Andres J Klein-Szanto

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10196. 2010
  2. pmc VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1698. 2008
  3. pmc WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome
    Maria I Nunez
    Department of Carcinogenesis, The University of Texas M, d, Anderson Cancer Center, Science Park Research Division, Smithville TX, USA
    BMC Cancer 5:64. 2005
  4. pmc Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells
    Mitsuteru Natsuizaka
    Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Carcinogenesis 31:1344-53. 2010
  5. pmc Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion
    Katharine D Grugan
    Gastroenterology Division, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Proc Natl Acad Sci U S A 107:11026-31. 2010
  6. pmc A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 71:6836-47. 2011
  7. pmc Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:4174-84. 2010
  8. pmc Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer
    Carmen Z Michaylira
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:5281-92. 2010
  9. pmc Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9
    Mahendra K Singh
    Departments of Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 70:8907-16. 2010
  10. pmc GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt
    Deborah A Altomare
    Women s Cancer, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 16:486-96. 2010

Collaborators

Detail Information

Publications36

  1. pmc VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10196. 2010
    ..These results show that VILIP-1 overexpression decreases the susceptibility to skin carcinogenesis in experimental mouse cancer models, thus supporting its role as a tumor suppressor gene...
  2. pmc VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1698. 2008
    ....
  3. pmc WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome
    Maria I Nunez
    Department of Carcinogenesis, The University of Texas M, d, Anderson Cancer Center, Science Park Research Division, Smithville TX, USA
    BMC Cancer 5:64. 2005
    ....
  4. pmc Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells
    Mitsuteru Natsuizaka
    Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Carcinogenesis 31:1344-53. 2010
    ..In aggregate, IGFBP3 may have a novel IGF-binding independent biological function in regulation of TGF-beta1-mediated EMT and cell invasion...
  5. pmc Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion
    Katharine D Grugan
    Gastroenterology Division, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Proc Natl Acad Sci U S A 107:11026-31. 2010
    ..These results highlight the potential benefit of the therapeutic targeting of HGF/Met signaling in ESCC and potentially other squamous cancers where this pathway is deregulated...
  6. pmc A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 71:6836-47. 2011
    ....
  7. pmc Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:4174-84. 2010
    ....
  8. pmc Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer
    Carmen Z Michaylira
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:5281-92. 2010
    ..Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer...
  9. pmc Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9
    Mahendra K Singh
    Departments of Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 70:8907-16. 2010
    ..These studies identify NEDD9 as a complex modulator of different aspects of mammary tumor growth...
  10. pmc GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt
    Deborah A Altomare
    Women s Cancer, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 16:486-96. 2010
    ..The broad long-term objective of this project was to use preclinical cancer models with precisely defined genetic lesions to elucidate the efficacy of targeting Akt with GSK690693...
  11. pmc Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis
    Craig W Menges
    Authors Affiliations Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida Verastem Inc, Cambridge, Massachusetts and Cancer Research Institute, Southern Medical University, Guangdong Province, PR China
    Cancer Res 74:1261-71. 2014
    ..These findings suggest that cooperativity between losses of Nf2 and Cdkn2a plays a fundamental role in driving the highly aggressive tumorigenic phenotype considered to be a hallmark of malignant mesothelioma...
  12. pmc Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development
    Jason A Watts
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Genet 7:e1002277. 2011
    ....
  13. pmc Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis
    Mitsuteru Natsuizaka
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 2144, USA
    FASEB J 26:2620-30. 2012
    ..Finally, IGFBP3 mRNA was found enriched to the polysomes. In aggregate, our study establishes IGFBP3 as a direct HIF-1α target gene and that polysome enrichment of IGFBP3 mRNA may permit continuous translation under hypoxic conditions...
  14. ncbi request reprint Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 421 Curie Boulevard, BRB II III, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:699-704. 2006
    ..The heterodimerization of PGHS1-PGHS2 may explain how the ductus arteriosus closes normally at birth in mice expressing PGHS2 Y385F, but not in PGHS2-null mice...
  15. pmc ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells
    Keneshia K Haenssen
    Department of Biochemistry and Molecular Biology, 245 N 15 Street, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Cell Sci 123:1373-82. 2010
    ....
  16. pmc IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts
    Kathryn E Hamilton
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Carcinogenesis 34:2647-54. 2013
    ..Taken together, these findings implicate IMP1 as a modulator of tumor growth and provide evidence for a novel role of IMP1 in early events in CRC metastasis. ..
  17. ncbi request reprint Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression
    Ricardo Lopez De Cicco
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:4480-8. 2004
    ..The pattern of expression of furin and vascular endothelial growth factor-C (VEGF-C), two key molecules in neoplasm development, was examined during the progression from normal epithelium to invasive SCC...
  18. pmc NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 139:2113-23. 2010
    ..However, the functional roles of Notch in esophageal squamous epithelial biology are unknown...
  19. doi request reprint Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma
    Jacqueline F Morris
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Pathol 44:766-76. 2013
    ..This nuclear localization and correlation with tumor differentiation in adenocarcinoma suggests a potentially important transcriptional and biochemical role of this phosphorylation site in carcinogenesis of this tumor type...
  20. pmc The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers
    Igor Makhlin
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 108:E84-90. 2011
    ..To investigate whether mammalian target of rapamycin (mTOR) inhibition by rapamycin is therapeutically efficacious in combination with cisplatin for bladder cancer...
  21. pmc Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 15:169-79. 2013
    ..02). Thus, we observed an increased susceptibility to UV in single furin transgenic mice that was not substantially enhanced in the double furin/PACE4 transgenic mice...
  22. pmc Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice
    Gabrielle S Wong
    Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 144:294-7. 2013
    ..Periostin might be a biomarker of the esophageal tumor microenvironment that can be used to detect preneoplastic lesions...
  23. pmc Promoter regulation of the visinin-like subfamily of neuronal calcium sensor proteins by nuclear respiratory factor-1
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 284:27577-86. 2009
    ..Our results further indicated that NRF-1 could be a regulatory factor for gene expression of the other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD...
  24. pmc In vivo selection for metastasis promoting genes in the mouse
    Kiranmai Gumireddy
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:6696-701. 2007
    ..These data identify a link between disulfide isomerases and tumor development, and provide a mechanism that modulates ErbB2 and PI3K signaling in the promotion of cancer progression...
  25. pmc Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice
    Marie Pier Tetreault
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 139:2124-2134.e9. 2010
    ..Its pathogenesis involves chronic epithelial irritation, although the factors involved in the inflammatory process and the mechanisms of carcinogenesis are unknown. We sought to develop a mouse model of this cancer...
  26. ncbi request reprint Inflammatory breast cancer (IBC): clues for targeted therapies
    Sandra V Fernandez
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 140:23-33. 2013
    ..Additionally, FC-IBC02 showed amplification of ALK and NOTCH3. These results indicate that MYC, ATAD2, CD44, NOTCH3, ALK and/or FAK1 may be used as potential targeted therapies against IBC. ..
  27. doi request reprint Dissecting Pin1 and phospho-pRb regulation
    Flavio Rizzolio
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 228:73-7. 2013
    ....
  28. pmc Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis
    Deborah A Altomare
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18828. 2011
    ..Furthermore, while inactivation of Arf appears to be crucial for MM pathogenesis, the inactivation of both p16(Ink4a) and p19(Arf) cooperate to accelerate asbestos-induced tumorigenesis...
  29. pmc The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation
    Takaomi Okawa
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:2788-803. 2007
    ....
  30. ncbi request reprint Frequent activation of AKT2 kinase in human pancreatic carcinomas
    Deborah A Altomare
    Human Genetic Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 87:470-6. 2002
    ..Overall, these data suggest that upstream perturbations of the PI3K/AKT pathway contribute to frequent activation of AKT2 in pancreatic cancer, which may contribute to the pathogenesis of this highly aggressive form of human malignancy...
  31. pmc Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
    Salvatore Cortellino
    Cancer Biology Program and Epigenetics and Progenitor Cells Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell 146:67-79. 2011
    ....
  32. ncbi request reprint Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1498-506. 2007
    ..These mice will provide a valuable reagent with which to elucidate the distinct roles of the COX enzymes in mammalian biology...
  33. ncbi request reprint Activation of the mTOR signaling pathway in renal clear cell carcinoma
    Victoria A Robb
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 177:346-52. 2007
    ..We determined the frequency of mTOR/p70S6 kinase signaling pathway activation in clear cell renal cell carcinoma...
  34. doi request reprint The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
    Qihong Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Nat Cell Biol 10:202-10. 2008
    ..Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs...
  35. doi request reprint Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study
    Russell J Schilder
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Clin Oncol 26:3418-25. 2008
    ..The association between the expression of certain markers and clinical outcome was investigated...
  36. ncbi request reprint AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    Deborah A Altomare
    Human Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 23:5853-7. 2004
    ..Collectively, these findings indicate that active AKT and downstream mTOR represent potentially important therapeutic and/or chemopreventive targets in ovarian cancer...