Zhiguang Li

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint Functional comparison of microarray data across multiple platforms using the method of percentage of overlapping functions
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, USA
    Methods Mol Biol 802:123-39. 2012
  2. doi request reprint Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys
    Zhenqiang Su
    ICF International at FDA s National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 24:1486-93. 2011
  3. doi request reprint MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver
    Tao Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 27:59-66. 2012
  4. doi request reprint MicroRNAs and their predicted target messenger RNAs are deregulated by exposure to a carcinogenic dose of comfrey in rat liver
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA
    Environ Mol Mutagen 52:469-78. 2011
  5. pmc Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
    PLoS ONE 7:e34394. 2012
  6. pmc The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
    Nat Biotechnol 28:827-38. 2010
  7. pmc Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles
    Zhiguang Li
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U, S, Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 10:S12. 2009
  8. doi request reprint Tissue-specific microRNA responses in rats treated with mutagenic and carcinogenic doses of aristolochic acid
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 9 Lvshun Road South, Dalian, Liaoning 116044, China and Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Mutagenesis 29:357-65. 2014
  9. pmc Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Genomics 11:609. 2010
  10. doi request reprint Increased expression of miR-34a in mouse spleen one day after exposure to N-ethyl-N-nitrosourea
    David Chen
    Little Rock Central High School, Little Rock, AR 72206, USA
    J Appl Toxicol 31:496-8. 2011

Detail Information

Publications11

  1. doi request reprint Functional comparison of microarray data across multiple platforms using the method of percentage of overlapping functions
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, USA
    Methods Mol Biol 802:123-39. 2012
    ..This method can also be used to compare the functional differences or similarities between experiments, projects, or laboratories...
  2. doi request reprint Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys
    Zhenqiang Su
    ICF International at FDA s National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 24:1486-93. 2011
    ..However, there is clearly a need for future investigations to better understand the advantages and limitations of RNA-Seq in toxicogenomics studies and environmental health research...
  3. doi request reprint MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver
    Tao Chen
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 27:59-66. 2012
    ....
  4. doi request reprint MicroRNAs and their predicted target messenger RNAs are deregulated by exposure to a carcinogenic dose of comfrey in rat liver
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA
    Environ Mol Mutagen 52:469-78. 2011
    ..Our data suggest that comfrey may exert its carcinogenic effects by disturbing miRNA expression resulting in altered mRNA levels of the DEM-targeted genes that are functionally associated with carcinogenesis...
  5. pmc Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America
    PLoS ONE 7:e34394. 2012
    ..In summary, 9 novel pre-miRNAs (14 novel mature miRNAs) were identified via combination of NGS, microarray and bioinformatics high-throughput technologies...
  6. pmc The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
    Nat Biotechnol 28:827-38. 2010
    ..The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis...
  7. pmc Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles
    Zhiguang Li
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U, S, Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 10:S12. 2009
    ..In this study, we investigated whether different platforms had a high consistency from the biologically functional perspective...
  8. doi request reprint Tissue-specific microRNA responses in rats treated with mutagenic and carcinogenic doses of aristolochic acid
    Fanxue Meng
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 9 Lvshun Road South, Dalian, Liaoning 116044, China and Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Mutagenesis 29:357-65. 2014
    ....
  9. pmc Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Genomics 11:609. 2010
    ..However, there is little information as to if or when expression changes of miRNAs occur in normal tissues after carcinogen exposure...
  10. doi request reprint Increased expression of miR-34a in mouse spleen one day after exposure to N-ethyl-N-nitrosourea
    David Chen
    Little Rock Central High School, Little Rock, AR 72206, USA
    J Appl Toxicol 31:496-8. 2011
    ..The result suggests that miR-34a expression responds sensitively to genotoxic insults within a short period after exposure of the mutagen, and therefore, this gene has the potential to be used as an indicator for genotoxin exposure...
  11. doi request reprint Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells
    Yongbin Zhang
    National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    ACS Nano 5:7020-33. 2011
    ..These findings suggest that surface functionalization of SWCNTs decreases ROS-mediated toxicological response in vitro...