John R Votaw

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT
    John R Votaw
    Department of Radiology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Synapse 44:203-10. 2002
  2. ncbi request reprint Modeling systemic and renal gadolinium chelate transport with MRI
    John R Votaw
    Department of Radiology, Emory University Hospital, Building A, AT622, 1365 Clifton Road, NE, Atlanta, GA 30322, USA
    Pediatr Radiol 38:S28-34. 2008
  3. pmc Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomog
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Med Chem 53:5549-57. 2010
  4. pmc Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress
    Fang Wu
    Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 33:1761-9. 2013
  5. doi request reprint Magnetic resonance imaging evaluation of renal structure and function related to disease: technical review of image acquisition, postprocessing, and mathematical modeling steps
    Richard A Jones
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Magn Reson Imaging 33:1270-83. 2011
  6. doi request reprint Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT
    Fabio P Esteves
    Department of Radiology, Emory University School of Medicine, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    J Nucl Cardiol 17:247-53. 2010
  7. pmc Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys
    Heather L Kimmel
    Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Synapse 66:501-8. 2012
  8. pmc Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter
    Fanxing Zeng
    Department of Radiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 52:62-73. 2009
  9. ncbi request reprint Comparison of low-pitch and respiratory-averaged CT protocols for attenuation correction of cardiac PET studies
    Jonathon A Nye
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    Med Phys 36:1618-23. 2009
  10. pmc Cortical activation during cocaine use and extinction in rhesus monkeys
    Leonard L Howell
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Psychopharmacology (Berl) 208:191-9. 2010

Detail Information

Publications56

  1. ncbi request reprint Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT
    John R Votaw
    Department of Radiology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Synapse 44:203-10. 2002
    ..Two advantages of this technique are: reduced variability in dose-response curves because the subject is his/her own control, and the (18)F label allows evaluation of longer-acting drugs...
  2. ncbi request reprint Modeling systemic and renal gadolinium chelate transport with MRI
    John R Votaw
    Department of Radiology, Emory University Hospital, Building A, AT622, 1365 Clifton Road, NE, Atlanta, GA 30322, USA
    Pediatr Radiol 38:S28-34. 2008
    ....
  3. pmc Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomog
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Med Chem 53:5549-57. 2010
    ..During the time period 40-80 min postinjection of [(18)F]9, the ratio of uptake in the putamen and caudate vs cerebellum uptake was > or = 4...
  4. pmc Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress
    Fang Wu
    Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA
    J Cereb Blood Flow Metab 33:1761-9. 2013
    ..These data indicate that the release of neuronal tPA or treatment with rtPA activate a cell signaling pathway in the synaptic space that promotes the detection and adaptation to metabolic stress. ..
  5. doi request reprint Magnetic resonance imaging evaluation of renal structure and function related to disease: technical review of image acquisition, postprocessing, and mathematical modeling steps
    Richard A Jones
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Magn Reson Imaging 33:1270-83. 2011
    ..The overall objective is to provide a roadmap for future developments in this evolving field of novel MRI applications...
  6. doi request reprint Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT
    Fabio P Esteves
    Department of Radiology, Emory University School of Medicine, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    J Nucl Cardiol 17:247-53. 2010
    ..To compare the diagnostic accuracy of Rb-82 myocardial perfusion three-dimensional (3D) PET with and without prompt-gamma compensation (PGC)...
  7. pmc Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys
    Heather L Kimmel
    Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Synapse 66:501-8. 2012
    ..These studies also indicate that acute cocaine administration decreases the availability of plasma membrane DAT for binding, even after cocaine is no longer blocking DA uptake as evidence by a return to basal DA levels...
  8. pmc Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter
    Fanxing Zeng
    Department of Radiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 52:62-73. 2009
    ..PET imaging in awake monkeys suggested that anesthesia influenced the binding potential of [(11)C]1 and [(11)C]4 at the NET...
  9. ncbi request reprint Comparison of low-pitch and respiratory-averaged CT protocols for attenuation correction of cardiac PET studies
    Jonathon A Nye
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    Med Phys 36:1618-23. 2009
    ..This study shows good agreement and negligible bias between low-pitch HCT and ACT protocols for attenuation correction of cardiac PET data...
  10. pmc Cortical activation during cocaine use and extinction in rhesus monkeys
    Leonard L Howell
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Psychopharmacology (Berl) 208:191-9. 2010
    ..Neuroimaging studies have begun to define neurobiological substrates underlying the acute effects of cocaine or cocaine cues in cocaine-dependent subjects...
  11. doi request reprint Magnetic resonance nephrourographic techniques and applications: how we do it
    Bobby Kalb
    Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Top Magn Reson Imaging 20:59-69. 2009
    ....
  12. pmc Acute brain metabolic effects of cocaine in rhesus monkeys with a history of cocaine use
    Porche Kirkland Henry
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Brain Imaging Behav 4:212-9. 2010
    ..The identification of brain regions progressively influenced by drug exposure may be highly relevant toward efforts to develop treatments for cocaine addiction...
  13. pmc Differences in neural activation for object-directed grasping in chimpanzees and humans
    Erin E Hecht
    Department of Anthropology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 33:14117-34. 2013
    ..This indicates a more "bottom-up" representation of observed action in the human brain and suggests that the evolution of tool use, social learning, and cumulative culture may have involved modifications of frontoparietal interactions. ..
  14. doi request reprint Magnetic resonance nephrourography: current and developing techniques
    Bobby Kalb
    Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Radiol Clin North Am 46:11-24, v. 2008
    ....
  15. pmc Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain
    Jonathon A Nye
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Nucl Med 49:2018-25. 2008
    ..The purpose of this study was to develop a reliable kinetic model to describe the uptake of (11)C-HOMADAM in the healthy human brain...
  16. doi request reprint Posterior bladder layering of excreted 18F-FDG on PET/CT
    Wanzhen Zeng
    Department of Radiology, Emory School of Medicine, Atlanta, Georgia, USA
    Nucl Med Commun 31:859-63. 2010
    ..This study was carried out to determine the frequency, characteristics and possible causes and clinical significance of occasionally observed posterior layering of excreted 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) in the bladder...
  17. pmc Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys
    Gunasingh J Masilamoni
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Brain 134:2057-73. 2011
    ..This suggests that the use of metabotropic glutamate receptor 5 antagonists may be a useful strategy to reduce degeneration of catecholaminergic neurons in Parkinson's disease...
  18. ncbi request reprint Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    Nachwa Jarkas
    Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:211-24. 2005
    ..Carbon-11-labeled N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (HOMADAM) was synthesized as a new serotonin transporter (SERT) imaging agent...
  19. ncbi request reprint Initial experience with the radiotracer anti-1-amino-3-[18F]Fluorocyclobutane-1-carboxylic acid (anti-[ 18F]FACBC) with PET in renal carcinoma
    David M Schuster
    Department of Radiology, Division of Nuclear Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Imaging Biol 11:434-8. 2009
    ..The present study examines anti-[(18)F]FACBC positron emission tomography uptake in patients with renal masses...
  20. ncbi request reprint Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography
    Nachwa Jarkas
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:75-86. 2005
    ..These results support the candidacy of [11C]EADAM as a radioligand for visualizing brain SERT using PET...
  21. ncbi request reprint Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans
    John R Votaw
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA
    Anesthesiology 101:1128-35. 2004
    ..The purpose of this study was to determine the dose-response curve for isoflurane altering the binding potential of one of these ligands ([F-18]FECNT) in humans...
  22. ncbi request reprint Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter
    Jonathan McConathy
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 31:705-18. 2004
    ..Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies...
  23. ncbi request reprint Isoflurane induces dopamine transporter trafficking into the cell cytoplasm
    Michael G Byas-Smith
    Department of Anesthesiology, Emory University Hospital, Emory University School of Medicine, Atlanta, Georgia 30022, USA
    Synapse 53:68-73. 2004
    ....
  24. ncbi request reprint Biodistribution and radiation dosimetry of the synthetic nonmetabolized amino acid analogue anti-18F-FACBC in humans
    Jonathon A Nye
    Division of Nuclear Medicine, Department of Radiology, Emory University, Atlanta, Georgia 30030, USA
    J Nucl Med 48:1017-20. 2007
    ..This study evaluated the whole-body radiation burden of anti-(18)F-FACBC in humans...
  25. ncbi request reprint Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT
    Margaret R Davis
    PET Center, Emory University, Atlanta, Georgia, USA
    J Nucl Med 44:855-61. 2003
    ....
  26. ncbi request reprint Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography
    Mark M Goodman
    Department of Radiology, Emory University, Atlanta, Georgia 30320, USA
    J Med Chem 46:925-35. 2003
    ..The high specific activity one-step radiolabeling preparation and high selectivity of [(123)I]ZIENT for SERT support its candidacy as a radioligand for mapping brain SERT sites...
  27. ncbi request reprint Initial experience with the radiotracer anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid with PET/CT in prostate carcinoma
    David M Schuster
    Division of Nuclear Medicine, Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Nucl Med 48:56-63. 2007
    ..There is little renal excretion compared with (18)F-FDG. The present study examines anti-(18)F-FACBC uptake in patients with newly diagnosed and recurrent prostate carcinoma...
  28. ncbi request reprint A comparison of AAPM TG-108 PET/CT shielding recommendations to measurements in an oncology center
    Jonathon A Nye
    Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Med Phys 36:5017-21. 2009
    ..This study compares TG-108 shielding calculations to measured data from an oncology PET/CT scanner...
  29. ncbi request reprint Individual kidney blood flow measured with contrast-enhanced first-pass perfusion MR imaging
    Diego R Martin
    Department of Radiology, Emory University School of Medicine, Building A, AT 622, 1365 Clifton Rd NE, Atlanta, GA 30322, USA
    Radiology 246:241-8. 2008
    ..This study demonstrates feasibility of the gadolinium chelate perfusion method for RBF measurement and discusses potential applications. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/246/1/241/DC1...
  30. pmc Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomograph
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, GA, USA
    J Med Chem 51:7788-99. 2008
    ..Chase studies with the SERT ligand 15 displaced [(18)F]1-[(18)F]4, but chase studies with the DAT ligand 16 did not displace [(18)F]1-[(18)F]4 thus indicating that the tracers were binding specifically to the SERT...
  31. ncbi request reprint Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent
    Christophe Plisson
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Med Chem 50:4553-60. 2007
    ..The in vivo evaluation of [18F]1 indicates that this radiotracer is a good candidate for mapping and quantifying CNS SERT...
  32. ncbi request reprint Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging
    Kimberly P Lindsey
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 309:959-69. 2004
    ..Moreover, the behavioral profile of DAT inhibitors may be influenced by actions at other monoamine transporters...
  33. pmc MR∕PET quantification tools: registration, segmentation, classification, and MR-based attenuation correction
    Baowei Fei
    Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Med Phys 39:6443-54. 2012
    ..This study is the development of quantification tools including MR-based AC for quantification in combined MR∕PET for brain imaging...
  34. pmc Face processing in the chimpanzee brain
    Lisa A Parr
    Yerkes National Primate Research Center, Atlanta, GA 30329, USA
    Curr Biol 19:50-3. 2009
    ..This pattern suggests similar object form topography in the ventral temporal cortex of chimpanzees and humans, in which faces may represent a special class of visual stimulus...
  35. ncbi request reprint Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 (N-fluoroalkyl) labeled 2beta-carbomethoxy-3beta-(4'-(3-furyl)phenyl)tropanes and -nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    J Med Chem 48:7080-3. 2005
    ..Radiolabeling and microPET brain imaging studies were performed with [(11)C]1, [(11)C]2, and [(18)F]3 to determine their utility as in vivo imaging agents...
  36. ncbi request reprint Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter
    Christophe Plisson
    Department of Radiology, Emory University, Atlanta, Georgia 30320, USA
    J Med Chem 47:1122-35. 2004
    ....
  37. ncbi request reprint Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands
    Nachwa Jarkas
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 51:271-81. 2008
    ....
  38. pmc Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain
    Fang Wu
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 32:9848-58. 2012
    ..Our data indicate that tPA activates a cell signaling pathway that allows neurons to sense and adapt to oxygen and glucose deprivation...
  39. ncbi request reprint Investigation of emission-transmission misalignment artifacts on rubidium-82 cardiac PET with adenosine pharmacologic stress
    David M Schuster
    Department of Radiology, Division of Nuclear Medicine, Emory University, Atlanta, GA, USA
    Mol Imaging Biol 10:201-8. 2008
    ..This study was undertaken to determine if artifacts from misalignment of cardiac emission to transmission data is present in adenosine stress studies and if the artifact could be reproduced by intentional misalignment in normal exams...
  40. ncbi request reprint Minimizing artifacts resulting from respiratory and cardiac motion by optimization of the transmission scan in cardiac PET/CT
    Jonathon A Nye
    Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, Georgia 30030, USA
    Med Phys 34:1901-6. 2007
    ..Further reduction in artifacts arising from cardiac drift is required and warrants an image registration solution...
  41. pmc Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys
    Heather L Kimmel
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 90:453-62. 2008
    ..Collectively, these results indicate that the rate of drug entry in brain can play an important role in the behavioral pharmacology of psychomotor stimulants...
  42. ncbi request reprint Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography
    Jeffrey S Stehouwer
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 49:6760-7. 2006
    ..Chase studies with citalopram and methylphenidate demonstrated that this uptake is the result of preferential binding to the SERT...
  43. ncbi request reprint The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies
    Thomas R Henry
    Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, Suite 6000, PO Drawer V, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuroimaging Clin N Am 14:517-35, ix. 2004
    ..The volume of reduced glucose metabolism is often widespread and even bilateral in focal epilepsies, although ictal onset zones typically are located at the sites of most severe hypometabolism within a larger volume of hypometabolism...
  44. ncbi request reprint Functional brain imaging alterations in acne patients treated with isotretinoin
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 162:983-91. 2005
    ..The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients...
  45. ncbi request reprint Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 17:3044-7. 2007
    ..Despite high in vitro affinity for the human NET, the high uptake of [(11)C]1 in the caudate and putamen excludes its use as an in vivo PET imaging agent for the NET...
  46. ncbi request reprint Donepezil HCl (E2020) maintains functional brain activity in patients with Alzheimer disease: results of a 24-week, double-blind, placebo-controlled study
    Larry Tune
    Wesley Woods Center at Emory University, Atlanta, GA, USA
    Am J Geriatr Psychiatry 11:169-77. 2003
    ..The authors evaluated the effects of donepezil (10 mg/day) versus placebo on brain glucose metabolism...
  47. doi request reprint Effect of menstrual cycle on resting brain metabolism in female rhesus monkeys
    James K Rilling
    Department of Anthropology, Emory University, Atlanta, Georgia 30322, USA
    Neuroreport 19:537-41. 2008
    ..In summary, the data suggest that in primates, fluctuations of ovarian hormones across the menstrual cycle influence activity in brain areas involved in emotion and its regulation...
  48. ncbi request reprint Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 16:3015-8. 2006
    ..Radiolabeling, in vitro film autoradiography, and micro-PET study were performed with [18F]FPPIP to determine its utility as a radioligand for amyloid plaque imaging in the brain of AD patients...
  49. pmc A comparison of resting-state brain activity in humans and chimpanzees
    James K Rilling
    Department of Anthropology, Center for Behavioral Neuroscience, Division of Psychobiology, Yerkes National Primate Research Center, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:17146-51. 2007
    ..Our results raise the possibility that the resting state of chimpanzees involves emotionally laden episodic memory retrieval and some level of mental self-projection, albeit in the absence of language and conceptual processing...
  50. ncbi request reprint In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys
    Kristin M Wilcox
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Synapse 58:220-8. 2005
    ..Overall, reinforcing effects were consistent with DAT effects determined with in vivo techniques. The results further support a role for the DAT in the abuse liability of local anesthetics...
  51. ncbi request reprint Task-specific recruitment of dorsal and ventral visual areas during tactile perception
    S C Prather
    Department of Neurology, Emory University School of Medicine, WMRB 6000, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuropsychologia 42:1079-87. 2004
    ..Activation of these areas in both visual and tactile tasks could reflect visual imagery during tactile perception, activity in multisensory representations, or both...
  52. ncbi request reprint Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents
    Jonathan McConathy
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:593-605. 2005
    ..Despite high in vitro affinity for the human NET, the uptake of [(11)C]3-BrPA in the brain and the heart was not displaceable with pharmacological doses of NET antagonists...
  53. ncbi request reprint A preliminary study of anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid for the detection of prostate cancer
    Shuntaro Oka
    Research Center, Nihon Medi physics Co, Ltd, Sodegaura, Kitasode, Chiba, Japan
    J Nucl Med 48:46-55. 2007
    ..Furthermore, using in vivo experiments, we examined the potential of anti-(18)F-FACBC for differentiating between PCa and inflammation and between PCa and benign prostatic hyperplasia (BPH)...
  54. ncbi request reprint AAPM Task Group 108: PET and PET/CT shielding requirements
    Mark T Madsen
    Radiology, University of Iowa, USA
    Med Phys 33:4-15. 2006
    ..Careful planning with the equipment vendor, facility architect, and a qualified medical physicist is necessary to produce a cost effective design while maintaining radiation safety standards...
  55. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  56. ncbi request reprint Regularized image reconstruction algorithms for positron emission tomography
    Ji Ho Chang
    Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
    IEEE Trans Med Imaging 23:1165-75. 2004
    ..In experiments using synthetic data and real phantom data, it was found that, for a fixed level of background noise, the contrast in the images produced by the proposed algorithms was the most accurate...