Genomes and Genes
Food and Drug Administration
Organization: Food and Drug Administration
- Development and validation of a magneto-hydrodynamic solver for blood flow analysisW Kainz
Center for Devices and Radiological Health, FDA, Silver Spring, MD, USA
Phys Med Biol 55:7253-61. 2010..Future studies will include the calculation of the MHD signals for anatomical models. We will vary the orientation of the static magnetic field to determine an optimized location for the measurement of the MHD blood flow signal...
- Using phiX174 DNA as an exogenous reference for measuring mitochondrial DNA copy numberMeagan B Myers
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Biotechniques 47:867-9. 2009....
- Scientific and regulatory perspectives on metabolizing enzyme-transporter interplay and its role in drug interactions: challenges in predicting drug interactionsLei Zhang
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
Mol Pharm 6:1766-74. 2009..Finally, the discussion will focus on the need to leverage current knowledge to obtain more meaningful drug interaction information...
- Analysis of polyhexamethylene biguanide in multipurpose contact lens solutionsAnne D Lucas
US Food and Drug Administration, Center for Devices and Radiological Health, OSEL DB, Silver Spring, MD 20993, USA
Talanta 80:1016-9. 2009..5% RSD. Storage and stability studies indicated that storage of MPS with PHMB for chemical analysis are not temperature dependent, but are affected by the composition of the container in which the contact lens solution is stored...
- Adherence and weight loss outcomes associated with food-exercise diary preference in a military weight management programLaura E Shay
Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, United States
Eat Behav 10:220-7. 2009..2% vs. 43.4%, p=.015) and exercise (60.6% vs. 31.2%, p=.001). Though no difference was seen between groups on weight management outcomes, these results suggest that diary preference affects adherence to diary use...
- Vibration effects of lab equipment on dissolution testing with USP paddle methodZongming Gao
Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St Louis, Missouri 63101, USA
J Pharm Sci 99:403-12. 2010..In the frequency range studied, root mean square (RMS) acceleration values above 0.01 g, in either vertical or horizontal direction, typically affected dissolution results...
- Prevalence of select psychiatric diagnoses in long-term care: 1997-2007Joseph E Regan
Centers for Medicare and Medicaid Services, 7500 Security Boulevard, Baltimore, MD 21244 1850, USA
Health Care Financ Rev 30:105-14. 2008..This information is collected from two groups of beneficiaries: those living in the community and those living in facilities. Information is obtained on specific medical diagnoses and conditions for beneficiaries residing in a facility...
- Compendia and anticancer therapy under MedicareKatherine Tillman
Centers for Medicare and Medicaid Services, Baltimore, Maryland, USA
Ann Intern Med 150:348-50. 2009....
- The salivary gland transcriptome of the neotropical malaria vector Anopheles darlingi reveals accelerated evolution of genes relevant to hematophagyEric Calvo
Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA
BMC Genomics 10:57. 2009..Here we present and analyze data from a comprehensive salivary gland (SG) transcriptome of the neotropical malaria vector Anopheles darlingi (subgenus Nyssorhynchus)...
- Expanding the role of health services research as a tool to reduce the public health burden of alcohol use disordersPeter J Delany
Substance Abuse and Mental Health Services Administration, Rockville, Maryland 20857, USA
Subst Use Misuse 43:1729-46. 2008..The paper concludes by outlining some of the steps taken by NIAAA to further the continuing development of alcohol health services research...
- Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrierJohn F Bowyer
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
Ann N Y Acad Sci 1139:127-39. 2008....
- Trends in out-of-pocket healthcare costs among older community-dwelling Medicare beneficiariesGerald F Riley
Office of Research, Development, and Information, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
Am J Manag Care 14:692-6. 2008..To describe trends in out-of-pocket healthcare costs, including insurance premiums, for older Medicare beneficiaries living in the community...
- Toxicity and detection of ricin and abrin in beveragesEric A E Garber
U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740, USA
J Food Prot 71:1875-83. 2008..Enzyme-linked immunosorbent assays of the samples administered by i.p. injection indicated a decrease in detectable toxin at 0.5 microg/ml...
- Imaging as a tumor biomarker in oncology drug trials for lung cancer: the FDA perspectiveN Petrick
National Institute of Biomedical Imaging and Bioengineering Center for Devices and Radiological Health Laboratory for the Assessment of Medical Imaging Systems, US Food and Drug Administration, Silver Spring, Maryland, USA
Clin Pharmacol Ther 84:523-5. 2008The US Food and Drug Administration (FDA) is committed to working with the oncology community to expedite the drug evaluation process in view of the many promising new oncology drugs under laboratory development and the time and expense ..
- Recent changes in Medicaid policy and their possible effects on mental health servicesJeffrey A Buck
Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA
Psychiatr Serv 60:1504-9. 2009..These changes will likely affect state mental health systems, mental health providers, and the nature of service delivery...
- Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activityJyotshnabala Kanungo
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Mol Cell Biochem 338:291-8. 2010....
- Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in ratsSherry A Ferguson
Division of Neurotoxicology, National Center for Toxicological Research FDA, United States
Neurotoxicol Teratol 32:373-82. 2010..These data extend those of our previous study (Garey et al., 2005 ) and demonstrate that overt preweaning neurobehavioral effects are apparent in rats exposed to acrylamide pre- and postnatally, but only at the highest doses tested...
- Two new ArrayTrack libraries for personalized biomedical researchJoshua Xu
Z Tech Corporation, ICF International company at NCTR, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA
BMC Bioinformatics 11:S6. 2010..An efficient data mining strategy and a set of sophisticated tools are necessary to help better understand and utilize the findings from genetic association studies...
- Lactational transfer of bisphenol A in Sprague-Dawley ratsDaniel R Doerge
Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCRT Road, Jefferson, AR 72079, USA
Toxicol Lett 199:372-6. 2010..Alternatively, studies that include lactational exposure and report minimal effects from BPA should consider the possibility that inadequate internal exposures were achieved during the critical postnatal period...
- Pharmacometrics 2020Jogarao V S Gobburu
Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA
J Clin Pharmacol 50:151S-157S. 2010..These goals should be of significance to all stakeholders who have a vested interest in drug development and therapeutics. The future of pharmacometrics depends on how well we all can deliver on the strategic goals...
- Oncomutations as biomarkers of cancer riskBarbara L Parsons
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Environ Mol Mutagen 51:836-50. 2010..Future research opportunities using oncomutation as an endpoint are described, including rodent to human extrapolation, dose-response assessment, and personalized medicine...
- Use of parenteral iron products and serious anaphylactic-type reactionsDiane K Wysowski
Office of Surveillance and Epidemiology, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA
Am J Hematol 85:650-4. 2010..Voluntary reports submitted to the Food and Drug Administration show anaphylactic reactions and symptoms for the four parenteral iron products...
- A resource for the assessment of lung nodule size estimation methods: database of thoracic CT scans of an anthropomorphic phantomMarios A Gavrielides
Division of Imaging and Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U S Food and Drug Administration, Silver Spring, MD, USA
Opt Express 18:15244-55. 2010..This resource complements public databases of clinical data and will contribute towards the development of procedures that will maximize the utility of CT imaging for lung cancer screening and tumor therapy evaluation...
- Pediatric cardiac devices--an FDA pediatrician's perspective of the challenges and potential solutionsFrancesca Dolcimascolo
FDA, Silver Spring, MD, USA
J Cardiovasc Transl Res 2:147-9. 2009The advancement of pediatric medical devices is an important challenge currently facing the Food and Drug Administration and the medical community. In this manuscript, the challenges are described and possible solutions presented.
- Regulatory use of computational toxicology tools and databases at the United States Food and Drug Administration's Office of Food Additive SafetyKirk B Arvidson
US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS 275, 5100 Paint Branch Parkway, College Park, MD 20740, USA
Expert Opin Drug Metab Toxicol 6:793-6. 2010..In this article, we provide an overview of the programs used in OFAS as well as a perspective on how to apply multiple QSAR tools in the review process of a new food-contact substance...
- Population pharmacokinetics with a very small sample sizeIftekhar Mahmood
Office of Blood Review and Research, Center for Biologic Evaluation and Research, Food and Drug Administration, Rockville Pike, MD 20852, USA
Drug Metabol Drug Interact 24:259-74. 2009..The population PK study with sparse sampling scheme may be useful for PK studies in neonates and very young children and in subjects with rare diseases where sample size is small...
- Enzyme-linked immunosorbent assay detection of melamine in infant formula and wheat food productsEric A E Garber
Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, Maryland 20740, USA
J Food Prot 73:701-7. 2010..5 microg/g, respectively. The ELISA kits provide an effective alternative for the analysis of samples suspected of containing melamine without relying on extensive sample preparation or expensive instrumentation...
- DNA, drugs and chariots: on a decade of pharmacogenomics at the US FDALawrence J Lesko
Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US FDA, HFD 850, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
Pharmacogenomics 11:507-12. 2010....
- PCR-based method for targeting 16S-23S rRNA intergenic spacer regions among Vibrio speciesMaria Hoffmann
Division of Microbiology, Office of Regulatory Science Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA
BMC Microbiol 10:90. 2010..Consequently, it is of paramount importance to have a method which is able to reliably and efficiently differentiate the numerous Vibrio species...
- How the US Food and Drug Administration evaluates the scientific evidence for health claimsKathleen C Ellwood
Center for Food Safety and Applied Nutrition, Office of Nutrition, Labeling, and Dietary Supplements, U S Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA
Nutr Rev 68:114-21. 2010..Several court decisions directed the US Food and Drug Administration (FDA) to provide for dietary supplement claims not meeting the significant scientific agreement ..
- Determination of iodide and thiocyanate in powdered milk and infant formula by on-line enrichment ion chromatography with photodiode array detectionRichard A Niemann
Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA
J Chromatogr A 1200:193-7. 2008..2 mg/kg LOQ); iodide was found at 0.3-1.3mg/kg (0.04 mg/kg LOQ). In 13 dry milk samples, thiocyanate was found at 27-38 mg/kg (1 mg/kg LOQ), and iodide was found at 1.8-3.2 mg/kg (0.2 mg/kg LOQ)...
- Screening biomaterials for stimulation of nitric oxide-mediated inflammationDaniel B Lyle
Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, FDA, 10903 New Hampshire Ave, Silver Spring, Maryland 20993 0002, USA
J Biomed Mater Res A 90:82-93. 2009..7 may serve as a convenient in vitro system to routinely screen biomaterials for potentially harmful macrophage-mediated inflammation whereby the safety of implanted medical devices might be compromised...
- Issues with statistical risks for testing methods in noninferiority trial without a placebo ARMH M James Hung
Division of Biometrics I, Office of Biostatistics, OTS CDER, FDA, Silver Spring, MD 20993 0002, USA
J Biopharm Stat 17:201-13. 2007..For the indirect statistical inference, the practical utility of any method that controls only the across-trial Type I error rate at a fixed small level is limited...
- FDA's review of scientific evidence for health claimsBarbara Schneeman
Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA
J Nutr 137:493-4. 2007..In order to meet its statutory responsibility for evaluation of health claims, the agency has developed guidelines for review of scientific evidence in support of a health claim...
- Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coliChristopher A Elkins
Division of Microbiology, National Center for Toxicological Research, 3900 NCTR Drive, Jefferson, AR 72079 9502, USA
Antimicrob Agents Chemother 51:923-9. 2007..In addition, our study has extended the range of substrates recognized by the AcrAB- and EmrAB-TolC systems...
- Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplementJohn C Reepmeyer
US Food and Drug Administration, Division of Pharmaceutical Analysis, St Louis, MO 63101, USA
J Pharm Biomed Anal 43:1615-21. 2007..The compound, named methisosildenafil, is a novel synthetic analogue of sildenafil in which the N-methylpiperazine moiety has been replaced with 2,6-dimethylpiperazine...
- A regulatory perspective on issues and approaches in characterizing human metabolitesKaren L Davis-Bruno
US Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, Maryland 20993, USA
Chem Res Toxicol 19:1561-3. 2006..A discussion of the need for, and the adequacy of, the assessment of human drug metabolites with specific regard to their potential as mediators of toxicity is presented from a regulatory perspective...
- Changes in financial burdens for health care: national estimates for the population younger than 65 years, 1996 to 2003Jessica S Banthin
Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD 20850, USA
JAMA 296:2712-9. 2006..Policymakers as well as physicians need to understand how rapidly rising health care costs are affecting specific groups of patients...
- Rapid quantitative and qualitative confirmatory method for the determination of monofluoroacetic acid in foods by liquid chromatography-mass spectrometryG O Noonan
US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA
J Chromatogr A 1139:271-8. 2007..8microg/L) was sufficient to confirm the presence of MFA in all spiked matrices. Repeatability tests at the low spiking levels yielded RSDs of approximately 7% for all matrices analyzed...
- Impact of microarray data quality on genomic data submissions to the FDAFelix W Frueh
US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluationand Research, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA
Nat Biotechnol 24:1105-7. 2006
- Simian foamy virus infection by whole-blood transfer in rhesus macaques: potential for transfusion transmission in humansArifa S Khan
Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland, USA
Transfusion 46:1352-9. 2006..The persistence of infectious virus in peripheral blood mononuclear cells (PBMNC) and the recent identification of some infected blood donors has raised safety concerns regarding potential virus transmission by blood transfusion...
- Use of nontraditional animals for evaluation of pharmaceutical productsAbigail Jacobs
Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA
Expert Opin Drug Metab Toxicol 2:345-9. 2006..Use of nontraditional animal species may be proposed by a drug sponsor to a reviewing division with supporting data and reasons for using a particular species...
- Stability profiles of drug products extended beyond labeled expiration datesRobbe C Lyon
Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, HFD 941, White Oak, Life Sciences Building 64, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993 0002, USA
J Pharm Sci 95:1549-60. 2006..The SLEP has been administered by the Food and Drug Administration for the United States Department of Defense (DOD) for 20 years...
- National estimates for mental health mutual support groups, self-help organizations, and consumer-operated servicesIngrid D Goldstrom
Substance Abuse and Mental Health Services Administration, U S Department of Health and Human Services, Rockville, MD 20857, USA
Adm Policy Ment Health 33:92-103. 2006..The array of services and supports provided within each of these types (MSG, SHO, COS) is reported, and implications for the President's New Freedom Commission on Mental Health recommendations are explicated...
- Interoperability: the key to the future health care systemDavid J Brailer
U S Department of Health and Human Services, Washington, DC, USA
Health Aff (Millwood) . 2005..The paper by Jan Walker and colleagues highlights some of these benefits. One critical question is whether the adoption of EMRs needs to wait for interoperability standards or whether it can proceed efficiently without them...
- First-generation blood substitutes: what have we learned? Biochemical and physiological perspectivesAbdu I Alayash
Center for Biologics Evaluation and Research, Food and Drug Administration, Laboratory of Biochemistry and Vascular Biology, Division of Hematology, National Institutes of Health Campus, Bethesda, MD 20892, USA
Expert Opin Biol Ther 7:665-75. 2007..Here the authors provide an overview of their research experiences, novel insights into the molecular basis of toxicities of these products and some lessons learned...
- Reliable comfort and meaningfulness at a sustainable costJoanne Lynn
Quality Measurement and Health Assessment Group, Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, Maryland 21244 1850, USA
J Palliat Med 10:660-4. 2007
- An observational study of cholecystectomy in patients receiving tegaserodAllen Brinker
Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA
Drug Saf 30:581-8. 2007..Registrational studies of patients treated with tegaserod for irritable bowel syndrome (IBS) suggest an increased risk for cholecystectomy versus treatment with placebo...
- Modeling microstructure development and release kinetics in controlled drug release coatingsDavid M Saylor
Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, Maryland 20903, USA
J Pharm Sci 98:169-86. 2009....
- Modifications and insights into a method for the analysis of the nitrogen mustard mechlorethamine by high-performance liquid chromatographyJohn C Reepmeyer
United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Phamaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St Louis, MO 63101, USA
Anal Chim Acta 616:78-84. 2008..The method has been extended to the analysis of mechlorethamine in aqueous solutions...
- Motive for nonmedical use of prescription pain relievers in the national survey on drug use and healthJames D Colliver
Division of Population Surveys, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Maryland 20857, USA
J Pain 9:487-9; discussion 494-6. 2008
- Survey of furan in heat processed foods by headspace gas chromatography/mass spectrometry and estimated adult exposureKim M Morehouse
Food and Drug Administration CFSAN, College Park, MD 20740, USA
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:259-64. 2008..15 microg kg(-1) body weight day(-1)). Estimates of mean exposure to furan for different subpopulations were calculated. For consumers 2 years and older, the intake is estimated to be about 0.2 microg kg(-1) body weight day(-1)...
- Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MSMayda I Lopez
Center for Veterinary Medicine, U S Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA
J Agric Food Chem 56:1553-9. 2008..The evaluation of matrix effects caused by honey of different floral origin is presented...
- In vitro model of colonization resistance by the enteric microbiota: effects of antimicrobial agents used in food-producing animalsR Doug Wagner
National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Antimicrob Agents Chemother 52:1230-7. 2008..The results of this study suggest that direct assessment of the effects of antimicrobial drugs on colonization resistance in an in vitro model can be useful in determining ADI values...
- Drug release phenomena within a hydrophobic starch acetate matrix: FTIR mapping of tablets after in vitro dissolution testingJari Pajander
Department of Pharmaceutics, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
J Pharm Sci 97:3367-78. 2008..Mapping showed that caffeine became localized in the lower part of the tablet unlike riboflavin. The hydrodynamic conditions during the in vitro release test might contribute to this differentiation...
- Vibration effects on dissolution tests with USP apparatuses 1 and 2Zongming Gao
Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St Louis, Missouri 63101, USA
J Pharm Sci 97:3335-43. 2008..The importance of vibration to dissolution test results depends on the vibration source, product being tested and the apparatus type...
- Statistics for risk assessment of chemical carcinogensJames J Chen
Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 25:281-312. 2007..This paper reviews statistical principles and procedures for qualitative and quantitative approaches to human risk assessment...
- Comparison of delivery characteristics from a combination metered-dose inhaler using the Andersen cascade impactor and the next generation pharmaceutical impactorChangning Guo
U S Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St Louis, Missouri 63101, USA
J Pharm Sci 97:3321-34. 2008....
- Use of multitoxin immunoaffinity columns for determination of aflatoxins and ochratoxin A in ginseng and gingerMary W Trucksess
U S Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA
J AOAC Int 90:1042-9. 2007....
- Indication and use of drug products used to treat attention-deficit/hyperactivity disorder: a cross-sectional study with inference on the likelihood of treatment in adulthoodAllen Brinker
Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
J Child Adolesc Psychopharmacol 17:328-33. 2007..We analyzed cross-sectional prescription claims data and data from a national survey of office-based physicians for further inference on the likelihood of treatment with ADHD medications into adulthood...
- Analysis of food for toxic elementsStephen G Capar
U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, Harvey W Wiley Federal Building, 5100 Paint Branch Parkway, College Park, MD 20740 3835, USA
Anal Bioanal Chem 389:159-69. 2007..The topics covered include contamination control, analytical sample treatment and the common analytical techniques used for food analysis...
- QA/QC: challenges and pitfalls facing the microarray community and regulatory agenciesLeming Shi
US Food and Drug Administration, Center for Toxicoinformatics, Division of Systems Toxicology, National Center for Toxicological Research, HFT 020, 3900 NCTR Road, Jefferson, AR 72079, USA
Expert Rev Mol Diagn 4:761-77. 2004..The US Food and Drug Administration has been proactive in promoting the use of pharmacogenomic data in drug development and has issued a ..
- INITIATION OF VIRUS SPECIFIC CD8+ T CELL RESPONSESMaryna Eichelberger; Fiscal Year: 2002..This proposal is designed as an essential step towards the development of more effective influenza vaccine. ..
- Accelerated Viral Inhibition AssayMaryna Eichelberger; Fiscal Year: 2006....
- Using Clinically-Enhanced Claims Data to Guide Selection of Coronary ProceduresHAROLD KILBURN; Fiscal Year: 2010....
- Using Clinically-Enhanced Claims Data to Guide Treatment of Acute Heart FailureMark Sonneborn; Fiscal Year: 2010..The database will be used to conduct a study of the comparative effectiveness of different drug treatments of patients hospitalized with acute worsening of congestive heart failure. ..