Walter H Watson

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Oxidation and nuclear localization of thioredoxin-1 in sparse cell cultures
    Jeanine C Spielberger
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Cell Biochem 104:1879-89. 2008
  2. ncbi request reprint Oxidation of nuclear thioredoxin during oxidative stress
    Walter H Watson
    Emory University School of Medicine, Department of Biochemistry, 1510 Clifton Road, Atlanta, GA 30322, USA
    FEBS Lett 543:144-7. 2003
  3. ncbi request reprint Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif
    Walter H Watson
    Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 278:33408-15. 2003
  4. ncbi request reprint Redox state of glutathione and thioredoxin in differentiation and apoptosis
    Walter H Watson
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
    Biofactors 17:307-14. 2003
  5. ncbi request reprint Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1
    Jason M Hansen
    Department of Medicine and Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Toxicol Sci 82:308-17. 2004
  6. ncbi request reprint Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells
    Yvonne S Nkabyo
    Department of Biochemistry, the Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1352-9. 2002
  7. pmc Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling
    Patrick J Halvey
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Room 225, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Biochem J 386:215-9. 2005
  8. ncbi request reprint Oxidation of the glutathione/glutathione disulfide redox state is induced by cysteine deficiency in human colon carcinoma HT29 cells
    Lauren T Miller
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 132:2303-6. 2002
  9. ncbi request reprint Thioredoxin and its role in toxicology
    Walter H Watson
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Toxicol Sci 78:3-14. 2004
  10. pmc The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase
    Mark C Carroll
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 281:28648-56. 2006

Collaborators

Detail Information

Publications12

  1. doi request reprint Oxidation and nuclear localization of thioredoxin-1 in sparse cell cultures
    Jeanine C Spielberger
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Cell Biochem 104:1879-89. 2008
    ....
  2. ncbi request reprint Oxidation of nuclear thioredoxin during oxidative stress
    Walter H Watson
    Emory University School of Medicine, Department of Biochemistry, 1510 Clifton Road, Atlanta, GA 30322, USA
    FEBS Lett 543:144-7. 2003
    ..Thus, the increase in nuclear Trx1 levels did not correspond to an increase in the overall reducing capacity of Trx1 in the nucleus...
  3. ncbi request reprint Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif
    Walter H Watson
    Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 278:33408-15. 2003
    ....
  4. ncbi request reprint Redox state of glutathione and thioredoxin in differentiation and apoptosis
    Walter H Watson
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
    Biofactors 17:307-14. 2003
  5. ncbi request reprint Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1
    Jason M Hansen
    Department of Medicine and Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Toxicol Sci 82:308-17. 2004
    ..In contrast, the ARE reporter was principally controlled by nuclear-targeted Trx-1 and not by GSH. The data show that the GSH and TRX systems have unique, compartmented functions in the control of transcriptional regulation by Nrf-2/ARE...
  6. ncbi request reprint Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells
    Yvonne S Nkabyo
    Department of Biochemistry, the Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1352-9. 2002
    ..Therefore, the measured 40-mV oxidation of the cellular GSH/GSSG couple or the 28-mV oxidation of the extracellular cysteine/cystine couple should be sufficient to function in signaling or regulation of differentiation in Caco-2 cells...
  7. pmc Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling
    Patrick J Halvey
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Room 225, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Biochem J 386:215-9. 2005
    ..Results showed that only cytosolic Trx1 undergoes significant oxidation. Thus EGF signalling involves subcellular compartmental oxidation of Trx1 in the absence of a generalized cellular oxidation...
  8. ncbi request reprint Oxidation of the glutathione/glutathione disulfide redox state is induced by cysteine deficiency in human colon carcinoma HT29 cells
    Lauren T Miller
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 132:2303-6. 2002
    ..If redox changes occur in vivo in association with variations in dietary Cys and its precursors, these changes could have important physiologic effects through altered redox signaling and control of cell proliferation and apoptosis...
  9. ncbi request reprint Thioredoxin and its role in toxicology
    Walter H Watson
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Toxicol Sci 78:3-14. 2004
    ....
  10. pmc The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase
    Mark C Carroll
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 281:28648-56. 2006
    ..Overall, these studies implicate a critical balance between cellular reductants such as glutaredoxin and copper activation pathways in controlling the disulfide and stability of SOD1 in vivo...
  11. pmc Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation
    Walter H Watson
    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Division of Toxicology, 615 N Wolfe Street, Room E7545, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 368:832-6. 2008
    ..Therefore, TrxR1 inhibition alone was not sufficient to oxidize Trx1, suggesting that Trx1-independent pathways should be considered when evaluating pharmacological and toxicological mechanisms involving TrxR1 inhibition...
  12. pmc Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells
    Kassim Traore
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Cell Physiol 216:276-85. 2008
    ..Together, this study suggested that TPA stimulated ROS generation as a second messenger to activate Erk1/2 via a redox-mediated inhibition of Erk1/2-directed phosphatase in ML-1 cells...