Fox Chase Cancer Center

Summary

Organization: Fox Chase Cancer Center
Country: USA

Top Publications

  1. doi Defining venous involvement in borderline resectable pancreatic cancer
    Yun Shin Chun
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 17:2832-8. 2010
  2. doi Survival after pancreatectomy with major arterial resection and reconstruction
    Karyn B Stitzenberg
    Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann Surg Oncol 15:1399-406. 2008
  3. pmc Dietary intake and breast density in high-risk women: a cross-sectional study
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Breast Cancer Res 9:R72. 2007
  4. ncbi Prostate cancer risk assessment program: a 10-year update of cancer detection
    Veda N Giri
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19012, USA
    J Urol 178:1920-4; discussion 1924. 2007
  5. ncbi Phase II trial of weekly docetaxel/irinotecan combination in advanced pancreatic cancer
    Barbara Burtness
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer J 13:257-62. 2007
  6. ncbi Remodeling chromatin for senescence
    Peter D Adams
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Aging Cell 6:425-7. 2007
  7. ncbi Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition
    Lainie Martin
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 25:2894-901. 2007
  8. ncbi Assessment of neutropenia-related quality of life in a clinical setting
    Mary E Ropka
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Oncol Nurs Forum 34:403-9. 2007
  9. ncbi The NCI's Cancer Information Service's Research Continuum Framework: integrating research into cancer education practice (1999-2004)
    Linda Fleisher
    Atlantic Region, Cancer Information Service, Fox Chase Cancer Center, Cheltenham, PA, USA
    J Cancer Educ 22:S41-8. 2007
  10. ncbi Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007

Scientific Experts

Detail Information

Publications62

  1. doi Defining venous involvement in borderline resectable pancreatic cancer
    Yun Shin Chun
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 17:2832-8. 2010
    ..There is no consensus about what degree of venous impingement constitutes borderline resectability...
  2. doi Survival after pancreatectomy with major arterial resection and reconstruction
    Karyn B Stitzenberg
    Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann Surg Oncol 15:1399-406. 2008
    ..We hypothesize that resection of a tumor-involved hepatic artery (HA) or celiac artery (CA) with reconstruction may offer a survival benefit to patients whose tumors were traditionally regarded as unresectable...
  3. pmc Dietary intake and breast density in high-risk women: a cross-sectional study
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Breast Cancer Res 9:R72. 2007
    ..The objective of the present study was to determine whether diet, a modifiable risk factor, is related to breast density among women at high genetic risk for breast cancer...
  4. ncbi Prostate cancer risk assessment program: a 10-year update of cancer detection
    Veda N Giri
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19012, USA
    J Urol 178:1920-4; discussion 1924. 2007
    ..Guidelines for screening men at high risk for prostate cancer remain under investigation. We report our 10-year cancer detection data from the Prostate Cancer Risk Assessment Program, a longitudinal screening program for men at high risk...
  5. ncbi Phase II trial of weekly docetaxel/irinotecan combination in advanced pancreatic cancer
    Barbara Burtness
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer J 13:257-62. 2007
    ..We have previously demonstrated the safety of docetaxel 35 mg/m(2) and irinotecan 50 mg/m(2) given on days 1, 8, 15, and 21 of a 35-day schedule...
  6. ncbi Remodeling chromatin for senescence
    Peter D Adams
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Aging Cell 6:425-7. 2007
    ..In this issue, Medrano and co-workers describe new insights into the protein complexes that regulate these changes in chromatin structure...
  7. ncbi Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition
    Lainie Martin
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 25:2894-901. 2007
    ..Current data regarding the role of bevacizumab and other novel agents in the treatment of ovarian carcinoma are summarized...
  8. ncbi Assessment of neutropenia-related quality of life in a clinical setting
    Mary E Ropka
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Oncol Nurs Forum 34:403-9. 2007
    ..To examine how neutropenia affects quality of life (QOL) and explore strategies to assess neutropenia-related QOL in clinical practice...
  9. ncbi The NCI's Cancer Information Service's Research Continuum Framework: integrating research into cancer education practice (1999-2004)
    Linda Fleisher
    Atlantic Region, Cancer Information Service, Fox Chase Cancer Center, Cheltenham, PA, USA
    J Cancer Educ 22:S41-8. 2007
    ....
  10. ncbi Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
    ..As observed in humans, p53 plays a protective role in colitis-associated neoplasia in the DSS model...
  11. ncbi Cost of cancer care: issues and implications
    Neal J Meropol
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 25:180-6. 2007
    ..Our overall goal is to frame debate about health policy concerns that influence the clinical practice of oncology...
  12. ncbi Are psychological interventions effective and accepted by cancer patients? II. Using empirically supported therapy guidelines to decide
    Sharon L Manne
    Psycho Oncology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Ann Behav Med 32:98-103. 2006
    ....
  13. ncbi ABCC10, ABCC11, and ABCC12
    Gary D Kruh
    Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Pflugers Arch 453:675-84. 2007
    ..The functional characteristics of MRP9 are currently unknown...
  14. ncbi Prevalence and correlates of sun protection and skin self-examination practices among cutaneous malignant melanoma survivors
    Sharon Manne
    Fox Chase Cancer Center, P1100, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Behav Med 29:419-34. 2006
    ....
  15. doi Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers
    Angela R Bradbury
    University of Chicago Center for Clinical Cancer Genetics, University of Chicago, Chicago, Illinois, USA
    Genet Med 10:161-6. 2008
    ..To evaluate prophylactic salpingo-oophorectomy uptake and timing among BRCA1/2 mutation carriers in a cancer risk assessment program...
  16. doi Obituary: Joshua Lederberg (1925-2008)
    Baruch S Blumberg
    Baruch S Blumberg is at the Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497
    Nature 452:422. 2008
  17. doi Phase I study of capecitabine and oxaliplatin in combination with the proteasome inhibitor bortezomib in patients with advanced solid tumors
    Steven J Cohen
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Am J Clin Oncol 31:1-5. 2008
    ..Thus, we performed this phase I study to document the safety and obtain preliminary efficacy data for the combination of capecitabine, oxaliplatin, and bortezomib...
  18. doi Parent opinions regarding the genetic testing of minors for BRCA1/2
    Angela R Bradbury
    University of Chicago, Chicago, IL, USA
    J Clin Oncol 28:3498-505. 2010
    ..Thus, we evaluated parent opinions regarding BRCA1/2 testing of minors, in general, and hypothetically, for parents' own minor child...
  19. pmc Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    J Virol 84:8308-15. 2010
    ..This analysis revealed that clonal expansion can occur among normal-appearing human hepatocytes...
  20. pmc Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls
    Brian L Egleston
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19130, USA
    Ann Clin Biochem 47:233-41. 2010
    ..However, assays to measure circulating hormone levels might not always be accessible. We sought to validate the empirical calculation of circulating bioavailable testosterone and oestradiol in children...
  21. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
    ....
  22. doi Young cervical cancer patients and fertility
    Sharon Schwartz
    Gynecologic Oncology, Surgery Division, Fox ChaseCancer Center, 333 Cottman Ave, Suite H3 182, Philadelphia, PA 19111, USA
    Semin Oncol Nurs 25:259-67. 2009
    ..To identify surgical methods of fertility preservation in cervical cancer and advanced reproductive technologies available to patients...
  23. pmc Identifying cluster subtypes for intentions to have colorectal cancer screening among non-compliant intermediate-risk siblings of individuals with colorectal cancer
    Sharon L Manne
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Health Educ Res 24:897-908. 2009
    ..Results provide an empirical typology for understanding motivations for CRCS among at-risk family members and may lead to the development of more effective interventions to improve screening uptake...
  24. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009
    ..The assay is validated, and its utility demonstrated in a comparison of the metal-dependent activities of HIV-1 and ASV IN proteins...
  25. pmc The role of primary androgen deprivation therapy in localized prostate cancer
    Yu Ning Wong
    Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Eur Urol 56:609-16. 2009
    ..Primary androgen deprivation therapy (PADT) is frequently used as a sole modality of treatment in men with localized prostate cancer, despite a lack of clinical trial data supporting its use...
  26. pmc Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
    ..The goal of this study was to analyze the direct effects of staged stroma-derived extracellular matrices on breast cancer cell behavior...
  27. doi A century of deciphering the control mechanisms of sex steroid action in breast and prostate cancer: the origins of targeted therapy and chemoprevention
    V Craig Jordan
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 9111 2497, USA
    Cancer Res 69:1243-54. 2009
    ..During the past 50 years, ideas about the value of antihormones translated effectively from the laboratory to improve clinical care, improve national survival rates, and significantly reduced the burden of cancer...
  28. pmc Mediterranean diet and breast density in the Minnesota Breast Cancer Family Study
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Nutr Cancer 60:703-9. 2008
    ..08, P = 0.72; P for interaction = 0.008). Our results confirm a previous suggestion that selected dietary patterns may be protective primarily in the presence of procarcinogenic compounds such as those found in tobacco smoke...
  29. ncbi Breast development, hormones and cancer
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Adv Exp Med Biol 630:52-6. 2008
    ....
  30. pmc The role of adjuvant and neoadjuvant therapy in gastrointestinal stromal tumors
    Margaret von Mehren
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA
    Curr Opin Oncol 20:428-32. 2008
    ..This review will discuss the available data on the use of imatinib in the adjuvant setting and the role of imatinib and sunitinib in the neoadjuvant setting...
  31. ncbi Acculturation and breast density in foreign-born, U.S. Chinese women
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 15:1301-5. 2006
    ..Future longitudinal research will examine whether the association is due to early-life factors, postmigration lifestyle changes, or perimenopausal exposures...
  32. ncbi Overview of non-Hodgkin's lymphoma
    Barbara Barnes Rogers
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Semin Oncol Nurs 22:67-72. 2006
    ..To provide an overview of non-Hodgkin's lymphoma (NHL)...
  33. ncbi New therapeutic strategies for soft tissue sarcomas
    Margaret von Mehren
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Curr Treat Options Oncol 4:441-51. 2003
    ..It will also be increasingly important to be committed to obtaining tumor tissue in these patients to validate hypotheses regarding tumor biology and the effectiveness of therapeutic agents...
  34. ncbi Metastasis of benign tumor cells in tuberous sclerosis complex
    Elizabeth Petri Henske
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Genes Chromosomes Cancer 38:376-81. 2003
    ..Hamartin and tuberin may play functional roles in the suppression of cell migration and/or metastasis, possibly through their regulation of the small GTPase Rho...
  35. ncbi A method for increased dose conformity and segment reduction for SMLC delivered IMRT treatment of the prostate
    Robert A Price
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 57:843-52. 2003
    ..The focus of this work is to develop a practical planning method that results in increased dose conformity and reduced treatment time for segmental multileaf collimation (sMLC) based intensity-modulated radiation therapy (IMRT) delivery...
  36. ncbi Replication of human hepatitis delta virus: recent developments
    John M Taylor
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111 2497, USA
    Trends Microbiol 11:185-90. 2003
    ..This mini-review focuses on advances gained over the last 2-3 years, together with an evaluation of HDV questions that are either unsolved or not yet solved satisfactorily...
  37. ncbi Role of adjuvant therapy in resected stage II/IIIA non-small-cell lung cancer
    B Movsas
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Oncology (Williston Park) 15:1549-58. 2001
    ..Future strategies include novel chemotherapy, methods to reduce toxicity, the emerging role of neoadjuvant therapy, and the promise of new biologic agents...
  38. ncbi In their own words: using the common sense model to analyze patient descriptions of cancer-related fatigue
    A M Barsevick
    Fox Chase Cancer Center in Philadelphia, PA, USA
    Oncol Nurs Forum 28:1363-9. 2001
    ..To describe cancer-related fatigue (CRF) from the perspective of individuals experiencing it and examine the fit of their descriptions with the concepts from the Common Sense Model (CSM)...
  39. ncbi Defining the optimal radiation dose with three-dimensional conformal radiation therapy for patients with nonmetastatic prostate carcinoma by using recursive partitioning techniques
    E M Horwitz
    Fox Chase Cancer Center, Department of Radiation Oncology, Philadelphia, Pennsylvania 19111, USA
    Cancer 92:1281-7. 2001
    ....
  40. ncbi Phase II radiation therapy oncology group trial of weekly paclitaxel and conventional external beam radiation therapy for supratentorial glioblastoma multiforme
    C J Langer
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 51:113-9. 2001
    ..The Radiation Therapy Oncology Group (RTOG) therefore mounted a Phase II study to determine the feasibility and efficacy of conventional EBRT and concurrent weekly TAX at its MTD...
  41. ncbi Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation
    J D Chapman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Semin Radiat Oncol 11:47-57. 2001
    ....
  42. pmc Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis
    Y Zhu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 75:311-22. 2001
    ..This observation was consistent with the possibility that some fraction of cccDNA was distributed to daughter cells in those infected hepatocytes that passed through mitosis...
  43. ncbi Role of hormones in mammary cancer initiation and progression
    I H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Mammary Gland Biol Neoplasia 3:49-61. 1998
    ..Understanding of such mechanisms is indispensable for developing a rational basis for its prevention and control...
  44. ncbi Posttraumatic stress disorder among mothers of pediatric cancer survivors: diagnosis, comorbidity, and utility of the PTSD checklist as a screening instrument
    S L Manne
    Fox Chase Cancer Center, Cheltenham, Pennsylvania 19012, USA
    J Pediatr Psychol 23:357-66. 1998
    ..Comorbidity of anxiety and depressive disorders, prevalence of subclinical PTSD, and the utility of a self-report measure as a screening instrument for PTSD were also investigated...
  45. ncbi Daily CT localization for correcting portal errors in the treatment of prostate cancer
    J Lattanzi
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 41:1079-86. 1998
    ..A daily CT simulation technique is presented to assess setup variations in portal placement and organ motion for the treatment of localized prostate cancer...
  46. ncbi Cystathionine beta-synthase deficiency in Georgia (USA): correlation of clinical and biochemical phenotype with genotype
    W D Kruger
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Hum Mutat 22:434-41. 2003
    ..We conclude that these two mutations occurred after ethnic socialization and that the CBS genotype is predictive of phenotype...
  47. ncbi NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence
    Kerry S Campbell
    Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Immunol 172:899-906. 2004
    ..In summary, all activating properties and surface expression of NKp44 are mediated through its association with DAP12, and the putative ITIM in the NKp44 cytoplasmic domain does not appear to attenuate activating function...
  48. ncbi Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Res 64:1181-9. 2004
    ....
  49. ncbi Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
    ..These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin...
  50. ncbi Is there still a role for hormonal therapy?
    M A Bookman
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Int J Gynecol Cancer 15:291-7. 2005
    ..As such, it is reasonable to consider a number of potential hormonal interventions related to the prevention and treatment of ovarian cancer...
  51. ncbi Elongated beamlets: a simple technique for segment and MU reduction for sMLC IMRT delivery on accelerators utilizing 5 mm leaf widths
    R A Price
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Phys Med Biol 50:N235-42. 2005
    ..This technique directly translates to a decreased MSF(mod) allowing for decreased leakage dose to the patient, a decreased risk of exceeding secondary shielding limits in pre-existing vaults, and shorter treatment times...
  52. ncbi Defining biochemical failure after radiotherapy with and without androgen deprivation for prostate cancer
    Mark K Buyyounouski
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 63:1455-62. 2005
    ..To compare several characteristics of alternative definitions of biochemical failure (BF) in men with extended follow-up after radiotherapy (RT) with or with androgen deprivation therapy (ADT) for prostate cancer...
  53. ncbi Comparison of intakes of US Chinese women based on food frequency and 24-hour recall data
    Marilyn Tseng
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Am Diet Assoc 105:1145-8. 2005
    ..These findings provide some assurance of the FFQ's adequacy for describing US Chinese women's intake of commonly consumed foods and selected nutrients. They also provide a basis for further improvements to, and evaluations of, the FFQ...
  54. ncbi Dosimetric verification of IMRT treatment planning using Monte Carlo simulations for prostate cancer
    J Yang
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Phys Med Biol 50:869-78. 2005
    ..These results suggest that heterogeneity correction should be used in dose calculation for prostate cancer with non-coplanar beam arrangements...
  55. ncbi Enhanced efficacy of therapy with antisense BCL-2 oligonucleotides plus anti-CD20 monoclonal antibody in scid mouse/human lymphoma xenografts
    Mitchell R Smith
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 3:1693-9. 2004
    ..This merits investigation in clinical trials...
  56. ncbi Clipped wings: epigenetic inactivation of APC
    Paul Cairns
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:965-6. 2004
  57. ncbi The porphobilinogen synthase catalyzed reaction mechanism
    Eileen K Jaffe
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Bioorg Chem 32:316-25. 2004
    ..The reaction appears to stall at a covalently bound almost-product intermediate that is poised for breakdown to product upon binding of a substrate molecule to an adjacent active site and a subsequent conformational change...
  58. ncbi Low complication rates are achievable after postmastectomy breast reconstruction and radiation therapy
    Penny R Anderson
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 59:1080-7. 2004
    ..To report our institution's experience of complications and cosmetic results among patients who underwent modified radical mastectomy followed by reconstruction and radiation therapy (RT)...
  59. ncbi Genotoxicity of steroidal estrogens
    Jose Russo
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Trends Endocrinol Metab 15:211-4. 2004
    ..In this article, we concentrate on discussing the role of estrogen receptors and the metabolic activation of 17beta-estradiol (E(2)) as mechanisms of breast cancer initiation...
  60. ncbi Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation
    Sharon Manne
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Pediatrics 113:1700-8. 2004
    ..To examine the prevalence and predictors of anxiety, depression, and posttraumatic stress disorder among mothers of children who underwent hematopoietic stem cell transplantation (HSCT)...
  61. ncbi Small molecule inhibition of hypoxia inducible factor-1alpha: a viable therapeutic approach?
    Kenneth D Tew
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Cancer Ther 3:245-6. 2004
  62. ncbi Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program
    K D Tew
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Pharmacol 50:149-59. 1996
    ..In contrast, none of the other enzymes or GSH had patterns of expression that resulted in an obvious correlation to the sensitivity or resistance of alkylating agents...

Research Grants62

  1. Couple-Focused Interventions for Breast Cancer Patients
    Sharon L Manne; Fiscal Year: 2010
    ..An exploratory aim evaluates the impact of ECG versus SG and UC on partner and couple-level functioning and on partner's perception of relationship support, intimacy, stress management, and intervention group support. ..
  2. Colon Cancer Screening for Cancer Patients' Families
    Sharon Manne; Fiscal Year: 2006
    ..After receiving the intervention information, participants will be interviewed again six months later regarding CRC screening behaviors and attitudes to assess the impact of the intervention. ..
  3. Facilitating Informed Decisions for MSI Testing
    Sharon Manne; Fiscal Year: 2007
    ..Very little is known about the adequacy of the informed consent process for this test. At Fox Chase Cancer Center, patients are provided with an explanation of MSI by their physician and a one-page written consent form...
  4. PSYCHOLOGICAL INTERVENTION FOR OVARIAN CANCER PATIENTS
    Sharon Manne; Fiscal Year: 2004
    ..Patients will be assessed using questionnaire methods pre- and post-intervention, and at 9-month post-intervention follow-up. ..
  5. PSYCHOLOGICAL INTERVENTION FOR OVARIAN CANCER PATIENTS
    Sharon L Manne; Fiscal Year: 2010
    ....
  6. Facilitating Parent Adaptation to Pediatric Transplant: The P-SCIP Trial
    Sharon L Manne; Fiscal Year: 2010
    ....
  7. Couple-Focused Interventions for Breast Cancer Patients
    Sharon Manne; Fiscal Year: 2009
    ..An exploratory aim evaluates the impact of ECG versus SG and UC on partner and couple-level functioning and on partner's perception of relationship support, intimacy, stress management, and intervention group support. ..
  8. Facilitating Parent Adaptation to Pediatric Transplant: The P-SCIP Trial
    Sharon Manne; Fiscal Year: 2009
    ....
  9. Tailored Intervention for Melanoma Patients' Families
    Sharon Manne; Fiscal Year: 2007
    ..396 family members will complete the study. Outcomes will be evaluated in terms of TCE, SSE and sun protection habits, as well as changes in attitudes and knowledge about CMM ..
  10. COUPLES DEALING WITH CANCER--ANALYSIS AND INTERVENTION
    Sharon Manne; Fiscal Year: 2002
    ..I am free to decide not to take part in the study. My decision whether or not to take part in the study will not affect the medical treatment of myself or my partner at the Universityof Pennsylvania Medical Center...
  11. COLON CANCER SCREENING FOR CANCER PATIENTS FAMILIES
    Sharon Manne; Fiscal Year: 2000
    ..Participants will be 490 siblings of patients diagnosed with adenocarcinoma of the colon or rectum at Fox Chase Cancer Center or Memorial Sloan-Kettering Cancer Center (MSKCC) between 1992 and 1995...
  12. Genomic Markers of Breast Cancer Prevention Induced by hCG in Women at High Risk
    Jose Russo; Fiscal Year: 2007
    ..This knowledge will serve as the basis for establishing novel genomic signatures as intermediate biomarkers for larger preventive clinical trials at the completion of this project. ..
  13. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2007
    ..abstract_text> ..
  14. Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast Cancer
    Jose Russo; Fiscal Year: 2007
    ....
  15. Center for Environment and Mammary Gland Development
    Jose Russo; Fiscal Year: 2007
    The Fox Chase Cancer Center in Philadelphia, Pennsylvania, the University of Alabama Comprehensive Cancer Center in Birmingham, Alabama, and the Mount Sinai School of Medicine in New York, New York, have joined efforts for organizing a ..
  16. ROLE OF MICROSATELLITE INSTABILITY IN BREAST CANCER
    Jose Russo; Fiscal Year: 2002
    ..The knowledge gained through this exploratory work will establish the basis for more in dept studies in the role of mismatch repair in breast cancer. ..
  17. 4-Hydroxyestradiol Receptor in Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
  18. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2005
    ..abstract_text> ..
  19. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2006
    ..abstract_text> ..
  20. Improving Marital Support For Couples Coping with Cancer
    Sharon Manne; Fiscal Year: 2007
    ..abstract_text> ..
  21. Couple-Focused Interventions for Breast Cancer Patients
    Sharon Manne; Fiscal Year: 2007
    ..An exploratory aim evaluates the impact of ECG versus SG and UC on partner and couple-level functioning and on partner's perception of relationship support, intimacy, stress management, and intervention group support. ..
  22. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
    A group of nine NIH-funded major users and four secondary NIH-funded users at Fox Chase Cancer Center request funds for a BD Biosciences LSR flow cytometer...
  23. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2005
    ..abstract_text> ..