Angamuthu Selvapandiyan

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc A novel semiquantitative fluorescence-based multiplex polymerase chain reaction assay for rapid simultaneous detection of bacterial and parasitic pathogens from blood
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Disease, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Mol Diagn 7:268-75. 2005
  2. pmc Role of centrins 2 and 3 in organelle segregation and cytokinesis in Trypanosoma brucei
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS ONE 7:e45288. 2012
  3. pmc Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis
    Parna Bhattacharya
    Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
    PLoS Negl Trop Dis 10:e0004963. 2016
  4. doi request reprint A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolates
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Transfusion 48:1787-98. 2008
  5. doi request reprint Methods to Evaluate the Preclinical Safety and Immunogenicity of Genetically Modified Live-Attenuated Leishmania Parasite Vaccines
    Sreenivas Gannavaram
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA
    Methods Mol Biol 1403:623-38. 2016
  6. pmc Live attenuated Leishmania donovani p27 gene knockout parasites are nonpathogenic and elicit long-term protective immunity in BALB/c mice
    Ranadhir Dey
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 190:2138-49. 2013
  7. ncbi request reprint Genetically modified live attenuated parasites as vaccines for leishmaniasis
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research, Bethesda, MD 20892, USA
    Indian J Med Res 123:455-66. 2006
  8. doi request reprint Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Immunol 183:1813-20. 2009
  9. pmc Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania
    Nancy Lee
    Laboratory of Bacterial, Parasitic, and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
    Eukaryot Cell 6:1745-57. 2007
  10. pmc A multiplex polymerase chain reaction microarray assay to detect bioterror pathogens in blood
    Keiko Tomioka
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    J Mol Diagn 7:486-94. 2005

Collaborators

Detail Information

Publications17

  1. pmc A novel semiquantitative fluorescence-based multiplex polymerase chain reaction assay for rapid simultaneous detection of bacterial and parasitic pathogens from blood
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Disease, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Mol Diagn 7:268-75. 2005
    ..The time necessary for performing this assay including sample preparation was less than 1.5 hours, making this a potentially useful method for rapidly diagnosing and monitoring the efficacy of drugs or vaccines in infected individuals...
  2. pmc Role of centrins 2 and 3 in organelle segregation and cytokinesis in Trypanosoma brucei
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS ONE 7:e45288. 2012
    ..Therefore, both centrin2 and 3 are involved in organelle segregation similar to centrin1 as was previously observed. In addition, we identified their role in kinetoplast division which may be also linked to overall mis-segregation...
  3. pmc Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis
    Parna Bhattacharya
    Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
    PLoS Negl Trop Dis 10:e0004963. 2016
    ..In this study we analyzed LdCen-/- parasite mediated modulation of innate and adaptive immune response in aged mice (18 months) and compared to young (2 months) mice...
  4. doi request reprint A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolates
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Transfusion 48:1787-98. 2008
    ..Diversity in clinical outcome, due to different species of Leishmania, and its presence in asymptomatic blood donors in endemic areas warrant development of methods that are sensitive and can rapidly identify infecting species...
  5. doi request reprint Methods to Evaluate the Preclinical Safety and Immunogenicity of Genetically Modified Live-Attenuated Leishmania Parasite Vaccines
    Sreenivas Gannavaram
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA
    Methods Mol Biol 1403:623-38. 2016
    ..Here we describe methods to test persistence in the immunized host and immunogenicity, and to identify biomarkers of vaccine safety and efficacy with particular reference to genetically attenuated Leishmania parasites. ..
  6. pmc Live attenuated Leishmania donovani p27 gene knockout parasites are nonpathogenic and elicit long-term protective immunity in BALB/c mice
    Ranadhir Dey
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 190:2138-49. 2013
    ..Our data show that genetically modified live attenuated Ldp27(-/-) parasites are safe, induce protective immunity even in the absence of parasites, and can provide protection against homologous and heterologous Leishmania species...
  7. ncbi request reprint Genetically modified live attenuated parasites as vaccines for leishmaniasis
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research, Bethesda, MD 20892, USA
    Indian J Med Res 123:455-66. 2006
    ....
  8. doi request reprint Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Immunol 183:1813-20. 2009
    ..braziliensis that causes mucocutaneous leishmaniasis. Results indicate that LdCen1(-/-) can be a safe and effective vaccine candidate against VL as well as mucocutaneous leishmaniasis causing parasites...
  9. pmc Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania
    Nancy Lee
    Laboratory of Bacterial, Parasitic, and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
    Eukaryot Cell 6:1745-57. 2007
    ..These findings suggest that Leishmania metacaspases are not responsible for the caspase-like activities reported in this organism and suggest a possible role for LdMCs as effector molecules in Leishmania PCD...
  10. pmc A multiplex polymerase chain reaction microarray assay to detect bioterror pathogens in blood
    Keiko Tomioka
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    J Mol Diagn 7:486-94. 2005
    ..This study represents proof of the concept of microarray technology to screen simultaneously for multiple bioterror pathogens in blood samples...
  11. doi request reprint Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum
    Babita Mahajan
    Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Rockville, Maryland 20852, USA
    J Biol Chem 283:31871-83. 2008
    ..These results provide the opportunity to further explore the role of centrins in cell division in malaria parasites and suggest novel targets to construct genetically modified, live attenuated malaria vaccines...
  12. pmc Centrin1 is required for organelle segregation and cytokinesis in Trypanosoma brucei
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Biol Cell 18:3290-301. 2007
    ..brucei...
  13. ncbi request reprint Microarray multiplex assay for the simultaneous detection and discrimination of hepatitis B, hepatitis C, and human immunodeficiency type-1 viruses in human blood samples
    Chu Chieh Hsia
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 356:1017-23. 2007
    ..Our data represent a proof-of-concept for the possible use of highly sensitive multiplex microarray assay to screen and confirm the presence of these viruses in blood donors and patients...
  14. ncbi request reprint Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania
    Angamuthu Selvapandiyan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Food and Drug Administration, Bethesda, MD 20892, USA
    J Biol Chem 279:25703-10. 2004
    ..The centrin null mutant defective in amastigote growth could be useful as a vaccine candidate against leishmaniasis...
  15. pmc Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice
    Parna Bhattacharya
    Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
    Infect Immun 83:3800-15. 2015
    ..These data suggest that infection with live attenuated parasites promotes a state of classical activation (M1 dominant) in macrophages that leads to the generation of protective Th1 responses in BALB/c mice. ..
  16. doi request reprint Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum
    Jacqueline Araújo Fiuza
    Laboratory of Cellular and Molecular Immunology, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 33:280-8. 2015
    ..Our results support further studies aiming to demonstrate the potential of genetically modified live attenuated L. donovani vaccine to control L. infantum transmission in endemic areas for CVL. ..
  17. ncbi request reprint Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovani
    Neena Goyal
    Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Mol Biochem Parasitol 145:147-57. 2006
    ..Further, identification of LdDCP now provides an opportunity to investigate Leishmania peptidases for their potential as drug and vaccine targets...