Shyh Ching Lo

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Identification and characterization of EBV genomes in spontaneously immortalized human peripheral blood B lymphocytes by NGS technology
    Haiyan Lei
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, RM, 1NN06, 29 Lincoln Dr, 20892 4555 Bethesda, MD, USA
    BMC Genomics 14:804. 2013
  2. pmc Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
    Shyh Ching Lo
    Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:15874-9. 2010
  3. pmc Mixed group of Rhizobiales microbes in lung and blood of a patient with fatal pulmonary illness
    Shyh Ching Lo
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration Silver Spring, Maryland 20993, USA
    Int J Clin Exp Pathol 8:13834-52. 2015
  4. pmc Isolation of novel Afipia septicemium and identification of previously unknown bacteria Bradyrhizobium sp. OHSU_III from blood of patients with poorly defined illnesses
    Shyh Ching Lo
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e76142. 2013
  5. pmc Isolation and characterization of two novel bacteria Afipia cberi and Mesorhizobium hominis from blood of a patient afflicted with fatal pulmonary illness
    Shyh Ching Lo
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e82673. 2013
  6. pmc Development of real-time PCR array for simultaneous detection of eight human blood-borne viral pathogens
    Natalia Pripuzova
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 7:e43246. 2012
  7. pmc In Vitro and In Vivo studies of monoclonal antibodies with prominent bactericidal activity against Burkholderia pseudomallei and Burkholderia mallei
    Shimin Zhang
    Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Clin Vaccine Immunol 18:825-34. 2011
  8. doi request reprint Differentially expressed genes and pathways induced by organophosphates in human neuroblastoma cells
    Tianwei Li
    Tissue Safety Laboratory Program, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Exp Biol Med (Maywood) 237:1413-23. 2012
  9. pmc DNA Sequence Signatures for Rapid Detection of Six Target Bacterial Pathogens Using PCR Assays
    Kenjiro Nagamine
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies and Division of Human Tissues, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA
    Microbiol Insights 8:7-14. 2015
  10. pmc Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations
    Haiyan Lei
    Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland
    Sci Rep 5:16706. 2015

Collaborators

  • Jing Zhang
  • Robert J Biggar
  • Jing Han
  • Bingjie Li
  • Guo Chiuan Hung
  • Shien Tsai
  • Haiyan Lei
  • Tianwei Li
  • Kenjiro Nagamine
  • Natalia Pripuzova
  • Shimin Zhang
  • Marina GutiĆ©rrez
  • JANET NEEQUAYE
  • Kishor Bhatia
  • Sidnei Epelman
  • Sam M Mbulaiteye
  • Francis Nkrumah
  • Richard Wang
  • Raj K Puri
  • Roger G Ptak
  • Hongtao Zhao
  • Hyung Yong Kim
  • Joe Rodriguez
  • Shaw Huey Feng

Detail Information

Publications12

  1. pmc Identification and characterization of EBV genomes in spontaneously immortalized human peripheral blood B lymphocytes by NGS technology
    Haiyan Lei
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, RM, 1NN06, 29 Lincoln Dr, 20892 4555 Bethesda, MD, USA
    BMC Genomics 14:804. 2013
    ..The purpose of this study was to examine if rapid detection and characterization of a viral agent could be effectively achieved by HTS using a platform that has become readily available in general biology laboratories...
  2. pmc Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
    Shyh Ching Lo
    Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:15874-9. 2010
    ....
  3. pmc Mixed group of Rhizobiales microbes in lung and blood of a patient with fatal pulmonary illness
    Shyh Ching Lo
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration Silver Spring, Maryland 20993, USA
    Int J Clin Exp Pathol 8:13834-52. 2015
    ..However, the above mentioned assays should help in rapidly detecting and identifying these previously unrecognized Rhizobiales microbes in patients. ..
  4. pmc Isolation of novel Afipia septicemium and identification of previously unknown bacteria Bradyrhizobium sp. OHSU_III from blood of patients with poorly defined illnesses
    Shyh Ching Lo
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e76142. 2013
    ..Our studies show that improvement of culture system plus effective use of NGS technology can facilitate findings of infections by unusual microbes in patients having poorly-defined, sometimes mysterious illnesses. ..
  5. pmc Isolation and characterization of two novel bacteria Afipia cberi and Mesorhizobium hominis from blood of a patient afflicted with fatal pulmonary illness
    Shyh Ching Lo
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e82673. 2013
    ..Specific probes and methods will be developed to re-examine the diseased lungs from patient's autopsy. ..
  6. pmc Development of real-time PCR array for simultaneous detection of eight human blood-borne viral pathogens
    Natalia Pripuzova
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 7:e43246. 2012
    ..Real-time PCR array for rapid detection of multiple viral pathogens should be highly useful in cases where the sample volume and the time of testing are limited, i.e. in the eligibility testing of tissue and organ donors...
  7. pmc In Vitro and In Vivo studies of monoclonal antibodies with prominent bactericidal activity against Burkholderia pseudomallei and Burkholderia mallei
    Shimin Zhang
    Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Clin Vaccine Immunol 18:825-34. 2011
    ..The result is compatible with that of our in vitro study. The MAbs with the highest protective efficacy are those reactive to either the capsular PS or LPS of the Burkholderia bacteria...
  8. doi request reprint Differentially expressed genes and pathways induced by organophosphates in human neuroblastoma cells
    Tianwei Li
    Tissue Safety Laboratory Program, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Exp Biol Med (Maywood) 237:1413-23. 2012
    ..In addition, these results could also contribute to the development of new prevention and/or therapeutic regimens against OP toxicity...
  9. pmc DNA Sequence Signatures for Rapid Detection of Six Target Bacterial Pathogens Using PCR Assays
    Kenjiro Nagamine
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies and Division of Human Tissues, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA
    Microbiol Insights 8:7-14. 2015
    ..The workflow could be widely applicable for the rapid development of PCR-based assays for a wide range of target bacteria, including those of biothreat agents. ..
  10. pmc Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations
    Haiyan Lei
    Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland
    Sci Rep 5:16706. 2015
    ..The distribution of BL EBVs was 48%, 8%, 24% and 20% for patterns A to D, respectively; the NPC EBV's were Pattern B, and EBV-WT was pattern D. Further work is needed to investigate the association between EBV LMP-1 patterns with BL. ..
  11. pmc Identification of DNA signatures suitable for use in development of real-time PCR assays by whole-genome sequence approaches: use of Streptococcus pyogenes in a pilot study
    Guo Chiuan Hung
    Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Clin Microbiol 50:2770-3. 2012
    ..The approach is readily applicable for designing molecular assays for rapid detection and characterization of various pathogenic bacteria...