excision...
  53. pmc Utility of the R.E.N.A.L. nephrometry scoring system in objectifying treatment decision-making of the enhancing renal mass
    Daniel Canter
    Department of Surgical Oncology, Division of Urology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 78:1089-94. 2011
    ....
  54. pmc Routine adrenalectomy is unnecessary during surgery for large and/or upper pole renal tumors when the adrenal gland is radiographically normal
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 185:1198-203. 2011
    ..We evaluated the radiographic and pathological incidence of adrenal involvement in patients undergoing renal surgery for renal cell carcinoma 7 cm or greater...
  55. doi Small-Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review
    Kyungsuk Jung
    Department of Medicine, Fox Chase Cancer Center, Philadelphia, PA Electronic address
    Clin Genitourin Cancer . 2016
    ..Small-cell carcinoma of the bladder is a poorly differentiated neoplasm with aggressive behavior. We analyzed clinical outcomes of patients who were treated at our institution to identify an optimal treatment strategy...
  56. pmc Comparison of testicular dose delivered by intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in patients with prostate cancer
    Jeffrey M Martin
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA
    Med Dosim 40:186-9. 2015
    ..There was a small but statistically significant increase in mean testicular dose delivered by VMAT compared with IMRT. Despite this, it unlikely that there is a clinically meaningful difference in testicular doses from either modality...
  57. pmc Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma
    Konstantin Golovine
    a Cancer Biology Program Fox Chase Cancer Center Philadelphia, PA, USA
    Cancer Biol Ther 16:743-9. 2015
    ..As such, PL and PL analogs hold promise as potential therapeutic agents for the treatment of metastatic RCC and the prevention of postoperative RCC recurrence. ..
  58. doi Residual Parenchymal Volume, Not Warm Ischemia Time, Predicts Ultimate Renal Functional Outcomes in Patients Undergoing Partial Nephrectomy
    Serge Ginzburg
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University, Philadelphia, PA
    Urology 86:300-5. 2015
    ..While residual functional parenchymal volume (FPV) is proposed as the key factor in predicting functional outcomes following NSS, efforts to curtail ischemia time continue to add technical complexity to partial nephrectomy...
  59. pmc Coexisting hybrid malignancy in a solitary sporadic solid benign renal mass: implications for treating patients following renal biopsy
    Serge Ginzburg
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania
    J Urol 191:296-300. 2014
    ..Concern regarding coexisting malignant pathology in benign renal tumors deters renal biopsy and questions its validity. We examined the rates of coexisting malignant and high grade pathology in resected benign solid solitary renal tumors...
  60. pmc The gatekeeper disparity--why do some medical schools send more medical students into urology?
    Alexander Kutikov
    Division of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Urol 185:647-52. 2011
    ..We evaluated the reasons why some medical schools consistently send more students into urology than others...
  61. ncbi Transrectal implantation of electromagnetic transponders following radical prostatectomy for delivery of IMRT
    Daniel Canter
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Can J Urol 18:5844-8. 2011
    ..Although emerging, our initial oncologic and functional outcomes have been promising...
  62. pmc Docetaxel-mediated apoptosis in myeloid progenitor TF-1 cells is mitigated by zinc: potential implication for prostate cancer therapy
    Peter Makhov
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 71:1413-9. 2011
    ..Induction of pre-mitotic arrest protects cells against docetaxel-mediated toxicity and affords therapeutic opportunities...
  63. pmc Evaluating overall survival and competing risks of death in patients with localized renal cell carcinoma using a comprehensive nomogram
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 19111, USA
    J Clin Oncol 28:311-7. 2010
    ....
  64. doi Contemporary Trends in the Utilization of Radiotherapy in Patients With Renal Cell Carcinoma
    Talha Shaikh
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA
    Urology 86:1165-73. 2015
    ..To examine the utilization of radiation therapy (RT) in patients with renal cell carcinoma (RCC) using a large national tumor registry...
  65. doi A review of interventional clinical trials in renal cell carcinoma: a status report from the ClinicalTrials.gov WebSite
    Matthew Zibelman
    Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA Electronic address
    Clin Genitourin Cancer 13:142-9. 2015
    ..The objective of this study was to assess the current landscape of clinical trials (CTs) in RCC to identify areas of strength and opportunities for improvement...
  66. pmc Anatomic complexity quantitated by nephrometry score is associated with prolonged warm ischemia time during robotic partial nephrectomy
    Jeffrey J Tomaszewski
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA Electronic address
    Urology 84:340-4. 2014
    ..To assess the association between nephrometry score (NS) and prolonged warm ischemia time (WIT) in patients undergoing robotic partial nephrectomy (RPN) for clinically localized renal masses...
  67. doi RENAL nephrometry scoring system: the radiologist's perspective
    Rosaleen B Parsons
    Department of Diagnostic Imaging, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    AJR Am J Roentgenol 199:W355-9. 2012
    ..The purpose of this article is to understand how the score is determined and review the five key features that contribute to the nephrometry score...
  68. pmc Prostate bed motion during intensity-modulated radiotherapy treatment
    Tracy Klayton
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Int J Radiat Oncol Biol Phys 84:130-6. 2012
    ..In this series, we report prostate bed localization and motion characteristics, using data collected from implanted radiofrequency transponders...
  69. doi The role of minimally invasive surgery in multifocal renal cell carcinoma
    Serge Ginzburg
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University, Philadelphia, PA 19111, USA
    Curr Urol Rep 13:202-10. 2012
    ..Short-term results suggest minimally invasive nephron-sparing surgery is safe, feasible, and should be considered as a potential treatment option for patients who present with multiple tumors in the same renal unit...
  70. pmc Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 32:1773-81. 2011
    ....
  71. ncbi Implantation of electromagnetic transponders following radical prostatectomy for delivery of IMRT
    Daniel Canter
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Can J Urol 17:5365-9. 2010
    ..We describe our technique of ultrasound-guided placement of these transponders into the prostate bed for adjuvant and salvage RT...
  72. pmc Zinc and zinc transporters in prostate carcinogenesis
    Vladimir Kolenko
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, PA 19111 2497, USA
    Nat Rev Urol 10:219-26. 2013
    ..Only then can the potential of zinc and zinc transport proteins be harnessed in the diagnosis and treatment of men with prostate cancer...
  73. doi Biochemical and clinical experience with real-time intraoperatively planned permanent prostate brachytherapy
    Wilhelm Lubbe
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Brachytherapy 11:209-13. 2012
    ..To evaluate patient characteristics and dosimetric parameters that predict biochemical failure (BCF) after real-time planned low-dose-rate prostate brachytherapy...
  74. doi Intensely positron emission tomography-avid benign adrenal adenoma
    Daniel Canter
    Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 78:1307-8. 2011
    ..The pathologic evaluation after laparoscopic adrenalectomy revealed a benign adrenal adenoma...
  75. pmc Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism
    Konstantin Golovine
    Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Cancer 9:183. 2010
    ..The prostate is one of the organs with highest levels of cadmium accumulation. Importantly, patients with prostate cancer appear to have higher levels of cadmium both in the circulation and in prostatic tissues...
  76. doi Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy
    Daniel Canter
    Departments of Urologic Oncology, Medical Oncology and Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 107:58-62. 2011
    ..To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC)...
  77. pmc Effects of increased cross-sectional imaging on the diagnosis and prognosis of adrenocortical carcinoma: analysis of the National Cancer Database
    Alexander Kutikov
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 186:805-10. 2011
    ..We assessed whether incidental screening due to imaging performed for other purposes has resulted in earlier detection or better outcomes in patients with adrenocortical carcinoma...
  78. ncbi Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms' tumor variant
    Zachary Piotrowski
    Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Can J Urol 17:5309-12. 2010
    ..A case of the rare, benign, Wilms' tumor (WT) variant, metanephric adenofibroma (MAF), is presented...
  79. pmc The rise and fall of prostate brachytherapy: use of brachytherapy for the treatment of localized prostate cancer in the National Cancer Data Base
    Jeffrey M Martin
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Cancer 120:2114-21. 2014
    ..In this study, the authors examined trends in brachytherapy use for localized prostate cancer using a large national cancer registry...
  80. doi Anthropometric differences in obese men with biochemical failure after radical retropubic prostatectomy
    Phillip Mucksavage
    Division of Urology, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Urol Oncol 30:590-5. 2012
    ..To investigate these differences, we used endorectal coil MRI (eMRI) data to directly measure fat thicknesses in obese men who underwent RRP...
  81. pmc Young age under 60 years is not a contraindication to treatment with definitive dose escalated radiotherapy for prostate cancer
    Tracy L Klayton
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia 19111, United States
    Radiother Oncol 101:508-12. 2011
    ..It is widely believed that younger prostate cancer patients are at greater risk of recurrence following radiotherapy (RT)...
  82. doi How Hugh Hampton Young's treatment of President Woodrow Wilson's urinary retention and urosepsis affected the resolution of World War I
    Ryan Fogg
    Temple University Hospital RF, and Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 186:1153-6. 2011
    ..The effects of these health problems are examined in the context of their implications on international affairs...
  83. pmc Renal masses herniating into the hilum: technical considerations of the "ball-valve phenomenon" during nephron-sparing surgery
    Brett Lebed
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 75:707-10. 2010
    ..However, PN is underutilized particularly in anatomically challenging cases. Often unrecognized is the tendency for central renal tumors to herniate into the renal sinus...
  84. doi The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 182:844-53. 2009
    ..We have developed and propose a standardized nephrometry scoring system (R.E.N.A.L. Nephrometry Score) to quantify the anatomical characteristics of renal masses on computerized tomography/magnetic resonance imaging...
  85. pmc Focal therapy for kidney cancer: a systematic review
    Alexander Kutikov
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Curr Opin Urol 19:148-53. 2009
    ..Laparoscopic and percutaneous minimally invasive ablative technologies are being increasingly employed in current urologic practice. We review recent literature regarding focal ablative treatments of SRMs...
  86. doi Splenogonadal fusion: a rare etiology of solid testicular mass
    Neil J Kocher
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA
    Urology 83:e1-2. 2014
    ..Splenogonadal fusion is an exceptionally rare, typically benign, congenital anomaly. Splenogonadal fusion should be included in the differential diagnosis of a left-sided testicular mass. ..
  87. doi The impact of residency match information disseminated by a third-party website
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Surg Educ 66:212-5. 2009
    ..We hypothesized that information on this website played a significant role in decision making throughout the urology residency match experience...