Affiliation: Fox Chase Cancer Center
- Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y)Yuwaraj Kadariya
Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
Biochem J 387:175-83. 2005..Our results show that the hMTAP expression is regulated by a CBF and that the distal one of two CCAAT motifs plays a major role in the transcriptional activation of hMTAP gene...
- Molecular characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase-deficient mutant clones of murine lymphoma cell line R1.1Yuwaraj Kadariya
Department of Laboratory Medicine, Mie University School of Medicine and Central Clinical Laboratories, Mie University Hospital, Tsu, Mie 514 8507, Japan
Cancer Sci 94:519-22. 2003..Thus, C223Y may account for the partial deficiency in the F clone, but the complete deficiency with a remarkably low MTAP mRNA level in the H5 clone may be a result of transcriptional abnormality in addition to C223Y mutation...
- Deletion of dinucleotide repeat (Delta 14 allele) in the methylthioadenosine phosphorylase (MTAP) promoter and the allelotype of MTAP promoter in the Japanese populationYuwaraj Kadariya
Department of Laboratory Medicine, Mie University Faculty of Medicine, Tsu, Mie 514 8507, Japan
Jpn J Cancer Res 93:369-73. 2002..These results indicated that the Delta 14 allele has nothing to do with MTAP deficiency in DHL-9. The Delta 14 allele is distributed among the general population irrespective of gender...