I P Pogribny

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Carcinog 46:187-97. 2007
  2. doi request reprint The role of microRNAs in the development and progression of chemical-associated cancers
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA Electronic address
    Toxicol Appl Pharmacol 312:3-10. 2016
  3. doi request reprint The role for microRNAs in drug toxicity and in safety assessment
    April K Marrone
    FDA National Center for Toxicological Research, Division of Biochemical Toxicology, Jefferson, AR, USA
    Expert Opin Drug Metab Toxicol 11:601-11. 2015
  4. doi request reprint DNA methylome alterations in chemical carcinogenesis
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA Electronic address
    Cancer Lett 334:39-45. 2013
  5. pmc Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States Electronic address
    Cancer Lett 342:223-30. 2014
  6. doi request reprint Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    FASEB J 27:2233-43. 2013
  7. doi request reprint Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease
    Igor P Pogribny
    NCTR, Division of Biochemical Toxicology, Jefferson, AR 72079, USA
    Expert Opin Drug Metab Toxicol 9:713-24. 2013
  8. doi request reprint Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Int J Oncol 42:1822-32. 2013
  9. pmc Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
    Volodymyr Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    FASEB J 26:4592-602. 2012
  10. pmc Environmental toxicants, epigenetics, and cancer
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Adv Exp Med Biol 754:215-32. 2013

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Carcinog 46:187-97. 2007
    ....
  2. doi request reprint The role of microRNAs in the development and progression of chemical-associated cancers
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA Electronic address
    Toxicol Appl Pharmacol 312:3-10. 2016
    ..It also emphasizes the potential for miRNA changes as early indicators of the carcinogenic process, markers for carcinogen exposure, and identification of chemical carcinogenic hazards...
  3. doi request reprint The role for microRNAs in drug toxicity and in safety assessment
    April K Marrone
    FDA National Center for Toxicological Research, Division of Biochemical Toxicology, Jefferson, AR, USA
    Expert Opin Drug Metab Toxicol 11:601-11. 2015
    ..In response to this need, the field of toxicology is rapidly expanding to identify key pathways involved in drug toxicity...
  4. doi request reprint DNA methylome alterations in chemical carcinogenesis
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA Electronic address
    Cancer Lett 334:39-45. 2013
    ..It also emphasizes the potential role for epigenetic changes to serve as markers for carcinogen exposure and carcinogen risk assessment. ..
  5. pmc Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States Electronic address
    Cancer Lett 342:223-30. 2014
    ....
  6. doi request reprint Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    FASEB J 27:2233-43. 2013
    ....
  7. doi request reprint Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease
    Igor P Pogribny
    NCTR, Division of Biochemical Toxicology, Jefferson, AR 72079, USA
    Expert Opin Drug Metab Toxicol 9:713-24. 2013
    ..The pathogenesis of diabetes mellitus and nonalcoholic fatty liver disease (NAFLD) is complex, and the underlying molecular mechanisms are only partially understood...
  8. doi request reprint Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Int J Oncol 42:1822-32. 2013
    ....
  9. pmc Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
    Volodymyr Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    FASEB J 26:4592-602. 2012
    ..These findings suggest that the PPARĪ±-regulated metabolism network is one of the key mechanisms determining interstrain susceptibility and severity of NAFLD in mice...
  10. pmc Environmental toxicants, epigenetics, and cancer
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Adv Exp Med Biol 754:215-32. 2013
    ....
  11. pmc Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Breast Cancer Res 12:314. 2010
    ....
  12. doi request reprint Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants
    Igor Koturbash
    National Center for Toxicological Research, Division of Biochemical Toxicology, Jefferson, AR 72079, USA
    Expert Opin Drug Metab Toxicol 8:597-606. 2012
    ..MicroRNAs (miRNAs) comprise a family of short non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Rapidly growing evidence indicates that miRNAs play a key role in drug (xenobiotic) metabolism...
  13. pmc Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 49:9-15. 2008
    ....
  14. doi request reprint DNA hypomethylation in the origin and pathogenesis of human diseases
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Cell Mol Life Sci 66:2249-61. 2009
    ..This review presents evidence suggesting the involvement of DNA hypomethylation in the pathogenesis of several major human pathologies, including cancer, atherosclerosis, Alzheimer's disease, and psychiatric disorders...
  15. ncbi request reprint Epigenetic events in tumorigenesis: putting the pieces together
    I P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Exp Oncol 32:132-6. 2010
    ....
  16. ncbi request reprint Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Mutat Res 619:30-7. 2007
    ..Thus, our findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state...
  17. doi request reprint The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 722:106-13. 2011
    ..These results signify the fundamental role of epigenetic alterations in genotoxic liver carcinogenesis...
  18. ncbi request reprint Methyl deficiency, alterations in global histone modifications, and carcinogenesis
    Igor P Pogribny
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Nutr 137:216S-222S. 2007
    ..These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD...
  19. doi request reprint Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Nutr Food Res 56:116-25. 2012
    ..In this review, we describe molecular changes and their role in pathogenesis of liver carcinogenesis induced by methyl deficiency...
  20. doi request reprint MicroRNA dysregulation during chemical carcinogenesis
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Epigenomics 1:281-90. 2009
    ....
  21. doi request reprint Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Int J Cancer 127:1785-94. 2010
    ..These results suggest that dysregulated miRNA expression may underlie the abnormal functioning of critical cellular processes associated with the cisplatin-resistant phenotype...
  22. pmc Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 644:17-23. 2008
    ....
  23. doi request reprint The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 235:305-11. 2009
    ....
  24. pmc Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Hepatol 51:176-86. 2009
    ..However, the role of epigenetic alterations in the genesis of hepatic steatosis and cause of individual susceptibilities to this pathological state are largely unknown...
  25. doi request reprint Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Brain Res 1237:25-34. 2008
    ..Together, these data suggest that the proper maintenance of the epigenomic landscape in normal brain depends on the adequate supply of essential nutrients involved in the metabolism of methyl groups...
  26. doi request reprint Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 669:56-62. 2009
    ..Additionally, the results indicate that epigenetic changes may be more reliable markers than DNA lesions of the carcinogenic process and carcinogen exposure...
  27. pmc Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Lab Invest 90:1437-46. 2010
    ..More important, our data provide a mechanistic link between alterations in miRNA expression and pathophysiological and pathomorphological features of NASH...
  28. ncbi request reprint Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 225:61-9. 2007
    ..The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen...
  29. ncbi request reprint Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation
    I P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 176:169-74. 2002
    ..None of the samples exhibited coding region mutations. Given that p53 mutations are rare in primary human liver tumors, these data suggest that transcriptional repression by p53 promoter methylation may contribute to tumor progression...
  30. ncbi request reprint Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets
    Nataliya Yu Lukyanova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mol Cancer Ther 6:1089-98. 2007
    ..Finally, deregulation of similar pathways may explain the existence and provide mechanism of cross-resistance of cancer cells to different types of chemotherapeutic agents...
  31. doi request reprint E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA
    Int J Cancer 126:2575-83. 2010
    ....
  32. ncbi request reprint Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues
    Igor P Pogribny
    Division of Biochemical Toxicology, FDA National Center for Toxicological Research, NCTR, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 548:53-9. 2004
    ..They also demonstrate that DNA hypomethylation is localized to tissue that undergoes carcinogenesis, and is not altered in non-target tissues...
  33. ncbi request reprint Age-related effects of methionine-enriched diet on plasma homocysteine concentration and methylation of hepatic DNA in rats
    I P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, USA
    Ukr Biokhim Zh (1999) 77:114-9. 2005
    ....
  34. pmc Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 625:62-71. 2007
    ..These data indicate the importance of epigenetic alterations in the mechanism of action of peroxisome proliferators and the key role of Pparalpha...
  35. ncbi request reprint Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Cell Cycle 7:3202-10. 2008
    ..This model illustrates that the Socs1 acts as classic tumor suppressor by preventing activation of the STAT3 and downregulation of Socs1 and consequent activation of STAT3 may be a crucial events leading to formation of HCC...
  36. ncbi request reprint De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
    Igor P Pogribny
    Division of Biochemical Toxicology, Federal Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 187:69-75. 2002
    ..Our data show that site-specific de novo methylation of 5' CpG island of p16 gene precedes tumor development and undergoes dynamic expansion during tumor progression...
  37. ncbi request reprint Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 27:1713-20. 2006
    ..These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis...
  38. ncbi request reprint Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats
    Igor P Pogribny
    National Center for Toxicological Research, Jefferson, AR 72078, National Cancer Institute, Bethesda, MD 20892 and University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 27:1180-6. 2006
    ....
  39. doi request reprint Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 29:638-46. 2008
    ..In conclusion, we have demonstrated that exposure of rats to genotoxic hepatocarcinogen 2-AAF, in addition to formation of 2-AAF-specific DNA lesions, resulted in substantial alterations in cellular epigenetic status...
  40. ncbi request reprint Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene
    B A Smith
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 379:61-8. 1997
    ..The extremely low recovery of point mutations from TGr lymphocytes suggests that DNP induces a substantial number of mutations by other mechanisms...
  41. doi request reprint Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Mol Carcinog 48:479-87. 2009
    ....
  42. ncbi request reprint Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite
    Tetyana V Bagnyukova
    Department of Biochemistry, Precarpathian National University, Ivano Frankivsk, Ukraine
    Environ Mol Mutagen 48:658-65. 2007
    ..The findings suggest that goldfish livers cope with arsenic-induced oxidative stress mainly through adaptive changes in the glutathione pool and antioxidant enzymes...
  43. doi request reprint Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Brain Res 1237:44-51. 2008
    ..Any of these events may compromise normal central nervous system function and contribute to the development of various neurological, behavioral, and neurocognitive dysfunctions...
  44. pmc Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats
    Athena Starlard-Davenport
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 31:376-81. 2010
    ..In conclusion, we demonstrate that epigenetic alterations precede formation of preneoplastic lesions indicating the significance of epigenetic events in induction of oncogenic pathways in early stages of carcinogenesis...
  45. ncbi request reprint Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    S J James
    Food and Drug Administration National Center for Toxicological Research, the Division of Biochemical Toxicology, Jefferson, AR 72079, USA
    Am J Clin Nutr 70:495-501. 1999
    ..Although advanced maternal age is a major risk factor for trisomy 21, most children with Down syndrome are born to mothers <30 y of age...
  46. ncbi request reprint Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AK 72079, USA
    Cancer Biol Ther 5:65-70. 2006
    ..Such epigenetic dysregulation may contribute to and may be indicative of the formation of a more aggressive tumor phenotype during tumor progression...
  47. pmc Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum
    S J James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Transl Psychiatry 4:e460. 2014
    ..Epigenetic regulation of the programmed on-off switches in gene expression that occur at birth and during early brain development warrants further investigation. ..
  48. ncbi request reprint The role of UDP-glucuronosyltransferases and drug transporters in breast cancer drug resistance
    A Starlard-Davenport
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Exp Oncol 32:172-80. 2010
    ..Those polymorphic variants that affect the clinical efficacy and confer drug resistance of chemotherapeutic agents, including hormonal therapies, taxanes, anthracyclines, and alkylating agents, in breast cancer...
  49. ncbi request reprint Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology
    S Jill James
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Nutr 132:2361S-2366S. 2002
    ..SAH-mediated DNA hypomethylation and associated alterations in gene expression and chromatin structure may provide new hypotheses for pathogenesis of diseases related to homocysteinemia...
  50. ncbi request reprint Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
    Igor P Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Dr, Jefferson, AR 72079, USA
    Mutat Res 593:80-7. 2006
    ..These results provide an experimental evidence and a mechanistic basis by which epigenetic alterations may contribute to the initiation and promotion steps of carcinogenesis...
  51. ncbi request reprint Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells
    Volodymyr Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Anal Biochem 356:202-7. 2006
    ....
  52. ncbi request reprint Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1238-45. 2008
    ....
  53. ncbi request reprint Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 133:3740S-3747S. 2003
    ..These insights in an experimental model are consistent with the possibility that DNA lesions may be a necessary prerequisite for the disruption of normal DNA methylation patterns in preneoplastic and neoplastic cells...
  54. ncbi request reprint Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    Cell Cycle 6:2010-8. 2007
    ..The results of this study show that deregulation of cellular epigenetic processes plays a crucial role in the mechanism of E(2)-induced mammary carcinogenesis in ACI rats, especially in the tumor initiation process...
  55. ncbi request reprint Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver
    Farah Esfandiari
    University of California Davis, School of Medicine, Department of Medical Pathology, Research 3, Room 3200A, 4645 Second Avenue, Sacramento, CA 95817, USA
    Carcinogenesis 24:1935-40. 2003
    ..Reduction of MeCP2 protein expression may influence the initiation and/or progression of hepatic cancer induced by methyl deficiency and may provide a useful marker of pre-neoplastic change...
  56. ncbi request reprint Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice
    Sahar Sibani
    Department of Pediatrics, McGill University Montreal Children s Hospital Research Institute, 4060 Ste Catherine Street West, Montreal, Quebec H3Z 2Z3, Canada
    Carcinogenesis 23:61-5. 2002
    ..As an increase in tumor numbers was observed only in folate- and choline-deficient mice with low levels of SAM and DNA hypomethylation, the modulatory role of folate may be dependent on the transformation state of the cell...
  57. pmc Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    Carole Yauk
    Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9
    Proc Natl Acad Sci U S A 105:605-10. 2008
    ..Changes in methylation can have widespread repercussions for chromatin structure, gene expression and genome stability. Potential health effects warrant extensive further investigation...
  58. pmc Global leukocyte DNA methylation is similar in African American and Caucasian women under conditions of controlled folate intake
    Juan Axume
    Human Nutrition and Food Science Department, Cal Poly Pomona, Pomona, California 91768, USA
    Epigenetics 2:66-8. 2007
    ....
  59. ncbi request reprint DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation
    Richard H Finnell
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston 77030, USA
    J Nutr 132:2457S-2461S. 2002
    ..However, these results suggest that an extended examination of changes in DNA methylation prior to GD 15 is required to unequivocally prove or disprove the hypothesis...
  60. pmc S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism
    Ivo Baric
    Department of Pediatrics, University Hospital Center, Kispaticeva 12, 10000 Zagreb, Croatia
    Proc Natl Acad Sci U S A 101:4234-9. 2004
    ..Gene analysis revealed two mutations in exon 4: a maternally derived stop codon, and a paternally derived missense mutation. We discuss reasons for biochemical abnormalities and pathophysiological aspects of AdoHcy hydrolase deficiency...
  61. pmc Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation
    Xiaoying Wang
    Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cancer Lett 270:132-43. 2008
    ..These data are the first indication that EndoG may be regulated by methylation of its gene promoter, and partially by histone acetylation, and that EndoG is essential for prostate cancer cell death in the used models...
  62. ncbi request reprint Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, T1K 3M4, Canada
    Carcinogenesis 28:1831-8. 2007
    ....
  63. ncbi request reprint Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells
    Vasil F Chekhun
    Department of Mechanisms of Anticancer Therapy, R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine
    Cancer Lett 231:87-93. 2006
    ..We hypothesize that acquirement of doxorubicin resistance of MCF-7 cells is associated with DNA hypomethylation of the promoter regions of the MDR1, GSTpi, MGMT, and Upa genes...
  64. doi request reprint Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
    Olga Kovalchuk
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Mol Cancer Ther 7:2152-9. 2008
    ....