Jonathan Chernoff

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells
    L E Arias-Romero
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 29:5839-49. 2010
  2. pmc Targeting Cdc42 in cancer
    Luis E Arias-Romero
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA 1 215 728 5319 1 215 728 3616
    Expert Opin Ther Targets 17:1263-73. 2013
  3. pmc The role of p21-activated kinase in the initiation of atherosclerosis
    K A Jhaveri
    Department of Microbiology, University of Virginia, Cardiovascular Research Center, Charlottesville, VA, USA
    BMC Cardiovasc Disord 12:55. 2012
  4. pmc Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
    Luis E Arias-Romero
    Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 73:3671-82. 2013
  5. pmc Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
    Sophie Cotteret
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Mol Cell Biol 26:3215-30. 2006
  6. pmc An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
    Sean W Deacon
    Basic Sciences Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Chem Biol 15:322-31. 2008
  7. ncbi request reprint Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
    Alexander Beeser
    Tumor Cell Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 280:36609-15. 2005
  8. ncbi request reprint Specificity profiling of Pak kinases allows identification of novel phosphorylation sites
    Ulrike E E Rennefahrt
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 282:15667-78. 2007
  9. pmc Group I Paks as therapeutic targets in NF2-deficient meningioma
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Oncotarget 6:1981-94. 2015
  10. ncbi request reprint Regulation of protein tyrosine phosphatase 1B by sumoylation
    Shrikrishna Dadke
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nat Cell Biol 9:80-5. 2007

Collaborators

Detail Information

Publications43

  1. pmc A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells
    L E Arias-Romero
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 29:5839-49. 2010
    ..These data imply that the Rac-Pak pathway is vital to ErbB2-mediated transformation and that Pak inhibitors represent plausible drug targets in breast cancers in which ErbB2 signaling is activated...
  2. pmc Targeting Cdc42 in cancer
    Luis E Arias-Romero
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA 1 215 728 5319 1 215 728 3616
    Expert Opin Ther Targets 17:1263-73. 2013
    ..This article will focus on one Rho family member, Cdc42, which is overexpressed in a number of human cancers, and which might provide new therapeutic targets in malignancies...
  3. pmc The role of p21-activated kinase in the initiation of atherosclerosis
    K A Jhaveri
    Department of Microbiology, University of Virginia, Cardiovascular Research Center, Charlottesville, VA, USA
    BMC Cardiovasc Disord 12:55. 2012
    ..The study addresses whether PAK1 contributes to inflammatory marker expression in endothelial cells at atherosclerosis-susceptible regions of arteries in vivo...
  4. pmc Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
    Luis E Arias-Romero
    Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 73:3671-82. 2013
    ..These data delineate a signaling pathway from ErbB2 to Pak to β-catenin that is required for efficient transformation of mammary epithelial cells, and suggest new therapeutic strategies in ErbB2-positive breast cancer...
  5. pmc Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
    Sophie Cotteret
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Mol Cell Biol 26:3215-30. 2006
    ..These results show that Pak5 shuttles from mitochondria to the nucleus and that the mitochondrial localization of Pak5 is vital to its effects on cell survival...
  6. pmc An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
    Sean W Deacon
    Basic Sciences Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Chem Biol 15:322-31. 2008
    ..These studies illustrate an alternative strategy for kinase inhibition and introduce a highly selective, cell-permeable chemical inhibitor of Pak...
  7. ncbi request reprint Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
    Alexander Beeser
    Tumor Cell Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 280:36609-15. 2005
    ..These findings suggest that Paks are required for the phosphorylation of c-Raf at Ser(338) in response to either growth factor, but that the mechanisms by which EGF and PDGF activate c-Raf are fundamentally different...
  8. ncbi request reprint Specificity profiling of Pak kinases allows identification of novel phosphorylation sites
    Ulrike E E Rennefahrt
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 282:15667-78. 2007
    ..Collectively, these results elucidate the specificity of Pak kinases and illustrate a general method for the identification of novel sites phosphorylated by Paks...
  9. pmc Group I Paks as therapeutic targets in NF2-deficient meningioma
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Oncotarget 6:1981-94. 2015
    ..Tumors dissected from treated animals exhibited an increase in apoptosis without notable change in proliferation. Collectively, these results suggest that Pak inhibitors might be useful agents in treating NF2-deficient meningiomas. ..
  10. ncbi request reprint Regulation of protein tyrosine phosphatase 1B by sumoylation
    Shrikrishna Dadke
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nat Cell Biol 9:80-5. 2007
    ..These results suggest that sumoylation, which has been implicated primarily in processes in the nucleus and nuclear pore, also modulates a key enzyme-substrate signalling complex that regulates metabolism and cell proliferation...
  11. ncbi request reprint Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction
    Alexander Beeser
    Tumor Cell Biology Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Methods 37:203-7. 2005
    ..Use of the TAT-based inhibitor provides a specific means to suppress a single group of Cdc42 and Rac effectors, which is useful in analyzing their function...
  12. ncbi request reprint Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells
    Anatilde M Gonzalez Guerrico
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:2307-16. 2005
    ..Decreased or absent VILIP-1 expression in SCC cell subpopulations may lead to a more advanced malignant phenotype characterized by changes in adhesive ability and increased cell motility, suggestive of a tumor suppressor function...
  13. ncbi request reprint Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts
    Shrikrishna Dadke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Biol Chem 278:40607-11. 2003
    ..These results show that PTP1B, best known as a negative regulator of the metabolic effects of insulin, is required for the effects of insulin on actin organization in immortalized fibroblasts...
  14. pmc p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
    Sophie Cotteret
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 23:5526-39. 2003
    ..These features make Pak5 unique among the Pak family and suggest that it plays an important role in apoptosis through BAD phosphorylation...
  15. pmc p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway
    Maria Radu
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 35:3990-4005. 2015
    ..Our results demonstrate that endothelial Pak2 is essential during embryogenesis and also for adult blood vessel maintenance, and they also pinpoint the Bmk1/Erk5 pathway as a critical mediator of endothelial Pak2 signaling. ..
  16. pmc Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization
    Rachelle E Kosoff
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA Cell and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
    Blood 125:2995-3005. 2015
    ..Together, these data establish a novel role for Pak2 as an important regulator of megakaryopoiesis, polyploidization, and cytoskeletal dynamics in developing megakaryocytes. ..
  17. pmc A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish
    Mollie L Kelly
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA Department of Biochemistry and Molecular Biology, Drexel University, Philadelphia, PA 19102, USA
    Dev Cell 29:350-9. 2014
    ..Our data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development. ..
  18. pmc Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells
    Luis E Arias-Romero
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Res 69:4582-8. 2009
    ..These findings identify a molecular mechanism by which PTP1B links an important oncogenic receptor tyrosine kinase to signaling pathways that promote aberrant cell division and survival in human breast epithelial cells...
  19. pmc The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers
    Igor Makhlin
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 108:E84-90. 2011
    ..To investigate whether mammalian target of rapamycin (mTOR) inhibition by rapamycin is therapeutically efficacious in combination with cisplatin for bladder cancer...
  20. doi request reprint The DeMSTification of mammalian Ste20 kinases
    Maria Radu
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Curr Biol 19:R421-5. 2009
    ..This minireview underlines our current understanding of how Mst1 and Mst2 are regulated, and how activation of these proteins influences cell survival and proliferation...
  21. ncbi request reprint The genetics of Pak
    Clemens Hofmann
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Cell Sci 117:4343-54. 2004
    ....
  22. ncbi request reprint Pak GITs to Aurora-A
    Sophie Cotteret
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Dev Cell 9:573-4. 2005
    ....
  23. pmc ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling
    Maria Radu
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 288:21117-25. 2013
    ..Our data suggest that ArhGAP15 plays a dual negative role in regulating small GTPase signaling, by acting at the level of the GTPase itself, as well interacting with its effector, Pak kinase. ..
  24. pmc PTP1B: a double agent in metabolism and oncogenesis
    Shu Chin Yip
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Trends Biochem Sci 35:442-9. 2010
    ..These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer...
  25. pmc Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development
    Christine M Lightcap
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA
    PLoS ONE 4:e6025. 2009
    ..Collectively, these results suggest that LC8 facilitates nuclear import of Pak1 and that this function is indispensable during vertebrate development...
  26. pmc p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 72:5966-75. 2012
    ..These findings establish Pak1 as a new target in KRAS-driven tumors and suggest a mechanism of action through the Erk, but not the Akt, signaling pathway...
  27. ncbi request reprint Protein-tyrosine phosphatase 1B as a potential drug target for obesity
    Shrikrishna Dadke
    Fox Chase Cancer Center, W 451, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:299-304. 2003
    ..In this review, we discuss the role of PTP1B in leptin and insulin signaling, as well as its potential as a drug target in the treatment of obesity...
  28. doi request reprint A tale of two Paks
    Luis E Arias-Romero
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, U S A
    Biol Cell 100:97-108. 2008
    ..In this review, we discuss recent advances in our understanding of the structure, regulation and function of these kinases, emphasizing the many differences between these two groups of signalling proteins...
  29. ncbi request reprint alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini
    Julie C Friedland
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 120:3700-12. 2007
    ....
  30. pmc The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein
    Sonali Jalan Rawat
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 288:8762-71. 2013
    ..These results suggest that hydrogen peroxide-stimulated Mst1 activates a positive feedback loop to sustain an oxidizing cellular state...
  31. pmc Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity
    Rachelle Kosoff
    Cancer Biology Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 288:974-83. 2013
    ..These data suggest that Pak2 plays a unique inhibitory role in mast cell degranulation by down-regulating RhoA via GEF-H1...
  32. pmc Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin
    Shu Chin Yip
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Cell Sci 125:310-6. 2012
    ..These results suggest that PTP1B regulates the tyrosine phosphorylation of a key inner nuclear membrane protein in a sumoylation- and cell-cycle-dependent manner...
  33. pmc p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e13791. 2010
    ..Here, we examine the effect of Pak inhibition on cells with diminished Merlin function...
  34. ncbi request reprint The cross-Rho'ds of cell-cell adhesion
    Zahara M Jaffer
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 279:35123-6. 2004
  35. ncbi request reprint Cell cycle-regulated phosphorylation of p21-activated kinase 1
    Debra A Thiel
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Curr Biol 12:1227-32. 2002
    ....
  36. pmc Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis
    Almudena Pacheco
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Biochem Cell Biol 42:13-6. 2010
    ..In this review, we summarize basic properties of group I Paks and discuss recently uncovered roles for these kinases in immune function and in viral infection...
  37. pmc Regulation of mammalian Ste20 (Mst) kinases
    Sonali J Rawat
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA
    Trends Biochem Sci 40:149-56. 2015
    ..Here we review the basic architecture of Mst signaling and function and discuss recent advances in our understanding of how these important kinases are regulated. ..
  38. pmc Molecular pathways: targeting the kinase effectors of RHO-family GTPases
    Tatiana Y Prudnikova
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Clin Cancer Res 21:24-9. 2015
    ....
  39. pmc Role of p21-activated kinases in cardiovascular development and function
    Mollie L Kelly
    Department of Biochemistry, Drexel University School of Medicine, Philadelphia, PA, USA
    Cell Mol Life Sci 70:4223-8. 2013
    ..In this review, we discuss aspects of Pak function relevant to cardiovascular biology as well as potential therapeutic implications of small-molecule Pak inhibitors in cardiovascular disease. ..
  40. ncbi request reprint p21-activated kinases: three more join the Pak
    Zahara M Jaffer
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Int J Biochem Cell Biol 34:713-7. 2002
    ..Here we summarize recent findings that shed light on the newly recognized Group II Paks (Pak4, Pak5, Pak6) and review both similarities and differences between kinases of the two Pak subgroups...
  41. pmc Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways
    Craig W Menges
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Res 10:1178-88. 2012
    ..Collectively, these data suggest that pharmacologic inhibition of group I PAKs may have therapeutic efficacy in tumors characterized by PAK activation...
  42. ncbi request reprint Rho-GTPases: new members, new pathways
    Elena M Sorokina
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, USA
    J Cell Biochem 94:225-31. 2005
    ..In this review, we focus on these newly discovered Rho-GTPases and discuss their role in signaling to the cytoskeleton and the nucleus...
  43. pmc Analysis of PTP1B sumoylation
    Sayanti Saha
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States
    Methods 65:201-6. 2014
    ..We have adapted several approaches to analyzing the sites and effects of sumoylation of PTP1B in cells and in vitro. The principal outline of the assays should be applicable to other enzymes as well. ..