Xue Wang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN16, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 330:23-9. 2009
  2. doi request reprint Differences in Activation of HIV-1 Replication by Superinfection With HIV-1 and HIV-2 in U1 Cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland
    J Cell Physiol . 2016
  3. doi request reprint IL-1β and IL-18 inhibition of HIV-1 replication in Jurkat cells and PBMCs
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA Electronic address
    Biochem Biophys Res Commun 473:926-30. 2016
  4. pmc Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, CBER FDA, Building 72, Rm 4322, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Viruses 8:. 2016
  5. doi request reprint Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN22 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 393:181-90. 2014
  6. pmc Highly pathogenic avian influenza A virus (H5N1) can be transmitted in ferrets by transfusion
    Xue Wang
    Lab of Molecular Virology, Building 29B, Rm 4NN22, Division of Emerging and Transfusion Transmitted Diseases, CBER FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA
    BMC Infect Dis 14:192. 2014
  7. doi request reprint Novel pandemic influenza A (H1N1) virus infection modulates apoptotic pathways that impact its replication in A549 cells
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Bethesda, MD 20892, USA Electronic address
    Microbes Infect 16:178-86. 2014
  8. doi request reprint HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells
    Xue Wang
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States
    Cell Signal 24:1414-9. 2012
  9. pmc Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells
    Xue Wang
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA
    Med Gas Res 1:8. 2011
  10. doi request reprint Changes in the level of apoptosis-related proteins in Jurkat cells infected with HIV-1 versus HIV-2
    Xue Wang
    Labaratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Cell Biochem 337:175-83. 2010

Collaborators

Detail Information

Publications25

  1. doi request reprint c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN16, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 330:23-9. 2009
    ..Collectively, these findings further corroborate the concept that gp120 plays an important role, via involvement of molecules such as c-FLIPL, in apoptotic cell death due to HIV-1 infection...
  2. doi request reprint Differences in Activation of HIV-1 Replication by Superinfection With HIV-1 and HIV-2 in U1 Cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland
    J Cell Physiol . 2016
    ..Cells infected with HIV-2 showed lower level of HIV-1 replication, suggesting that co-infection with HIV-2 may result in slower progression toward AIDS. J. Cell. Physiol. 9999: 1-8, 2016. © 2016 Wiley Periodicals, Inc...
  3. doi request reprint IL-1β and IL-18 inhibition of HIV-1 replication in Jurkat cells and PBMCs
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA Electronic address
    Biochem Biophys Res Commun 473:926-30. 2016
    ..1 cells. These results indicate that IL-1β and IL-18 are able to inhibit HIV-1 replication, and their effects may be due to signaling through apoptosis involved in inactivation of caspase-3 activity. ..
  4. pmc Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, CBER FDA, Building 72, Rm 4322, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Viruses 8:. 2016
    ..These data indicate that HIV-1 replication can be activated by pH1N1 virus in HIV-1-infected cells resulting in induction of cell death through apoptotic pathways. ..
  5. doi request reprint Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN22 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 393:181-90. 2014
    ....
  6. pmc Highly pathogenic avian influenza A virus (H5N1) can be transmitted in ferrets by transfusion
    Xue Wang
    Lab of Molecular Virology, Building 29B, Rm 4NN22, Division of Emerging and Transfusion Transmitted Diseases, CBER FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA
    BMC Infect Dis 14:192. 2014
    ..The infectivity of virus in blood and the potential for virus transmission by transfusion has not been investigated...
  7. doi request reprint Novel pandemic influenza A (H1N1) virus infection modulates apoptotic pathways that impact its replication in A549 cells
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Bethesda, MD 20892, USA Electronic address
    Microbes Infect 16:178-86. 2014
    ..In the p38 superfamily, p38α expression increased viral RNA production, while expression of p38β and p38γ decreased. These data indicated that influenza virus induces apoptotic signaling pathways, which benefit virus replication...
  8. doi request reprint HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells
    Xue Wang
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States
    Cell Signal 24:1414-9. 2012
    ..The results indicate that HIV is able to induce the autophagic signaling pathway in HIV-infected host cells, which may be required for HIV infection-mediated apoptotic cell death...
  9. pmc Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells
    Xue Wang
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA
    Med Gas Res 1:8. 2011
    ..The Fas-dependent apoptotic pathway has been implicated in several models of lung or vascular injury. Carbon monoxide, an enzymatic product of heme oxygenase-1, exerts antiapoptotic effects at low concentration in vitro and in vivo...
  10. doi request reprint Changes in the level of apoptosis-related proteins in Jurkat cells infected with HIV-1 versus HIV-2
    Xue Wang
    Labaratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Cell Biochem 337:175-83. 2010
    ....
  11. pmc Stability and infectivity of novel pandemic influenza A (H1N1) virus in blood-derived matrices under different storage conditions
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, CBER FDA, Bethesda, MD 20892, USA
    BMC Infect Dis 11:354. 2011
    ..Furthermore the effect of storage on virus stability and infectivity has not been well studied...
  12. doi request reprint Molecules from apoptotic pathways modulate HIV-1 replication in Jurkat cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 414:20-4. 2011
    ..We also discuss the effects of MAPK signaling pathways and apoptosis on HIV-1 replication...
  13. doi request reprint Some mechanisms of FLIP expression in inhibition of HIV-1 replication in Jurkat cells, CD4+ T cells and PBMCs
    Jiying Tan
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
    J Cell Physiol 228:2305-13. 2013
    ..We also found that cFLIP expression downregulated Fas expression and inactivated FADD in the Fas-mediated apoptotic pathway. The inactivated FADD also inhibited HIV-1 replication...
  14. doi request reprint Effect of sex steroid hormones on replication and transmission of major HIV subtypes
    Viswanath Ragupathy
    Laboratory of Molecular Virology, Division of Emerging Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Electronic address
    J Steroid Biochem Mol Biol 138:63-71. 2013
    ..Little is known about the role of sex hormone effects on HIV Subtypes pathogenesis. The aim of our study was to determine sex hormone effects on replication and transmissibility of HIV subtypes...
  15. pmc Sensitive Detection and Simultaneous Discrimination of Influenza A and B Viruses in Nasopharyngeal Swabs in a Single Assay Using Next-Generation Sequencing-Based Diagnostics
    Jiangqin Zhao
    DETTD OBRR CBER, Food and Drug Administration, Silver Spring, MD, 20993, United States of America
    PLoS ONE 11:e0163175. 2016
    ....
  16. pmc CRF22_01A1 is involved in the emergence of new HIV-1 recombinants in Cameroon
    Jiangqin Zhao
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 RockvillePike, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 60:344-50. 2012
    ..Our studies show that novel recombinants between CRF22_01A1 and other clades and recombinant forms may be emerging in Cameroon that could contribute to the future global diversity of HIV-1 in this region and worldwide...
  17. pmc Identification of Host Micro RNAs That Differentiate HIV-1 and HIV-2 Infection Using Genome Expression Profiling Techniques
    Krishnakumar Devadas
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA
    Viruses 8:. 2016
    ..Putative functional targets of these miRNAs include genes involved in signal transduction, metabolism, development and cell death. ..
  18. pmc Rapid detection and differentiation of swine-origin influenza A virus (H1N1/2009) from other seasonal influenza A viruses
    Jiangqin Zhao
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Viruses 4:3012-9. 2012
    ..This new method may be useful for simultaneous detection and subtyping of influenza A viruses and can be rapidly modified to detect other emerging influenza strains in public health settings...
  19. pmc Sensitive detection assays for influenza RNA do not reveal viremia in US blood donors
    Susan L Stramer
    American Red Cross Scientific Support Office, Gaithersburg, MD, USA
    J Infect Dis 205:886-94. 2012
    ..We present an assessment of the prevalence of seasonal and 2009 H1N1 influenza viremia (via RNA testing) in blood donor populations using multiple sensitive detection assays...
  20. pmc Comparative analysis of cell culture and prediction algorithms for phenotyping of genetically diverse HIV-1 strains from Cameroon
    Viswanath Ragupathy
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    AIDS Res Ther 6:27. 2009
    ..Here we report a comparative analysis of viral tropism of strains circulating in Cameroon where diverse and emerging variant strains are prevalent...
  21. pmc Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected blood donors or individuals in Africa
    Shixing Tang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Transfusion 51:463-8. 2011
    ....
  22. pmc Current Approaches for Diagnosis of Influenza Virus Infections in Humans
    Sai Vikram Vemula
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA
    Viruses 8:96. 2016
    ..This review discusses diagnostic approaches currently available for detection of influenza viruses in humans. ..
  23. pmc Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay
    Jiangqin Zhao
    Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    BMC Biotechnol 10:74. 2010
    ....
  24. pmc Viremia associated with fatal outcomes in ferrets infected with avian H5N1 influenza virus
    Xue Wang
    Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS ONE 5:e12099. 2010
    ..Our observations further substantiate pathogenicity of H5N1 and further indicate that viremia may be a bio-marker for fatal outcomes in H5N1 infection...
  25. pmc Characterization of immune responses to capsid protein p24 of human immunodeficiency virus type 1 and implications for detection
    Shixing Tang
    Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Clin Vaccine Immunol 17:1244-51. 2010
    ..The data provide the foundation for development and refinement of new assays for improved p24 antigen testing as future tools for rapid and accurate diagnosis as part of early intervention strategies and estimations of incidence...