John P Hoffman

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. doi request reprint Status of neoadjuvant therapy for resectable pancreatic cancer
    John P Hoffman
    Fox Chase Cancer Center and Temple University School of Medicine, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Surg Oncol Clin N Am 19:411-8. 2010
  2. doi request reprint Significance of pathologic response to preoperative therapy in pancreatic cancer
    Yun Shin Chun
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 18:3601-7. 2011
  3. doi request reprint Five year results of US intergroup/RTOG 9704 with postoperative CA 19-9 ≤90 U/mL and comparison to the CONKO-001 trial
    Adam C Berger
    Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 84:e291-7. 2012
  4. pmc The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 81:1328-35. 2011
  5. ncbi request reprint The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Division of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:235-40; discussion 240. 2004
  6. doi request reprint Survival after pancreatectomy with major arterial resection and reconstruction
    Karyn B Stitzenberg
    Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann Surg Oncol 15:1399-406. 2008
  7. ncbi request reprint Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: analysis of histopathology and outcome
    Aaron R Sasson
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Gastrointest Cancer 34:121-8. 2003
  8. ncbi request reprint Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:2000-9. 2007
  9. ncbi request reprint Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:1081-91. 2007
  10. ncbi request reprint Peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreas
    Ingrid M Meszoely
    Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:208-13; discussion 213-4. 2004

Collaborators

Detail Information

Publications41

  1. doi request reprint Status of neoadjuvant therapy for resectable pancreatic cancer
    John P Hoffman
    Fox Chase Cancer Center and Temple University School of Medicine, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Surg Oncol Clin N Am 19:411-8. 2010
    ..This article focuses on the effects of the trials and studies conducted on neoadjuvant therapy and also on the hindrances and limitations that must be overcome for this therapy to gain widespread traction...
  2. doi request reprint Significance of pathologic response to preoperative therapy in pancreatic cancer
    Yun Shin Chun
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 18:3601-7. 2011
    ..Pathologic response to preoperative therapy is increasingly recognized as an important prognostic factor in solid tumors. The impact of pathologic response on survival in pancreatic adenocarcinoma is not well established...
  3. doi request reprint Five year results of US intergroup/RTOG 9704 with postoperative CA 19-9 ≤90 U/mL and comparison to the CONKO-001 trial
    Adam C Berger
    Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 84:e291-7. 2012
    ..This report analyzes 5-year survival by serum level of tumor marker CA 19-9 of ≤90 vs >90 U/mL and compares results to the those of the CONKO-001 trial...
  4. pmc The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 81:1328-35. 2011
    ....
  5. ncbi request reprint The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Division of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:235-40; discussion 240. 2004
    ..After curative PD for pancreatic cancer, the ratio of metastatic to examined lymph nodes is an important prognostic factor and should be evaluated in stratification schemes for future clinical trials investigating adjuvant treatments...
  6. doi request reprint Survival after pancreatectomy with major arterial resection and reconstruction
    Karyn B Stitzenberg
    Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann Surg Oncol 15:1399-406. 2008
    ..We hypothesize that resection of a tumor-involved hepatic artery (HA) or celiac artery (CA) with reconstruction may offer a survival benefit to patients whose tumors were traditionally regarded as unresectable...
  7. ncbi request reprint Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: analysis of histopathology and outcome
    Aaron R Sasson
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Gastrointest Cancer 34:121-8. 2003
    ..Although retrospective,this series suggests an improvement in survival in patients treated with neoadjuvant therapy...
  8. ncbi request reprint Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:2000-9. 2007
    ..Resection offers the only reasonable probability for cure, but at the cost of perioperative morbidity and potential mortality. Clinical decision making remains difficult...
  9. ncbi request reprint Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:1081-91. 2007
    ..Resection offers the only reasonable probability for cure, but at the cost of marked perioperative morbidity and potential mortality. Clinical decision making remains difficult...
  10. ncbi request reprint Peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreas
    Ingrid M Meszoely
    Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:208-13; discussion 213-4. 2004
    ..Long-term survival may be achieved, therefore aggressive treatment should strongly be considered...
  11. ncbi request reprint Preoperative chemoradiation therapy for adenocarcinoma of the pancreas: The Fox Chase Cancer Center experience, 1986-2003
    Ingrid M Meszoely
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Surg Oncol Clin N Am 13:685-96, x. 2004
    ..This article reviews the Fox Chase Cancer Center experience of preoperatively and postoperatively delivered adjuvant chemotherapy and radiation therapy for localized adenocarcinoma of the pancreas...
  12. pmc Impact of preoperative therapy on patterns of recurrence in pancreatic cancer
    Pavlos Papavasiliou
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    HPB (Oxford) 16:34-9. 2014
    ..A theoretical advantage of preoperative therapy in pancreatic adenocarcinoma is that it facilitates the early treatment of micrometastases and reduces postoperative systemic recurrence...
  13. doi request reprint Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma
    Steven J Cohen
    Department of Medical Oncology, Fox Chase Cancer Center, Jeanes Hospital, Philadelphia, PA 19111 2497, USA
    Pancreas 37:154-8. 2008
    ....
  14. ncbi request reprint Significance of common hepatic artery lymph node metastases during pancreaticoduodenectomy for pancreatic head adenocarcinoma
    Fernando Cordera
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania, 19111, USA
    Ann Surg Oncol 14:2330-6. 2007
    ..In some institutions, if metastatic disease is detected intraoperatively in these lymph nodes, the tumor is considered unresectable and a curative operation is not performed. No solid data exist to support this practice...
  15. ncbi request reprint En bloc resection for locally advanced cancer of the pancreas: is it worthwhile?
    Aaron R Sasson
    Department of Surgical Oncology, Temple University School of Medicine, Philadelphia, PA 19111, USA
    J Gastrointest Surg 6:147-57; discussion 157-8. 2002
    ....
  16. doi request reprint Partial stomach-partitioning gastrojejunostomy and the success of this procedure in terms of palliation
    Rodrigo Arrangoiz
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Am J Surg 206:333-9. 2013
    ..In the 1990s, partial stomach-partitioning gastrojejunostomy (PSPG) was introduced. Benefits of this method are that it preferentially shunts food away from the obstructed duodenum or pylorus, thus reducing reflex emesis...
  17. doi request reprint Defining venous involvement in borderline resectable pancreatic cancer
    Yun Shin Chun
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 17:2832-8. 2010
    ..There is no consensus about what degree of venous impingement constitutes borderline resectability...
  18. ncbi request reprint Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Division of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:169-73; discussion 173-4. 2004
    ..Preoperative CRT and BD significantly reduce these levels in patients with periampullary cancers. Antiangiogenic therapy aimed at interrupting the VEGF pathway appears to be a logical target in periampullary cancer...
  19. pmc Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704
    Adam C Berger
    Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 26:5918-22. 2008
    ..CA 19-9 is an important tumor marker in patients with pancreatic adenocarcinoma. A secondary end point of Radiation Therapy Oncology Group trial 9704 was prospective evaluation of the ability of postresectional CA 19-9 to predict survival...
  20. ncbi request reprint Preoperative versus postoperative adjuvant therapy for adenocarcinoma of the pancreas
    John P Hoffman
    Department of Surgical Oncology, Fox Chase Cancer Center, Temper University School of Medicine, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Adv Surg 43:189-98. 2009
    ..Phase II trials for both resectable and borderline resectable tumors suggest that longer median survival can be obtained by a policy of preoperative AT. We will watch the European RCT with great interest...
  21. ncbi request reprint Undetectable preoperative levels of serum CA 19-9 correlate with improved survival for patients with resectable pancreatic adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann Surg Oncol 11:644-9. 2004
    ..Serum levels of CA19-9 have been shown to correlate with both recurrence and survival in patients with pancreatic cancer. However, little is known about the prognosis for patients with undetectable levels of serum CA19-9...
  22. ncbi request reprint Is reporting of recurrence data important in pancreatic cancer?
    Michael O Meyers
    Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 11:304-9. 2004
    ..The purpose of this study was to identify patients with recurrent pancreatic cancer and to determine whether treatment after recurrence had any effect on outcome...
  23. ncbi request reprint Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer
    Ahmad L Subhi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 10:7290-6. 2004
    ..Ornithine decarboxylase is a key enzyme in the regulation of polyamine metabolism. The aim of this study is to analyze MTAP and ornithine decarboxylase (ODC) expression in primary pancreatic tumor specimens...
  24. doi request reprint Initial experience with laparoscopic hepatic resection at a comprehensive cancer center
    Andrew A Gumbs
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, C 308, Philadelphia, PA 19111, USA
    Surg Endosc 26:480-7. 2012
    ..As a result, the initial experience of a surgeon with advanced MIS HPB training at a national cancer center was reviewed...
  25. doi request reprint Clinical Stage T1 micropapillary urothelial carcinoma presenting with metastasis to the pancreas
    Daniel Canter
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Urology 79:e9-10. 2012
    ..To our knowledge, this case represents the first report of a solitary metastatic urothelial carcinoma to the pancreas...
  26. ncbi request reprint CA 19-9 levels predict results of staging laparoscopy in pancreatic cancer
    Andreas Karachristos
    Department of Surgery, Temple University Hospital, Philadelphia, Pennsylvania, USA
    J Gastrointest Surg 9:1286-92. 2005
    ..On the contrary, patients with elevated CA 19-9 have an increased probability of metastatic disease, and these patients may benefit from diagnostic laparoscopy...
  27. doi request reprint Neoadjuvant chemoradiation and duration of chemotherapy before surgical resection for pancreatic cancer: does time interval between radiotherapy and surgery matter?
    Kathryn T Chen
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 21:662-9. 2014
    ..Using our database, we evaluated these relationships and the effect on overall and progression-free survival...
  28. doi request reprint Laparoscopic pancreatoduodenectomy: a review of 285 published cases
    Andrew A Gumbs
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 18:1335-41. 2011
    ..As the technique becomes more diffuse, issues regarding the adequacy of oncologic margins and lymph node retrieval need to be addressed...
  29. doi request reprint Laparoscopic radical cholecystectomy and Roux-en-Y choledochojejunostomy for gallbladder cancer
    Andrew A Gumbs
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, C 308, Philadelphia, PA 19111, USA
    Surg Endosc 24:1766-8. 2010
    ..This video reviews the minimally invasive approaches to preoperatively suspected gallbladder cancer...
  30. ncbi request reprint Colon carcinoma cells induce CXCL11-dependent migration of CXCR3-expressing cytotoxic T lymphocytes in organotypic culture
    Klara Berencsi
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Immunol Immunother 56:359-70. 2007
    ....
  31. ncbi request reprint Hydronephrosis does not preclude curative resection of pelvic recurrences after colorectal surgery
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 12:786-92. 2005
    ..Hydronephrosis has been documented previously to portend a poor prognosis, and some consider it a contraindication to attempted resection. It was our goal to review our experience and either confirm or refute these conclusions...
  32. ncbi request reprint Nonneoplastic celiac axis occlusion in patients undergoing pancreaticoduodenectomy
    Jeffrey M Farma
    Department of Surgery, Temple University Hospital, Philadelphia, PA, USA
    Am J Surg 193:341-4; discussion 344. 2007
    ..Identifying this is critical in planning for pancreaticoduodenectomy. We reviewed 332 patients treated with pancreaticoduodenectomy, and identified 14 patients with celiac artery occlusion...
  33. pmc An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
    Jungsun Kim
    Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 5157, USA
    Cell Rep 3:2088-99. 2013
    ..Thus, rare events allow iPSC technology to provide a live human cell model of early pancreatic cancer and insights into disease progression. ..
  34. ncbi request reprint Frequent activation of AKT2 kinase in human pancreatic carcinomas
    Deborah A Altomare
    Human Genetic Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 87:470-6. 2002
    ..Overall, these data suggest that upstream perturbations of the PI3K/AKT pathway contribute to frequent activation of AKT2 in pancreatic cancer, which may contribute to the pathogenesis of this highly aggressive form of human malignancy...
  35. ncbi request reprint Preoperative chemoradiation in the management of adenocarcinoma of the body of the pancreas
    Juan P Arnoletti
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 68:330-5; discussion 335-6. 2002
    ..In this poor-prognostic subset of patients with pancreatic cancer preoperative chemoradiation followed by an aggressive surgical approach was associated with resectability and long-term survival of a significant minority of patients...
  36. ncbi request reprint Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer
    Steven J Cohen
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Clin Colorectal Cancer 6:125-32. 2006
    ....
  37. ncbi request reprint Neoadjuvant therapy in pancreatic cancer
    Roderick M Quiros
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    Cancer Invest 25:267-73. 2007
    ..This article reviews the use of neoadjuvant therapy in the treatment of pancreatic cancer...
  38. pmc The anatomic course of the first jejunal branch of the superior mesenteric vein in relation to the superior mesenteric artery
    Pavlos Papavasiliou
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Surg Oncol 2012:538769. 2012
    ..009). Conclusion. The first jejunal branch of the SMV has a highly variable course in relation to the SMA and has a higher incidence of an anterior location in this population than previously reported...
  39. doi request reprint Laparoscopic completion radical cholecystectomy for T2 gallbladder cancer
    Andrew A Gumbs
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue C 308, Philadelphia, PA 19111, USA
    Surg Endosc 24:3221-3. 2010
    ....
  40. ncbi request reprint Partial stomach-partitioning gastrojejunostomy for malignant duodenal obstruction
    Cletus A Arciero
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Am J Surg 191:428-32. 2006
    ....
  41. ncbi request reprint Pancreatic resection for locally advanced primary and metastatic nonpancreatic neoplasms
    James F Pingpank
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Am Surg 68:337-40; discussion 340-1. 2002
    ..The ability to obtain disease-free margins through en bloc resection is a key component of therapy...