Kyoko Hayakawa

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
  2. pmc Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 197:87-99. 2003
  3. ncbi request reprint Evidence of marginal-zone B cell-positive selection in spleen
    Lijun Wen
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Immunity 23:297-308. 2005
  4. doi request reprint Positive and negative selection of natural autoreactive B cells
    Richard R Hardy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Adv Exp Med Biol 750:227-38. 2012
  5. ncbi request reprint Association of B-1 B cells with follicular dendritic cells in spleen
    Lijun Wen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6918-26. 2005
  6. ncbi request reprint Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
  7. pmc Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors
    Ben Rowley
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Autoimmun 29:236-45. 2007
  8. pmc Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111
    J Exp Med 213:3007-3024. 2016
  9. doi request reprint B cells generated by B-1 development can progress to chronic lymphocytic leukemia
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Ann N Y Acad Sci 1362:250-5. 2015
  10. doi request reprint A developmental switch between fetal and adult B lymphopoiesis
    Yue Sheng Li
    Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Ann N Y Acad Sci 1362:8-15. 2015

Collaborators

  • Yan Zhou
  • D Allman
  • Richard Hardy
  • Susan A Shinton
  • Lijun Wen
  • Yue Sheng Li
  • Daiju Ichikawa
  • Lingjuan Tang
  • Joni Brill-Dashoff
  • Masanao Asano
  • Ben Rowley
  • Anna Velcich
  • Anthony M Formica
  • Susan Shinton

Detail Information

Publications15

  1. ncbi request reprint Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
    ..Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity...
  2. pmc Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 197:87-99. 2003
    ..These findings demonstrate that B-1 positive selection, resulting in the production of natural serum ATA, arises independently from the major pathway of BM B cell development and selection...
  3. ncbi request reprint Evidence of marginal-zone B cell-positive selection in spleen
    Lijun Wen
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Immunity 23:297-308. 2005
    ..These data indicate that positive selection can occur in developing B cells and that BCR signal strength is a key factor in deciding between two functionally distinct mature B cell compartments in the microenvironment of the spleen...
  4. doi request reprint Positive and negative selection of natural autoreactive B cells
    Richard R Hardy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Adv Exp Med Biol 750:227-38. 2012
    ....
  5. ncbi request reprint Association of B-1 B cells with follicular dendritic cells in spleen
    Lijun Wen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6918-26. 2005
    ..These results indicate that B-1 B cells are the first B cells to express fully mature levels of CXCR5, thereby promoting the development of FDC...
  6. ncbi request reprint Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
    ....
  7. pmc Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors
    Ben Rowley
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Autoimmun 29:236-45. 2007
    ..Here, we examine another possible bottleneck to the B1 cell repertoire: light chain pairing with V(H)11 heavy chain, finding very significant preferences...
  8. pmc Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111
    J Exp Med 213:3007-3024. 2016
    ..Thus, there is a genetic predisposition inherent in B-1 development generating restricted BCRs and self-renewal capacity, with both features contributing to potential for progression to CLL...
  9. doi request reprint B cells generated by B-1 development can progress to chronic lymphocytic leukemia
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Ann N Y Acad Sci 1362:250-5. 2015
    ..Analysis of the mice has been key in understanding the importance of the BCR and BCR signaling for generating different B cell subsets and for investigating the cellular origin of B-CLL. ..
  10. doi request reprint A developmental switch between fetal and adult B lymphopoiesis
    Yue Sheng Li
    Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Ann N Y Acad Sci 1362:8-15. 2015
    ..While such cells serve a useful role in clearance of senescent cells and in certain immune responses, they also carry the risk of progression to leukemia/lymphoma later in life. ..
  11. pmc Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells
    Daiju Ichikawa
    Fox Chase Cancer Center, Philadelphia, PA 19111 Keio University Faculty of Pharmacy, Tokyo 105 8512, Japan
    J Immunol 194:606-14. 2015
    ..B17 mice, and this autoantibody is specifically produced by the MZ B cell subset. Thus, our findings reveal that AGcA is a natural autoantibody associated with MZ B cells. ..
  12. pmc Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a
    Yan Zhou
    Fox Chase Cancer Center, Philadelphia, PA 19111
    J Exp Med 212:569-80. 2015
    ....
  13. ncbi request reprint Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells
    Richard R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Immunol Rev 197:60-74. 2004
    ..Together, these constrain VH11 generation to fetal development and may favor production of B cells with the prototype VH11Vkappa9 BCR...
  14. pmc Perspectives on fetal derived CD5+ B1 B cells
    Richard R Hardy
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Eur J Immunol 45:2978-84. 2015
    ..It remains to be determined whether such human B cells have a higher propensity to leukemic progression. This review describes our recent research with CD5(+) B cells and presents our perspective on their role in disease. ..
  15. ncbi request reprint Selection of natural autoreactive B cells
    Richard R Hardy
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Clin Exp Rheumatol 33:S80-6. 2015
    ..Finally, different fates of developing ATA B cells encountering high levels self-antigen may be accounted for by variations in the response of newly formed B cells arising from foetal and adult development...