Affiliation: Evanston Northwestern Healthcare
- Genotype/phenotype of familial pancreatic cancerRandall E Brand
Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, and Section of Gastroenterology, Evanston Northwestern Healthcare, 2100 Pfingsten Road, Glenview, IL 60026, USA
Endocrinol Metab Clin North Am 35:405-15, xi. 2006..The aim of this article is to review the challenges in identifying pancreatic cancer-prone families and how environmental factors interact with genetic factors in these families...
- The specificity of amylin for the diagnosis of pancreatic adenocarcinomaRandall E Brand
Department of Internal Medicine, Evanston Northwestern Healthcare, Glenview, IL 60025, USA
Int J Gastrointest Cancer 31:123-8. 2002....
- Advances in counselling and surveillance of patients at risk for pancreatic cancerRandall E Brand
Evanston Northwestern Healthcare, Evanston, Illinois, USA
Gut 56:1460-9. 2007
- Risk factors for pancreatic adenocarcinoma: are we ready for screening and surveillance?Randall Brand
Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Evanston Northwestern Healthcare, Glenview, IL 60026, USA
Curr Gastroenterol Rep 7:122-7. 2005..It is recommended that surveillance be performed on these high-risk individuals in a research setting to allow for the development of a successful detection strategy...
- Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?Venkata Muddana
Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Pancreas 39:1215-9. 2010..We also tested the hypothesis that PDGF-[beta] polymorphisms in combination with environmental risk factors such as alcohol and smoking are associated with CP...
- Inherited pancreatic cancer syndromesSheila Solomon
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Cancer J 18:485-91. 2012..Because the best methods for surveillance have not been established, the recommendation to refer at-risk patients to centers with ongoing research programs in pancreatic cancer surveillance is supported...
- Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitisThomas Liggett
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois
Cancer 116:1674-80. 2010..In this article, the authors describe a methylation profile of cell-free plasma DNA that distinguished CP from PanCa with >90% accuracy...
- Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosaVladimir Turzhitsky
Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
Dis Markers 25:313-21. 2008....
- Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study groupMichelle A Anderson
Department of Medicine, University of Michigan, Ann Arbor, MI, USA
Pancreatology 16:83-94. 2016..Pain in patients with chronic pancreatitis (CP) remains the primary clinical complaint and source of poor quality of life. However, clear guidance on evaluation and treatment is lacking...
- Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012Michael R Rickels
Department of Medicine, University of Pennsylvania, Philadelphia, PA 15213, USA
Pancreatology 13:336-42. 2013..Diabetes and glucose intolerance are common complications of chronic pancreatitis, yet clinical guidance on their detection, classification, and management is lacking...
- BRCA1 and pancreatic cancer: pedigree findings and their causal relationshipsHenry T Lynch
Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
Cancer Genet Cytogenet 158:119-25. 2005....
- Hereditary factors in pancreatic cancerHenry T Lynch
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha NE 68178, USA
J Hepatobiliary Pancreat Surg 9:12-31. 2002..If changes in these putative biomarkers are observed, endoscopic retrograde cholangiopancreatography (ERCP) would be the next diagnostic step. We conclude with a discussion of ethical concerns about this research...
- Familial pancreatic carcinoma in JewsHenry T Lynch
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68131, USA
Fam Cancer 3:233-40. 2004..Attention should also be given to the search for mutations predisposing to PC in Jews so that opportunities to learn more about the disease's pathogenesis, as well as screening and control, may take place...
- Identification of high-risk pancreatic cancer-prone familiesRandall E Brand
Northwestern University Feinberg School of Medicine, Division of Gastroenterology, Evanston Northwestern Healthcare, 2100 Pfingston Road, B230, Glenview, IL 60025, USA
Gastroenterol Clin North Am 33:907-18. 2004..Ultimately, this knowledge could be applied to the more common sporadic form of pancreatic cancer, where diagnosis is almost always late, and prognosis remains quite grim...
- Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndromeHenry T Lynch
Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
Cancer 94:84-96. 2002....
- Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smokingRhonda M Brand
Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
World J Gastroenterol 12:4485-91. 2006..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients...
- ErbB2 oncogene antibodies differentiate between the normal and diseased pancreas, and between chronic pancreatitis and pancreatic cancerJens Standop
UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA
Oncol Rep 12:1309-15. 2004..The utilized ErbB2 antibodies discriminate between the normal pancreas, chronic pancreatitis and pancreatic cancer. Hence, these antibodies seem to present an additional useful aid in the surgical pathology of pancreatic diseases...
- Decreasing malathion application time for lice treatment reduces transdermal absorptionRhonda M Brand
Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, 1001 University Place, Evanston, IL 60201, USA
Int J Pharm 301:48-53. 2005..Our concern of over exposing children to malathion has led us to examine whether significantly more malathion will penetrate transdermally when applied for the recommended 8 h than for a shorter but apparently equally effective period...
- The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitisDavid A Sass
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Pancreatology 6:297-300. 2006..Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP...
- ErbB2 growth factor receptor, a marker for neuroendocrine cells?Jens Standop
UNMC Eppley Institute, University of Nebraska Medical Center, Omaha, NE, USA
Pancreatology 5:44-58. 2005..To validate our findings and to understand the reasons for the reported differences in the frequency of ErbB2 overexpression in pancreatic cancer, the following studies were performed...
- A prospective study of gastric emptying and its relationship to the development of nausea, vomiting, and anorexia after autologous stem cell transplantationJohn K DiBaise
Section of Gastroenterology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Am J Gastroenterol 100:1571-7. 2005..We sought to define the prevalence of gastric emptying abnormalities and their relationship to the development of nausea, vomiting, and anorexia in patients undergoing HDT and autologous SCT...
- ErbB2 oncogene expression supports the acute pancreatitis-chronic pancreatitis sequenceJens Standop
Eppley Institute, University of Nebraska Medical Center, Omaha, 68198 6805, USA
Virchows Arch 441:385-91. 2002..In conclusion, the similarities in the immunoreactivity of anti-ErbB2 antibodies in recurrent acute pancreatitis and chronic pancreatitis support the hypothesis that acute pancreatitis can be a forerunner of chronic pancreatitis...
- Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancerHenry T Lynch
Department of Preventive Medicine, Creighton University Medical School, 2500 California Plaza, Omaha, NE 68178, USA
Fam Cancer 3:229-32. 2004..Additional biopsies should be taken of any flat lesions, masses, or strictures. Prophylactic colectomy may then be indicated when severe dysplasia is confirmed by knowledgeable pathologists...
- Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia riskHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Gastroenterology 135:1069-78. 2008..To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo...
- Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical studyHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, G208, Evanston, Illinois 60201, USA
Dis Colon Rectum 51:1381-6. 2008..In this study, we assessed the translatability of spectral slope analysis to human colorectal cancer screening...
- Genetic predisposition to pancreatic cancer: a brief reviewJulia B Greer
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 102:2564-9. 2007
- Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapiesMurielle Mimeault
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
Pancreas 31:301-16. 2005..The molecular mechanisms associated with antitumoral properties and the clinical benefits of gemcitabine alone or in combination with other cytotoxic agents for the treatment of pancreatic cancer are discussed...
- Optical markers in duodenal mucosa predict the presence of pancreatic cancerYang Liu
Biomedical Engineering Department, Northwestern University, Illinois, USA
Clin Cancer Res 13:4392-9. 2007..We propose a novel approach to predict pancreatic cancer through the assessment of the adjacent periampullary duodenal mucosa without any interrogation of the pancreatic duct or imaging of the pancreas...
- Value of preoperative upper endoscopy in patients undergoing laparoscopic gastric bypassTallal M Zeni
Minimally Invasive Surgery Center, Department of Surgery, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
Obes Surg 16:142-6. 2006..Preoperative evaluation of patients undergoing laparoscopic Roux-en-Y gastric bypass (LRYGBP) has included esophagogastroduodenoscopy (EGD) with little data to substantiate its use...
- Multiplexed analysis of glycan variation on native proteins captured by antibody microarraysSongming Chen
Van Andel Research Institute, 333 Bostwick, Grand Rapids, Michigan 49503, USA
Nat Methods 4:437-44. 2007..Antibody arrays for glycan detection are highly effective for profiling variation in specific glycans on multiple proteins and should be useful in diverse areas of glycobiology research...
- MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implicationsMahefatiana Andrianifahanana
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
Am J Gastroenterol 101:2319-29. 2006..In the present study, we established the pathobiological association of various cytokines and MUC4 in pancreatic tumor tissues and tumor cell lines...
- Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screeningAnna L Zisman
Department of Internal Medicine, Evanston Northwestern Healthcare, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
Arch Intern Med 166:629-34. 2006..Although hereditary predisposition is commonly used, the effect of exogenous risk factors has remained largely unexplored. To address this, we analyzed the age at presentation and location of CRC in relation to alcohol and tobacco use...
- Phase I trial of fixed dose rate infusion gemcitabine with gefitinib in patients with pancreatic carcinomaBenedito A Carneiro
Department of Medicine, Kellogg Cancer Care Center, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
Cancer Invest 25:366-71. 2007..To determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of gemcitabine using a fixed dose rate infusion (FDRI) in combination with gefitinib in patients (pts) with pancreatic adenocarcinoma (PCa)...